ACE-2-Receptors of the Epidermis, Dermal Vascular Walls and Sebaceous Gland Cells: The Way of COVID-19 Entry into the Body?

2020 ◽  
Author(s):  
Stefan Bittmann
Keyword(s):  
Clinical Trials ◽  
Viral Infection ◽  
Sebaceous Gland ◽  
The Body ◽  
Viral Agent ◽  
Therapy Options ◽  
Vascular Walls ◽  
Fish Market ◽  
The World ◽  
The Usa

Since the outbreak near a fish market in Wuhan, China, in December 2019, researchers have been searching for an effective therapy to control the spreading of the new coronavirus SARS-CoV-2 and inhibit COVID-19 infection. Many countries like Italy, Spain, and the USA were ambushed by this viral agent. To date, more than 2.5 million people were infected with SARS-CoV-2. There is no clear answer, why SARS-CoV-2 infects so many people so fast. To date of April 2020, no effective drug has been found to treat this new severe viral infection. There are many therapy options under review and clinical trials were initiated to get clearer information, what kind of drug can help in this devastating and serious situation. The world has no time.

Indian Pharmaceuticals Industry in Global Scenario: An Appraisal

2020 ◽  
Vol 22 (3) ◽  
pp. 424-429
Author(s):  
Prabal Chakraborty
Keyword(s):  
Clinical Trials ◽  
Cost Effectiveness ◽  
Intellectual Property Rights ◽  
Strategic Alliances ◽  
Direct Investment ◽  
Multinational Companies ◽  
Fdi Inflows ◽  
The World ◽  
The Usa ◽  
Offshore Plants

Today, the Indian pharmaceuticals industry is recognised the world over due to the quality and cost-effectiveness of its products. At present, globally it is one of the fastest-growing industries and contributes 2.4 per cent value wise and 10 per cent volume wise globally. India alone accounts for 20 per cent of global exports in generics. In 2016, the Indian pharma industry exported USD16.89 billion and is expected to touch USD40 billion by 2020. The present generics market has immense potentiality for foreign direct investment (FDI) inflows, and worth USD14.53 billion of FDI inflows came in between April 2000 and December 2016. We have witnessed that Indian pharma companies go for joint ventures with multinational companies, make strategic alliances and co-promotions, contract research and manufacturing services, export, acquisitions and mergers, focus on new markets other than the USA and Europe, buy offshore plants and increase stakes in other companies. India is also becoming an attractive investment for the clinical trials market. The objective of this paper is to analyse the Indian pharmaceuticals industry—opportunity and threats, strategies of the Indian companies particularly after trade-related aspects of intellectual property rights (TRIPS).

Role of Vitamins, Minerals and Herbs in Strengthening immune system against the newly Emerging Viral Disease SARS-CoV-2

2021 ◽  
pp. 309-315
Author(s):  
Ajay I. Patel ◽  
Pooja R. Maru ◽  
Ashok B. Patel ◽  
Amitkumar J. Vyas ◽  
Nilesh K. Patel
Keyword(s):  
Immune System ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
Viral Disease ◽  
The Body ◽  
Primary Stage ◽  
The Social ◽  
The World

The Coronavirus Disease 2019 (COVID-19) is caused by severe acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection Attack mainly on the immune system of the body. The current pandemic situation of COVID-19 has broken the social-economical Condition of the World. The Available Allopathic drug Paramedical system is attempting to manage the symptoms. But, there are no significant effects of the available drug system. So, it is better to move toward a supplement system that improves the body's immune system. Herbs, Minerals, and Vitamins can be boosting body immunity and prevent the respiratory Viral Disease SARS-CoV-2. It gives its response in the Primary Stage of COVID-19. So, it is better to towards the natural herbals, Minerals, and vitamins which can improve the immunity of the body and it can possibly prevent the viral infection.

Postmillennial cancer narratives: feminism and postfeminism in Eve Ensler’s In the Body of the World

2019 ◽  
Vol 21 (2) ◽  
pp. 235-252
Author(s):  
Marta Fernández-Morales
Keyword(s):  
Meaning Making ◽  
Uterine Cancer ◽  
The Body ◽  
First Century ◽  
Narrative Strategies ◽  
The World ◽  
Health And Illness ◽  
The Usa ◽  
Twenty First Century ◽  
Vagina Monologues

In the context of a new wave of women’s activism for equality, the body is once again at the centre of the discussion today, in the USA and globally. Analysing American discourses about health and illness at the turn of the twenty-first century, Tasha Dubriwny has argued that the current narratives are dominated by neoliberal and postfeminist philosophies that have thrived in a framework of biomedicalisation and self-surveillance. What happens, then, when a successful feminist artist is diagnosed with uterine cancer? How does Eve Ensler, author of The Vagina Monologues and founder of V-Day, face the fact that her life may have a painful ending? How does a woman so aware of her physical and psychological self come to terms with illness? Is she willing to put her political project aside to become a patient? Through a close reading of Ensler’s uterine cancer memoir In the Body of the World, and focusing particularly on its structure and narrative strategies, this article situates her work within the corpus of female literature about health and illness in the twenty-first century, exploring her meaning-making process in the light of the current tensions between feminism and postfeminism.

scholarly journals Rethinking Remdesivir for COVID-19: A Bayesian Reanalysis of Trial Findings

2020 ◽  
Author(s):  
Sarahanne Miranda Field ◽  
Joyce M. Hoek ◽  
Ymkje Anna de Vries ◽  
Maximilian Linde ◽  
Merle-Marie Pittelkow ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Mortality Rate ◽  
Clinical Improvement ◽  
Primary Outcome ◽  
Secondary Outcome ◽  
Moderate Evidence ◽  
The World ◽  
The Usa ◽  
Regulatory Bodies ◽  
Take All

Following testing in clinical trials, the use of remdesivir for treatment of COVID-19 has been authorized for use in parts of the world, including the USA and Europe. These early authorizations were largely based on results from two clinical trials. A third study published by Wang et al. was deemed inconclusive. We demonstrate the utility of Bayesian reanalyses in the context of non-significant results like the Wang et al. trial. Results of a reanalysis of the three trials show ambiguous evidence for the primary outcome of clinical improvement and moderate evidence against efficacy of remdesivir for the secondary outcome of mortality rate. We recommend that regulatory bodies take all available evidence into account for endorsement decisions.

scholarly journals LATENTIATED PRODRUG APPROACH OF DRUGS: AN OVERVIEW

2021 ◽  
pp. 19-30
Author(s):  
DHARUN P. R. ◽  
ISMAIL Y. ◽  
VIJAYA VARA PRASAD M.
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Adverse Events ◽  
20Th Century ◽  
The Body ◽  
Specific Site ◽  
Conventional Drug ◽  
The World ◽  
Major Criterion

Prodrugs, with their capability of declining the adverse events and elevating the bioavailability of certain drugs, have captured enormous attention throughout the world since the 20th century. The versatility of the prodrugs that are inert and after administration releasing the parent moiety for the desired effect has become a major criterion for the scientists to incorporate this to alleviate the undesired effects of a conventional drug. About 10% of the prevailing drugs are prodrugs and their usage is being amplified owing to its critical application in cancer therapy, toxicity alleviation, and specificity. The purpose of this review is to understand the prodrugs, strategies incorporated in designing the prodrugs, applications, their crucial benefits in targeted action at a specific site of the body, their advantageous effects in chemotherapy. Also, to be acknowledged with the ongoing clinical trials and researches on prodrugs and some notable marketed prodrugs in a depth manner.

scholarly journals Ongoing Clinical and Immunization Trials for Novel Zoonotic Covid -19 Pandemic

2021 ◽  
pp. 85-93
Author(s):  
Ramya Kumari B. S.
Keyword(s):  
Clinical Trials ◽  
Mortality Rate ◽  
Infectious Diseases ◽  
Phase I ◽  
Viral Infection ◽  
Host Cell ◽  
Phase Iii ◽  
Specific Level ◽  
Contagious Diseases ◽  
The World

Some of the contagious diseases have created history and also remains with us today. So it becomes utmost important to understand such infectious diseases and exploring their remedies. One such disease which has created havoc across the globe is COVID-19, caused by an agent SARS CoV-2 virus. The current threat of coronavirus is the human health and economy, which can be overcome by the development of a target vaccine at a specific level by blocking the entry of virus inside the host cell. This step not only will reduce the morbidity and mortality rate associated with this viral infection but will also improve upon the prevailing economy crisis. Hence, this review chapter aims at the ongoing clinical and immunization trials for novel zoonotic COVID-19 pandemic. Currently the clinical trials are happening throughout the world and all the trials are to be registered in publicly available domain which is recommended by ICMJE. Different phase of trials in various parts of the globe, includes Phase-I to Phase-III and insights of vaccine developers involved in the development of COVID vaccines are the focused areas in this review chapter.

scholarly journals Favipiravir: A Critical Review of Pharmacology, Pre-Clinical Data, and Emerging Clinical Uses in COVID-19

2021 ◽  
Vol 9 (8) ◽  
pp. 2521-2527
Author(s):  
Anuja S. Motule
Keyword(s):  
Clinical Trials ◽  
Drug Treatment ◽  
Viral Infection ◽  
Clinical Data ◽  
Critical Review ◽  
Virus Disease ◽  
Antiviral Drug ◽  
Veterinary Drugs ◽  
Evidence Based ◽  
The World

Abstract: Since last two years, whole world is going through the pandemic situation of Corona Virus Disease-19 (COVID-19). It caused more than 43 lakhs deaths worldwide. COVID-19 outbreak all over the world has led the researchers and Scientists to develop drugs or vaccines to prevent the spreading of this virus. Due to the unavailabity of proper drug treatment, various veterinary drugs are trying in humans. It is one of such type of antiviral drug which was previously used in treatment of viral infection in animals and birds. In this article, we have tried to provide a comprehensive, evidence-based review of this drug in the context of the present pandemic to elucidate its role in the management of COVID-19. Keywords: Favipiravir; Pharmacology; COVID-19; Antiviral; Clinical trials.

scholarly journals Integrated methods of combating sheep ectoparasites

2021 ◽  
Vol 258 ◽  
pp. 04038
Author(s):  
S. Mavlanov ◽  
U. Soatov ◽  
SH. Kholmatov ◽  
A. Amirov ◽  
U. Irgashev
Keyword(s):  
Growth And Development ◽  
The Body ◽  
Milk Productivity ◽  
The World ◽  
The Usa ◽  
Integrated Methods ◽  
Meat Productivity ◽  
Biological Methods

Recently, in various countries of the world, in particular, the USA, Germany, Canada, India and Russia, tangible results have been achieved in the use of biological methods for combating zoophilic insects and ecoparasites, the use of microbiological and pyrethroid preparations with a plant base. Zoophilic insects and mites as ecto- and endoparasites parasitize on the body of animals and people cause infestation, that is, parasitosis (entomoses and acarosis), as a result of which the milk productivity of cattle decreases to 30-40 percent, meat productivity annually decreases by 10-12 kilograms, and also negatively affect the growth and development of young animals and lead to death.

COVID-19 infection: A review of summarized Clinical trials study for the treatment

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Afzal Hussain ◽  
Ashfaq Hussain ◽  
Chandan Kumar Verma
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
Rna Virus ◽  
Antiviral Treatment ◽  
Pharmaceutical Drugs ◽  
The World ◽  
Amoxicillin Clavulanate ◽  
Bevacizumab Injection

Background: Coronavirus Disease 2019 (COVID-19) is a widely infectious and pathogenic viral infection due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that has arisen in Wuhan, China, and spread throughout the world. Coronavirus is indeed an enveloped RNA virus of the genus Betacoronavirus, which is transmitted to birds, humans as well as other mammals. The fastest human to human transition has been generally established. On July 19, 2020, WHO has been reported total confirmed cases: 1,40, 43,176, total confirmed new cases: 1,66,735, total deaths: 5,97,583, total new deaths: 4,496 globally. Material & Methods: In this review, the Clinical trial database is analyzed and systematically summarized drugs which are in the recruiting phase and the completion phase of the clinical trial. Results: Total 383 clinical trials are listed, involving more than 350 medicines such as Deferoxamine, Favipiravir, DAS181, Tocilizumab Injection, Sarilumab, Placebo, Sildenafil citrate tablets, Sargramostim, Lopinavir/ritonavir, Remdesivir, Bevacizumab, Tetrandrine, Fingolimod, Methylprednisolone, Plaquenil, Tocilizumab, Hydroxychloroquine, Abidol hydrochloride, Bevacizumab Injection, Methylprednisolone, Amoxicillin-clavulanate, Moxifloxacin, Sarilumab, Darunavir, and Cobicistat, etc. Conclusion: There is no commercially authorized antiviral treatment or vaccine suitable for use against COVID-19. However, Clinical trials represent an effective approach because they facilitate the development of new types of pharmaceutical drugs.

scholarly journals Global Big Data confirm Remdesivir to be a Recommended Antiviral Drug to Fight COVID-19

2020 ◽  
Vol 55 (4) ◽  
Author(s):  
Maslichah Mafruchati
Keyword(s):  
Data Mining ◽  
Clinical Trials ◽  
Big Data ◽  
Information Search ◽  
Antiviral Drug ◽  
Google Trends ◽  
The Internet ◽  
Relevance Score ◽  
The World ◽  
The Usa

COVID-19 is the latest deadly virus to haunt the world. The virus is so contagious it needs a precise drug for treating patients who contract it. The purpose of this study is to observe trends and relevant points of information about Remdesivir in global big data. This article describes a new method of collecting data, namely data mining from Google trends. The subjects under consideration is how Remdesivir is used in the USA, Russia, and India, as they are the current countries with the most COVID-19-positive cases. This method enabled us to discover how many topics on the internet related to Remdesivir, as well as how strong the relevance of this topic was in those three countries. The results shows that the USA had the biggest relevance score in the information search (8.86 points), but the information trends were quite static. Russia had fluctuating trends but the lowest relevance score. India had a dynamic trend recently and a higher relevance score than Russia. It can be concluded that medical authorities are the cause behind information trends for Remdesivir in these three countries that have approved clinical trials for the use of Remdesivir as a COVID-19 treatment.

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