scholarly journals Seroprevalence of Yellow fever, Chikungunya, and Zika virus at a community level in the Gambella Region, South West Ethiopia

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0253953
Author(s):  
Getahun Asebe ◽  
Daniela Michlmayr ◽  
Gezahegne Mamo ◽  
Woldaregay Erku Abegaz ◽  
Adugna Endale ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Igg Antibodies ◽  
Cross Sectional ◽  
Blood Samples ◽  
History Of ◽  
Arboviral Diseases ◽  
The Individual ◽  
Study Participants

Yellow fever (YF), Chikungunya (CHIK), and Zika(ZIK) are among re-emerging arboviral diseases of major public health concern. Despite the proximity of the Gambella Region to South Sudan where arboviral cases have been recorded repeatedly the current epidemiological situation is unclear in this part of southwest Ethiopia. Therefore, we conducted a community-based seroprevalence survey of YF virus (YFV), CHIK virus (CHIKV), and ZIK virus (ZIKV) infections in two selected districts. A cross-sectional study was conducted in two locations of the Gambella region (Lare and Itang) to investigate the seroprevalence of these viruses’ infections. Blood samples were collected from the study participants and screened for IgG antibodies specific to YFV and CHIKV infections using enzyme-linked immunosorbent assays (ELISA). For the detection of ZIKV specific IgG antibodies, Blockade-of-binding ELISA was used. Data were analyzed using the STATA version 13.1 Softwares. A total of 150 individuals (96 males and 54 females, age ranging from 18 to 65 years, mean age ± SD = 35.92 ± 10.99) participated and provided blood samples. Among the 150 samples 135, 90, and 150 were screened for YFV, CHIKV, and ZIKV, respectively. Hence, 2.9% (95% CI: 1.1–7.7%), 15.6% (95% CI: 9.3–24.8%), and 27.3% (95% CI: 20.7–35.3%) of samples tested positive for IgG antibodies to YFV, CHIKV, and ZIKV infections, respectively. Among the individual seropositive for ZIKV, YFV and CHIKV, only six, one and three had a history of residence outside the Gambella region respectively. Agro-pastoral occupation was significantly associated with a higher prevalence of IgG against CHIKV (AOR = 14.17; 95%CI: 2.30, 87.30) and residency in the Lare district (AOR = 11; 95%CI: 3.31, 39.81) was found to be significantly associated with a higher prevalence of IgG against ZIKV. Our findings revealed the occurrence of YFV, CHIKV and ZIKV infections in the study locations.

Detection of Genetic markers associated with Plasmodium falciparum drug resistance among malaria patients in Kaduna State, Nigeria

2021 ◽  
Vol 42 (2) ◽  
pp. 206-213
Author(s):  
G.Y. Benjamin ◽  
H.I. Inabo ◽  
M.H.I. Doko ◽  
B.O. Olayinka
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Phylogenetic Tree ◽  
Genetic Markers ◽  
Cross Sectional Study ◽  
Sub Saharan Africa ◽  
Health Concern ◽  
Cross Sectional ◽  
Blood Samples ◽  
Test Kit

Malaria is a disease of public health concern in Nigeria and sub-Saharan Africa. It is caused by intracellular parasites of the genus Plasmodium. The aim of this study was to detect genetic markers associated with Plasmodium falciparum drug resistance among malaria patients in Kaduna State, Nigeria. The study was a cross-sectional study that lasted from May 2018 to October 2018. Three hundred blood samples were collected from consenting individuals attending selected hospitals, in the three senatorial districts of Kaduna State, Nigeria. Structured questionnaire were used to obtain relevant data from study participants. The blood samples were screened for malaria parasites using microscopy and rapid diagnostic test kit. Polymerase Chain Reaction was used for detection of the drug resistance genes. Pfcrt, pfmdr1, pfdhfr, pfdhps and pfatpase6 genes were detected at expected amplicon sizes from the malaria positive samples. The pfatpase6 PCR amplicons were sequenced and a phylogenetic tree was created to determine their relatedness. Result showed that Pfcrt (80%) had the highest prevalence, followed by pfdhfr (60%), pfmdr1 (36%) and pfdhps (8%). Pfatpase6 was also detected in 73.3% of the samples, and a phylogenetic tree showed relatedness between the pfatpase6  sequences in this study and those deposited in the GenBank. In conclusion, the study detected that Plasmodium falciparum genes were associated with drug resistance to commonly used antimalarials.

scholarly journals First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses

2020 ◽  
Vol 17 (16) ◽  
pp. 5700
Author(s):  
Zhijun Zou ◽  
Wei Liu ◽  
Chen Huang ◽  
Chanjuan Sun ◽  
Jialing Zhang
Keyword(s):  
Childhood Asthma ◽  
Cross Sectional Study ◽  
Individual Characteristics ◽  
First Year ◽  
Cross Sectional ◽  
Childhood Health ◽  
History Of ◽  
Household Environment ◽  
One Year ◽  
The Individual

Background: Associations of early antibiotics exposures with childhood asthma, allergies, and airway illnesses are debated. Objectives: We aimed to investigate associations of first-year antibiotics exposure with childhood asthma, allergies, and airway illnesses. Methods: A cross-sectional study was conducted among preschoolers in Shanghai, China during 2011–2012. A questionnaire regarding household environment and lifestyles and childhood health outcomes was reported by the child’s parents. Results: In total, 13,335 questionnaires (response rate: 85.3%) were analyzed and 3049 (24.1%) children had first-year antibiotics exposure. In the multivariate logistic regression analyses, first-year antibiotics exposure had significant associations with the higher odds of lifetime-ever pneumonia (adjusted OR, 95% CI: 2.15, 1.95–2.37), croup (1.46, 1.24–1.73), wheeze (1.44, 1.30–1.60), asthma (1.38, 1.19–1.61), food allergy (1.29, 1.13–1.46), and allergic rhinitis (1.23, 1.07–1.41), and as well as current (one year before the survey) common cold (≥3 times) (1.38, 1.25–1.52), dry cough (1.27, 1.13–1.42), atopic dermatitis (1.25, 1.09–1.43), wheeze (1.23, 1.10–1.38), and rhinitis symptoms (1.15, 1.04–1.26). These associations were different in children with different individual characteristics (age, sex, family history of atopy, and district) and other early exposures (breastfeeding, home decoration, pet-keeping, and environmental tobacco smoke). Conclusions: Our results indicate that first-year antibiotics exposure could be a strong risk factor for childhood pneumonia, asthma, allergies, and their related symptoms. The individual characteristics and other early exposures may modify effects of early antibiotic exposure on childhood allergies and airway illnesses.

Factors influencing breast cancer awareness: a cross-sectional study in China

2020 ◽  
Vol 9 (10) ◽  
pp. 679-689
Author(s):  
Na Liu ◽  
Ping Li ◽  
Jie Wang ◽  
Ping-ping Guo ◽  
Xue-hui Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Health Information ◽  
Information Literacy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cancer Awareness ◽  
Cross Sectional ◽  
Breast Cancer Awareness ◽  
History Of ◽  
Study Participants

Aim: This study aimed to explore the factors that influence breast cancer awareness. Materials & methods: A community-based cross-sectional study was conducted between January and April 2019 in Changchun, Jilin Province, China. Results: A total of 274 women were recruited for this cross-sectional study. Participants had a moderate level of breast cancer awareness (median = 76.50 [68.75, 84.00]). Women in the action/maintenance stages reported higher breast cancer awareness (p = 0.044). Women's breast cancer awareness was positively associated with high health information literacy level, husbands' higher educational degrees, seeing doctors after detecting abnormal breast changes and living within a short distance from the nearest hospital. Conclusion: History of screening and higher health information literacy levels are important positive factors linked to higher breast cancer awareness.

scholarly journals Awareness and Perception of Thromboembolism and Thromboprophylaxis among Hospitalized Patients in Jordan

2020 ◽  
Vol 15 (1) ◽  
pp. 72-80
Author(s):  
Anan S. Jarab ◽  
Sayer Al-Azzam ◽  
Rawan Badaineh ◽  
Tareq L. Mukattash ◽  
Razan Bsoul
Keyword(s):  
Educational Level ◽  
Cross Sectional Study ◽  
Hospitalized Patients ◽  
Personal History ◽  
High Educational Level ◽  
Cross Sectional ◽  
Vein Thrombosis ◽  
Validated Questionnaire ◽  
History Of ◽  
Study Participants

Background and Objective: Despite the established importance of thromboprophylaxis in patients with Venous Thromboembolism (VTE), a limited number of studies have assessed the awareness of VTE and thromboprophylaxis therapy among the affected patients. The aim of the current study was to assess awareness and to explore variables associated with awareness about VTE and its thromboprophylaxis. Methods: A cross-sectional study was conducted on hospitalized patients who received thromboprophylaxis (5000 units of heparin subcutaneously (SC) q8-12h, or 30-40 mg of enoxaparin SC once daily). In addition to the sociodemographic variables, awareness and perception of VTE and its thromboprophylaxis were assessed using a validated questionnaire. Multiple logistic regressions were conducted to build a model of variables significantly associated with VTE awareness. Results: A total of 225 patients participated in the study, with only 38.2% and 22.2% of the participants being aware of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) respectively. Logistic regression showed that the participants with low educational level had 3.046 value, with the odds being not aware of DVT or PE compared with participants with high educational level. Participants without a personal history of VTE had 7.374 value, with the odds being not aware of DVT or PE compared with those who had a personal history of VTE. Participants who had a negative perception of VTE had 2.582 value, with the odds being not aware of DVT or PE compared with participants who had a positive perception and those who did not have any information about DVT or PE had 13.727 value, with the odds being not aware of DVT or PE. Conclusion: The findings reveal that there is a lack of awareness about VTE and its thromboprophylaxis among the study participants. Patients with lower educational level and those with no history of previous VTE need awareness improvement about VTE and its thromboprophylaxis. Clinical Pharmacists need to focus on providing information about VTE and improving patients’ perception about VTE and its thromboprophylaxis with the aim of improving the awareness about VTE, and hence the better health outcome.

scholarly journals Evaluating Relationships between Visceral Fat Measures and Adipokines Concentrations among Women with a History of Preeclampsia

2019 ◽  
Vol 37 (11) ◽  
pp. 1140-1145
Author(s):  
Suchitra Chandrasekaran ◽  
Darcy Barry ◽  
Susan Melhorn ◽  
Thomas Easterling ◽  
Hilary Gammill ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Secondary Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Anthropometric Data ◽  
Cross Sectional ◽  
Blood Samples ◽  
Plasma Adiponectin ◽  
History Of

Abstract Objective We sought to evaluate associations between postpartum plasma adipokine concentrations among women with a history of preeclampsia (PE) without severe features (MPE), PE with severe features (SPE), and no PE (NPE). We also investigated relationships between adipokines and computed tomography (CT)-quantified measures of visceral fat (VF) area (VFA) and subcutaneous fat area (SCFA). Study Design We performed a secondary analysis of data collected as part of a previously performed cross-sectional study at our institution. Women with and without a history of PE were recruited in 10 years after delivery. VFA and SCFA measures were performed by CT scan. Anthropometric data and peripheral blood samples from subjects were collected concurrently. Results Plasma adiponectin concentrations (µg/mL) were significantly lower among MPE (18.5 ± 7.1) compared with NPE (27.3 ± 13.8) and SPE (25.7 ± 9.6). Leptin (p = 0.32) and resistin (p = 0.93) concentrations were similar among the groups. Adiponectin concentrations more closely aligned with VFA (β = −0.001, p = 0.03), while resistin concentrations trended toward correlating with SCFA (β = 0.02, p = 0.05). Leptin was not preferential to VFA or SCFA. Conclusion VF distribution may contribute to the variation in PE phenotype. Adiponectin specifically may be a promising marker representing VFA.

scholarly journals Relationship of ABO and Rh blood groups with history of gastritis in the undergraduate medical and dental students: a cross-sectional study

2017 ◽  
Vol 13 (4) ◽  
pp. 372-377
Author(s):  
Nilu Manandhar ◽  
Kushal Bhattarai
Keyword(s):  
Blood Group ◽  
Cross Sectional Study ◽  
Dental Students ◽  
Blood Groups ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Second Year ◽  
Study Participants ◽  
Medical And Dental Students

Background & Objectives: The various ABO and Rh blood groups with different distribution frequencies in the general population have been found to be associated with different diseases, most notably gastritis. Many studies have claimed Rh groups to be indifferent to such association. Nonetheless, ABO group is found to linked with chronic gastritis. The aim of this study was to estimate the frequencies of ABO and Rh blood groups and the gastritis amongst the first and second year undergraduate medical and dental students; and to study their relationships. Materials & Methods: In a descriptive, cross-sectional study, 247 study participants were enrolled. After procuring clearance from the institutional review committee and the informed and written consent from the study participants, data collection was done on the variables, year of study (first or second year), gender, blood groups (ABO and Rh) and history of gastritis (present or absent).Results: Blood group O was the commonest (n=99; 40.1%) followed by group B (n=77; 31.2%). Similarly, 239 (96.8%) participants were Rh-positive as compared to 8 (3.2%) Rh-negative. Interestingly, 46 (18.6%) of the participants reported positive history of gastritis. Participants with blood group O had the greatest odds (OR=1.64) of having history of gastritis compared with those with other blood groups combined. Distribution of study participants based on gender and history of gastritis in either systems of blood grouping shoed no significant difference in their proportions (p>0.05). Conclusion: In light of the above findings, further longitudinal studies can be designed to better asses the relationship.

scholarly journals Retrospective Analysis of Metabolic Syndrome: Prevalence and Distribution in Executive Population in Urban Pakistan

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Niloufer Sultan Ali ◽  
Ali Khan Khuwaja ◽  
Adnan-ur-Rahman ◽  
Kashmira Nanji
Keyword(s):  
Metabolic Syndrome ◽  
Health Care Providers ◽  
Final Analysis ◽  
Analysis Data ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Care Providers ◽  
Cross Sectional ◽  
Factors Associated ◽  
History Of

Background. Metabolic Syndrome (MetS) is a major public health concern. Objective. The aim of this study was to estimate the frequency of MetS, its components, and factors associated with MetS amongst apparently healthy individuals in Pakistan. Methods. A retrospective cross-sectional study was conducted at the executive Clinics of Aga Khan Hospital, Pakistan. Medical records of patients aged ≥18 years visiting the clinics from July 2011 to December 2011 were consecutively reviewed. Records in which either MetS components data or 10% of overall data was missing were excluded. A total of 1329 participants’ records was included in final analysis. Data was analyzed using SPSS version 19 and multivariable logistic regression was used to identify the factors associated with MetS. Results. A total of 847 (63.7%) participants had MetS; mean age of the participants were 47.6 ± 11.6 years. About 70.4% were males and 29.6% were females. Approximately 70% of participants had BMI ≥25 kg/m2. MetS was associated with male gender (AOR = 2.1; 95% C.I: 1.6–3.2) and history of diabetes among parents (AOR = 3.0; 95% C.I: 1.6–6.0). Conclusion. This study shows that a large proportion of population has MetS and is overweight or obese. This requires urgent interventions on part of health care providers’ especially family physicians. Educating masses about life style factors can make a difference. Further researches on this issue are warranted.

scholarly journals Prevalence of positive TST among Healthcare workers in high-burden TB setting in Peru

2020 ◽  
Author(s):  
Juana Sedamano ◽  
Alvaro Schwalb ◽  
Rodrigo Cachay ◽  
Carlos Zamudio ◽  
Cesar Ugarte-Gil ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Cross Sectional Study ◽  
Positive Tuberculin Skin Test ◽  
Control Measures ◽  
Occupational Hazard ◽  
Cross Sectional ◽  
High Burden ◽  
History Of ◽  
The Individual ◽  
Prevalence Ratios

Abstract Background: Tuberculosis (TB) transmission has long been recognized as an important occupational hazard for healthcare workers (HCWs). HCWs possess a 5.8% annual risk of exposure and three times greater risk of developing active TB than the general population.Methods: We conducted an observational cross-sectional study between September 2014 and March 2015 among HCWs in a high-burden TB setting in Lima to estimate the prevalence of positive Tuberculin Skin Test (TST) and to investigate factors associated with a positive TST.Results: 240 participants were included in the analysis; TST was administered to 190 (79.2%) while the rest were exempt due to a previous positive TST result, history of TB or refused the test. A positive TST result was found among 56.2% of participants who were applied the TST (95% CI: 49.22% - 63.55%). When considering those who had a previous positive TST result and those with a history of TB, the prevalence was 64.3% (95% CI: 57.8% - 70.3%). No significant differences were observed between clinical/paramedical and administrative staff in the health center. The use of N95 mask during work hours was reported by 142 (69.9%) participants. Prevalence ratios (PR) show that workers with more than 120 months as a HCW were 1.44 times more likely to be TST positive. The multivariate analysis found that HCWs with over 10 years of service were 1.52 times more likely to be TST positive.Conclusion: This study supports previous reports that TB infection is an occupational hazard for HCWs. Prevention of TB transmission through control measures, as well as timely diagnosis of LTBI in this selected risk group, is critical for the individual and for public health.

scholarly journals Timing of presentation and correlation with computed tomography in pediatric patients with minor head trauma

2018 ◽  
Vol 5 (6) ◽  
pp. 2038
Author(s):  
Karthick Jayapal ◽  
Hassan Adnan Mansour
Keyword(s):  
Computed Tomography ◽  
Head Trauma ◽  
Cross Sectional Study ◽  
Minor Head Trauma ◽  
Cross Sectional ◽  
Increased Risk ◽  
Key Factor ◽  
History Of ◽  
Study Participants ◽  
Type Of Injury

Background: The presentation of minor head trauma warrants immediate and accurate diagnosis for early clinical management among children. Computed Tomography is the gold standard tool for the diagnosis of Traumatic Brain Injury (TBI) among the children. The timing of presentation may have a significant role in predicting the incidence of TBI. This study was done to compare the CT findings among children who presented within and after 24 hours with minor head trauma.Methods: This cross-sectional study was carried out among 992 children between 2-15 years reporting with a history of head injury. All the participants were clinically examined, and relevant history of type of injury and timing of presentation was recorded. CT scan was taken as per PECARN criteria. Data was entered and analysed using SPSS ver 15 software.Results: Majority of the participants belonged to 6-10 years of age (45.2%) and were males (58.5%). About 81.7% of the participants presented within 24 hours. The overall prevalence of TBI among the study participants was 58.6% [55.5-61.6].It was observed that hematoma predominantly presented after 24 hours (74.2%) and majority of the falls presented after 24 hours (92.8%).Patients who presented after 24 hours were at increased risk of presenting as TBI (67.03%) compared to those presenting within 24 hours (56.8%;p<0.05).Conclusions: This study has emphasized the need for including the timing of presentation as a key factor for facilitating early diagnosis and rapid case management of pediatric head trauma.

scholarly journals ASSOCIATION OF SEROPOSITIVITY FOR CMV IGM AND IGG WITH ADVERSE PREGNANCY OUTCOME

2021 ◽  
Vol 71 (3) ◽  
pp. 831-35
Author(s):  
Ambreen Amna ◽  
Farkhunda Nadeem ◽  
Amin Fahim ◽  
Altaf Hussian Jatoi ◽  
Kanwal Abbas ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Adverse Pregnancy Outcome ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
University Hospital ◽  
Igg Antibodies ◽  
Cross Sectional ◽  
History Of ◽  
Adverse Pregnancy ◽  
Reproductive Age Group

Objective: To find out the prevalence of antibodies against cytomegalovirus and their association with adverse pregnancy outcome in women, at Isra University Hospital Hyderabad. Study Design: Cross-sectional study. Place and Duration of Study: Department of Gynaecology & Obstetrics, Isra University Hospital (IUH) Hyderabad, from Jan to Jun 2018. Methodology: Cytomegalovirus IgM and IgG antibodies in 305 women of reproductive age group were measured using the Enzyme Linked Fluorescent Assaysystem kit. Results: The combined positivity of anti cytomegalovirus IgG and IgM antibodies was 93 (30.40%). About 37 (37.37%) and 28 (34.14%) women were found to be seropositive for cytomegalovirus antibodies who had history of spontaneous miscarriage and recurrent miscarriages respectively. Conclusion: Higher association of seropositivity for cytomegalovirus IgM and IgG with bad obstetrical history and low economy was found.

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