scholarly journals ROLE OF THERMOGRAPHY IN ASSESSMENT OF MYGENOUS JOINT DISORDER

2019 ◽  
Vol 12 (3) ◽  
pp. 1241-1247
Author(s):  
Nida Fathima ◽  
Sreedevi Dharman
Keyword(s):  
Clinical Trials ◽  
Skin Temperature ◽  
Diagnostic Tool ◽  
Orofacial Pain ◽  
Screening Method ◽  
High Specificity ◽  
The Body ◽  
Large Sample Size ◽  
Facial Region ◽  
Joint Disorder

The main objective of this review was to identity the usage of thermography in diagnosis of orofacial pain. Thermography is a method of measurement of skin temperature distribution on the body over a given period of time. Hence using the skin temperature, an advantages result can be obtained in identifying diseased condition in orofacial region. This article highlights the basics of thermography as a diagnostic tool in dentistry in identifying orofacial pain. PUBMED and Google Scholar were searched to identify all the clinical trials which evaluated the use of thermography in diagnosis of orofacial pain. The included studies involved 6 clinical trials. From all the included studies, an advantages result was obtained by using thermography in assessing orofacial disorders between symptomatic and asymtomatic patient’s. All the findings obtained, suggest that thermography can be helpful in evaluating myogenous temperomandibular joint disorder and can be used as a clinical screening method and for improving diagnostic accuracy. In few studies, the sensitivity of thermography in the diagnosis of orofacial disorder is low, but has high specificity which helped in evaluation of orofacial disorder and is therefore applicable to patients with orofacial pain. Thermography benefits by locating the temperature difference between symptomatic and asymtomatic facial region thus indicating its aid in diagnoses of orofacial disorder. However due to liminted evidence and short term studies, it is recommended that more of long term studies with large sample size should be emphasised to use thermography as routine diagnostic tool in identifying orofacial disorder.

scholarly journals Evidence-Based Therapeutic Benefits of Cupping Therapy (Ḥijāma): A Comprehensive Review

2021 ◽  
Vol 11 (4-S) ◽  
pp. 258-262
Author(s):  
Hina V Kouser ◽  
Mohd Nayab ◽  
Ayesha Tehseen ◽  
Shaista Mahfooz ◽  
Baig Ruqaiyya ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Skin Surface ◽  
Cupping Therapy ◽  
The Body ◽  
Large Sample Size ◽  
Comprehensive Review ◽  
Therapeutic Benefits ◽  
Long Duration ◽  
Ancient Times

Ilaj bi’l tadbeer (regimenal therapy) is one of the preferred treatment methods used in Unani system of medicine since ancient times. Ḥijāma is one of the effective modalities of treatment in Ilaj bi’l tadbeer. It is a unique therapeutic procedure in which cup like vessels are placed on the body surface by creating a vacuum to either let out blood from below the skin surface or just plain suction without bloodletting. The objective of this comprehensive review paper is to address the claims of Unāni physicians and clinical studies conducted on the efficacy of Ḥijāma. Various published clinical trials showed the efficacy of Ḥijāma in the management of a number of diseases. Though, the effect showed by some clinical trials was short term. Hence, it is suggested that rigorous, well-designed, controlled, randomized and long duration follow up clinical trials on large sample size are to be conducted by trained clinicians or researchers to establish the efficacy of Ḥijāma in the management of various diseases. Keywords: Ilaj bi’l tadbeer, Ḥijāma, Therapeutic Benefits

638-P: Innovative Diagnostic Tool for Assessment of Plantar Skin Temperature to Spot Diabetes-Related Foot Complications

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 638-P
Author(s):  
ARATI A. SHAHADE ◽  
ANUJ A. SHAHADE ◽  
AMBRISH M. SHAHADE ◽  
SAGAR P. WAGH ◽  
SHOUNAK OZARKAR
Keyword(s):  
Skin Temperature ◽  
Diagnostic Tool ◽  
Foot Complications

ACE-2-Receptors of the Epidermis, Dermal Vascular Walls and Sebaceous Gland Cells: The Way of COVID-19 Entry into the Body?

2020 ◽  
Author(s):  
Stefan Bittmann
Keyword(s):  
Clinical Trials ◽  
Viral Infection ◽  
Sebaceous Gland ◽  
The Body ◽  
Viral Agent ◽  
Therapy Options ◽  
Vascular Walls ◽  
Fish Market ◽  
The World ◽  
The Usa

Since the outbreak near a fish market in Wuhan, China, in December 2019, researchers have been searching for an effective therapy to control the spreading of the new coronavirus SARS-CoV-2 and inhibit COVID-19 infection. Many countries like Italy, Spain, and the USA were ambushed by this viral agent. To date, more than 2.5 million people were infected with SARS-CoV-2. There is no clear answer, why SARS-CoV-2 infects so many people so fast. To date of April 2020, no effective drug has been found to treat this new severe viral infection. There are many therapy options under review and clinical trials were initiated to get clearer information, what kind of drug can help in this devastating and serious situation. The world has no time.

Associated change in plantar temperature and sweating after transthoracic endoscopic T2–3 sympathectomy for palmar hyperhidrosis

2001 ◽  
Vol 95 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Han-Jung Chen ◽  
Cheng-Loong Liang ◽  
Kang Lu
Keyword(s):  
Skin Temperature ◽  
Temperature Change ◽  
The Body ◽  
Palmar Hyperhidrosis ◽  
Compensatory Sweating ◽  
Content Type ◽  
Postoperative Changes ◽  
The Face ◽  
The Difference ◽  
Fine Print

Object. Transthoracic endoscopic T2–3 sympathectomy is currently the treatment of choice for palmar hyperhidrosis. Compensatory sweating of the face, trunk, thigh, and sole of the foot was found in more than 50% of patients who underwent this procedure. The authors conducted this study to investigate the associated intraoperative changes in plantar skin temperature and postoperative plantar sweating. Methods. One hundred patients with palmar hyperhidrosis underwent bilateral transthoracic endoscopic T2–3 sympathectomy. There were 60 female and 40 male patients who ranged in age from 13 to 40 years (mean age 21.6 years). Characteristics studied included changes in palmar and plantar skin temperature measured intraoperatively, as well as pre- and postoperative changes in plantar sweating and sympathetic skin responses (SSRs). In 59 patients (59%) elevation of plantar temperature was demonstrated at the end of the surgical procedure. In this group, plantar sweating was found to be exacerbated in three patients (5%); plantar sweating was improved in 52 patients (88.1%); and no change was demonstrated in four patients (6.8%). In the other group of patients in whom no temperature change occurred, increased plantar sweating was demonstrated in three patients (7.3%); plantar sweating was improved in 20 patients (48.8%); and no change was shown in 18 patients (43.9%). The difference between temperature and sweating change was significant (p = 0.001). Compared with the presympathectomy rate, the rate of absent SSR also significantly increased after sympathectomy: from 20 to 76% after electrical stimulation and 36 to 64% after deep inspiration stimulation, respectively (p < 0.05). Conclusions. In contrast to compensatory sweating in other parts of the body after T2–3 sympathetomy, improvement in plantar sweating was shown in 72% and worsened symptoms in 6% of patients. The intraoperative plantar skin temperature change and perioperative SSR demonstrated a correlation between these changes.

Tumor Microenvironment-Triggered In-Situ Cancer Vaccines with Dual Immunogenic Cell Death Inductions for Elevated Antitumor and Antimetastatic Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jun Lin ◽  
Binbin Ding ◽  
Pan Zheng ◽  
Dong Li ◽  
Meifang Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Microenvironment ◽  
Immune Responses ◽  
Cancer Immunotherapy ◽  
Cancer Vaccines ◽  
High Specificity ◽  
The Body ◽  
Immunogenic Cell Death ◽  
Specific Antigens

Cancer vaccine is to make tumor-specific antigens into vaccines, which then are injected back into the body to activate immune responses for cancer immunotherapy. Despite the high specificity and therapeutic...

Non-Ceruloplasmin Copper as a Stratification Biomarker of Alzheimer’s Disease Patients: How to Measure and Use It

2021 ◽  
Vol 18 ◽  
Author(s):  
Rosanna Squitti ◽  
Mariacarla Ventriglia ◽  
Alberto Granzotto ◽  
Stefano L. Sensi ◽  
Mauro Ciro Antonio Rongioletti
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Cognitive Impairment ◽  
Cost Effective ◽  
The Elderly ◽  
The Body ◽  
Eligibility Criterion ◽  
Growing Body ◽  
Proper Balance

: Alzheimer’s disease (AD) is a type of dementia very common in the elderly. A growing body of recent evidence has linked AD pathogenesis to copper (Cu) dysmetabolism in the body. In fact, a subset of patients affected either by AD or by its prodromal form known as Mild Cognitive Impairment (MCI) have been observed to be unable to maintain a proper balance of Cu metabolism and distribution and are characterized by the presence in their serum of increased levels of Cu not bound to ceruloplasmin (non-ceruloplasmin Cu). Since serum non-ceruloplasmin Cu is a biomark- er of Wilson's disease (WD), a well-known condition of Cu-driven toxicosis, in this review, we pro- pose that in close analogy with WD, the assessment of non-ceruloplasmin Cu levels can be exploit- ed as a cost-effective stratification and susceptibility/risk biomarker for the identification of some AD/MCI individuals. The approach can also be used as an eligibility criterion for clinical trials aim- ing at investigating Cu-related interventions against AD/MCI.

scholarly journals Hysteroscopy is Gold standard in Uterine evaluation for Infertility, but HSG still has a place

2021 ◽  
Vol 12 (4) ◽  
pp. 98-104
Author(s):  
Manisha Bajaj ◽  
Rajib Roy ◽  
Motiur Rahman ◽  
Joydeb Roychowdhury
Keyword(s):  
Predictive Value ◽  
False Negative ◽  
Screening Method ◽  
Uterine Cavity ◽  
High Specificity ◽  
Filling Defect ◽  
Endometrial Polyp ◽  
Care Hospital ◽  
Saline Infusion Sonography ◽  
First Choice

Background: Uterine abnormalities, congenital or acquired are implicated as causal factor in 10%-15% of infertile couplesreporting for treatment. Hysteroscopy, hysterosalpingography (HSG), saline-infusion-sonography and USG are available for evaluation of uterine cavity. HSG helps in initial evaluation of a sub-fertile woman, but hysteroscopy is gold standardas itallows direct visualisation ofintrauterine pathology and treatment in same-setting, if required. Aims and Objective: To describe hysteroscopic findings of infertile patients and compare the observations with their respective HSG findings. Materials and Methods: It’s a prospective analysis of 105 women with infertility who attendedtertiary-care hospital during 18 monthsfulfilling pre-defined inclusion and exclusion criteria. All cases were evaluated with both HSG and hysteroscopy, observations were recorded and co-related with each other. Results: Among 105 cases, maximum (76.19%) were 25-35 years of age. The primary infertility accounted for 68.57% cases.Abnormal HSG findings observed in 19 cases (20%), most common being filling-defect.Hysteroscopy detected abnormalities in 39 cases (37.14%), commonest being endometrial polyp. Out of 39 cases of abnormal uterine cavity detected on hysteroscopy only 19 were picked-up by HSG, rest 20 cases failed to be identified. The strength of agreement between hysteroscopy and HSG calculated is moderate (Kappa=0.505). Conclusion: As HSG hadlow false positivity (03%), high positive-predictive-value (90.48%) and negative-predictive-value (76.19%) and high specificity (96.96%) it is still considered as a first-choice screening method of uterine cavity. However, high false-negative-value (51.28%)of HSG makes Hysteroscopy a better diagnostic test. HSG couldn’t differentiate endometrial polyp, adhesions and submucous fibroid, shown them as filling defect only.

scholarly journals Gene Xpert a Promising Tool in Diagnosis of Extrapulmonary TB in Developing Countries

2021 ◽  
Vol 39 (1) ◽  
pp. 26-30
Author(s):  
Jabin Akhter ◽  
MA Hassan Chowdhury
Keyword(s):  
Developing Countries ◽  
Diagnostic Tool ◽  
Ethical Issues ◽  
Diagnostic Delay ◽  
Cross Sectional Study ◽  
The Body ◽  
Clinical Samples ◽  
Cross Sectional ◽  
Conventional Culture ◽  
Promising Tool

Introduction: Although Tuberculosis mostly affects lungs in about 85% cases, but can cause lesion almost in every part of the body. Extrapulmonary TB (EPTB) accounts for 15 to 20% which involves other parts of the body beside the lungs. There are several methods that can diagnose Pulmonary TB (PTB) conclusively , but extrapulmonary TB is very difficult to diagnose till now especially in resource limited settings. Though it is not communicable but diagnostic delay has made it significant cause of morbidity and mortality. The snidy was aimed to find out the Gene Xpert as one of the diagnostic tool for EPTB. Methods: A laboratory based descriptive cross sectional study was conducted over a period of  17  months  from January 2017 to May 2018 to ascertain the performance of Gene Xpert technique as a diagnostic tool for EPTB. Data were collected through checklist and a total of 77 clinical samples were collected purposively with prior infom,ed consent from suspected EPTB patients following ethical issues. Laboratory investigations were  perfomed  at Rhodolphe Merieux Laboratory, Chittagong, Bangladesh with Gene Xpert MTB/Ri f assay, conventional culture (LJ media) and Microscopy (ZN stain) for the presence of Mycobacteium tuberculosis (MTB). Results: Among the 77 samples from suspected cases, seven(9.09%) from CSF, one(!.29%) from pus and one(l .29%) from lymphnode specimens were positive by Gene Xpert MTB/Rif assay.Only one(1.29%) CSF specimen  was found to be culture and microscopy positive which was Gene Xpert positive also. Except one specimen from pus that is both Gene Xpert and microscopy positive but culture negative, no other specimens from EPTB cases were culture and microscopy positive. Conclusion: Diagnosis of EPTB is challenging in worldwide. As it is paucibacillary, routine diagnostic test in detecting MTB is difficult. Gene X pert showed promising outcome in early detection of life threatening EPTB cases like TB meningitis which is common in developing countries. JOPSOM 2020; 39(1): 26-30

scholarly journals Peptide hormone relaxin: from bench to bedside

2018 ◽  
Vol 314 (6) ◽  
pp. R753-R760 ◽  
Author(s):  
Maria Jelinic ◽  
Sarah A. Marshall ◽  
Dennis Stewart ◽  
Elaine Unemori ◽  
Laura J. Parry ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Animal Models ◽  
Animal Studies ◽  
Ischemia Reperfusion ◽  
Peptide Hormone ◽  
The Body ◽  
Cervical Ripening ◽  
Matrix Remodeling ◽  
Vitro Fertilization

The peptide hormone relaxin has numerous roles both within and independent of pregnancy and is often thought of as a “pleiotropic hormone.” Relaxin targets several tissues throughout the body, and has many functions associated with extracellular matrix remodeling and the vasculature. This review considers the potential therapeutic applications of relaxin in cervical ripening, in vitro fertilization, preeclampsia, acute heart failure, ischemia-reperfusion, and cirrhosis. We first outline the animal models used in preclinical studies to progress relaxin into clinical trials and then discuss the findings from these studies. In many cases, the positive outcomes from preclinical animal studies were not replicated in human clinical trials. Therefore, the focus of this review is to evaluate the various animal models used to develop relaxin as a potential therapeutic and consider the limitations that must be addressed in future studies. These include the use of human relaxin in animals, duration of relaxin treatment, and the appropriateness of the clinical conditions being considered for relaxin therapy.

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