Exenterative surgery to improve quality of life on men with locally advanced, symptomatic castration-resistant prostate cancer.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 77-77
Author(s):  
Friederike Haidl ◽  
Florian Hartmann ◽  
David A. Pfister ◽  
Axel Heidenreich
Keyword(s):  
Quality Of Life ◽  
Statistical Tests ◽  
Symptom Relief ◽  
Locally Advanced ◽  
Well Being ◽  
Preoperative Imaging ◽  
Free Survival ◽  
Castration Resistant ◽  
Local Progression

77 Background: Invasion of the urinary bladder and/or the rectum by locally advanced castration sensitive (CSPC) or castration resistant PCA (CRPC) can result in debilitating symptoms with a significant negative impact on the patient’s well-being. Local progression might develop despite the application of new life prolonging agents. It was the purpose to retrospectively review the surgical and oncological outcome following pelvic exenteration surgery (PES) for locally advanced and symptomatic CRPC. Methods: Retrospective, single-centre, dual surgeon study of 103 men with symptomatic locally progressive and symptomatic CS- and CRPC treated between 2008 and 2019. Primary endpoint was symptomatic free survival (SFS) and the secondary endpoint were overall survival (OS) and complications defined by Clavien-Dindo criteria. Statistical tests were two-tailed with a p-value <0.05 considered to indicate significance. Symptom-free survival and cancer specific survival were calculated using Kaplan-Meier analysis. Results: 9 (8.7%), 71 (68.8%) and 21 (22.4%) patients underwent radical prostatectomy, radical cystoprostatectomy or anterior and posterior exenteration, resp. After a median follow-up of 36.5 (3 – 123) months, the SFS at 1 and 3 years was 89.2% (n=89) and 64.1% (n=66). The median SFS was 27.9 months. 78.6% of the patients were symptom-free during their remaining lifetime. OS at 1 and 3 years was 92.2% and 43.7%, respectively, and the median OS was 33.6 months. Clavien-Dindo grade 2, 3 and 4 complications developed in 31 (30.6%), 12 (12%) and 8 (8.1%), respectively. Conclusions: PES is a technically feasible approach in well-selected patients resulting in symptom relief of > 90% of patients which covered almost 80% of the remaining life time. Adequate preoperative imaging studies, endoscopic evaluation and extensive surgical experience is mandatory to achieving a benefit for the individual patient with improvement of quality of life.

scholarly journals Singing as a health-promoting activity in elderly care: a qualitative, longitudinal study in Norway

2020 ◽  
Vol 25 (5) ◽  
pp. 404-418
Author(s):  
Kari Bjerke Batt-Rawden ◽  
Kristi Stedje
Keyword(s):  
Quality Of Life ◽  
Nursing Homes ◽  
Elderly Care ◽  
Symptom Relief ◽  
Well Being ◽  
Educational Programme ◽  
Standards Of Care ◽  
Older Person ◽  
Positive Effects

Background The current standards of care of the older person recommend employing non-pharmacological approaches to challenges, including safe approaches to managing pain and stress, enhancing symptom relief, and fostering independent lifestyles with the highest quality of life possible. More research is needed to enable nurses and other medical staff to use singing and music-based interventions, to access singing-based programmes, and promote a greater use of choirs in nursing homes. A solid basis of positive experiences and feedback through evidence in practice is required to help promote support for such activities. Aims To identify, explore and describe experiences, attitudes, beliefs, issues, processes and changes among nurses, carers and leaders in reference to implementation of the educational programme ‘Singing Nursing Homes’, Norway. To increase knowledge and understanding of how an educational song programme could become an integral part of nursing practice and quality of care in nursing and care homes, and identify why this would be constructive. Since its inception in 2015, ‘Singing Norway’ wanted to offer a professional, evidence-based programme for nursing homes throughout the country. Methods A longitudinal, qualitative and explorative approach. In-depth interviews and focus group interviews of female employees ( n = 19) from three nursing homes in Norway, 2018. Results Nursing home employees perceived singing to have potential benefits for their patients, such as reducing uneasiness, increased comfort, well-being and joy, improved sleep, and believed singing had the potential to reduce the need for medication and prevent accidents among their patients. By facilitating opportunities for learning and practice, staff in nursing homes were able to use singing as part of their ‘art of caring’, enhancing environmental care for the older person. Singing was found to have positive effects for the patients, their relatives and the staff, which improved the psychosocial working climate overall. Conclusions Singing interventions could be a vital component for the enhancement of health, well-being and quality of life for the patients and staff in nursing homes.

Quality of Life after Laparoscopic Cholecystectomy for Biliary Dyskinesia in the Pediatric Population: A Pilot Study

2012 ◽  
Vol 78 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Damian Maxwell ◽  
Stephanie Thompson ◽  
Bryan Richmond ◽  
Jillian McCagg ◽  
Adam Ubert
Keyword(s):  
Quality Of Life ◽  
Laparoscopic Cholecystectomy ◽  
Pilot Study ◽  
Pediatric Population ◽  
Symptom Relief ◽  
Well Being ◽  
Biliary Dyskinesia ◽  
Gallbladder Ejection Fraction

This pilot study examined symptom relief and quality of life in pediatric patients who received laparoscopic cholecystectomy surgery at our institution for biliary dyskinesia. We used two validated questionnaires: the Child Health Questionnaire (CHQ-PF28), to assess general well-being, and the Gastrointestinal Quality of Life Index (GIQLI), to measure gastrointestinal-related health. After Institutional Review Board approval, all patients under the age of 18 years who underwent laparoscopic cholecystectomy for biliary dyskinesia between November 2006 and May 2010 received mailed questionnaires. Preoperative and postoperative data were retrospectively collected from respondents and included age, race, symptoms, gallbladder ejection fraction values, pathologic findings, and clinical course. Of 89 patients meeting inclusion criteria, 21 responded. Mean age at surgery was 13.08 years (range, 8 to 17 years). The most common preoperative symptoms consisted of nausea (100%), postprandial pain (90.5%), right upper quadrant pain (81.0%), and vomiting (66.7%). Mean long-term follow-up interval was 18.9 months (range, 7 to 40 months; SD 10.37). Patients with long-term symptom relief reported significantly higher GIQLI scores than those with enduring symptoms. Examination of the results from the CHQ-PF28 revealed significantly lower scores than a general U.S. pediatric sample in both the Physical and Psychosocial Summary Measures ( P < 0.05). Children experiencing long-term symptom cessation after laparoscopic cholecystectomy reported higher quality of life than those who had incomplete or only short-term relief. However, regardless of the degree of symptom relief, the degree of quality of life experienced by our study sample of patients with biliary dyskinesia is lower than that of a comparable U.S. pediatric sample.

Quality of life in poor prognosis patients with locally advanced non-small cell lung cancer (LA-NSCLC) undergoing a phase II study of concurrent cetuximab and definitive thoracic radiotherapy followed by docetaxel and cetuximab.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e17559-e17559
Author(s):  
Lora Thompson ◽  
Martine Extermann ◽  
Thomas J. Dilling ◽  
Jongphil Kim ◽  
Binglin Yue ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Locally Advanced ◽  
Well Being ◽  
Thoracic Radiotherapy ◽  
Significant Difference ◽  
Specific Symptoms

e17559 Background: A single institution prospective clinical trial was conducted to examine the safety and efficacy of concurrent cetuximab and definitive thoracic radiotherapy followed by docetaxel plus cetuximab. Quality of life (QOL) was assessed as a secondary endpoint. Survival and toxicity data are presented separately. Methods: Eligible pts with unresectable stage IIA or IIIB LA-NSCLC, who also had ECOG PS 2 OR weight loss ≥5% in 3 months OR age >70, completed QOL measures at baseline, after concurrent cetuximab/radiotherapy (recovery), and after docetaxol/cetuximab (consolidation). Scores were calculated for Activities of Daily Living (ADL), Instrumental Activities of Daily Living (IADL), Fatigue Symptom Inventory (FSI) worst fatigue, FSI fatigue interference, and Functional Assessment of Cancer Therapy – Lung Trial Outcome Index (FACT-L TOI). FACT-L TOI assessed physical (e.g., nausea) and functional (e.g., difficulty sleeping) well-being as well as lung cancer specific symptoms (e.g., shortness of breath, cough). Descriptive and t-test results are presented. Results: Pts (N = 27) were primarily male (67%) and non-Hispanic Caucasian (96%) with mean age of 73 years. High attrition between recovery (N = 22) and consolidation (N = 10) occurred. Compared to baseline, pts reported higher levels of worst fatigue (p < .03) and fatigue interference (p = .01) at recovery. There was a decline in IADLs (p = .01) but no significant difference in ADLs or FACT-L TOI. Further examination of FACT subscales revealed declines in physical (p < .0001) and functional (p = .02) well-being but improvement in lung cancer specific symptoms (p < .0001). A similar pattern is found for comparisons between baseline and consolidation (ps < .05). There were no significant differences between recovery and consolidation. Conclusions: Although pts experienced declines in QOL across most domains after concurrent cetuximab and radiotherapy, there was improvement in lung cancer specific symptoms. Pts were also able to maintain their ability to perform ADLs. High attrition after recovery is a notable limitation.

Quality of life study in patients with unresectable locally advanced or metastatic pancreatic cancer treated with gemcitabine in combination with nab-paclitaxel versus gemcitabine alone:ax-panc-sy001: A phase II randomized study.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 346-346 ◽  
Author(s):  
Suayib Yalcin ◽  
Faysal Dane ◽  
Berna Oksuzoglu ◽  
Nuriye Yildirim ◽  
Abdurrahman Isikdogan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pancreatic Cancer ◽  
Disease Progression ◽  
Response Rate ◽  
Locally Advanced ◽  
Hazard Ratio ◽  
Combination Group ◽  
Combination Regimen ◽  
Free Survival

346 Background: Although clinical efficacy of gemcitabine in combination with nabpaclitaxel has been shown to be superior to single agent gemcitabine in a randomize phase 3 trial, data are lacking on the quality of life of this combination regimen as first-line therapy in patients with unresectable locally advanced or metastatic pancreatic adenocarcinoma. Methods: We randomly assigned 125 patients with an Eastern Cooperative Oncology Group performance status score of 0 or 1 to receive gemcitabine, 1000 mg/m2 plus nabpaclitaxel 125 mg/m2 or gemcitabine at a dose of 1000 mg per square meter weekly for 7 of 8 weeks and then weekly for 3 of 4 weeks. Treatment continued until disease progression or unacceptable toxicity. The primary end point was 3-months deterioration-free rate (percentage of patients free from definitive deterioration) and quality of life of patients. Results: The median overall survival was 9.92 months in the gemcitabine plus nabpaclitaxel group as compared with 5.95 months in the gemcitabine group (hazard ratio for death, 0.642, 95% confidence interval, 0.422 to 0.866; p < 0.038). Median progression-free survival was 6.28 months in the combination group and 3.22 months in the gemcitabine group (hazard ratio for disease progression, 0.582; 95% CI, 0.391 to 0.866; p < 0.008). The objective response rate was 37.1% in the combination group versus 23.7% in the gemcitabine group (p < 0.009). Median time to deterioration was 3.68 months in the gemcitabine arm versus 5.36 months in the combination arm. More data on quality of life will be presented. Conclusions: As compared with gemcitabine, gemcitabine plus nabpaclitaxel was associated with an overall and progressive free survival advantage, with increased response rate, without increasing toxicity and deterioration of quality of life. Gemcitabine and nabpaclitaxel combination regimen with this form is a preferable option for the treatment of patients with advanced pancreatic cancer Clinical trial information: EudraCT: 2013-004180-32.

Health-related quality of life and caregiver perspectives in glioblastoma survivors: a mixed-methods study

2019 ◽  
pp. bmjspcare-2019-001777
Author(s):  
Karin Piil ◽  
Ib Jarle Christensen ◽  
Kirsten Grunnet ◽  
Hans Skovgaard Poulsen
Keyword(s):  
Quality Of Life ◽  
Progression Free Survival ◽  
Well Being ◽  
Mixed Methods Study ◽  
Health Related Quality ◽  
Free Survival ◽  
Related Quality ◽  
Health Related

BackgroundThe purpose of antineoplastic treatment of high-grade glioma (HGG) is to achieve progression-free survival with delayed neurological and cognitive deterioration. Health-related quality of life (HRQOL) has become increasingly important next to more traditional outcome measures such as progression-free survival. However, the clinical outcome of long-term, HGG survivors and their caregivers’ quality of life is poorly understood.ObjectiveThis study aims to address HRQOL and perspectives on the daily life experiences of long-term survivors (LTS) with HGG and their caregivers.MethodsThis mixed-methods study applies a convergent design using identical sampling. Separate telephone interviews with patients diagnosed for more than 3 years and their caregivers were conducted. Patients filled out self-reported questionnaires; the Hospital Anxiety and Depression Scale, the Functional Assessment of Cancer Therapy (FACT), General and Brain (FACT-Br), and the Leisure Time Physical Activity Questionnaire.ResultsThree themes shared by patients and their caregivers were identified: searching for meaningful activities, selecting information that enhances self-management strategies and protection for safety reasons. Ten per cent showed moderate depressive symptoms, which is lower compared with the newly diagnosed. The HRQOL scores seem to be rated higher than the normative sample. The FACT-Br total score indicated that a previously identified significant increase in the emotional well-being of 1-year survivors was the same or improved. A central finding is that the LTS expressed frustration and sadness due to their reduced ability to manage work and daily life activities. Caregivers are challenged throughout the entire trajectory, and patient safety issues are a key concern for them.ConclusionsThe LTS desire participation in satisfying, meaningful activities that consider their cognitive and physical capacities. Advance care planning must be a key component in future research, as discussing life strategies can enhance positive beliefs, which are apparently imperative to their well-being.Trial registration number Clinical Trial.gov: NCT02965144

scholarly journals Quality of life of family caregivers of children with microcephaly

2021 ◽  
Vol 43 ◽  
pp. e54159
Author(s):  
Layla Beatriz Melo de Oliveira ◽  
Aline Costa de Oliveira ◽  
Daniel de Macêdo Rocha ◽  
Márcia Teles de Oliveira Gouveia ◽  
Rosana dos Santos Costa ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Family Caregivers ◽  
Short Form ◽  
Statistical Tests ◽  
Descriptive Analysis ◽  
Well Being ◽  
Daily Basis ◽  
Cross Sectional Study ◽  
Cross Sectional

Assess the quality of life of family caregivers of children with microcephaly. This is an analytical cross-sectional study developed in Teresina-PI, carried out in a rehabilitation center. For data collection a form was used to investigate the sociodemographic profile and the Medical Outcomes Study 36 - Item Short-Form Health Survey instrument to assess quality of life. For data analysis, we used the statistical tests Student's t, ANOVA, U- Mann Whitney and Kruskal-Wallis. The descriptive analysis of the results showed that the functional capacity domain presented the most impairment by obtaining the highest score. The dimensions vitality and pain showed the lowest averages, representing the less affected domains. The associations between the sociodemographic characteristics and the domains of quality of life were significant between the variables marital status and pain, education and the domains vitality and emotional aspect, and between employment status and general health status. The quality of life of family caregivers presented losses related to the change of routine and the difficulties faced on a daily basis, highlighting the importance of covering the health of caregivers within the assistance offered to children with special needs, contributing to the well-being of those who care and consequently of those who are cared for.

Joint Ventures: Helping Those With Rheumatoid Arthritis Live Well

2013 ◽  
Vol 23 (2) ◽  
pp. 91-100 ◽  
Author(s):  
Aggie Stewart
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Stress Reduction ◽  
Symptom Relief ◽  
Well Being ◽  
Inflammatory Disorder ◽  
Yoga Therapy ◽  
Chronic Inflammatory Disorder ◽  
Stiffness Loss

Objectives: Rheumatoid arthritis (RA) is an autoimmune, chronic inflammatory disorder that causes pain, swelling, stiffness, loss of joint function, and reduced quality of life. Yoga therapy may help individuals with RA manage stress and increase well-being. This study focused on the identification of therapeutic objectives and a methodology to achieve symptom relief, regain function, and enhance quality of life for individuals with RA. Methods: Four women with RA participated in private yoga therapy sessions for 2.5 months. Assessment based, tailored home practices were developed and modified to address participant - identified goals. Results: Participants reported decreased pain, fatigue, swelling, and flares; increased energy; pain-free range of motion and strength around affected joints; and a heightened sense of well-being. Conclusions: Tailored yoga therapy that emphasizes stress reduction may be beneficial for individuals with RA.

scholarly journals Neuropsychiatric symptoms, quality of life and caregivers’ burden in dementia

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 905-914
Author(s):  
Réka Majer ◽  
Olar Adeyi ◽  
Zsuzsa Bagoly ◽  
Viktória Simon ◽  
László Csiba ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rating Scale ◽  
Statistical Tests ◽  
Neuropsychiatric Symptoms ◽  
Well Being ◽  
Disease Assessment ◽  
Illness Intrusiveness ◽  
The Impact ◽  
The Relationship

AbstractThe objective of this research is to identify the relationship between the neuropsychiatric symptoms (NPSs) of patients with major neurocognitive disorder (mNCD), their quality of life, illness intrusiveness and the caregiver’s burden. We assessed 131 patients with mNCD. Examination methods included WHO well-being index short version, illness intrusiveness rating scale, Alzheimer’s Disease Assessment Scale-Cog, Mini Mental State Examination and neuropsychiatric inventory. The results were analysed using standard statistical tests. In our sample, the prevalence of NPSs is 100%. A significant correlation (p < 0.0001) was observed with quality of life and illness intrusiveness. Additionally, a strong relationship was observed between NPSs and the caregiver’s burden (r = 0.9). The result is significantly twice as much stronger in comparison to the relationship between NPS and cognitive symptoms (r = 0.4). This is the first study in Hungary to assess the impact of NPS on the burden of relatives and quality of life. NPS had twice stronger impact on caregivers’ burden than cognitive decline. However, further studies are needed to assess the sub-syndromes in mNCD in relation to NPS.

scholarly journals Kesejahteraan Psikologis dan Kualitas Hidup Penderita Diabetes Mellitus Type 2

2019 ◽  
Vol 1 (2) ◽  
pp. 256-265
Author(s):  
Sasmiyanto Sasmiyanto
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Diabetes Mellitus Type 2 ◽  
Statistical Tests ◽  
Well Being ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
Psychological Well Being

The purpose of this study is to prove the correlation between psychological well-being and quality of life of people with type 2 diabetes mellitus in Bondowoso. This type of research is a correlational study with a cross sectional approach. The results of the study based on statistical tests found the average value of the psychological well-being of clients 120.5778 which can be said to be quite good. The quality of life of respondents has an average score of 53,389 which can be said to be quite good. The results of statistical analysis show that the p value is 0.004. Conclusion, there is a significant relationship between psychological well-being and quality of life of people with diabetes mellitus. The effect of psychological effects on the condition of the body is huge.   Keywords: Diabetes Mellitus type 2, Psychological Well-being, Quality of Life

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