Relationships Between 24-h LH and Testosterone Concentrations and With Other Pituitary Hormones in Healthy Older Men

Abstract Objective To investigate the relationship between LH and T, which characteristics associate with the strength of this relationship, and their interrelationships with GH, TSH, cortisol, and ACTH. Design Hormones were measured in serum samples collected every 10 min during 24 h from 20 healthy men, comprising 10 offspring of long-lived families and 10 control subjects, with a mean (SD) age of 65.6 (5.3) years. We performed cross-correlation analyses to assess the relative strength between two timeseries for all possible time shifts. Results Mean (95% CI) maximal correlation was 0.21 (0.10–0.31) at lag time 60 min between LH and total T concentrations. Results were comparable for calculated free, bioavailable, or secretion rates of T. Men with strong LH-T cross-correlations had, compared to men with no cross-correlation, lower fat mass (18.5 (14.9–19.7) vs. 22.3 (18.4–29.4) kg), waist circumference (93.6 (5.7) vs. 103.1 (12.0) cm), hsCRP (0.7 (0.4–1.3) vs. 1.8 (0.8–12.3) mg/L), IL-6 (0.8 (0.6–1.0) vs. 1.2 (0.9–3.0) pg/mL), and 24-h mean LH (4.3 (2.0) vs. 6.1 (1.5) U/L), and stronger LH-T feedforward synchrony (1.5 (0.3) vs. 1.9 (0.2)). Furthermore, T was positively cross-correlated with TSH (0.32 (0.21–0.43)), cortisol (0.26 (0.19–0.33)), and ACTH (0.26 (0.19–0.32)). Conclusions LH is followed by T with a delay of 60 min in healthy older men. Men with a strong LH-T relationship had more favorable body composition, inflammatory markers, LH levels, and LH-T feedforward synchrony. We observed positive correlations between T and TSH, cortisol, and ACTH.

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Relationship Between 24-Hour Serum LH and Testosterone Concentrations and Their Interrelationships With Other Pituitary Hormones in Healthy Older Men

Journal of the Endocrine Society ◽

10.1210/jendso/bvab048.1290 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. A633-A633

Author(s):

Evie van der Spoel ◽

Ferdinand Roelfsema ◽

Diana van Heemst

Keyword(s):

Body Composition ◽

Inflammatory Markers ◽

Older Men ◽

Pituitary Hormones ◽

Relative Strength ◽

Chronological Age ◽

Hormonal Changes ◽

Serum Samples ◽

Serum Lh ◽

Cross Correlations

Abstract Background: With ageing, LH levels rise while T levels decline in men, although this decline in T levels could also be caused by a change in health status, including body composition, inflammation, and comorbidities. Not only levels of LH and T change with age, but levels of other pituitary hormones also change concomitantly with age. It could be hypothesized that these hormonal changes are synchronized with each other. Objective: In this study, we aimed to determine the relationship between 24-h serum LH and T concentrations in healthy older men. Besides, we aimed to determine which health factors, including body composition, metabolic and inflammatory markers, and LH-T related markers are associated with the strength of this LH-T relationship. Furthermore, we explored the interrelationships between LH and T with 24-h serum concentrations of GH, TSH, cortisol, and ACTH. Design: Hormones were measured in serum samples collected every 10 min during 24 h from 20 healthy men, comprising 10 offspring of long-lived families and 10 control subjects, with a mean (SD) age of 65.6 (5.3) years. We performed cross-correlation analyses to assess the relative strength between two 24-h hormone concentration series for all possible time shifts. Results: A mean (95% confidence interval) maximal correlation coefficient of 0.21 (0.10 – 0.31) at lag time 60 min was found between LH and total T concentrations. Results were comparable for calculated free, bioavailable, or secretion rates of T. Men with strong LH-T cross-correlations had, compared to men with no LH-T relationship, lower fat mass (18.5 (14.9 – 19.7) vs. 22.3 (18.4 – 29.4) kg), waist circumference (93.6 (5.7) vs. 103.1 (12.0) cm), hsCRP levels (0.7 (0.4 – 1.3) vs. 1.8 (0.8 – 12.3) mg/L), IL-6 levels (0.8 (0.6 – 1.0) vs. 1.2 (0.9 – 3.0) pg/mL), and 24-h mean LH levels (4.3 (2.0) vs. 6.1 (1.5) U/L), and stronger LH-T feedforward synchrony (1.5 (0.3) vs. 1.9 (0.2)). Furthermore, T was positively cross-correlated with TSH (0.32 (0.21 – 0.43)), cortisol (0.26 (0.19 – 0.33)), and ACTH concentrations (0.26 (0.19 – 0.32)). Conclusions: LH concentrations were followed by T concentrations/secretion with a delay of 60 min in healthy older men, which is in line with literature. Men with a strong LH-T relationship had more favorable body composition, inflammatory markers, 24-h mean LH levels, and LH-T feedforward synchrony. In contrast, chronological age and 24-h mean T levels were not associated with the strength of the LH-T relationship. This observation could indicate that LH and health markers play a bigger role in determining the strength of LH-T cross-correlations than T and chronological age. Furthermore, we observed positive correlations between T and TSH, cortisol, and ACTH concentrations. These exploratory analyses could indicate that T and other hormones are driven by a common regulator or that there is crosstalk between these hormones.

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Time-Series and Dynamic Cross-Correlations Analysis on Unexpected Information: Evidence from Media News and Online Postings

Fluctuation and Noise Letters ◽

10.1142/s021947752050011x ◽

2019 ◽

Vol 19 (02) ◽

pp. 2050011

Author(s):

Yan Li ◽

Xiangyu Kong ◽

Xiao Li ◽

Zuochao Zhang

Keyword(s):

Mass Media ◽

New Media ◽

Trading Volume ◽

Cross Correlation ◽

Short Term ◽

Cross Correlations ◽

The Cross ◽

The One ◽

The Relationship

In this paper, we investigate the relationship between unexpected information from postings and news, and the unexpected information is measured by the residual of regressions of trading volume on numbers of news or postings. We mainly find that (i) There are significant positive contemporaneous correlations between the unexpected information coming from postings and different kinds of news; the correlation between the unexpected information coming from postings and new media news is stronger than that between the unexpected information coming from postings and mass media news; (ii) The unexpected information coming from postings could cause the unexpected information coming from news, but only the unexpected information coming from the mass media news could cause that coming from postings; (iii) There are persistent power-law cross-correlations between the unexpected information coming from postings and that coming from mass media news and new media news. The cross-correlation between the unexpected information coming from postings and new media news is more persistent than the one between the unexpected information coming from postings and mass media news. The cross-correlations are all more stable in long term than in short term. We attribute our findings above to the dissemination speed of the information on the Internet.

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X-ray cross-correlation analysis of the low-mass X-ray binary 4U 1636-53

Proceedings of the International Astronomical Union ◽

10.1017/s1743921314010655 ◽

2014 ◽

Vol 10 (S306) ◽

pp. 397-399

Author(s):

Ya-Juan Lei

Keyword(s):

Correlation Function ◽

Correlation Analysis ◽

Cross Correlation ◽

X Rays ◽

X Ray ◽

Cross Correlation Analysis ◽

Low Mass ◽

Cross Correlations ◽

The Cross ◽

Positive Correlations

AbstractWe analyze the cross-correlation function of the soft and hard X-rays of the atoll source 4U 1636-53 with RXTE data. The results show that the cross-correlations evolve along the different branches of the color-color diagram. At the lower left banana states, we have both positive and ambiguous correlations, and positive correlations are dominant for the lower banana and the upper banana states. The anti-correlation is detected at the top of the upper banana states. The cross-correlations of two atoll sources 4U 1735-44 and 4U 1608-52 have been studied in previous work, and the anti-correlations are detected at the lower left banana or the top of the upper banana states. Our results show that, in the 4U 1636-53, the distribution of the cross-correlations in the color-color diagram is similar to those of 4U 1735-44 and 4U 1608-52, and confirm further that the distribution of cross-correlations in color-color diagram could be correlated with the luminosity of the source.

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Clinical and Serological Biomarkers of Treatment’s Response in Multiple Sclerosis Patients Treated Continuously with Interferonβ-1b for More than a Decade

CNS & Neurological Disorders - Drug Targets ◽

10.2174/1871527317666180917095256 ◽

2018 ◽

Vol 17 (10) ◽

pp. 780-792 ◽

Cited By ~ 5

Author(s):

Laura Iulia Bărcuţean ◽

Andreea Romaniuc ◽

Smaranda Maier ◽

Zoltan Bajko ◽

Anca Moţăţăianu ◽

...

Keyword(s):

Multiple Sclerosis ◽

Demographic Data ◽

Active Form ◽

Positive Influence ◽

Serum Samples ◽

Disability Score ◽

Positive Correlations ◽

Multiple Sclerosis Patients ◽

Factor Α ◽

Serological Biomarkers

Introduction: We evaluated the peripheral immune panel of Multiple Sclerosis (MS) patients treated for more than 10 years with interferon-beta1b (IFNβ-1b) and aimed to identify possible biomarkers of treatment response. Material and Methods: Serum samples from 70 MS patients treated with IFNβ-1b more than a decade were analysed for 15 cytokines, that were correlated with the disability score, annual relapse ratio (ARR): the total number of relapses-ARR_0, relapse on treatment-ARR_1 and demographic data. Two groups were defined based on the levels of disability, calculated using the Expanded Disability Status Scale (EDSS): G1 – recurrent-remissive and G2 – secondary-progressive. Furthermore, we split the patients based on gender (G1_f, G1_m, G2_f, G2_m). Results: The ARR was reduced after treatment was instituted. We found positive correlations between IL_25 and EDSS in G1_f and G2_f, tumor necrosis factor α (TNFα) and ARR_1 and ARR_0 in G1, and IL_17F with ARR_1. Negative correlations were for IL_25 and ARR_0 and ARR_1. SCD40L intensely positively correlated with IL_31 in G1 and G2. Conclusion: After more than a decade of treatment, IFNβ-1b offers good results by reducing relapses and slowing disability progression. Several biomarkers can be used to assess the patient’s response. High levels of IL_17 and TNFα will indicate a more active form of the disease. IL-25 may exert a positive influence in male MS patients and should be considered for future studies, together with the co-modulation between sCD40L and IL_31. Our method allowed us to screen the peripheral immune panel and can be used for assessing the peripheral levels of the above-mentioned cytokines.

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Detrended Multiple Cross-Correlation Coefficient applied to solar radiation, air temperature and relative humidity

Scientific Reports ◽

10.1038/s41598-019-56114-6 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 2

Author(s):

Andrea de Almeida Brito ◽

Heráclio Alves de Araújo ◽

Gilney Figueira Zebende

Keyword(s):

Relative Humidity ◽

Solar Radiation ◽

Solar Energy ◽

Correlation Coefficient ◽

Air Temperature ◽

Cross Correlation ◽

Global Solar Radiation ◽

Meteorological Variables ◽

Hourly Data ◽

Cross Correlations

AbstractDue to the importance of generating energy sustainably, with the Sun being a large solar power plant for the Earth, we study the cross-correlations between the main meteorological variables (global solar radiation, air temperature, and relative air humidity) from a global cross-correlation perspective to efficiently capture solar energy. This is done initially between pairs of these variables, with the Detrended Cross-Correlation Coefficient, ρDCCA, and subsequently with the recently developed Multiple Detrended Cross-Correlation Coefficient, $${\boldsymbol{DM}}{{\boldsymbol{C}}}_{{\bf{x}}}^{{\bf{2}}}$$DMCx2. We use the hourly data from three meteorological stations of the Brazilian Institute of Meteorology located in the state of Bahia (Brazil). Initially, with the original data, we set up a color map for each variable to show the time dynamics. After, ρDCCA was calculated, thus obtaining a positive value between the global solar radiation and air temperature, and a negative value between the global solar radiation and air relative humidity, for all time scales. Finally, for the first time, was applied $${\boldsymbol{DM}}{{\boldsymbol{C}}}_{{\bf{x}}}^{{\bf{2}}}$$DMCx2 to analyze cross-correlations between three meteorological variables at the same time. On taking the global radiation as the dependent variable, and assuming that $${\boldsymbol{DM}}{{\boldsymbol{C}}}_{{\bf{x}}}^{{\bf{2}}}={\bf{1}}$$DMCx2=1 (which varies from 0 to 1) is the ideal value for the capture of solar energy, our analysis finds some patterns (differences) involving these meteorological stations with a high intensity of annual solar radiation.

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Maternal immune response and air pollution exposure during pregnancy: insights from the Early Markers for Autism (EMA) study

Journal of Neurodevelopmental Disorders ◽

10.1186/s11689-020-09343-0 ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

Heather E. Volk ◽

Bo Park ◽

Calliope Hollingue ◽

Karen L. Jones ◽

Paul Ashwood ◽

...

Keyword(s):

Air Pollution ◽

Intellectual Disability ◽

Prenatal Screening ◽

Maternal Serum ◽

Serum Samples ◽

Maternal Immune Activation ◽

Early Markers ◽

Air Pollution Exposure ◽

Pollution Exposure ◽

The Relationship

Abstract Background Perinatal exposure to air pollution and immune system dysregulation are two factors consistently associated with autism spectrum disorders (ASD) and other neurodevelopmental outcomes. However, little is known about how air pollution may influence maternal immune function during pregnancy. Objectives To assess the relationship between mid-gestational circulating levels of maternal cytokines/chemokines and previous month air pollution exposure across neurodevelopmental groups, and to assess whether cytokines/chemokines mediate the relationship between air pollution exposures and risk of ASD and/or intellectual disability (ID) in the Early Markers for Autism (EMA) study. Methods EMA is a population-based, nested case–control study which linked archived maternal serum samples collected during weeks 15–19 of gestation for routine prenatal screening, birth records, and Department of Developmental Services (DDS) records. Children receiving DDS services for ASD without intellectual disability (ASD without ID; n = 199), ASD with ID (ASD with ID; n = 180), ID without ASD (ID; n = 164), and children from the general population (GP; n = 414) with no DDS services were included in this analysis. Serum samples were quantified for 22 cytokines/chemokines using Luminex multiplex analysis technology. Air pollution exposure for the month prior to maternal serum collection was assigned based on the Environmental Protection Agency’s Air Quality System data using the maternal residential address reported during the prenatal screening visit. Results Previous month air pollution exposure and mid-gestational maternal cytokine and chemokine levels were significantly correlated, though weak in magnitude (ranging from − 0.16 to 0.13). Ten pairs of mid-pregnancy immune markers and previous month air pollutants were significantly associated within one of the child neurodevelopmental groups, adjusted for covariates (p < 0.001). Mid-pregnancy air pollution was not associated with any neurodevelopmental outcome. IL-6 remained associated with ASD with ID even after adjusting for air pollution exposure. Conclusion This study suggests that maternal immune activation is associated with risk for neurodevelopmental disorders. Furthermore, that prenatal air pollution exposure is associated with small, but perhaps biologically relevant, effects on maternal immune system function during pregnancy. Additional studies are needed to better evaluate how prenatal exposure to air pollution affects the trajectory of maternal immune activation during pregnancy, if windows of heightened susceptibility can be identified, and how these factors influence neurodevelopment of the offspring.

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The Relationship between Dynamic Balance and Jumping Tests among Adolescent Amateur Rugby Players. A Preliminary Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18010312 ◽

2021 ◽

Vol 18 (1) ◽

pp. 312

Author(s):

Bartosz Wilczyński ◽

Jakub Hinca ◽

Daniel Ślęzak ◽

Katarzyna Zorena

Keyword(s):

Injury Risk ◽

Dynamic Balance ◽

Study Data ◽

Balance Test ◽

Risk Of Injury ◽

Counter Movement Jump ◽

Increased Risk ◽

Positive Correlations ◽

The Relationship ◽

Rugby Players

Rugby is a demanding contact sport. In light of research, poor balance, reduced jumping ability, muscle strength, and incorrect landing patterns might contribute to the increased risk of injury in athletes. Investigating the relationship between tests assessing these abilities might not only allow for the skillful programming of preventive training but also helps in assessing the risk of injury to athletes. Thus, the main purpose of this study was to investigate the relationship between dynamic balance, vertical and horizontal jumps, and jump-landings movement patterns. Thirty-one healthy amateur adolescent rugby players (age: 14.3 ± 1.6 years, height 171.4 ± 9.7 cm, body mass 80 ± 26 kg) participated in the study. Data were collected by the Y-balance Test (YBT), Counter Movement Jump (CMJ), Single Leg Hop for Distance (SLHD), and Landing Error Score System (LESS). Significant positive correlations were found between SLHD both legs (SLHDb) and YBT Composite both legs (COMb) (r = 0.51, p = 0.0037) and between SLHDb and CMJ (r = 0.72, p < 0.0001). A relationship was also observed between the CMJ and YBT COMb test (r = 0.51, p = 0.006). Moderate positive correlations were found between the dominant legs in SLHD and the posterolateral (r = 0.40, p = 0.027), posteromedial (r = 0.43, p = 0.014), and composite (r = 0.48, p = 0.006) directions of the YBT. These results indicate that variables that are dependent on each other can support in the assessment of injury-risk and in enhancing sports performance of young athletes.

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Objective and Subjective Outcomes in Patients with Hearing Aids: A Cross-Sectional, Comparative, Associational Study

Audiology and Neurotology ◽

10.1159/000516623 ◽

2021 ◽

pp. 1-9

Author(s):

Xunyi Wang ◽

Yun Zheng ◽

Gang Li ◽

Jingzhe Lu ◽

Yan Yin

Keyword(s):

Hearing Aids ◽

Patient Reported Outcomes ◽

Cross Sectional ◽

Patient Reported ◽

Objective Tests ◽

The Difference ◽

Potential Factors ◽

Positive Correlations ◽

The Relationship ◽

Subjective Outcomes

Introduction: Outcome assessment for hearing aids (HAs) is an essential part of HA fitting and validation. There is no consensus about the best or standard approach for evaluating HA outcomes. And, the relationship between objective and subjective measures is ambiguous. This study aimed to determine the outcomes after HA fitting, explore correlations between subjective benefit and acoustic gain improvement as well as objective audiologic tests, and investigate several variables that may improve patients’ perceived benefits. Methods: Eighty adults with bilateral symmetrical hearing loss using HAs for at least 1 month were included in this study. All subjects completed the pure tone average (PTA) threshold and word recognition score (WRS) tests in unaided and aided conditions. We also administered the Chinese version of International Outcome Inventory for Hearing Aids (IOI-HA), to measure participants’ subjective benefits. Objective HA benefit (acoustic gain improvement) was defined as the difference in thresholds or scores between aided and unaided conditions indicated with ΔPTA and ΔWRS. Thus, patients’ baseline hearing levels were taken into account. Correlations were assessed among objective audiologic tests (PTA and WRS), acoustic gain improvement (ΔPTA and ΔWRS), multiple potential factors, and IOI-HA overall scores. Results: PTA decreased significantly, but WRS did not increase when aided listening was compared to unaided listening. Negative correlations between PTAs and IOI-HA scores were significant but weak (r = −0.370 and r = −0.393, all p < 0.05). Significant weak positive correlations were found between WRSs and IOI-HA (r = 0.386 and r = 0.309, all p < 0.05). However, there was no correlation among ΔPTA, ΔWRS, and IOI-HA (r = 0.056 and r = −0.086, all p > 0.05). Moreover, 2 nonaudiological factors (age and daily use time) were significantly correlated with IOI-HA (r = −0.269 and r = 0.242, all p < 0.05). Conclusions: Correlations among objective audiologic tests, acoustic gain, and subjective patient-reported outcomes were weak or absent. Subjective questionnaires and objective tests do not reflect the same hearing capability. Therefore, it is advisable to evaluate both objective and subjective outcomes when analyzing HA benefits on a regular basis and pay equal attention to nonaudiological and audiological factors.

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The Influence of Countermovement Jump Protocol on Reactive Strength Index Modified and Flight Time: Contraction Time in Collegiate Basketball Players

Sports ◽

10.3390/sports7020037 ◽

2019 ◽

Vol 7 (2) ◽

pp. 37 ◽

Cited By ~ 3

Author(s):

Aaron Heishman ◽

Brady Brown ◽

Bryce Daub ◽

Ryan Miller ◽

Eduardo Freitas ◽

...

Keyword(s):

Force Plate ◽

Flight Time ◽

Contraction Time ◽

Strength Index ◽

Countermovement Jump ◽

Basketball Players ◽

Arm Swing ◽

Collegiate Basketball ◽

Positive Correlations ◽

The Relationship

The purpose of the present investigation was to evaluate differences in Reactive Strength Index Modified (RSIMod) and Flight Time to Contraction Time Ratio (FT:CT) during the countermovement jump (CMJ) performed without the arm swing (CMJNAS) compared to the CMJ with the arm swing (CMJAS), while exploring the relationship within each variable between jump protocols. A secondary purpose sought to explore the relationship between RSIMod and FT:CT during both jump protocols. Twenty-two collegiate basketball players performed both three CMJNAS and three CMJAS on a force plate, during two separate testing sessions. RSIMod was calculated by the flight-time (RSIModFT) and impulse-momentum methods (RSIModIMP). CMJ variables were significantly greater during the CMJAS compared to CMJNAS (p < 0.001). There were large to very large correlations within each variable between the CMJAS and CMJNAS. There were significant positive correlations among RSIModFT, RSIModIMP, and FT:CT during both the CMJAS (r ≥ 0.864, p < 0.001) and CMJNAS (r ≥ 0.960, p < 0.001). These findings identify an increase in RSIMod or FT:CT during the CMJAS, that may provide independent information from the CMJNAS. In addition, either RSIMod or FT:CT may be utilized to monitor changes in performance, but simultaneous inclusion may be unnecessary.

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Effects of Elevated Temperatures on the Compressive Strength of HFCC

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.261-263.416 ◽

2011 ◽

Vol 261-263 ◽

pp. 416-420 ◽

Cited By ~ 1

Author(s):

Fu Ping Jia ◽

Heng Lin Lv ◽

Yi Bing Sun ◽

Bu Yu Cao ◽

Shi Ning Ding

Keyword(s):

Compressive Strength ◽

Elevated Temperature ◽

Fly Ash ◽

Room Temperature ◽

Elevated Temperatures ◽

Relative Strength ◽

Ordinary Concrete ◽

Residual Compressive Strength ◽

Fly Ash Concrete ◽

The Relationship

This paper presents the results of elevated temperatures on the compressive of high fly ash content concrete (HFCC). The specimens were prepared with three different replacements of cement by fly ash 30%, 40% and 50% by mass and the residual compressive strength was tested after exposure to elevated temperature 250, 450, 550 and 650°C and room temperature respectively. The results showed that the compressive strength apparently decreased with the elevated temperature increased. The presence of fly ash was effective for improvement of the relative strength, which was the ratio of residual compressive strength after exposure to elevated temperature and ordinary concrete. The relative compressive strength of fly ash concrete was higher than those of ordinary concrete. Based on the experiments results, the alternating simulation formula to determine the relationship among relative strength, elevated temperature and fly ash replacement is developed by using regression of results, which provides the theoretical basis for the evaluation and repair of HFCC after elevated temperature.

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