Effect of herbal extract of anting-anting (Acalypha australis) on blood glucose level of Balb/C mice with induction of Streptozotocin

2011 ◽  
Vol 9 (1) ◽  
pp. 12-16
Author(s):  
RIZKY OCKTARINI ◽  
DIDING HERI PRASETYO ◽  
IPOP SJARIFAH
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
T Test ◽  
Herbal Extract ◽  
Control Group ◽  
Buffer Solution ◽  
Control Group Design ◽  
Post Test

Ocktarini R, Prasetyo DH, Sjarifah I. 2011. Effect of herbal extract of anting-anting (Acalypha australis) on blood glucose level of Balb/C mice with induction of Streptozotocin. Biofarmasi 9: 12-16. This study was conducted to determine the effect of herbal extract of anting-anting (Acalypha australis L.) on the decrease of blood glucose level of Balb/C mice induced with Streptozotocin. This research was an experimental laboratory with pre and post-test control group design, conducted in Laboratory of Biochemistry and Histology, Faculty of Medicine, Sebelas Maret University, Surakarta. The test animals used were 16 male mice, about 4-6 weeks of age with approximately 20-30 grams induced with Streptozotocin in 0.02 M citric buffer solution, and a dose of 65 mg/kg body weight. Furthermore, the mice were divided into two groups (Metformin in a dose of 1.3 mg/mice/day and herbal extract of anting-anting 1000 mg/kg BB/day) randomly, each group consisted of 8 mice. All mice were observed for GDS level after 14 days treatment period. The data obtained was processed by using the Independent-Samples T-test statistical test (unpaired t-test) with SPSS for Microsoft Windows Release 18.0. Mean of decreased GDS levels on Metformin group vs herbal extract of anting-anting (145.87 mg/dl vs 144.62 mg/dl, p=0.965). The treatment of herbal extract of anting-anting in a dose of 1000 mg/kg body weight/day could decrease blood glucose level of Balb/C mice induced with Streptozotocin that equal with Metformin.

scholarly journals The effect of daun sendok (Plantago major) extract on the blood glucose level of Balb/C mice induced by streptozotocin

2010 ◽  
Vol 8 (2) ◽  
pp. 66-71
Author(s):  
PUTRI SATRIANY ◽  
R. P. ANDRI PUTRANTO ◽  
IPOP SYARIFAH
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Simple Random Sampling ◽  
Control Group ◽  
Plantago Major ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels

Satriany P, Putranto RPA, Syarifah I. 2010. The effect of daun sendok (Plantago major) extract on the blood glucose level of Balb/C mice induced by streptozotocin. Biofarmasi 8: 66-71. This research aimed to determine the effect of daun sendok (Plantago major L.) extract on the blood glucose level of Balb/C mice induced by streptozotocin. This study was a laboratory experimental pre and post-test control group design. The subjects used were 16 male mice. Then, mice were induced with streptozotocin by a dose of 65 mg/kg body weight intraperitoneally freshly dissolved in 0.02 M citrate saline buffer. Mice used were mice with blood glucose levels â‰¥200 mg/dL. Furthermore, mice were divided into 2 groups by a simple random sampling. Group 1 was given metformin in a dose of 1.3 mg/mice/day and group 2 was given daun sendok extract in a dose of 1000 mg/kg body weight/day. At the 2nd week, it was measured for the glucose levels from the blood of mice tail by a Blood Glucose Stick Meter (Gluco DrTM). The data obtained were statistically analyzed by independent samples t-test by using SPSS Programme for Microsoft Windows release 17.0. The significance was set at p<0.05. The difference of average blood glucose levels pre vs post experiment, metformin group was -145.87 mg/dL and daun sendok group was -85.00 mg/dL (p=0.024). The experiment results showed that daun sendok extract in a dose of 1000 mg/kg body weight/day could reduce the blood glucose levels in Balb/C mice induced by streptozotocin.

scholarly journals Pemberian ekstrak air buah sawo (Manilkara zapota L.) menurunkan kadar glukosa darah tikus (rattus norvegicus) diabetes mellitus

2016 ◽  
Vol 3 (3) ◽  
pp. 180
Author(s):  
Effatul Afifah
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels

<p><strong>ABSTRACT</strong><br /><br /><em><strong>Background</strong>: Diabetes mellitus (DM) is a chronic metabolic problem disorder characterized by hyperglicemia which is caused by insulin deficiency produced by β-pancreas cells, thus causing abnormalities of carbohydrate, protein, and fat metabolism, and tend to cause complications. </em></p><p><em><strong>Objectives</strong>: To know the effect of sapodilla extract water on blood glucose level of diabetic induce mice. </em></p><p><em><strong>Methods</strong>: This was an experimental study with pre-post control group design. Sapodilla extract water (EABS) was fed to group of mice with alloxan diabetes induction. Twenty four DM induced mice were separated into 4 groups, e.g. control without and with medication of glibenclamide, EABS 1 (treated with 3.6 mL/200 g body weight), and EABS 2 (treated with 7.2 mL/200 g body weight). Mice were then measured for their blood glucose level at the day of 3, 14, and 30. </em></p><p><em><strong>Results</strong>: EABS 1 and EABS 2 decreased blood glucose levels at week of 1st, 2nd, and 3rd after induction. The greatest reduction was shown by EABS 2 at the 3rd week. EABS decreased blood glucose level of mice induced DM and signifi cantly shown at glibenclamide group, followed by EABS 2 and EABS 1.</em></p><p><em><strong>Conclusions</strong>: EABS reduced blood glucose levels of diabetic mice and signifi cantly shown for glibenclamide group, followed by EABS 2 and EABS 1.</em></p><p><strong>KEYWORDS</strong>:<em> diabetes mellitus, sapodilla extract water, blood glucose</em></p><p><br /><strong>ABSTRAK</strong></p><p><em><strong>Latar belakang</strong>: Diabetes mellitus (DM) merupakan penyakit gangguan metabolik kronis yang ditandai dengan hiperglikemia yang disebabkan oleh kekurangan insulin yang dihasilkan oleh sel β-pankreas sehingga menimbulkan kelainan metabolisme karbohidrat, protein dan lemak, dan cenderung menimbulkan komplikasi.</em></p><p><em><strong>Tujuan</strong>: Mengetahui efek pemberian ekstrak buah air sawo terhadap kadar glukosa darah tikus yang diinduksi DM.</em></p><p><em><strong>Metode</strong>: Penelitian ini merupakan penelitian eksperimental murni dengan rancangan pre-post test control group design dengan memberikan intervensi ekstrak buah air sawo (EABS) pada kelompok tikus yang diberikan induksi DM menggunakan aloksan. Sebanyak 24 tikus yang diinduksi DM dikelompokkan ke dalam 4 perlakuan, antara lain kontrol tanpa dan dengan pengobatan glienclamide, EABS 1 (diberi 3,6 mL/200 g berat badan), dan EABS 2 (7,2 mL/200 g berat badan). Tikus diukur kadar gula darahnya pada hari ke-3, 14, dan 30. </em></p><p><em><strong>Hasil</strong>: EABS mampu menurunkan kadar glukosa darah pada tikus, baik pada kelompok EABS 1 maupun EABS 2 pada minggu ke-1, ke-2, dan ke-3 setelah induksi. Hasil penurunan kadar glukosa yang paling besar terjadi pada kelompok EABS 2 pada minggu ke-3 perlakuan. EABS dapat menurunkan kadar glukosa darah tikus yang diinduksi DM dan paling signifi kan terjadi pada kelompok glibenclamide diikuti oleh EABS 2 dan EABS 1.</em></p><p><em><strong>Kesimpulan</strong>: EABS mampu menurunkan kadar glukosa darah pada tikus yang diinduksi alloxan.</em></p><p><strong>KATA KUNCI</strong><em>: diabetes mellitus, ekstrak air buah sawo, glukosa darah</em></p>

Effects of cold stress, alprazolam and phytomedicine in combination with stress on blood glucose and haematogical parameter of the male albino rat

2020 ◽  
Vol 22 ◽  
pp. 37-44
Author(s):  
Piyasi Bhattacharjee ◽  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Cold Stress ◽  
Glucose Level ◽  
Withania Somnifera ◽  
Treated Group ◽  
Control Group ◽  
Root Extract ◽  
Albino Rat

The present study conducted to investigate the haematological changes and changes of blood glucose level in male albino rat due to cold stress. In this experiment normal 12:12 light dark phases were maintained for all the groups. Control group was kept at normal room temperature (22 ± 1). A (4°C), B in (0°C), C (4°C and 0.30 mg alprazolam / kg body weight /animal), D (0°C and 0.30 mg alprazolam/ kg body weight/ animal. E2 group was treated with (4°C and 1000 mg/kg body weight methanolic extract of Withania somnifera root extract /animal). F2 group was treated with (0°C and 1000 mg/kg body weight methanolic root extract of Withania somnifera / animal). The blood glucose level was significantly increased in stressed rats compared to the control animals. The results were also consistent with the exposure to the stress and chronic restraint stress. Action of Alprazolam over cold stress treated group significantly reduced the blood glucose level. Whereas methanolic root extract of Withania somnifera in low and high doses also showed significant effects to the control anxiety like effects on blood glucose level. Alprazolam + different stress treated groups in different experiment at conditions show significant changes in its haematological parameters in comparison to the stress treated group. Whereas herbal medicine (i.e., methanolic root extract of Withania somnifera) when applied to different stress treated group showed more significant result, compared to the Alprazolam+ different stress treated groups. The positive safe anti stress effects of the herbal plant medicine prove that the tribal medicines have the potentiality to act effectively and can be used as safe medicine for antistress purposes.

scholarly journals Effects of ginger juice on blood glucose in alloxan induced diabetes mellitus in rats

2015 ◽  
Vol 23 (1) ◽  
pp. 14-17 ◽  
Author(s):  
Selima Sultana ◽  
Md Ismail Khan ◽  
Hasanur Rahman ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Rokhsana Dil Afroz
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Zingiber Officinale ◽  
Control Group ◽  
Fasting Blood Glucose Level ◽  
Medical College ◽  
Group D

Objective: To find out the effects of ginger (Zingiber officinale) juice blood glucose in alloxan induced-diabetes mellitus in rats. Methods: This experimental study was done in the Department of Pharmacology & Therapeutics, Dhaka Medical College, Dhaka, in collaboration with the Departments of Pathology, Ibrahim Medical College, Dhaka between January and December 2009. This experimental animal study was divided into two parts, which were Experiment-1 and Experiment-2. Experiment 1 comprises of 12 rats and divided into 2 groups each group having 6 rats. Rats of group-A was non-diabetic normal control group and group-B was fed with ginger (Zingiber officinale) in a dose of 4ml/kg body weight orally through Ryle’s tube. Experiment-2 comprised of 12 rats divided into 2 groups each containing 6 rats labeled as group C, group D. Rats of groups C administered alloxan 150 mg/kg intraperitoneally on the 2nd day of the study. Rats of group D were administered alloxan 150mg /kg intraperitoneally and ginger (4ml/kg of body weight orally) on the 2nd day of the study. Results: The fasting blood glucose level at day 12 in the rats treated with ginger (Zingiber officinale) 4 ml /kg body weight orally daily for 12 days showed reduction in fasting blood glucose level as compared to control group, but not significant, which indicates that ginger has no effect in lowering blood glucose of normal rats. The fasting blood glucose levels at day 12 in the rats of group D (treated with ginger and alloxan) showed highly significant reduction in fasting blood glucose level as compared to diabetic control group (p<0.002). Conclusion: Consumption of ginger produced a significant antihyperglycemic effect in experimentally induced diabetic rats. DOI: http://dx.doi.org/10.3329/jdmc.v23i1.22687 J Dhaka Medical College, Vol. 23, No.1, April, 2014, Page 14-17

scholarly journals Pemberian ekstrak daun cincau (Mesona palustris BL) oral meningkatkan jumlah sel β pankreas dan menurunkan gula darah puasa pada tikus putih (Rattus norvegicus) jantan galur Wistar diabetes

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Fatimah Zahra ◽  
Anak A.G. Budhiarta ◽  
Wimpie Pangkahila
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Treatment Group ◽  
Fasting Blood Glucose ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Pancreatic Cells ◽  
Post Test

Abstract: Grass jelly leaf is a traditional Indonesian beverage that is believed to be beneficial for our health. This study was carried out to observe the increased number of pancreatic  cells and the decreased fasting blood glucose in male Wistar rats with diabetes induced by streptozotocin (STZ). This was a pure experimental study with a post-test only control group design. Subjects were 36 male rats divided into 2 groups: the control group (P0), given glibenclamide dose 0.09 mg /200 g rat body weight and 2 ml aquadest as placebo; and the treatment group (P1), given glibenclamide 0.09 mg/200mg rat body weight and grass jelly leaf extract 54 mg/200 mg rat body weight. Pancreatic  cell count and blood glucose examination were performed after 28 days of treatment. The results showed that the number of pancreatic  cells in the treatment group (P1) was statistically higher than of the control group (P0) (56.72±5.644 vs 29.11±2.698 cells (P ≤0.001). In addition, the fasting blood glucose level of the treatment group (P1) was statistically lower than of the control group (P0) (79.50±37.75mg/dl vs 191.00±123.15mg/dl) (P <0.001). Conclusion: The administration of grass jelly extract increased pancreatic β cells and decreased fasting blood glucose level in diabetic male rats. Keywords: grass jelly extract, fasting blood sugar, pancreatic beta cells, diabetes mellitus Abstrak: Daun cincau atau grass jelly (Mesona palustris BL) merupakan bahan minuman tradisional Indonesia yang dipercaya bermanfaat untuk kesehatan. Penelitian ini dilakukan untuk mengetahui adanya peningkatan jumlah sel β pankreas dan penurunan kadar gula darah puasa pada tikus Wistar diabetes yang diinduksi streptozotocin (STZ). Jenis penelitian ialah eksperimental murni dengan post-test only control group design. Subyek penelitian ialah 36 ekor tikus putih jantan, dibagi menjadi 2 kelompok, yaitu: kelompok kontrol (P0) yang diberikan glibenklamid oral dosis 0,09 mg/200gr BB tikus dan 2 ml aquadest sebagai plasebo; dan kelompok perlakuan (P1) yang diberikan glibenklamid oral dosis 0,09 mg/200 gr BB tikus dan ekstrak daun cincau dosis 54 mg/200gr BB tikus. Penghitungan jumlah sel β pankreas dan pengukuran gula darah dilakukan setelah 28 hari perlakuan. Hasil penelitian menunjukkan bahwa kelompok perlakuan (P1) memiliki jumlah sel β pankreas yang secara statistik lebih tinggi dibandingkan kelompok kontrol (P0) (56,72±5,644 sel/lapang pandang vs 29,11±2,698 sel/lapang pandang) (P ≤0,001). Selain itu, kelompok perlakuan (P1) memiliki kadar gula darah puasa yang secara statistik lebih rendah dibandingkan kelompok kontrol (P0) (79,50±37,75 mg/dl vs 191,00±123,15 mg/dl) (P <0,001). Simpulan: Pemberian ekstrak daun cincau (Mesona palustris BL) meningkatkan jumlah sel β pankreas dan menurunkan kadar gula darah puasa pada tikus (Rattus novergicus) jantan galur Wistar diabetes.Kata kunci: ekstrak daun cincau, gula darah puasa, sel beta pankreas, diabetes melitus

scholarly journals Penerapan Modifikasi Psikoedukasi Pada Penderita Diabetes Mellitus Tipe2

2018 ◽  
Vol 6 (2) ◽  
pp. 147
Author(s):  
Nailiy Huzaimah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Family Support ◽  
Glucose Level ◽  
Self Efficacy ◽  
Diabetes Management ◽  
Self Management ◽  
Control Group ◽  
Control Group Design

Controlled blood glucose level is one of the success indicator of the diabetes management. A good comprehension, high self-efficacy, and good family support is needed to encourage and strengthen the effort of individuals to achieved good behavioral diabetes self-management, which helped to control blood glucose level. This study aimed to determine the Psychoeducation Modification’s effects on comprehension, self-efficacy, family support, behavioral diabetes self-management, and blood glucose level of people with type 2 diabetes mellitus (T2DM). This study used pre and post test control group design. Respondents of this research are population with T2DM and their families who are undergoing outpatient treatment at Internal Medicine Outpatient Unit of Dr. H. Moh. Anwar Sumenep Hospital (n = 40). Collecting data included the patients comprehension, self-efficacy, behavioral self-management of diabetes, family support, and random blood glucose level. Data collection used questionnaires and the laboratory test of blood glucose level, then analyzed by a different test with the α value

scholarly journals Pengaruh Relaksasi Terhadap Penurunan Kadar Gula Darah Pada Pasien Diabetes Mellitus Tipe 2 di Sebuah Rumah Sakit di Tasikmalaya

2008 ◽  
Vol 12 (2) ◽  
pp. 108-114
Author(s):  
Asep Kuswandi ◽  
Ratna Sitorus ◽  
Dewi Gayatri
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Nursing Intervention ◽  
T Test ◽  
Control Group ◽  
Before And After ◽  
And Control

AbstrakTeknik relaksasi dapat menurunkan kadar gula darah pasien melalui penurunan stres. Penelitian ini bertujuan mengetahui perbedaan kadar gula darah pasien diabetes mellitus sebelum dan sesudah relaksasi di salah satu rumah sakit di Tasikmalaya, Jawa Barat. Penelitian ini merupakan penelitian kuantitatif dengan desain kuasi eksperimen menggunakan kontrol. Sampel berjumlah 100 responden, terdiri dari masing-masing 50 responden pada kelompok intervensi kontrol. Perbedaan kadar gula darah sebelum dan sesudah latihan relaksasi dengan diuji dengan paired-sample T test. Hasil menunjukkan terjadi penurunan kadar gula darah Rerata sebesar 53,6 mg/dL sesudah relaksasi, dengan nilai p = 0,000. Angka penurunan tertinggi terjadi pada hari ketujuh relaksasi dan angka terendah terjadi pada hari ketiga. Penelitian ini menyimpulkan relaksasi dapat menurunkan kadar gula darah pasien diabetes mellitus. AbstractRelaxation is a basic nursing intervention of to decrease the blood glucose level of diabetes mellitus patients. The aim of this study was to compare blood glucose level before and after relaxation on the experiment and control group of type 2 diabetes mellitus patients at a hospital in Tasikmalaya, West Java. This quasi experiment study with control group involved 100 participants, divided equally into the experiment and control group. Fifty participants were trained the relaxation technique whilst the control group didn’t. The difference of blood glucose level before and after relaxation was examined by the pairedsample T test. The blood level serum were significantly decreased about 53,6 mg/dL after relaxation with p value 0,000. The decreasing rate reached its highest on seventh day after relaxation whereas the lowest was on the third day after relaxation. In conclusion, relaxation can decrease the blood glucose level of the diabetic mellitus type 2 patients.

scholarly journals The effect of Averrhoa bilimbi stem extract on the blood glucose level of white rats induced by alloxan

2017 ◽  
Vol 14 (2) ◽  
pp. 56-62
Author(s):  
CAHYANING GUSTI AGRIANI ◽  
KISRINI KISRINI ◽  
RUBEN DHARMAWAN
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Positive Control ◽  
Drug Group ◽  
Positive Control Group ◽  
Control Group ◽  
White Rats ◽  
Stem Extract

Agriani CN, Kisrini, Dharmawan R. 2016. The effect of Averrhoa bilimbi stem extract on the blood glucose level of white rats induced by alloxan. Biofarmasi 14: 56-62. The purpose of this research is to find out the effect of belimbing wuluh stem (Averrhoa bilimbi L.) extract due to the blood glucose level in white rats (Rattus norvegicus) induced by alloxan. This research is a laboratory experiment using experimental control group pre-post test design. Subjects of this research are 25 white male rats (Rattus norvegicus), 2 months of age and 200 g of body weight. Subjects were divided into five groups. All groups were induced by 25 mg/200 g body weight/day of alloxan for three days. On the day of fourth, blood sample was collected from orbital vein of white rats for the measurement of the first blood glucose level (T1). Furthermore, the positive control group received 12,6 mg/200 g body weight/day of metformin, then the first, second, and third group received of each 25, 50, and 100 mg/200 g body weight/day of belimbing wuluh stem extract. On the fifteenth day of treatment, blood samples were collected again from the orbital vein of white rats for the measurement of the second blood glucose level (T2). The measurement of blood glucose was using spectrophotometer with the Glucose GOD PAP method. Then the data were analyzed by using One way ANOVA. Blood glucose rate after induction has subtracted from blood glucose rate after drug given. After that the data would be change in to mean data that represents as: negative control group = 24,4; positive control group 103,4; first given drug group = 83,4; second given drug group = 102,4; and third given drug group = 102,2 (in mg/100 mL unit). The statistical analysis by using One way ANOVA shows a significant difference in blood glucose level among the five groups of treatment with p-value = 0,000. Post Hoc Test shows that the first, second, and third group have the same effectively as the positive control group to decrease the blood glucose level with p > 0,05.

scholarly journals PENGARUH SEREAL BERBAHAN SAGU DAN Moringa oleifera TERHADAP KADAR GLUKOSA DARAH TIKUS YANG DIINDUKSI ALOKSAN - IN PRESS -

2019 ◽  
Vol 6 (2) ◽  
Author(s):  
Melin Novidinisa Herada Putri ◽  
A'immatul Fauziyah ◽  
Taufik Maryusman
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Moringa Oleifera ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
White Rats

The Effects of Cereal Made From Sagu and Moringa oleifera on the Blood Glucose Level of Alloxan-Induced RatsDiabetes Mellitus (DM) type 2 could increase oxidative stress and blood glucose level. Resistant starch compounds in Cersa Mori have an antidiabetic properties.This research aimed to analyze the effect of Cersa Mori on fasting blood glucose (FBG) level of diabetic white rats induced by alloxan. This is a true experimental study with a randomized pre-post control group design using 27 male Wistar strain rats divided into 3 groups randomly, i.e (KN) feed and aquades, (KP) glibenclamide 0.126mg/200gBB/day, (P) Cersa Mori 5g/200gBB/day. KP and P groups were given alloxan 125 mg/KgBB subcutaneously and the intervention was carried out for 30 days. FBG level was measured using the GOD-PAP method. The results of Paired T-Test showed the effect of Cersa Mori on lowering FBG level in hyperglycemic rats (P=0,006). One-Way ANOVA test showed that Cersa Mori reduced FBG level, which was equalent to those given glibenclamide (P=0,366). It can be concluded that giving Cersa Mori 5g/200gBB/day for 30 days had a significant effect on lowering FBG level. Keywords: alloxan; Cersa Mori; diabetic rats; fasting blood glucose level; resistant strachABSTRAKDiabetes Mellitus (DM) tipe 2 dapat memicu stres oksidatif dan meningkatkan kadar glukosa darah puasa (GDP). Senyawa pati resisten dalam sereal siap saji Cersa Mori memiliki sifat antidiabetik. Penelitian ini bertujuan menganalisis pengaruh pemberian Cersa Mori terhadap kadar glukosa darah tikus putih diabetes yang diinduksi aloksan. Penelitian true-experimental ini menggunakan randomized pre-post control group design. Sampel sebanyak 27 ekor tikus jantan galur Wistar dibagi menjadi 3 kelompok secara acak yaitu; (KN) pakan dan akuades, (KP) glibenklamid 0,126 mg/200gBB/hari, (P) Cersa Mori 5g/200gBB/hari. KP sampai P diberikan aloksan 125 mg/KgBB secara subkutan dan intervensi dilakukan selama 30 hari. Pengukuran GDP menggunakan metode GOD-PAP. Hasil Uji-T menunjukkan pengaruh Cersa Mori dalam menurunkan GDP tikus hiperglikemia (P=0,006). Uji ANOVA satu arah menunjukkan penurunan GDP pada kelompok Cersa Mori (P) setara dengan tikus yang diberi glibenklamid (P=0,366). Dengan demikian dapat disimpulkan bahwa pemberian Cersa Mori dosis 5g/200gBB/hari selama 30 hari berpengaruh terhadap penurunan GDP secara signifikan. 

scholarly journals EFFECT OF INJECTABLE COMBINATION ESTROGEN-PROGESTERON AND PROGESTERON-ONLY CONTRACEPTIVES ON GLUCOSE AND MALONDIALALDEHID SERUM

2020 ◽  
Vol 4 (2) ◽  
pp. 118-123
Author(s):  
Dwi Retna Prihati ◽  
Paryono Paryono ◽  
Wiwin Rohmawati
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Hormonal Contraception ◽  
Test Group ◽  
Control Group ◽  
Treatment Groups ◽  
Level Increase ◽  
Post Test ◽  
Experimental Laboratory

Injectable hormonal contraception has been the most favorable contraception method in Indonesia in 2013 and its number reaches 4,128,115 acceptors (48.56%). The estrogen and progesterone contents in injectable contraception could cause stress, increased appetite, decreased leptin level and insulin resistance, eventually leading to increased blood glucose and serum malondialaldehyde levels. This study aims to observe the main effect of use of combined estrogen-progesteron and only progesteron injectable hormonal contraceptions on glucose level in blood and malondialaldehyde (MDA) level in serum. This is an experimental laboratory study. It uses Randomized pre-post test group research design for glucose level and randomized post test with control for malondialaldehyde level. The data are analyzed using Anova. The significance value is p<0.01. 28 samples are divided into 7 groups and each group consists of 4 samples, namely one control group and 6 treatment groups consisting of P1 combined dose 0.54 mg, P2 combined dose 1.08 mg, P3 combined dose 1.62 mg, P4 DMPA dose 2.7 mg, P5 DMPA dose 5.4 mg, P6 DMPA dose 8.1 mg.  Only DMPA contraception at 0.54 mg dose influences the blood glucose level increase by p = 0.00. Only DMPA contraception at 8.1 mg dose does not influence serum MDA level by p = 0.1. The conclusion is DMPA contraception has greater potential of causing blood glucose level increase than the combined contraception. Combined and DMPA contraceptions share the risk of increasing serum MDA level.

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