Patient and caregiver experience with an online, open-access, standardized, evidence-based, cancer drug and supportive care educational platform.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e18811-e18811
Author(s):  
Jeffrey A Gilreath ◽  
James A. Stuart ◽  
Brandon Wilds ◽  
Mimi Lo ◽  
Anthony Greenly ◽  
...  
Keyword(s):  
Open Access ◽  
Online Education ◽  
Supportive Care ◽  
English Language ◽  
Drug Information ◽  
Unmet Need ◽  
Cancer Drug ◽  
Evidence Based ◽  
Additional Information ◽  
Education Levels

e18811 Background: An open-access, web-based platform was developed to provide standardized, evidence-based information, that is cancer regimen-specific and supportive care focused. Online content was provided in the English language only for more than 200 anti-neoplastic regimens. A survey was conducted to determine reasons adult patients and their caregivers seek internet-based cancer drug information, and to evaluate if there is an unmet need for improved oncology therapy education. Methods: Between February 2020 and January 2021, patients and caregivers completed an online anonymous, English language survey deployed on the website www.chemoexperts.com. Results: A total of 1,021 website users responded. The majority of users were from North America (75%). Female respondents comprised 65% of the population and users self-identified as being a patient (67%), or family member/caregiver (33%). The mean age of respondents was 60.7 years (+ 16.2). Roughly two-thirds (66.4%) had a college degree. The majority of respondents reported they were either currently receiving (59.6%), or planning to receive (27.4%) treatment, however patients of all education levels, and in all phases of treatment (before, during, and after) sought online drug information. Clinical drug information education was reportedly provided by a doctor (68.9%), nurse (40.9%), physician assistant or nurse practitioner (23.8%), or pharmacist (15%), while 23% did not receive any education from clinical staff. Modes of education received by participants included printed material (73.9%), teaching in person (52.3%), and/or other internet sites (27.5%). Reasons for visiting the website were reported as follows: seeking additional information (92%), did not know what questions to ask (12%), looking at treatment alternatives (10%), forgot to ask questions (5%), not enough information given (11%), not enough time to ask questions (5%), and afraid to ask questions (2%). Respondents could mark all reasons. Among content sections, the percentage of users reported the side effect section as being the most useful. However, section usefulness varied based upon age, phase of treatment, and baseline education level. Overall, 86% reported finding the information they were looking for on the website. Conclusions: The majority of respondents received education from a health care provider, but not all. It is possible that the current pandemic prevented some patients from receiving education when in-person teaching was not available. However, many patients and caregivers still use the internet to seek additional drug information. These data highlight a continued unmet need for patients using online sources when searching for cancer drug and supportive care information. Further work is required to determine whether supplemental online, education can improve outcomes while reducing adverse effects.

The Speech-Language Assessment of English Language Learning Students: A Non-Standardized Approach

2013 ◽  
Vol 14 (4) ◽  
pp. 95-101 ◽  
Author(s):  
Robert Kraemer ◽  
Allison Coltisor ◽  
Meesha Kalra ◽  
Megan Martinez ◽  
Bailey Savage ◽  
...  
Keyword(s):  
Language Learning ◽  
Language Impairment ◽  
Specific Language Impairment ◽  
English Language ◽  
Language Assessment ◽  
The United States ◽  
English Language Learning ◽  
Assessment Practices ◽  
Evidence Based ◽  
English Speaking

English language learning (ELL) children suspected of having specific-language impairment (SLI) should be assessed using the same methods as monolingual English-speaking children born and raised in the United States. In an effort to reduce over- and under-identification of ELL children as SLI, speech-language pathologists (SLP) must employ nonbiased assessment practices. This article presents several evidence-based, nonstandarized assessment practices SLPs can implement in place of standardized tools. As the number of ELL children SLPs come in contact with increases, the need for well-trained and knowledgeable SLPs grows. The goal of the authors is to present several well-establish, evidence-based assessment methods for assessing ELL children suspected of SLI.

Cholangiokarzinome

Praxis ◽  
2002 ◽  
Vol 91 (34) ◽  
pp. 1352-1356
Author(s):  
Harder ◽  
Blum
Keyword(s):  
Supportive Care ◽  
Evidence Based Medicine ◽  
Best Supportive Care ◽  
Evidence Based ◽  
Systemische Chemotherapie ◽  
Chirurgische Resektion ◽  
Multimodale Therapiekonzepte ◽  
Based Medicine

Cholangiokarzinome oder cholangiozelluläre Karzinome (CCC) sind seltene Tumoren des biliären Systems mit einer Inzidenz von 2–4/100000 pro Jahr. Zu ihnen zählen die perihilären Gallengangskarzinome (Klatskin-Tumore), mit ca. 60% das häufigste CCC, die peripheren (intrahepatischen) Cholangiokarzinome, das Gallenblasenkarzinom, die Karzinome der extrahepatischen Gallengänge und das periampulläre Karzinom. Zum Zeitpunkt der Diagnose ist nur bei etwa 20% eine chirurgische Resektion als einzige kurative Therapieoption möglich. Die Lebertransplantation ist wegen der hohen Rezidivrate derzeit nicht indiziert. Die Prognose von nicht resektablen Cholangiokarzinomen ist mit einer mittleren Überlebenszeit von sechs bis acht Monaten schlecht. Eine wirksame Therapie zur Verlängerung der Überlebenszeit existiert aktuell nicht. Die wichtigste Massnahme im Rahmen der «best supportive care» ist die Beseitigung der Cholestase (endoskopisch, perkutan oder chirurgisch), um einer Cholangitis oder Cholangiosepsis vorzubeugen. Durch eine systemische Chemotherapie lassen sich Ansprechraten von ca. 20% erreichen. 5-FU und Gemcitabine sind die derzeit am häufigsten eingesetzten Substanzen, die mit einer perkutanen oder endoluminalen Bestrahlung kombiniert werden können. Multimodale Therapiekonzepte können im Einzellfall erfolgreich sein, müssen jedoch erst in Evidence-Based-Medicine-gerechten Studien evaluiert werden, bevor Therapieempfehlungen für die Praxis formuliert werden können.

scholarly journals Intelligibility in English as a lingua franca – The interpreters’ perspective

2020 ◽  
Vol 9 (2) ◽  
pp. 173-193
Author(s):  
Karin Reithofer
Keyword(s):  
English Language ◽  
Language Skills ◽  
Background Knowledge ◽  
Evidence Based ◽  
Training Methods ◽  
Lingua Franca ◽  
Factors Affecting ◽  
Specialist Knowledge ◽  
Written Questions ◽  
Subordinate Role

AbstractThis article aims at examining the topic of ELF intelligibility from the interpreters’ perspective. Therefore, the focus is put on listener factors affecting intelligibility in settings typical for interpreting i.e. monologic settings. Data from various intelligibility studies are compared with results from a study that tested an ELF user’s intelligibility in a conference-like ELF setting and examined the influence of listener variables such as background knowledge, familiarity with ELF use or proficiency in English. In this study, an Italian speaker gave an impromptu speech in English to participants who subsequently were asked to answer written questions on the topic. The results showed that listeners with more experience in ELF settings reached the highest score in the test, while participants with specialist knowledge were unable to profit from it. The participants’ English language skills played a rather subordinate role. The findings of this study may prove useful for considerations in interpreter training and can contribute to the development of concrete, evidence-based training methods for interpreters in the interpreting sub-skill of comprehension.

Recent Advances: Antiinfectives

1995 ◽  
Vol 29 (10) ◽  
pp. 1035-1040 ◽  
Author(s):  
Laurie L Briceland ◽  
John D Cleary ◽  
Courtney V Fletcher ◽  
Daniel P Healy ◽  
Charles A Peloquin
Keyword(s):  
Infectious Diseases ◽  
English Language ◽  
Data Extraction ◽  
Information Service ◽  
Ulcer Disease ◽  
Additional Information ◽  
Study Selection ◽  
Enterococcus Spp ◽  
Scientific Meetings ◽  
Clinically Significant

Objective: To update readers on the significant changes in infectious diseases pharmacotherapy. Data Sources: An Index Medians and Iowa Drug Information Service search (1993–1994) of English-language literature pertaining to the selected topic areas was performed. Additional information from abstracts presented at scientific meetings were identified by the authors. Study Selection and Data Extraction: All identified studies were screened and those judged relevant to the update were evaluated. Data Synthesis: New or clinically significant data since 1992 that related to peptic ulcer disease, microbial resistance (e.g., Enterococcus spp., Streptococcus pneumoniae, Mycobacterium tuberculosis, Candida albicans), immunomodulators, and AIDS were evaluated and compared with previous data. Conclusions: There have been several exciting and significant changes in infectious diseases pharmacotherapy evident from this review.

Patients' Supportive Care Needs Beyond the End of Cancer Treatment: A Prospective, Longitudinal Survey

2009 ◽  
Vol 27 (36) ◽  
pp. 6172-6179 ◽  
Author(s):  
Jo Armes ◽  
Maggie Crowe ◽  
Lynne Colbourne ◽  
Helen Morgan ◽  
Trevor Murrells ◽  
...  
Keyword(s):  
Negative Affect ◽  
Supportive Care ◽  
Unmet Needs ◽  
Unmet Need ◽  
Hormone Treatment ◽  
Longitudinal Survey ◽  
Supportive Care Needs ◽  
Fear Of Recurrence ◽  
Care Needs ◽  
Prospective Longitudinal

Purpose To estimate prevalence and severity of patients' self-perceived supportive care needs in the immediate post-treatment phase and identify predictors of unmet need. Patients and Methods A multicenter, prospective, longitudinal survey was conducted. Sixty-six centers recruited patients for 12 weeks. Patients receiving treatment for the following cancers were recruited: breast, prostate, colorectal, and gynecologic cancer and non-Hodgkin's lymphoma. Measures of supportive care needs, anxiety and depression, fear of recurrence, and positive and negative affect were completed at the end of treatment (T0) and 6 months later (T1). Results Of 1,850 patients given questionnaire packs, 1,425 (79%) returned questionnaires at T0, and 1,152 (62%) returned questionnaires at T1. Mean age was 61 years; and most respondents were female (69%) and had breast cancer (57%). Most patients had no or few moderate or severe unmet supportive care needs. However, 30% reported more than five unmet needs at baseline, and for 60% of these patients, the situation did not improve. At both assessments, the most frequently endorsed unmet needs were psychological needs and fear of recurrence. Logistic regression revealed several statistically significant predictors of unmet need, including receipt of hormone treatment, negative affect, and experiencing an unrelated significant event between assessments. Conclusion Most patients do not express unmet needs for supportive care after treatment. Thirty percent reported more than five moderate or severe unmet needs at both assessments. Unmet needs were predicted by hormone treatment, negative mood, and experiencing a significant event. Our results suggest that there is a proportion of survivors with unmet needs who might benefit from the targeted application of psychosocial resources.

Application of Bacterial Nanocellulose in the Cancer Drug Delivery: A Review

2021 ◽  
Vol 27 ◽  
Author(s):  
Mina Shahriari-Khalaji ◽  
Maryam Zarkesh ◽  
Zahra Nozhat
Keyword(s):  
Drug Delivery ◽  
English Language ◽  
High Ratio ◽  
Cancer Drug ◽  
Chemical Components ◽  
Bacterial Nanocellulose ◽  
Review Study ◽  
Cancer Drug Delivery ◽  
Pharmaceutical Agents ◽  
Key Terms

: Bacterial nanocellulose (BNC) is one of the natural biopolymers with unique features, the most important of which are nontoxicity, biocompatibility, high tensile profile, nanofiber structure, and purity. The current review aimed to summarize the latest development in BNC-based biomaterials in cancer drug delivery. The original articles were found by searching key databases including PubMed, Scopus, and Web of Scientific and using key terms such as “bacterial nanocellulose OR bacterial cellulose OR BNC” AND “cancer OR carcinoma OR tumor”. The obtained data were in a wide timeframe and the English language. Totally, 350 articles were found from the three main databases (i.e., 106, 251, and 173 articles from PubMed, Scopus, and the Web of Science, respectively). In general, 32 articles met the inclusion criteria after duplicate removal and screening according to the aim of the present review study. In this review study, different applications of the bacterial nanocellulose were considered for cancer drug delivery in addition to describing advanced methods that may be applied to improve therapeutic potency while reducing the adverse effects of chemodrugs by decreasing their dosages. The high ratio of the surface area-to-volume and easy modifications of their chemical components lead BNC potential use as an appropriate matrix structure for the binding and controlled release of various pharmaceutical agents, specifically for topical or transdermal administrations. In addition, BNC-based products regulate the release of hydrophobic and hydrophilic compounds, therefore, provide appropriate materials related to cancer drug delivery. However, undoubtedly, further developments of BNC-based products as cancer drug delivery systems require more extensive investigations.

scholarly journals Biomarkers for sepsis: past, present and future

2016 ◽  
Vol 10 (4) ◽  
pp. 301 ◽  
Author(s):  
Giuseppe Chesi ◽  
Natale Vazzana ◽  
Claudio Giumelli
Keyword(s):  
Clinical Practice ◽  
Risk Stratification ◽  
Supportive Care ◽  
Early Identification ◽  
Antibiotic Stewardship ◽  
Treatment Strategies ◽  
Severe Infection ◽  
Antibiotic Use ◽  
Evidence Based ◽  
Drug Resistant

Sepsis is a complication of severe infection associated with high mortality and open diagnostic issues. Treatment strategies are currently limited and essentially based on prompt recognition, aggressive supportive care and early antibiotic treatment. In the last years, extensive antibiotic use has led to selection, propagation and maintenance of drug-resistant microorganisms. In this context, several biomarkers have been proposed for early identification, etiological definition, risk stratification and improving antibiotic stewardship in septic patient care. Among these molecules, only a few have been translated into clinical practice. In this review, we provided an updated overview of established and developing biomarkers for sepsis, focusing our attention on their pathophysiological profile, advantages, limitations, and appropriate evidence-based use in the management of septic patients.

scholarly journals quantitative analysis of the open access business and economics journals

2015 ◽  
Vol 9 (1) ◽  
Author(s):  
Fayaz Ahmad LOAN ◽  
Refhat- UN-NISA ◽  
Asmat ALI
Keyword(s):  
Open Access ◽  
Online Survey ◽  
English Language ◽  
Actual Number ◽  
Open Access Journals ◽  
Economic Journals ◽  
The World ◽  
Economics Journals ◽  
Article Processing Charges ◽  
Linguistic Assessment

The main purpose of the paper is to study the publishing trends of the open access business and economics journals available in the Directory of Open Access Journals (DOAJ). The online survey was conducted for collection of data and quantitative method was applied for data analysis. The data were collected from the December 10-20, 2013 about more than six hundred business and economic journals and later presented in tabular forms to reveal the findings in accordance with desired objectives. The findings show that 607 business and economics journals are listed in the DOAJ and are published fromthe 67 countries of the world. The maximum number of journals (88, 14.50%) is published from Brazil, and during the first decade (2001-2010) of the 21st century (382, 62.93%). The linguistic assessment shows that the open access business and economics journals are mostly monolingual (405, 66.72%) and the majority of these are published in English language (498, 82.04%). The results also reveal that the majority of the business and economics journals (415, 68.37%) doesn’t charge publication fees to authors whereas almost one-fourth (147, 24.22%) of the journals demand article processing charges. The study does not explore the whole World Wide Web, but only the DOAJ and therefore, figures do not represent the actual number of the open access business and economics journals available online. The study is very beneficial for the business and economics scientists, academicians, researchers, information experts and open access advocates across the globe.

scholarly journals Channel-independent recreation of artefactual signals in chronically recorded local field potentials using machine learning

2022 ◽  
Vol 9 (1) ◽  
Author(s):  
Marcos Fabietti ◽  
Mufti Mahmud ◽  
Ahmad Lotfi
Keyword(s):  
Machine Learning ◽  
Open Access ◽  
Short Term Memory ◽  
The Body ◽  
Data Sets ◽  
Additional Information ◽  
Machine Learning Model ◽  
Signal Characteristics ◽  
Wide Range ◽  
Memory Network

AbstractAcquisition of neuronal signals involves a wide range of devices with specific electrical properties. Combined with other physiological sources within the body, the signals sensed by the devices are often distorted. Sometimes these distortions are visually identifiable, other times, they overlay with the signal characteristics making them very difficult to detect. To remove these distortions, the recordings are visually inspected and manually processed. However, this manual annotation process is time-consuming and automatic computational methods are needed to identify and remove these artefacts. Most of the existing artefact removal approaches rely on additional information from other recorded channels and fail when global artefacts are present or the affected channels constitute the majority of the recording system. Addressing this issue, this paper reports a novel channel-independent machine learning model to accurately identify and replace the artefactual segments present in the signals. Discarding these artifactual segments by the existing approaches causes discontinuities in the reproduced signals which may introduce errors in subsequent analyses. To avoid this, the proposed method predicts multiple values of the artefactual region using long–short term memory network to recreate the temporal and spectral properties of the recorded signal. The method has been tested on two open-access data sets and incorporated into the open-access SANTIA (SigMate Advanced: a Novel Tool for Identification of Artefacts in Neuronal Signals) toolbox for community use.

scholarly journals Effect of COVID-19 Pandemic on Anxiety in Rheumatology Patients Taking Immunosuppressive Drugs

2020 ◽  
Author(s):  
Tugba Izci Duran ◽  
Seyyid Bilal Acikgoz ◽  
Cemal Gurbuz ◽  
Aysegul Ucar ◽  
Gokhan Yavuzbilge ◽  
...  
Keyword(s):  
Musculoskeletal Diseases ◽  
Demographic Data ◽  
Immunosuppressive Drugs ◽  
High Risk Group ◽  
Anxiety Symptoms ◽  
Healthy Controls ◽  
Treatment Team ◽  
Additional Information ◽  
Education Levels ◽  
Anxiety Levels

Abstract Introduction: Coronavirus disease 2019 (COVID-19) pandemic is a public health emergency that is causing international concern. Patients with medical comorbidities are more likely to be infected and have a worse prognosis. The purpose of this study was to determine the prevalence of anxiety due to COVID-19 pandemic in patients with rheumatic and musculoskeletal diseases (RMDs) who used immunosuppressive drugs during the initial stage of the COVID-19 pandemic and to identify the risk and protective factors that cause anxiety.Methods: A total of 145 patients with RMDs aged ≥18 years who used regular immunosuppressive drugs and 95 healthy controls were included in the study. An anonymous survey comprising questions regarding the COVID-19 pandemic was used, and the Beck anxiety inventory (BAI) was used to measure the anxiety levels of participants. Additional information was collected such as demographic data, current RMDs, immunosuppressive drugs used, information and concerns about COVID-19, and the source of information about COVID-19.Results: About 42.1% patients reported that the epidemic caused concern due to the drug they were using, and 33.8% rated their concerns as moderate and severe. The BAI scores of patients and healthy controls were 4 (0-52) and 3 (0-18) respectively. According to the BAI scores, 16.5% patients had moderate to severe anxiety symptoms; and comparison of the groups showed that the anxiety level of the patient group was significantly higher (38.6% vs. 18.9%, p=0.001). Female had more anxiety symptoms in both groups (p<0.005). In addition, anxiety was lower in patients with higher education levels (p=0.039).Conclusion: It should be ensured that patients in the high-risk group are not provided false information, the patients are individually informed, and they trust the treatment team. Providing online or smartphone-based psychoeducation and psychological interventions may be considered for these patients with high anxiety levels.

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