scholarly journals Elevated Umbilical Cord Ghrelin Concentrations in Small for Gestational Age Neonates

2003 ◽  
Vol 88 (9) ◽  
pp. 4324-4327 ◽  
Author(s):  
Juliet Farquhar ◽  
Mark Heiman ◽  
Alfred C. K. Wong ◽  
Richard Wach ◽  
Philippe Chessex ◽  
...  
Keyword(s):  
Birth Weight ◽  
Umbilical Cord ◽  
Gestational Age ◽  
Plasma Concentrations ◽  
Physiological Role ◽  
Z Score ◽  
Term Neonates ◽  
Maternal Hypertension ◽  
The Difference ◽  
Intrauterine Malnutrition

Ghrelin has orexigenic effects. It is present in umbilical cord plasma in full-term neonates, raising the prospect that ghrelin plays a role in fetal and neonatal energy balance. We measured ghrelin in small (SGA), appropriate (AGA), and large (LGA) for gestational age neonates and evaluated whether ghrelin levels are modulated by neonatal insulin and glucose concentrations. Plasma concentrations of ghrelin, insulin, and glucose were measured in cord blood sampled at birth in 123 SGA, AGA, and LGA neonates (gestational age, 24–41 wk) born to mothers with and without diabetes. Ghrelin was detected in samples from all infants. Its concentration was 40% higher in SGA neonates (mean ± sd, 2436 ± 657 pg/ml) compared with AGA (1738 ± 380) and LGA (1723 ± 269) neonates. There was a positive correlation between ghrelin and gestational age in AGA/LGA (r = 0.23; P < 0.05) and a negative correlation in SGA (r = −0.67; P < 0.005) neonates. Therefore, the difference in ghrelin between SGA and AGA/LGA neonates decreases with advancing gestational age. Birth weight z-score, maternal hypertension, and glucose concentrations were significant determinants of ghrelin concentrations. In conclusion, SGA neonates present with higher umbilical cord ghrelin plasma concentrations than AGA/LGA neonates. Ghrelin may play a physiological role in fetal adaptation to intrauterine malnutrition.

scholarly journals Impact of size at birth and postnatal growth on metabolic and neurocognitive outcomes in prematurely born school-age children

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoo Jinie Kim ◽  
Seung Han Shin ◽  
Eun Sun Lee ◽  
Young Hwa Jung ◽  
Young Ah Lee ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Infants ◽  
Gestational Age ◽  
Growth Velocity ◽  
Postnatal Growth ◽  
School Age ◽  
Z Score ◽  
Neurodevelopmental Outcomes ◽  
Neurocognitive Outcomes ◽  
Size At Birth

AbstractPrematurity, size at birth, and postnatal growth are important factors that determine cardiometabolic and neurodevelopmental outcomes later in life. In the present study, we aimed to investigate the associations between the size at birth and growth velocity after birth with cardiometabolic and neurodevelopmental outcomes in preterm infants. Fifty-six preterm infants born at < 32 weeks of gestation or having a birth weight of < 1500 g were enrolled and categorized into small for gestational age (SGA) and appropriate for gestational age (AGA) groups. Anthropometric and cardiometabolic parameters were assessed at school-age, and the Korean Wechsler Intelligence Scale for Children, fourth edition (K-WISC-IV) was used for assessing the intellectual abilities. The growth velocity was calculated by changes in the weight z-score at each time period. Multivariate analysis was conducted to investigate the associations of growth velocity at different periods with cardiometabolic and neurodevelopmental outcomes. Forty-two (75%) were classified as AGA and 25% as SGA. At school-age, despite the SGA children showing significantly lower body weight, lean mass index, and body mass index, there were no differences in the cardiometabolic parameters between SGA and AGA groups. After adjusting for gestational age, birth weight z-score, weight z-score change from birth to discharge and sex, change in weight z-score beyond 12 months were associated with a higher systolic blood pressure, waist circumference, and insulin resistance. Full-scale intelligent quotient (β = 0.314, p = 0.036) and perceptional reasoning index (β = 0.456, p = 0.003) of K-WISC-IV were positively correlated with postnatal weight gain in the neonatal intensive care unit. Although cardiometabolic outcomes were comparable in preterm SGA and AGA infants, the growth velocity at different time periods resulted in different cardiometabolic and neurocognitive outcomes. Thus, ensuring an optimal growth velocity at early neonatal period could promote good neurocognitive outcomes, while adequate growth after 1 year could prevent adverse cardiometabolic outcomes in preterm infants.

Neonatal Outcomes at Extreme Prematurity by Gestational Age Versus Birth Weight in a Contemporary Cohort

2021 ◽  
Author(s):  
Elizabeth B. Ausbeck ◽  
Phillip Hunter Allman ◽  
Jeff M. Szychowski ◽  
Akila Subramaniam ◽  
Anup Katheria
Keyword(s):  
Birth Weight ◽  
Umbilical Cord ◽  
Gestational Age ◽  
Predictive Value ◽  
Neonatal Death ◽  
Controlled Trial ◽  
Neonatal Morbidity ◽  
Mortality And Morbidity ◽  
Severe Morbidity ◽  
Multicenter Randomized Controlled Trial

Objective The aim of the study is to describe the rates of neonatal death and severe neonatal morbidity in a contemporary cohort, as well as to evaluate the predictive value of birth gestational age (GA) and birth weight, independently and combined, for neonatal mortality and morbidity in the same contemporary cohort. Study Design We performed a secondary analysis of an international, multicenter randomized controlled trial of delayed umbilical cord clamping versus umbilical cord milking in preterm infants born at 23 0/7 to 31 6/7 weeks of gestation. The current analysis was restricted to infants delivered <28 weeks. The primary outcomes of this analysis were neonatal death and a composite of severe neonatal morbidity. Incidence of outcomes was compared by weeks of GA, with planned subanalysis comparing small for gestational age (SGA) versus non-SGA neonates. Multivariable logistic regression was then used to model these outcomes based on birth GA, birth weight, or a combination of both as primary independent predictors to determine which had superior ability to predict outcomes. Results Of 474 neonates in the original trial, 180 (38%) were included in this analysis. Overall, death occurred in 27 (15%) and severe morbidity in 139 (77%) neonates. Rates of mortality and morbidity declined with increasing GA (mortality 54% at 23 vs. 9% at 27 weeks). SGA infants (n = 25) had significantly higher mortality compared with non-SGA infants across all GAs (p < 0.01). There was no difference in the predictive value for neonatal death or severe morbidity between the three prediction options (GA, birth weight, or GA and birth weight). Conclusion Death and severe neonatal morbidity declined with advancing GA, with higher rates of death in SGA infants. Birth GA and birth weight were both good predictors of outcomes; however, combining the two was not more predictive, even in SGA infants. Key Points

Neurotoxicity of Hexachlorophene in the Human: I. A Clinicopathologic Study of 248 Children

PEDIATRICS ◽  
1974 ◽  
Vol 54 (6) ◽  
pp. 689-695
Author(s):  
Robert M. Shuman ◽  
Richard W. Leech ◽  
Ellsworth C. Alvord
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Newborn Infants ◽  
Whole Body ◽  
Human Beings ◽  
Term Neonates ◽  
Experimental Animals ◽  
Clinicopathologic Study ◽  
Neurotoxic Effects ◽  
Sick Children

To assess the susceptibility of human beings to the neurotoxic effects of hexachlorophene demonstrated in experimental animals, a blind clinicopathologic analysis was made of 248 children coming to autopsy over a 7.5-year period in the two Seattle institutions to which practically all premature or sick children are referred. Repeated whole-body bathing of premature newborn infants in 3% hexachlorophene-bearing soap (undiluted pHisoHex) is associated with a vacuolar encephalopathy of the brainstem reticular formation. The prevalence of the vacuolar encephalopathy appears to be related to the number of exposures to hexachlorophene, to the concentration of hexachiorophene, to the birth weight (gestational age), to the length of survival and to the thoroughness of rinsing. From these observations we conclude that hexachlorophene should not be used on neonates under 1,400 gm birth weight and should be used only sparingly in full-term neonates with thorough rinsing.

scholarly journals DISTRIBUSI FREKUENSI FAKTOR PENYEBAB KEJADIAN ASFIKSIA PADA BAYI BARU LAHIR DI RS. FADHILLAH KOTA PRABUMULIH TAHUN 2017

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Maria Septiana Maria Septiana
Keyword(s):  
Birth Weight ◽  
Umbilical Cord ◽  
Gestational Age ◽  
Maternal Age ◽  
Placenta Previa ◽  
Secondary Data ◽  
Maternal Factors ◽  
Premature Babies ◽  
Severe Infections ◽  
Abnormal Bleeding

Komplikasi yang menjadi penyebab kematian bayi baru lahir yang terbanyak yaitu asfiksia. penyebab terjadinya asfiksia ada 3 yaitu, faktor ibu (preeklamsi dan eklamsia, perdarahan abnormal yang disebabkan karena plasenta previa atau solusio plasenta, partus lama, demam selama persalinan, infeksi berat, kehamilan post matur, usia ibu kurang dari 20 tahun atau lebih dari 35 tahun), faktor bayi (bayi prematur, persalinan sulit, kelainan konginetal, air ketuban bercampur mekonium), faktor tali pusat (lilitan tali pusat, tali pusat pendek, simpul tali pusat dan prolapsus tali pusat) Metode penelitian : Pengambilan data dalam penelitian ini menggunakan data sekunder dengan pendekatan retrospektif. Hasil Penelitian : Faktor penyebab kejadian asfiksia pada bayi baru lahir berdasarkan faktor ibu yaitu mayoritas terjadi pada usia ibu 20-35 tahun sebanyak 16 (51,6%), , paritas10 (32,3%), umur kehamilan 18 (58,1%) dan berdasarkan faktor dari bayi yaitu mayoritas terjadi pada berat lahir bayi >2500 gram sebanyak 12 (38,7%), dan jenis persalinan yang mengalami asfiksia pada persalinan normal sebanyak 10 (32,3%). Kesimpulan : Faktor penyebab kejadian asfiksia pada bayi baru lahir di RS Fadhilah Kota Prabumulih yaitu dari faktor ibu yaitu mayoritas terjadi pada usia ibu 20-35 tahun, paritas multipara, umur kehamilan 37-42 minggu dan dari faktor bayi yaitu bayi dengan berat lahir >2500 gram dan jenis persalinan normal.     ABSTRACT Asphyxia is one of the complications that become the largest cause of death. Therevare three cause of asphyxia, namely, maternal factors (preeclampsia and eclampsia, abnormal bleeding caused by placenta previa or placental abruption, prolonged labor, fever during labor, severe infections, pregnancy post mature, maternal age less than 20 years old or over 35 years ), factor infants (premature babies, difficult delivery, konginetal disorders, meconium-stained amniotic fluid mixes), factor umbilical cord (umbilical cord loops, short umbilical cord, knot the cord and umbilical cord prolapse). Athere are 31 cose of asphyxia in Fadhilah Hospital. Objective : Knowing the factors that cause asphyxia in newborns at RS Fadhilah Prabumulih City. Methods : Collecting data in this study using secondary data with retrospective approach Result: Factors that cause asphyxia in newborns by maternal factors that occur in the majority of maternal age 20-35 years as many as 16 (51.6%), parity 10 (32.3%), gestational age 18 (58.1%) and by factors of which the majority occur in infants birth weight> 2500 g were 12 (38.7%), and the type of delivery that asphyxiated the normal labor as much as 10 (32.3%). Conclusion : Factors that cause asphyxia in newborns at PKU Muhammadiyah Hospital in Bantul 2016 ie from the maternal factors that occur in the majority of maternal age 20-35 years, multiparas parity, gestational age of 37-42 weeks and infant factors that infants with birth weight> 2500 gram and type of normal deliveries.

Bioactive and immunoreactive FSH and immunoreactive inhibin concentrations in the ovine fetus

1992 ◽  
Vol 134 (2) ◽  
pp. 287-295 ◽  
Author(s):  
D. J. Phillips ◽  
P. R. Smith ◽  
D. A. Heath ◽  
L. A. Condell ◽  
K. P. McNatty
Keyword(s):  
Pituitary Gland ◽  
Gestational Age ◽  
Plasma Concentrations ◽  
Female Group ◽  
Ovine Fetus ◽  
The Difference

ABSTRACT The bioactive (B) and immunoreactive (I) pituitary contents/concentrations of FSH, together with the plasma concentrations of B-FSH, I-FSH and I-inhibin were determined in ovine fetuses at days 55, 75, 90 and 135 of gestation (day 145 = term). The pituitary contents and concentrations of B-FSH and I-FSH increased in both sexes with gestational age. The female fetuses had significantly (P <0·01) higher pituitary contents/concentrations of B-FSH and I-FSH than the male fetuses at days 75 and 135. The pituitary B/I ratios of FSH were not significantly different with age or sex. The plasma concentrations of B-FSH remained relatively constant from days 75 to 135, with no significant differences between sexes or with age. In contrast, the plasma concentrations of I-FSH reached a peak at day 90 and then declined towards term in both sexes. At all gestational ages except day 55, the female fetuses had significantly (P <0·05) higher plasma concentrations of I-FSH than the males. In both sexes, the plasma B/I ratios of FSH were lowest at day 90 and had increased again by day 135, with the male fetuses having significantly (P <0·05) higher B/I ratios compared with the female group at days 75 and 135 but not at day 90. At all gestational ages, the plasma concentrations of I-inhibin declined throughout gestation in the female fetuses, whereas in the males they reached a nadir at day 75 and then increased towards term. The concentrations of I-inhibin were significantly (P <0·01) higher in the male fetuses compared with the females. Collectively, these data suggest that there are changes in the forms of FSH present in the pituitary gland and plasma throughout gestation in the ovine fetus. Moreover, they infer that the difference between the sexes in FSH synthesis and/or secretion may be attributed in part to the circulating concentrations of inhibin. Journal of Endocrinology (1992) 134, 287–295

scholarly journals Cord Malaria Infection, Complement Activation, Oxidative Stress, Gestational Age, and Birth Weight, Characterized by High Plasmodium falciparum Prevalence in Bamenda, Cameroon

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Oumar Mahamat ◽  
Kidio Gisele Ndum ◽  
Sumo Laurentine ◽  
Ntonifor Ngum Helen
Keyword(s):  
Oxidative Stress ◽  
Birth Weight ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Negative Correlation ◽  
Gestational Age ◽  
Blood Samples ◽  
Total Antioxidant ◽  
Weak Negative Correlation ◽  
And Oxidative Stress

Background. It is unknown whether the presence of Plasmodium falciparum malaria parasites in umbilical cord blood denotes activation of complement and oxidative stress to affect the duration of pregnancy and birth weight. Methods. In a cross-sectional study conducted from January to April 2019 in Bamenda, Cameroon, cord blood samples were collected from 300 women at delivery. Parasitaemia was determined microscopically. Babies’ weight and age of gestation were recorded. Plasma levels of complement and oxidative stress were measured by specific tests. Results. Cord blood malaria prevalence was 21.33%. Babies with an infected cord showed a low birth weight and gestation age than those with uninfected cords. More babies with infected cords had LBW (6.25%) compared to the counterparts (5.50%). The levels of parasitaemia and the babies’ weight showed a weak positive correlation. The prevalence of preterm and postterm birth was 4.33% and 24.33% respectively, with a weak negative correlation between the age of gestation and the umbilical cord parasitaemia. There was correlation between cord parasitaemia and levels of complement haemolytic activity titter (CH50) and specific classical pathway activity (CPA) in cord blood. CH50 and CPA levels, however, were significantly higher in infected cord blood samples, compared with uninfected cord blood samples. CH50 showed a negative correlation with the birth weight and gestational age in infected cord blood samples. The levels of total oxidative stress (TOS) and total antioxidant defense were significantly lower in infected cord blood than uninfected. TOS displayed a positive correlation with the density of parasitaemia and a weak negative correlation with the birth weight and gestational age in infected cord blood. Conclusion. Cord blood infection lowers the complement haemolytic titter, oxygen radicals and total antioxidant defense in neonates. This lowering of complement haemolytic titter and oxygen radical compounds in umbilical cord malaria are associated with low birth weight and preterm birth.

scholarly journals Efficacy of a First Course of Ibuprofen for Patent Ductus Arteriosus Closure in Extremely Preterm Newborns According to Their Gestational Age-Specific Z-Score for Birth Weight

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124804 ◽  
Author(s):  
Doriane Madeleneau ◽  
Marie-Stephanie Aubelle ◽  
Charlotte Pierron ◽  
Emmanuel Lopez ◽  
Juliana Patkai ◽  
...  
Keyword(s):  
Birth Weight ◽  
Patent Ductus Arteriosus ◽  
Gestational Age ◽  
Ductus Arteriosus ◽  
Z Score ◽  
Extremely Preterm ◽  
Patent Ductus Arteriosus Closure ◽  
Preterm Newborns ◽  
Patent Ductus

scholarly journals Pathological staging of chorioamnionitis contributes to complications in preterm infants

2020 ◽  
Vol 46 (1) ◽  
Author(s):  
Jiayu Miao ◽  
Zhuxiao Ren ◽  
Yunbei Rao ◽  
Xin Xia ◽  
Jianlan Wang ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Infants ◽  
Gestational Age ◽  
Intraventricular Hemorrhage ◽  
Independent Risk Factor ◽  
Late Onset ◽  
Obstetrics And Gynecology ◽  
Single Center ◽  
Pathological Staging ◽  
The Difference

Abstract Objective To investigate the effect of pathological staging of chorioamnionitis (CA) on complications in preterm infants; Methods A single-center, retrospective study was conducted to choose singleton preterm infants (gestational age < 37 weeks) from the Department of Obstetrics and Gynecology in our hospital from December 2016 to December 2017. The basic data and placental pathological results were retrospectively collected. According to the placental pathological results of whether inflammation infiltrating amnion, CA 0/I phase was classified into non-amnionitis group, CA II/III phase was classified into amnionitis group, the incidence of common complications in preterm infants was compared. Further, logistic regression was used to analyze the effects of amnionitis on complications after being adjusted to gestational age, birth weight and thrombocytopenia. Results A total of 221 preterm infants were enrolled, including 186 cases in non-amnionitis group and 35 cases in amnionitis group. The gestational age of amnionitis group (32.00 ± 2.71 weeks) was significantly lower than non-amnionitis group (34.14 ± 2.06 weeks), birth weight (1.93 ± 0.64 kg) was significantly lower than that of non-amnionitis group (2.26 ± 0.58 kg), and the hospital stay in amnionitis group was significantly longer (25.71 ± 19.23 days), all of the difference above was statistically significant(P < 0.05). The incidence of intraventricular hemorrhage (IVH) in amnionitis group (37.14%) was significantly higher than that in non-amnionitis group (13.98%) (P = 0.002), and the risk of IVH was significantly increased by amnionitis (OR = 3.636, 95%CI: 1.632–8.102); after correction of gestational age, birth weight and thrombocytopenia, the risk of IVH was still significantly increased (OR = 2.471, P = 0.046, 95% CI: 1.015–6.015). And the late-onset IVH was more common (P = 0.009). Conclusion Amnionitis leads to a significant reduction in gestational age and birth weight in preterm infants, and it is an independent risk factor for IVH.

scholarly journals Temporal Trends in Gestational Diabetes Prevalence, Treatment, and Outcomes at Aarhus University Hospital, Skejby, between 2004 and 2016

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Per Glud Ovesen ◽  
Jens Fuglsang ◽  
Mette Bisgaard Andersen ◽  
Charlotte Wolff ◽  
Olav Bjørn Petersen ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Diabetes ◽  
Insulin Therapy ◽  
Gestational Age ◽  
Temporal Trends ◽  
University Hospital ◽  
Large For Gestational Age ◽  
Z Score ◽  
Glucose Levels ◽  
Obesity And Diabetes

Background. The prevalence of gestational diabetes (GDM) is increasing worldwide. The most important risk of GDM in pregnancy is excessive fetal growth, increasing the risk of complications during delivery as well as long-term complications like obesity and diabetes in both the mother and the offspring. Method. All women with GDM who delivered a singleton between 2004 and 2016 were included. The treatment of GDM patients sought to achieve normal blood glucose levels, primarily by diet and exercise. If the glycemic targets were not reached, insulin therapy was initiated. Birth weight and birth weight Z-score was calculated corrected for gender and gestational age at delivery. Results. The study included 1910 women. The number of GDM women increased significantly each year over the course of the study, as did the proportion requiring insulin therapy. Birth weight and birth weight Z-score fell significantly over the years largely due to a decrease in large for gestational age frequency from 29% to around 19%. Conclusion. During the last 13 years, the number of women diagnosed with GDM has increased. Furthermore, the proportion of GDM women receiving insulin treatment has increased. The birth weight in diet-treated women has been virtually normal for the last 5 years of the reported period.

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