Dendritic polymers composed of glycerol and succinic acid: Synthetic methodologies and medical applications

2004 ◽  
Vol 76 (7-8) ◽  
pp. 1375-1385 ◽  
Author(s):  
N. R. Luman ◽  
Terry Kim ◽  
M. W. Grinstaff
Keyword(s):  
Succinic Acid ◽  
Medical Applications ◽  
Dendritic Polymers ◽  
Synthetic Methodology ◽  
Design And Synthesis ◽  
Characterization Techniques ◽  
Medical Materials ◽  
Synthetic Methodologies ◽  
Dendritic Macromolecule

Research on dendrimers continues to expand as further advances in synthetic methodology and characterization techniques translate to additional applications. Recently, dendritic polymers composed of the natural metabolites glycerol and succinic acid were synthesized, functionalized, and evaluated as new medical materials. The design and synthesis of poly(glycerol-succinic acid) dendritic polymers are discussed, including comparing and contrasting the convergent versus the divergent methodologies for preparing such macromolecules. Finally, a photocrosslinkable dendritic macromolecule was prepared and successfully used to close linear corneal lacerations as well as to secure LASIK flaps.

scholarly journals Design and Synthesis of Fluoro Analogues of Vitamin D

2021 ◽  
Vol 22 (15) ◽  
pp. 8191
Author(s):  
Fumihiro Kawagoe ◽  
Sayuri Mototani ◽  
Atsushi Kittaka
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Fluorine Atom ◽  
Chemical Properties ◽  
Molecular Structures ◽  
Physical And Chemical Properties ◽  
Design And Synthesis ◽  
Synthetic Methodologies ◽  
Physical And Chemical ◽  
And Chemical Properties

The discovery of a large variety of functions of vitamin D3 and its metabolites has led to the design and synthesis of a vast amount of vitamin D3 analogues in order to increase the potency and reduce toxicity. The introduction of highly electronegative fluorine atom(s) into vitamin D3 skeletons alters their physical and chemical properties. To date, many fluorinated vitamin D3 analogues have been designed and synthesized. This review summarizes the molecular structures of fluoro-containing vitamin D3 analogues and their synthetic methodologies.

Biodegradable Materials Application: Experience of the Russian Technological Platform “Medicine of the Future”

2016 ◽  
Vol 683 ◽  
pp. 440-446
Author(s):  
Ilia P. Kaminskii ◽  
Anna V. Lozhnikova ◽  
Gennadiy G. Fomin ◽  
Mikhail Chikov
Keyword(s):  
Composite Materials ◽  
Materials Science ◽  
European Patent ◽  
Medical Applications ◽  
Industrial Property ◽  
Biodegradable Composite ◽  
Federal Institute ◽  
Inventive Activity ◽  
The Future ◽  
Medical Materials

This paper describes the establishment of the new joint laboratory for medical materials science in Tomsk in the framework of the Technology Platform “Medicine of the Future”. The objective of this paper is to analyze the promising research areas within Medicine and Healthcare in the field of medical materials science. The study has been carried out using patent analysis and the method of critical technologies. The research object is the science and technology thematic area “biodegradable composite materials for medical applications”. According to the analysis of patent databases of the Federal Institute of Industrial Property (Russia) and the European Patent Office, the authors have made conclusions concerning the level of inventive activity with regard to “biodegradable composite materials for medical applications”, and determined the common and distinct country features of patent activity in medical materials science. Besides, the authors have suggested a new approach to improving the inventive activity in Russia and abroad, based on the method of critical technologies.

Catalytic asymmetric synthesis of 1,3-enyne scaffolds: design and synthesis of conjugated nitro dienynes as novel Michael acceptors and development of a new synthetic methodology

2014 ◽  
Vol 50 (14) ◽  
pp. 1745-1747 ◽  
Author(s):  
Xiang Li ◽  
Fangzhi Peng ◽  
Mingtao Zhou ◽  
Mingjie Mo ◽  
Ruirui Zhao ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Enantioselective Synthesis ◽  
Synthetic Methodology ◽  
Design And Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Michael Acceptors ◽  
Catalytic Asymmetric

A catalytic enantioselective synthesis of 1,3-enynes for the development of nitro dienynes as novel Michael acceptors has been developed.

Recent progress in the design and synthesis of nanofibers with diverse synthetic methodologies: characterization and potential applications

2020 ◽  
Vol 44 (23) ◽  
pp. 9581-9606 ◽  
Author(s):  
Soroush Soltani ◽  
Nasrin Khanian ◽  
Thomas Shean Yaw Choong ◽  
Umer Rashid
Keyword(s):  
Recent Progress ◽  
Design And Synthesis ◽  
Potential Applications ◽  
Synthetic Methodologies

The advancements of nanotechnology, particularly nanomaterials science, have produced a broad range of nanomaterials including nanofibers, nanorods, nanowires and etc., which have been technically and practically examined over various applications.

scholarly journals Geomimetic approaches in the design and synthesis of metal-organic frameworks

2019 ◽  
Vol 377 (2149) ◽  
pp. 20180221 ◽  
Author(s):  
Igor Huskić ◽  
Tomislav Friščić
Keyword(s):  
Metal Organic Framework ◽  
Science And Technology ◽  
Metal Organic Frameworks ◽  
Environmentally Friendly ◽  
Accelerated Ageing ◽  
Theme Issue ◽  
Design And Synthesis ◽  
Synthetic Materials ◽  
Metal Organic ◽  
Synthetic Methodologies

The recent discovery of minerals with metal-organic framework (MOF) structures has challenged the view of MOFs as purely synthetic materials. At the same time, the application of geo-inspired synthetic methodologies, such as accelerated ageing and pseudomorphic replication, has enabled a cleaner, more environmentally friendly synthesis of MOFs from mineral-like feedstocks, as well as the assembly of materials with structure controlled at both micro- and meso-scales. These almost concomitant developments have highlighted the previously unknown relationships between geology and MOF chemistry. Here, we outline examples of MOF structures found in minerals, and note geologically inspired approaches to MOF synthesis, as a means to highlight how the emergent geomimetic concepts in MOF chemistry can lead to advances in the design and synthesis of MOFs. This article is part of the theme issue ‘Mineralomimesis: natural and synthetic frameworks in science and technology’.

Genetic fabrication of functional silk mats with improved cell proliferation activity for medical applications

2019 ◽  
Vol 7 (11) ◽  
pp. 4536-4546 ◽  
Author(s):  
Yuancheng Wang ◽  
Sheng Xu ◽  
Riyuan Wang ◽  
Wenjing Chen ◽  
Kai Hou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Tissue Repair ◽  
Medical Applications ◽  
Cell Proliferation Activity ◽  
Proliferation Activity ◽  
Medical Materials

Functional silk mats with improved cell proliferation activity are promising medical materials to accelerate damaged wound healing and tissue repair.

Metal–organic frameworks with Lewis acidity: synthesis, characterization, and catalytic applications

CrystEngComm ◽  
2017 ◽  
Vol 19 (29) ◽  
pp. 4066-4081 ◽  
Author(s):  
Zhigang Hu ◽  
Dan Zhao
Keyword(s):  
Heterogeneous Catalysis ◽  
Lewis Acid ◽  
Metal Organic Frameworks ◽  
Acid Sites ◽  
Lewis Acidity ◽  
Lewis Acid Sites ◽  
Design And Synthesis ◽  
Characterization Techniques ◽  
Metal Organic ◽  
Catalytic Applications

In this highlight, we review the recent development in the design and synthesis of metal–organic frameworks with Lewis acidity, the characterization techniques of Lewis acid sites, and their applications in heterogeneous catalysis.

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

Tailoring microstructures of materials through biomimetics

1993 ◽  
Vol 51 ◽  
pp. 500-501
Author(s):  
Mehmet Sarikaya ◽  
Ilhan A. Aksay
Keyword(s):  
Chemical Properties ◽  
Design And Synthesis ◽  
Structure Sensitive ◽  
Macro Scale ◽  
Methods Of Synthesis ◽  
Successive Level ◽  
Engineering Materials ◽  
Physical And Chemical ◽  
And Chemical Properties ◽  
Synthesis Of Materials

Biomimetics involves investigation of structure, function, and methods of synthesis of biological composite materials. The goal is to apply this information to the design and synthesis of materials for engineering applications.Properties of engineering materials are structure sensitive through the whole spectrum of dimensions from nanometer to macro scale. The goal in designing and processing of technological materials, therefore, is to control microstructural evolution at each of these dimensions so as to achieve predictable physical and chemical properties. Control at each successive level of dimension, however, is a major challenge as is the retention of integrity between successive levels. Engineering materials are rarely fabricated to achieve more than a few of the desired properties and the synthesis techniques usually involve high temperature or low pressure conditions that are energy inefficient and environmentally damaging.In contrast to human-made materials, organisms synthesize composites whose intricate structures are more controlled at each scale and hierarchical order.

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