scholarly journals Potency of commonly retailed antibiotics in pharmacies found in Adama, Oromia regional state, Ethiopia

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0253971
Author(s):  
Demelash Demissie ◽  
Teshome Geremew ◽  
Adinew Zewdu Chernet ◽  
Musa Mohammed Ali
Keyword(s):  
Bacterial Infections ◽  
Large Scale ◽  
Clinical Laboratory ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Storage Conditions ◽  
Cross Sectional Study ◽  
Diffusion Method ◽  
Cross Sectional ◽  
Expiry Date

Introduction Antibiotics are commonly used for the treatment and prevention of bacterial infections. The potency of antibiotics can be affected by factors such as temperature, light, moisture, and storage conditions. Inappropriate storage and transportation of antibiotics may lead to loss of potency earlier than the expiry date. The aim of this study was to determine the potency and associated factors of commonly retailed antibiotics. Method Institution-based cross-sectional study was conducted on commonly retailed antibiotics in pharmacies that are available in Adama, Ethiopia from March 2018 to June 2018. This study focused on commonly ordered antibiotics such as amoxicillin, azithromycin, ciprofloxacin, and ceftriaxone. Antibiotics to be tested were selected by using a simple random sampling technique. Socio-demographic and related data were collected using a semi-structured questionnaire. Antibiotic susceptibility testing was performed using the disc diffusion method as described in the Clinical Laboratory Standard Institute guideline. Results Mean inhibition zones of amoxicillin, ciprofloxacin, azithromycin, and ceftriaxone were 14.2 ± 4 mm, 30.9 ± 4.2 mm, 17.47 ± 3.83 mm, and 32.7±1.8 respectively. Out of 164 antibiotics tested, 61% passed the potency test. The potency of antibiotics varies across different countries in which 53.7% and 54.6 of antibiotics from India and Ethiopia passed the potency test. All ceftriaxone tested in this study passed the potency test. Factors such as air condition of pharmacy (X2 = 4.27; p = 0.039), source of all antibiotics (X2 = 5.41; p = 0.02), and source of amoxicillin (X2 = 4.73; p = 0.03) were significantly associated with potency of antibiotics. Conclusions About 40% of antibiotics tested in the current study did not pass the potency test; this warrants further investigation to identify the magnitude of the problem and its causes at a large scale.

scholarly journals Multidrug-Resistant Shigellosis among Children Aged below Five Years with Diarrhea at Banadir Hospital in Mogadishu, Somalia

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Bilan Sheikh Ali Nor ◽  
Nelson Chengo Menza ◽  
Abednego Moki Musyoki
Keyword(s):  
Clinical Laboratory ◽  
Sampling Technique ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Diffusion Method ◽  
Cross Sectional ◽  
Children Under Five ◽  
Under Five ◽  
Resource Limited

Globally, shigellosis remains the second leading cause of diarrhea-associated deaths among children under five years of age, and the infections are disproportionately higher in resource-limited settings due to overcrowding, poor sanitation, and inadequate safe drinking water. The emergence and global spread of multidrug-resistant (MDR) Shigella are exacerbating the shigellosis burden. We adopted a cross-sectional study design to determine the distribution and antimicrobial susceptibility (AST) patterns of Shigella serogroups among children aged below five years presenting with diarrhea at Banadir Hospital in Mogadishu, Somalia, from August to October 2019. Stool and rectal swab samples were collected from 180 children consecutively enrolled using a convenient sampling technique and processed following standard bacteriological methods. AST was determined using the Kirby–Bauer disc diffusion method and interpreted as per the Clinical Laboratory Standard Institute (2018) guidelines. Shigellosis prevalence was 20.6% (37/180), and S. flexneri (26/37 (70.3%)) was the predominant serogroup. All the serogroups were 100% resistant to ampicillin (AMP), trimethoprim-sulfamethoxazole (SXT), and tetracycline (TE). Ceftriaxone (CRO) resistance was the highest among S. sonnei (66.7%) isolates. 19.2% of S. flexneri and S. sonnei (50%) serogroups were resistant to ciprofloxacin (CIP), but all S. dysenteriae type 1 isolates remained (100%) susceptible. Forty percent of CIP-susceptible S. dysenteriae type 1 were resistant to CRO. Seven MDR Shigella phenotypes were identified, dominated by those involving resistance to AMP, SXT, and TE (100%). Our findings showed a high prevalence of shigellosis with S. flexneri as the most predominant serogroup among children under five years of age in Banadir Hospital, Somalia. AMP and SXT are no longer appropriate treatments for shigellosis in children under five years in Banadir Hospital. MDR Shigella strains, including those resistant to CIP and CRO, have emerged in Somalia, posing a public health challenge. Therefore, there is an urgent need for AMR surveillance and continuous monitoring to mitigate the further spread of the MDR Shigella strains in Banadir Hospital and beyond.

scholarly journals Compliance with Standard Precautions and Associated Factors among Healthcare Workers in Gondar University Comprehensive Specialized Hospital, Northwest Ethiopia

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Tariku Gebre Haile ◽  
Eshetu Haileselassie Engeda ◽  
Abdella Amano Abdo
Keyword(s):  
Healthcare Workers ◽  
Associated Factors ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Northwest Ethiopia ◽  
Management Support ◽  
Standard Precautions ◽  
Cross Sectional ◽  
Specialized Hospital

Background. In many studies, compliance with standard precautions among healthcare workers was reported to be inadequate.Objective.The aim of this study was to assess compliance with standard precautions and associated factors among healthcare workers in northwest Ethiopia.Methods.An institution-based cross-sectional study was conducted from March 01 to April 30, 2014. Simple random sampling technique was used to select participants. Data were entered into Epi info 3.5.1 and were exported to SPSS version 20.0 for statistical analysis. Multivariate logistic regression analyses were computed and adjusted odds ratio with 95% confidence interval was calculated to identify associated factors.Results.The proportion of healthcare workers who always comply with standard precautions was found to be 12%. Being a female healthcare worker (AOR [95% CI] 2.18 [1.12–4.23]), higher infection risk perception (AOR [95% CI] 3.46 [1.67–7.18]), training on standard precautions (AOR [95% CI] 2.90 [1.20–7.02]), accessibility of personal protective equipment (AOR [95% CI] 2.87 [1.41–5.86]), and management support (AOR [95% CI] 2.23 [1.11–4.53]) were found to be statistically significant.Conclusion and Recommendation.Compliance with standard precautions among the healthcare workers is very low. Interventions which include training of healthcare workers on standard precautions and consistent management support are recommended.

scholarly journals Urinary tract infections and antibiotic susceptibility among the patients attending B & D hospital of Lalitpur, Nepal

2016 ◽  
Vol 7 (5) ◽  
pp. 47-51 ◽  
Author(s):  
Yadav Prasad Joshi ◽  
Shreejeet Shrestha ◽  
Russell Kabir ◽  
Anita Thapa ◽  
Parbati Upreti ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Tract Infection ◽  
Antibiotic Susceptibility ◽  
Bacterial Infections ◽  
Antimicrobial Agents ◽  
Cross Sectional Study ◽  
Diffusion Method ◽  
Disk Diffusion Method ◽  
Cross Sectional ◽  
Tract Infections

Background:Urinary tract infection is the most common bacterial infections in humans and serious health problem in many parts of the world. It has become more complicated in treatment due to different pathogens and increasing resistant to antimicrobial agents. This study aims to investigate the prevalence of urinary tract infection and antibiotic susceptibility patterns of pathogens among the patients attending in B & B hospital Nepal.Materials and Methods:A hospital based cross sectional study was conducted in between April 2010 to March 2011. Urine samples were collected from clinically suspected patients and tested bacteriologically using standard procedures. Antimicrobial susceptibility test was performed for isolated pathogen using the Kirby-Bauer disk diffusion method according to Clinical and Laboratory Standards Institute guidelines.Results:Out of 1260 examined specimens 25.24 % were positive and majority 61.64% were females.  The most common pathogens isolated were Escherichia coli (66.67%), Enterococcus (7.55%) and Staphylococcus (6.60 %). The drug resistant among the positive cases were reported. The highest resistant of positive cases was found with Cefexime (87.88%) and Enterococcus with Ampicillin (66.67%) and Staphyllococcus with Cloxacillin (66.67%). The highest susceptibility was for Vancomycin and Ampicillin i.e. 33.33% in each.Conclusion:The findings showed that E. coli isolates were the predominant pathogen and the presence of bacterial isolates with very high resistance to the commonly prescribed drugs. As drug resistance among bacterial pathogens is an evolving process and serious issue. Therefore, routine surveillance and monitoring studies should be conducted to provide physicians knowledge on the updated and most effective empirical treatment of UTIs. Asian Journal of Medical Sciences Vol.7(5) 2016 47-51

scholarly journals Study on Seroprevalence and Associated Factors of Bovine Brucellosis in Selected Districts of Afar National Regional State, Afar, Ethiopia

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Wossene Negash ◽  
Teshager Dubie
Keyword(s):  
Associated Factors ◽  
Jugular Vein ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Bovine Brucellosis ◽  
Sample Collection ◽  
Cross Sectional ◽  
Afar Region ◽  
Sterile Needle

Bovine brucellosis is among the top five diseases primarily threatening both public health and livestock economy. Available data are limited to central and highland areas of the country leaving documented literature on the disease in cattle to be found hardly in pastoral and agropastoral regions of the country. As a result, the magnitude and extent of the disease remained to be investigated. A cross-sectional study design was conducted on local Afar cattle aged six months and above from February 2017 to January 2019 in selected districts of Afar region. Technically, study districts and kebeles were selected purposively whereas simple random sampling technique was applied to select cattle owners and individual animals for sample collection. An average of 8 ml whole blood was drawn of jugular vein into plain vacutainer tube using sterile needle. Using Thrusfield formula, a total of 420 blood samples were collected. The sera were tested by RBPT and CFT tests for detection of Brucella antibodies. Data were analyzed using Stata v14.0. Of the 420 sera tested by RBPT, 50 were positive for Brucella antibodies providing an overall animal level prevalence of 11.9% and those RBPT positive sera were further retested by specific and sensitive confirmatory CFT test and 24 of the retested samples had come positive for the disease providing an overall individual animal seroprevalence of 5.7% over the three districts. Of the 3 associated factors (sex, age, and district) considered, only sex had significantly associated ( P < 0.05 : 0.036 ) with the disease. To estimate the strength of sex impact, odds ratio was generated using bivariate and multivariate logistic regression analyses with 95% CI and P < 0.05 providing OR of 2.484 (1.061–5.815) and 2.514 (1.041–6.07), respectively. Hence, the computations revealed that male cattle were 2.484 and 2.514 times more likely at higher risk for the disease as compared to their female counterparts.

scholarly journals Faktor-Faktor Yang Mempengaruhi Penyapihan Bayi Umur Kurang Dari 6 Bulan Melalui Studi Cross Section

2021 ◽  
pp. 88-95
Author(s):  
Dahniar Dahniar ◽  
Nurdiana Nurdiana ◽  
Abdul Halim
Keyword(s):  
Employment Status ◽  
Nutritional Value ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Birth Spacing ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Study Approach ◽  
Nutritional Needs

Weaning too early can affect the growth of the baby and the mother often ignores the nutritional needs of the baby. In addition, malnutrition is more common today than during the first 4-6 months of life. This is because many families do not understand the special needs of babies and are unable to provide food with good nutritional value. The type of research used is a survey with a cross-sectional study approach. The population is all mothers who have babies aged 6 months and the sample is all mothers who have babies aged 6 months. The sampling technique was simple random sampling. The results showed that there was a significant effect between mothers who did weaning for less than 6 months with education = 0.006. There is a significant effect between mothers who do weaning for less than 6 months with employment status = 0.008. There is a significant effect between mothers who do weaning less than 6 months with birth spacing = 0.007.

scholarly journals The Relationship Between Clean Water Sources And The Incidence Of Diarrhea In Kampung Baru Resident At Ngagelrejo Wonokromo Surabaya

2019 ◽  
Vol 5 (3) ◽  
pp. 124
Author(s):  
I Made Subhawa Harsa
Keyword(s):  
Sampling Technique ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Water Sources ◽  
Primary Data ◽  
Rank Test ◽  
Cross Sectional ◽  
Entire Study ◽  
Significance Level ◽  
Low Socioeconomic

Abstract Water is a good medium for bacterial growth, so that contamination is happening especially if less attention in terms of hygiene and sanitation. The use of bed water sources can increase the risk of diarrhea. Diarrhea is one of the environmentally based disease is a major cause of morbidity and mortality. Kampung Baru village located around Jagir Kali Surabaya Most people are in the middle to low socioeconomic level.  The lifestyle of them, also pays less attention to environmental hygiene and sanitation, so that it can cause water pollution which can increase the risk of diarrhea. This study was an observational analytic cross sectional study. Entire study population villagers of Kampung Baru. A sample of 75 respondents drawn with simple random sampling technique. The data used is primary data obtained through the distribution of questionnaires, interviews, and observations. Data analysis using the Spearman rank test with a significance level (α = 0.1). The results showed that 53,3% affected diarrhea and 46,7% didn’t affected (P =0.087, r=0.463). The results showed a medium correlation between the source of water with the incidence of diarrhea in Kampung Baru Resident At Ngagelrejo Wonokromo Surabaya. Keyword : Diarrhae, Water Sanitation

scholarly journals NUTRITIONAL STATUS AMONG PRIMARY SCHOOL GOING CHILDREN LIVING IN URBAN AREA OF SINDH PAKISTAN

1970 ◽  
Vol 7 (1) ◽  
pp. 62-65
Author(s):  
Muhammad Faisal Qureshi ◽  
Aneeta Rathore ◽  
Nandlal Seerani ◽  
Sumera Qureshi ◽  
Bisharat Faisal ◽  
...  
Keyword(s):  
Primary School ◽  
Primary Schools ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Developed Countries ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Head Of School ◽  
Multi Stage

Background: Children's health is very important for their better learning and timely nourishment everywhere in the world. Malnutrition among school going children has remained a big challenge in under developed countries. Methods: Cross-sectional study was conducted among 422 children of four Government Primary schools of Qasimabad, district Hyderabad after taking the proper consent and administration approval from the head of school. Multi stage simple random sampling technique was adopted. Study was approved from Institutional review board of Health Services Academy Islamabad. Results: Out of total, 217 (51.4%) were boys and 205 (48.6%) were girls. Mean Height of boys and girls were 128.09 cm (±SD 12.90) and 130.36 cm (±SD 12.50) respectively. Mean Weight of boys was 25.27 Kgs (±SD 6.17) while in girls mean Weight was 26.83 Kgs (±SD 7.03). 17.57 cm (±SD 2.34) was mean MUAC for all participants and mean BMI was 15.42 (±SD 2.02). Prevalent of stunting and wasting were 24.4% and 18.3% respectively. While in 13.7% thinness (BMI for age) was seen. Stunting was statistically significant in girls 9-10 year (p value=.015, CI: .118-.823, OR=.311) and 11-≥12 years (p value=.018, CI: .215-.874, OR=.434). Pallor was more in girls (17%) and Dental caries were higher in boys (20.8%). Insufficient breakfast was done by 347 (82.2%), whereas 75 (17.8%) were doing sufficient breakfast. 341 (80.8%) students became ill during last year, out of that 80 (19%) were having history of hospitalization. Conclusion: Poor polices and lack of food aid interventions regarding health of primary school going children was assessed during this study.

scholarly journals Analysis of Knowledge and Perception of Implementation of Informed Consent in Patient Pre Operations in HVA Toeloengredjo Pare Hospital

2018 ◽  
Vol 1 (2) ◽  
pp. 16-25
Author(s):  
Rudy Surya K. Hedo
Keyword(s):  
Informed Consent ◽  
Linear Regression ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Informed Consent Form ◽  
Independent Variable ◽  
Cross Tabulation ◽  
Analysis Of Knowledge

Incompleteness and inaccuracy of charging informed consent in patient’s pre-operation is a problem related to patient safety, professionalism, behavior, and quality culture. The research objective is to analyze the knowledge and perception of the Implementation of Informed Consent in Patients with Pre-Operations at RS HVA Toeloengredjo Pare. Design Cross-sectional study using. The population is the preoperative patient at RS HVA Toeloengredjo Pare.exclusion criteria using simple random sampling technique. The independent variable of research is the knowledge and perception of the patient, and the dependent variable of the study is the completeness and accuracy of implementation preoperative patient's informed consent. Data were collected by questionnaire and a check list, then the data were analyzed using linear regression with a <0.05 and cross tabulation analysis. The results showed most respondents have sufficient knowledge of as many as 69 respondents (44,8%), most respondents have the perception that quite as much as 82 respondents (53.2%), linear regression showed that the variables significantly affect the perception of completeness informed consent (p = 0.000) and in the knowledge variables significantly affect the accuracy of informed consent (p = 0.006). The conclusion of this study is to increase knowledge and perception, will support the implementation of the informed consent form completeness and accuracy of informed consent.

scholarly journals Hubungan antara Perilaku Sanitasi Lingkungan dengan Kejadian Demam Berdarah Dengue (DBD) di Wilayah Kerja Puskesmas Tarus

2020 ◽  
Vol 2 (2) ◽  
pp. 15-23
Author(s):  
Rusmini Marslan Arsyad ◽  
Engelina Nabuasa ◽  
Enjelita M. Ndoen
Keyword(s):  
Community Health ◽  
Health Center ◽  
Community Health Center ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Environmental Sanitation ◽  
Study Approach

DHF is one of the widespread  infectious diseases in Indonesia, with an increased infected number of sufferers. DHF case is closely related to environmental sanitation, wich causes the availability of breeding places for the Aedes aegypti mosquito vectors. The study was to determine the relationship between environmental sanitation behavior and the case of DHF in the working area of the Tarus Community Health Center in 2020. The study design was descriptive-analytical with a cross-sectional study approach. The sample was_99 respondents taken by simple random sampling technique. Data was collected from interviews and analyzed using the Chi-square test. The results showed that the varuabels of  knowledge (p = 0.000), attitudes (p = 0.021), and actions to environmental sanitation (p = 0.000) were related to the DHF case. The Tarus Community Health Center should increase outreach activities and family empowerment efforts related to the prevention and control of DHF.

Determinant of Practice of Birth Preparedness and Complication Readiness Plan Among Pregnant Women at Debretabor, North west Ethiopia: A Community Based Cross Sectional Study.

2020 ◽  
Author(s):  
Berhan Tsegaye Negash
Keyword(s):  
Pregnant Women ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Birth Preparedness ◽  
Cross Sectional ◽  
Complication Readiness ◽  
Preparedness Plan ◽  
Education Status ◽  
Partner Involvement

Abstract Background: Nearly all of maternal deaths in the world occurred in sub-Saharan African countries. As Ethiopian demographic health survey report, there were 412 maternal deaths per 100,000 live births in 2016. Delays in decision to seek and receive care are the main causes of these deaths. Birth preparedness and complication readiness plan has been globally endorsed pivotal strategy to decrease these delays. Therefore, this study was aimed to assess the level of practice and factors associated with practice of birth preparedness plan among pregnant women. Methods: Community based cross-sectional study was done among 356 pregnant women selected by simple random sampling technique from July 1-30/2017 in Debretabor town. We selected samples by simple random sampling technique. Data were collected using interview administered questionnaire. Then, we coded, cleaned and entered data through Epidata version 3.1. Finally, exported and analyzed by SPSS. Logistic regression analysis was done to identify association between explanatory variables and practice of birth preparedness and complication plan. An adjusted odds ratio with 95% confidence interval and p-value less than 0.05 was computed to determine the level of significance in multi-variable logistic regression model.Results: Prevalence of birth preparedness and complication readiness plan was 73.9% in this study. primary education status (AOR=3.2,95%CI,1.3-7.8) and secondary educational status (AOR=4.1,95%CI,1.6-10.3), Primigravida (AOR=4.7,95%CI,1.9-11.3), partner involvement in birth preparedness and complication readiness plan (AOR=3.4,95%CI,1.9-6.1), initiating antenatal care in first trimester and media exposure (AOR=1.9,95%CI,1.0-3.3) were significantly associated factors with birth preparedness and complication readiness plan in this study. Conclusions: Level of practice of birth preparedness and complication readiness plan was high in the current study. Higher education status, early ante-natal care initiation, partner involvement in birth preparedness and exposure to media were the factors associated with practice of birth preparedness and complication readiness. Therefore, emphasize on continues education through media, design educational curriculum which should include birth preparedness plan, increase partner participation in birth preparedness and complication readiness plan. Furthermore, early initiation of antenatal care is mandatory.

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