Acute Bouts of Assisted Cycling Improves Cognitive and Upper Extremity Movement Functions in Adolescents With Down Syndrome

2014 ◽  
Vol 52 (2) ◽  
pp. 124-135 ◽  
Author(s):  
Shannon D. R. Ringenbach ◽  
Andrew R. Albert ◽  
Chih-Chia (JJ) Chen ◽  
Jay L. Alberts

Abstract The aim of this study was to examine the effectiveness of 2 modes of exercise on cognitive and upper extremity movement functioning in adolescents with Down syndrome (DS). Nine participants randomly completed 3 interventions over 3 consecutive weeks. The interventions were: (a) voluntary cycling (VC), in which participants cycled at their self-selected pedaling rate; (b) assisted cycling (AC), in which the participants' voluntary pedaling rates were augmented with a motor to ensure the maintenance of 80 rpm; and (c) no cycling (NC), in which the participants sat and listened to music. Manual dexterity improved after AC, but not after VC or NC. Measures of cognitive function, including reaction time and cognitive planning, also improved after AC, but not after the other interventions. Future research will try to uncover the mechanisms involved in the behavioral improvements found after an acute bout of assisted cycling in adolescents with DS.

Medicina ◽  
2019 ◽  
Vol 55 (2) ◽  
pp. 43 ◽  
Author(s):  
Shengyan Sun ◽  
Paul D. Loprinzi ◽  
Hongwei Guan ◽  
Liye Zou ◽  
Zhaowei Kong ◽  
...  

Background and Objectives: Limited research has evaluated the effects of acute exercise on cognition under different conditions of inspired oxygenation. Thus, the purpose of this study was to examine the effects of high-intensity interval exercise (HIE) under normoxia (inspired fraction of oxygen (FIO2): 0.209) and moderate hypoxia (FIO2: 0.154) on cognitive function. Design: A single-blinded cross-over design was used to observe the main effects of exercise and oxygen level, and interaction effects on cognitive task performance. Methods: Twenty inactive adults (10 males and 10 females, 19–27 years old) performed a cognitive task (i.e., the Go/No-Go task) before and immediately after an acute bout of HIE under normoxic and hypoxic conditions. The HIE comprised 10 repetitions of 6 s high-intensity cycling against 7.5% body weight interspersed with 30 s passive recovery. Heart rate, peripheral oxygen saturation (SpO2) and rating of perceived exertion were monitored. Results: The acute bout of HIE did not affect the reaction time (p = 0.204, η2 = 0.083) but the accuracy rate decreased significantly after HIE under both normoxic and hypoxic conditions (p = 0.001, η2 = 0.467). Moreover, moderate hypoxia had no influence either on reaction time (p = 0.782, η2 = 0.004) or response accuracy (p = 0.972, η2 < 0.001). Conclusions: These results indicate that an acute session of HIE may impair response accuracy immediately post-HIE, without sacrificing reaction time. Meanwhile moderate hypoxia was found to have no adverse effect on cognitive function in inactive young adults, at least in the present study.


1995 ◽  
Vol 81 (3) ◽  
pp. 739-745 ◽  
Author(s):  
Nobuyuki Inui ◽  
Masah Yamanishi ◽  
Shinji Tada

The purpose of this study was to examine the serial information processing in adolescents with mental retardation, autism, and Down syndrome by using a serially patterned tracking task. Analyses indicated that 7 adolescents with mental retardation, 8 with autism, and 3 with Down syndrome had significantly slower and more variable simple reaction times than did 10 college students. Also, the autistic adolescents had significantly faster mean simple reaction time than those with Down syndrome. On a task of tracking serial light stimulation, mentally retarded adolescents had significantly faster reaction time than college students. The autistic subjects excessively had faster anticipatory reaction times than did the subjects in the other three groups. On the other hand, adolescents with Down syndrome had markedly slower and more variable reaction times than did adolescents with non-Down-syndrome mental retardation. As for motor organization of keystrokes on the tracking task, mentally retarded adolescents responded with six movements, in which these individuals pressed a series of keys 1, 2, 3, 4, 5, and 6, as a chunk, as exhibited by college students. Adolescents with autism and Down syndrome, however, did not produce this movement-output chunking.


2017 ◽  
Vol 5 (2) ◽  
pp. 252-266 ◽  
Author(s):  
Danielle Nesbitt ◽  
Sergio L. Molina ◽  
Maria Teresa Cattuzzo ◽  
Leah E. Robinson ◽  
David Phillips ◽  
...  

This paper examined relationships between qualitative (developmental sequences) and quantitative (time) performance in rising from a supine position in early childhood. One hundred twenty two children ranging in age from 3 to 5 years were videotaped for five trials of rising from a supine position. Children’s performance on the supine-to-stand (STS) task was quite variable in terms of both qualitative movement patterns and time (mean = 2.37 s, SD = .60). Results: Component sequences were moderately to strongly correlated with each other (r = .387 to .791). Upper-extremity (r = –.383) and axial (r = –.416) component levels also were inversely correlated with STS time. Results indicated a strong coordinative link between the development of trunk control (i.e., axial movement) and upper-extremity movement levels (r = .791), and together they demonstrated the strongest impact on the ability to rise quickly. These data provide important information relating to a child’s motor development that may have clinical relevance for diagnosis. It provides also a greater understanding on how to improve performance on this task. Future research should examine qualitative and quantitative aspects of STS performance to understand its predictive utility as a lifespan assessment of motor competence and its potential importance as a measure to predict healthrelated variables and functional capability across the lifespan.


1991 ◽  
Vol 8 (3) ◽  
pp. 234-241 ◽  
Author(s):  
Sheila E. Henderson ◽  
Sheelagh M. Illingworth ◽  
John Allen

This study addressed the question of whether there is a specific reaction time deficit in individuals with Down syndrome. To investigate this question, the manual and vocal reaction times of 18 Down syndrome and 2 control groups were compared. One control group consisted of intellectually handicapped children matched on intellectual ability, the other consisted of younger nonhandicapped children also of similar mental age. The results confirmed that a specific RT deficit does indeed exist and is present for both manual and vocal responses.


2018 ◽  
Vol 17 (4) ◽  
pp. 27-35
Author(s):  
Vincenzo G. Nocera, MS ◽  
Angela J. Wozencroft, PhD ◽  
Dawn P. Coe, PhD, FACSM

This systematic review of the literature examined the impact of physical activity on cognitive performance in youth with Down syndrome (DS). A comprehensive search resulted in the identification of 20 articles that were screened with five studies included in the qualitative analysis. In the studies analyzed, both acute and chronic moderate intensity physical activity protocols were utilized as well as a variety of cognitive assessments evaluating different components of cognitive function (ie, reaction time, inhibition, planning, working memory, and manual dexterity). Overall, this review found a positive relationship between acute and chronic physical activity and cognitive function. These relationships are consistent with the literature in typically developing youth. The findings of this review show promising results that consistent participation in moderate levels of physical activity may lead to higher levels of cognition function in youth with DS. Practical implications and future research are discussed in the article.


2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1271.1-1272
Author(s):  
S. Derham ◽  
J. Lewis ◽  
E. Dures ◽  
F. Cramp

Background:Adults with fibromyalgia frequently report symptoms of cognitive dysfunction, often referred to as fibrofog. However primary research exploring cognitive dysfunction in the lives of adults with fibromyalgia is very limited (Kravitz and Katz, 2015).Objectives:The aim of this review was to (i) synthesise the qualitative literature on the lived experiences of cognitive dysfunction in adults with fibromyalgia, (ii) develop common themes through thematic analysis and (iii) identify knowledge gaps to inform future research and clinical practice in this area.Methods:Seven electronic databases (MEDLINE, Embase, CINAHL, PsycINFO, Amed, Scopus and OpenGrey), reference lists of key articles and two high impact qualitative journals were searched from 1990 to November 2018. Articles were eligible for inclusion if they reported primary qualitative data exploring the experiences of cognitive dysfunction in adults with fibromyalgia. Included studies were appraised using the Critical Appraisal Skills Programme (CASP) qualitative checklist and extracted data analysed using narrative synthesis. SD conducted critical appraisal and data extraction on all included studies. FC, JL and ED reviewed five papers each. All papers were reviewed by two co-authors. Of the 1413 records identified, 15 studies were selected for inclusion.Results:These studies included 208 women and 22 men with fibromyalgia, aged 18 to 72 years and representing seven different countries. Duration of diagnosis was four months to 34 years. Fourteen studies used interviews and one used focus groups. None of the included studies focussed exclusively on cognitive function in adults with fibromyalgia. Three studies identified themes specific to cognitive dysfunction and fibromyalgia symptoms. The remaining 12 studies presented relevant data intertwined with the overall lived experiences of fibromyalgia.Cognitive dysfunction, as a part of fibromyalgia, was often unpredictable. Problems with memory and concentration that were most commonly reported were emotionally distressing and affected functional and vocational activities. Participants found communication effortful, with a negative impact on work, leisure and social activities. Stress, fear and worry around perceived cognitive changes were commonly expressed. Lost employment or changed work roles and relationships, due to cognitive difficulties, had negative impacts for many participants. The terms cognitive dysfunction and fibrofog were used interchangeably within the studies, but lacked common definition. This introduced uncertainty around whether participants and authors were describing the same phenomenon.Conclusion:Adults with fibromyalgia experience unpredictable and emotionally impactful difficulties related to cognitive dysfunction. Functional impact was broad-reaching, particularly around work ability and lost employment opportunities. It is unclear how cognitive symptoms in fibromyalgia related to co-morbid symptoms such as pain, fatigue and poor sleep. Further research focusing on the full impact of cognitive function on the lives of adults with fibromyalgia is recommended to inform clinical practice. Research to establish clarity of definition of the terms cognitive dysfunction and fibrofog within fibromyalgia is highly recommended.References:[1]Kravitz H, Katz R. Fibrofog and fibromyalgia: a narrative review and implications for clinical practice. Rheumatology International. 2015;35(7):1115-25.Acknowledgments:This work is supported by the National Institute for Heath Research [ICA-PCAF-2018-01-078 to SD]Disclosure of Interests:Sandra Derham: None declared, Jenny Lewis: None declared, Emma Dures Grant/research support from: Independent Learning Grant from Pfizer, combined funding for a research fellow from Celgene, Abbvie and Novartis, Paid instructor for: A fee from Novartis to deliver training to nurses., Fiona Cramp: None declared


2017 ◽  
Vol 3 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Ligia C. S. Fonseca ◽  
Annika K. Nelke ◽  
Jörg Bahm ◽  
Catherine Disselhorst-Klug

Abstract:Coping strategies of patients with obstetric brachial plexus palsy (OBPP) are highly individual. Up to now, individual movement performance is assessed by visual observations of physicians or therapists - a procedure, which is highly subjective and lacks objective data. However, objective data about the individual movement performance are the key to evidence-based and individualized treatment. In this paper, a new approach is presented, which provides objective information about the upper extremity movement performance of patients with OBPP. The approach is based on the use of accelerometers in combination with a classification procedure. The movement performance of 10 healthy volunteers and 41 patients with OBPP has been evaluated by experienced physiotherapists and has been assigned to one of 4 categories representing the Mallet Scale (MS) IV to I. Three triaxial-accelerometers were placed at chest, upper arm and wrist of the affected side of the patient. Acceleration signals have been recorded during repetitive movements with relevance regarding daily life. Here, especially the results from the “hand to mouth” task are presented. From the 9 recorded acceleration signals 13 relevant features were extracted. For each of the 13 features 4 thresholds have been determined distinguishing best between the 4 patient categories of the MS and the healthy subjects. With respect to the thresholds each feature value has been assigned to the discrete numbers 0, 1, 2, 3 or 4. Afterwards, each discrete number has been weighted by a factor regarding the correlation between the feature’s value and the MS score. The resulting weighted discrete numbers of all 13 features have been added resulting in a score, which quantifies the individual upper extremity movement performance. Based on this score the movement performance of each patient has been assigned to the classes “very good”, “good”, “regular” and “bad”. All movements of the 10 healthy volunteers were classified as “very good”. The movement performance of two patients MS IV were classified as “very good” as well and the movements of the other 16 patients as “good”. The movements of the entire group of MS III patients fell into the class “regular”. Just one MS II patient was assigned to the class “regular” while the others were classified as “bad”. It was not possible to classify the movements of MS I patients. This was mainly due to the fact that none of these patients MS I was able to complete the task successfully. The developed approach demonstrated its ability to quantify the movement performance of upper extremity movements based on accelerometers. This provides an easy to use tool to assess patient’s movement strategies during daily tasks for diagnosis and rehabilitation.


Author(s):  
Yuichi Suzuki

Abstract A subtest of the LLAMA test battery (LLAMA_D) has been proposed as a potential test of implicit learning aptitude. To improve its construct validity, in the present study, the original LLAMA_D (a) instructions for incidental learning were modified, and (b) confidence ratings of test responses and (c) reaction time (RT) measurements were added. This revised LLAMA_D was administered along with the other LLAMA subtests (LLAMA-B, -E, and -F). Unconscious knowledge that may (not) result from the exposure was assessed through the relationship between the accuracy/RT and confidence ratings. The results suggest that LLAMA_D accuracy largely reflects conscious retrieval of previously heard sound sequences. However, an index derived from the LLAMA_D RT measure (coefficient of variance) was associated with an aspect of oral fluency, which is presumably dependent on proceduralization. Several recommendations are proposed to redesign and extend LLAMA_D as a potential aptitude test for proceduralization.


Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 586 ◽  
Author(s):  
Hamilton Roschel ◽  
Bruno Gualano ◽  
Sergej M. Ostojic ◽  
Eric S. Rawson

There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing, brain function, and recovery from trauma). This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., creatine synthesis enzyme deficiencies, mild traumatic brain injury, aging, Alzheimer’s disease, depression). Despite this, the optimal creatine protocol able to increase brain creatine levels is still to be determined. Similarly, supplementation studies concomitantly assessing brain creatine and cognitive function are needed. Collectively, data available are promising and future research in the area is warranted.


2021 ◽  
pp. 107755952199417
Author(s):  
Katherine R. Brendli ◽  
Michael D. Broda ◽  
Ruth Brown

It is a common assumption that children with disabilities are more likely to experience victimization than their peers without disabilities. However, there is a paucity of robust research supporting this assumption in the current literature. In response to this need, we conducted a logistic regression analysis using a national dataset of responses from 26,572 parents/caregivers to children with and without disabilities across all 50 states, plus the District of Columbia. The purpose of our study was to acquire a greater understanding of the odds of victimization among children with and without intellectual disability (ID), while controlling for several child and parent/adult demographic correlates. Most notably, our study revealed that children with ID have 2.84 times greater odds of experiencing victimization than children without disabilities, after adjusting for the other predictors in the model. Implications for future research and practice are discussed.


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