scholarly journals DEVELOPMENT OF A METHOD FOR PRODUCING (-)-17-ALLYL-4,5Ά-EPOXY-3,14-DIHYDROXYMORPHINAN-6-ONE

2021 ◽  
pp. 299-305
Author(s):  
Aleksandr Ivanovich Kalashnikov ◽  
Dar'ya Aleksandrovna Kulagina ◽  
Valeriy Viktorovich Malykhin ◽  
Sergey Viktorovich Sysolyatin
Keyword(s):  
Clinical Practice ◽  
Economic Efficiency ◽  
Raw Material ◽  
Target Product ◽  
Complete Conversion ◽  
Opiate Antagonist ◽  
Plant Materials ◽  
Step Process ◽  
Boron Tribromide ◽  
The Cost

Naloxone ((-)-17-allyl-4,5ά-epoxy-3,14-dihydroxymorphinan-6-one) is a pure opiate antagonist of a competitive type devoid of morphine-like activity and is widely used in clinical practice. The main raw material for the production of naloxone is thebaine, which is extracted from plant materials. This study presents a seven-step process for preparing naloxone with a yield of 35% (based on thebaine). Previously known methods of obtaining are characterized by the yield of the target product in terms of thebaine not higher than 20%. The greatest losses are recorded at the stage of obtaining oxycodone from thebaine and at the stage of O-demethylation of codeine. The use of formic acid in the hydrogenation process provides a more complete conversion of the intermediate product, and the use of boron tribromide in the environment of chloroalkanes at the stage of O-demethylation leads to the production of naloxone with a yield of more than 70%. A detailed study of the stages of obtaining oxycodone and noroxycodone allows to reduce the consumption of reagents and the time spent in the reactor, which is essential for reducing the cost of the final product. The proposed method is superior to those known in terms of productivity and economic efficiency and can be used for the development of industrial technology for the production of naloxone and its derivatives.

scholarly journals Research in the field of evaluation of anfo explosive preparation installations, Tests and results

2021 ◽  
Vol 342 ◽  
pp. 01003
Author(s):  
Stefan Ilici ◽  
Edward Gheorghiosu ◽  
Daniela Rus ◽  
Ciprian Jitea
Keyword(s):  
Economic Efficiency ◽  
Raw Material ◽  
Operating Parameters ◽  
Explosive Mixture ◽  
Long Term Storage ◽  
Manufacturing Facilities ◽  
The Cost ◽  
External Stimuli ◽  
Term Storage

The technical-economic efficiency of rock extraction works depends significantly on the drilling and blasting works as well as the adjacent costs. The cost of the explosive is an important component in these and the generalization of the widespread use of the use of bulk explosives (ANFO) has generated a significant reduction in the cost. Making the explosive close to the place of use in fixed or semi-stationary installations on the quarry stage eliminates the costs related to storage or long-term storage, transport, escort, security. However, installations for the manufacture of ANFO type explosives must consistently produce a simple quality explosive mixture. The quality lies in the participation of the precursors as well as in the degree of homogenization, stability and a good behavior to external stimuli that can lead to sensibility to initiation stimuli or inhibition of sensitivity where the harmful influence of moisture in the raw material or environment must be emphasized. The paper presents tests and results obtained in recent years for such installations used by several companies in Romania performed under the supervision of INSEMEX specialists. These assessments were completed with the certification of explosives manufacturing facilities for the specified operating parameters as well as for explosives.

scholarly journals ESTIMATION OF COSTS AND ECONOMIC EFFICIENCY OF GENOME-WIDE SEQUENCING IN RUSSIA AND FOREIGN COUNTRIES: FACTOR ANALYSIS

Issues of Law ◽  
2020 ◽  
Vol 20 (3) ◽  
pp. 97-104
Author(s):  
T.G. Suranova ◽  
◽  
Г.Н. Суворов ◽  
С.С. Зенин ◽  
◽  
...  
Keyword(s):  
Factor Analysis ◽  
Clinical Practice ◽  
Cost Effectiveness ◽  
Genome Sequencing ◽  
Economic Efficiency ◽  
Full Genome ◽  
Full Genome Sequencing ◽  
Genome Wide ◽  
Foreign Countries ◽  
The Cost

The tendency to reduce the cost of genome sequencing observed in the last decade raises the question of the feasibility of investing in the healthcare system when integrating this technology into clinical practice. In addition, it is necessary to identify factors that will contribute to lower costs and stimulate additional investment in this area. It is also necessary to evaluate the cost-effectiveness of full-genome sequencing for diagnostic and pharmacogenomic applications

Resource efficiency in deinked pulp production: a review

TAPPI Journal ◽  
2014 ◽  
Vol 13 (11) ◽  
pp. 37-43 ◽  
Author(s):  
LIISA KOTANEN ◽  
MIKA KÖRKKÖ ◽  
ARI ÄMMÄLÄ ◽  
JOUKO NIINIMÄKI
Keyword(s):  
Waste Disposal ◽  
Resource Efficiency ◽  
Raw Material ◽  
Ecological Strategy ◽  
Recycled Paper ◽  
Paper Production ◽  
Recycled Pulp ◽  
Current State ◽  
The Cost ◽  
Pulp Production

The use of recovered paper as a raw material for paper production is by far the most economical and ecological strategy for the disposal of waste paper. However, paper production from recovered paper furnish generates a great amount of residues, and the higher the demand requirements for the end product, the higher the amount of rejected material. The reason for this is that the selectivity of the deinking process is limited; therefore, some valuable components are also lost in reject streams. The rejection of usable components affects the economics of recycled paper production. As the cost of waste disposal continues to increase, this issue is becoming more and more severe. This paper summarizes the current state of the resource efficiency in recycled pulp production and provides information on the volumes of rejected streams and the usable material within them. Various means to use these reject streams are also discussed, including the main findings of a recent thesis by the main author. This review summarizes current internal and external use of reject streams generated in the deinking operations.

PROMOTING THE NATURAL RESTORATION OF LIPNYAKS OF THE KASMARSKY DISTRICT FORESTRY OF THE ZIANCHURINSKY FORESTRY

2020 ◽  
Vol 37 (3) ◽  
pp. 76-82
Author(s):  
L.V. Mazitova ◽  
Keyword(s):  
Economic Efficiency ◽  
Natural Regeneration ◽  
Forest Area ◽  
Natural Restoration ◽  
The Creation ◽  
The Cost

The article presents the results of studying various measures to promote the natural renewal of lime forests in the Kasmarsky uchastkovoye forestry of the Zianchurinsky forestry. The data on lime forests within the boundaries of the forestry were studied, and the calculation of the economic efficiency of promoting natural regeneration was carried out. The use of evenly-gradual and continuous narrow-cut logging in the conditions of the Zianchurinsky forest area in the Kasmar district forest area will avoid the creation of expensive forest crops. The cost of creating forest crops is 10,719. 4 rubles per 1 ha, and the cost of preserving and caring for the forest during evenly-gradual logging is 4,237. 9 rubles, and solid narrow-cutting-3,469. 33 rubles.

SELISIH BIAYA PRODUKSI SEBAGAI ALAT PENGENDALIAN MANAJEMEN PT INDO PUSAKA BERAU

2019 ◽  
Vol 3 (02) ◽  
pp. 397
Author(s):  
SAFITRI NURHIDAYATI ◽  
RIZKI AMELYA SYAM
Keyword(s):  
Raw Materials ◽  
Field Research ◽  
Analytical Tool ◽  
Production Costs ◽  
Raw Material ◽  
Labor Costs ◽  
Material Costs ◽  
Library Research ◽  
The Difference ◽  
The Cost

This study aims to analyze whether the difference that occurs in the cost of raw materials, direct labor, and factory overhead costs between the standard costs and the actual costs in PLTU LATI is a difference that is favorable or unfavorable. Data collection techniques with field research and library research. The analytical tool used is the analysis of the difference in raw material costs, the difference in direct labor costs and the difference in factory overhead costs. The hypothesis in this study is that the difference allegedly occurs in the cost of raw materials, direct labor costs, and factory overhead costs at PT Indo Pusaka Berau Tanjung Redeb is a favorable difference. The results showed that the difference in the cost of producing MWh electricity at PT Indo Pusaka Berau Tanjung Redeb in 2018, namely the difference in the price of raw material costs Rp. 548,029.80, - is favorable, the difference in quantity of raw materials is Rp. 957,216,602, - is (favorable) , the difference in direct labor costs Rp 2,602,642,084, - is (unfavorable), and the difference in factory overhead costs Rp 8,807,051,422, - is (favorable) This shows that the difference in the overall production cost budget is favorable or profitable. This beneficial difference shows that the company is really able to reduce production costs optimally in 2018.  

THE COST OF FEDERAL MONEY, HELLS CANYON AND ECONOMIC EFFICIENCY: Part II

1958 ◽  
Vol 11 (2) ◽  
pp. 114-128
Author(s):  
OTTO ECKSTEIN ◽  
JOHN V. KRUTILLA
Keyword(s):  
Economic Efficiency ◽  
The Cost ◽  
Hells Canyon

Use of Sugarcane Bagasse Ashes as Raw Material in the Replacement of Fluxes for Applications on Porcelain Tile

2016 ◽  
Vol 881 ◽  
pp. 383-386 ◽  
Author(s):  
Raimundo J.S. Paranhos ◽  
Wilson Acchar ◽  
Vamberto Monteiro Silva
Keyword(s):  
Mechanical Properties ◽  
Environmental Impact ◽  
Physical Properties ◽  
Sugarcane Bagasse ◽  
Sintering Temperature ◽  
Raw Materials ◽  
Raw Material ◽  
The Cost ◽  
Potential Use ◽  
Porcelain Tile

This study evaluated the potential use of Sugarcane Bagasse Ashes (SBA) as a flux, replacing phyllite for the production of enamelled porcelain tile. The raw materials of the standard mass components and the SBA residue were characterized by testing by XRF, XRD, AG, DTA and TGA. Test samples were fabricated, assembled in lots of 3 units and sintered at temperatures of 1150 ° C to 1210 ° C. The results of the physical properties, mechanical properties and SEM of the sintered samples, showed that the formulation, G4 - in which applied 10% of SBA replacing phyllite, sintering temperature 1210 ° C showed better performance as the previously mentioned properties due to the formation of mullite crystals, meeting the prerequisites of standards for enamelled porcelain tile, while reducing the environmental impact and the cost of production.

scholarly journals PEMANFAATAN LIMBAH FLY ASH DARI PEMBAKARAN BATUBARA PADA PEMBUATAN SEMEN PCC (PORTLAND COMPOSITE CEMENT) DI PT SEMEN XYZ LAMPUNG

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Dwi Septiyana Sari ◽  
◽  
Susanti Sundari
Keyword(s):  
Compressive Strength ◽  
Fly Ash ◽  
Raw Materials ◽  
Testing Machine ◽  
Technical Aspect ◽  
Raw Material ◽  
Physical Test ◽  
Composite Cement ◽  
The Difference ◽  
The Cost

Abstract This study discusses the use of fly ash waste from coal burning on the manufacture of PCC (Portland composite cement) at PT. XYZ Lampung. The purpose of this research is to look at the technical studies and the efficiency of raw materials in the use of fly ash in cement making, in this case PCC cement (Portland Composite Cement). The steps taken in analyzing the data in this study were viewed from a technical aspect by means of a physical test, namely the cement compressive strength test at the age of 3 days, 7 days, and 28 days using the Compression Testing Machine. This test was conducted to see the comparison of the compressive strength of PCC cement using limestone and fly ash as raw materials, then calculate the difference in raw material costs in the year before and after the replacement of limestone with fly ash. The results showed that cement with the addition of fly ash after 3 days, 7 days and 28 days had an increased compressive strength value, which increased 21.69%, 16.07% and 8.05% respectively of the compressive strength of cement using limestone. The use of fly ash as a substitute for limestone has an effect on the cost of raw materials, where the difference between the cost of raw materials in 2019 and the cost of raw materials in 2018 is Rp. 39,440,952,074.

scholarly journals ECONOMIC EFFICIENCY OF TABLE GRAPEVINE VARIETIES’ CULTIVATION

Russian vine ◽  
2020 ◽  
Vol 14 ◽  
pp. 85-89
Author(s):  
N.A Tikhomirova ◽  
◽  
M.R. Beibulatov ◽  
N.A. Urdenko ◽  
R.A. Buival ◽  
...  
Keyword(s):  
Economic Efficiency ◽  
Agricultural Practices ◽  
Climatic Conditions ◽  
Cost Of Care ◽  
Important Condition ◽  
High Productivity ◽  
Care Technology ◽  
The Cost ◽  
Grape Varieties ◽  
Intensive Development

The economic efficiency of the cultivation of grapes as a branch of agriculture depends on the adaptation of grape varieties to the soil and climatic conditions of the place of growth. When developing new agricultural practices and technological solutions for the cultivation of grapes, it is necessary to assess the econom-ic efficiency of the proposed innovative ap-proaches. The cultivation of such grape varie-ties is becoming important and relevant, which, with high productivity and the use of differen-tiated care technology, require minimal costs when servicing the bushes and harvesting. In-creasing labor productivity in the viticulture industry is the most important condition for the intensive development of production. One of these conditions today is the formation of a bush according to the technology element, the shape of a bush AZOS-1, which allows to re-duce the cost of care and harvesting of grapes. The conducted research on the technology of cultivation of table grape varieties in connec-tion with the use of a new form of bush made it possible to economically substantiate the economic efficiency of growing grapes.

scholarly journals PRODUCTION OF EXTRACTS FROM VEGETABLE RAW MATERIALS BY CARBON DIOXIDE

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
K. Gafurov ◽  
B. Muhammadiev ◽  
Sh. Mirzaeva ◽  
F. Kuldosheva
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Co2 ◽  
Raw Materials ◽  
Maximum Yield ◽  
Volumetric Flow Rate ◽  
Extraction Process ◽  
Raw Material ◽  
Critical Conditions ◽  
Plant Materials ◽  
Laboratory Setup

The unique properties of supercritical carbon dioxide as a solvent are widely used for extraction. In supercritical media, the dissolution of molecules of various chemical nature is possible. The purpose of this investigation was to study the extraction process and obtain extracts from valuable regional plant materials by applying CO2 extraction under pre- and supercritical conditions. The objects of research were: ground seeds of melon, pumpkin and licorice roots, as well as mint leaves, mulberry and jida flowers. For extraction, a laboratory setup was used that allows extraction when the CO2 is supplied by a high-pressure plunger pump in the sub- and supercritical state using a heat pump. The pressure range is 3-15 MPa, temperatures 295–330 K, and the volumetric flow rate above the critical CO2 is 800–900 g. Experiments with ground seeds of melon and pumpkin showed that as a result of 4 sequentially performed extraction cycles on a single load with supercritical CO2 parameters ( 315–330 K; 3–7.5 MPa) the decrease in the mass of melon seeds was 90 g (pumpkins 80 g). During the total extraction time (2.5 hours), 20 kg of CO2 were pumped through the reactor (25 l at 290 K and 6.8 MPa), while the average oil content in the extract was 4 g per 1 kg of CO2 (3.0 g per 1 l of SС-CO2) In experiments with jida flowers, the maximum amount of solid extractable substance (2% by weight of the raw material) was obtained at a temperature in the extractor of 308 K and a pressure of 7.5 MPa. Upon extraction under critical conditions in collection 2, the liquid phase was absent; only a yellow-green paste was released in it. According to the results of experiments with mint leaves, the maximum yield of a greenish liquid was observed at T = 315 K and P = 4 MPa., Mulberry - at T = 306 K and P = 6.0 MPa. The results of the extraction of oils and extracts from ground seeds of melon, pumpkin and licorice roots, as well as mint leaves, mulberries and jida flowers confirm that the maximum yield of the extracted substance is achieved with supercritical CO2 parameters in the extractor (310 K, 7.5 MPa). When liquid CO2 is extracted (300 K and 6-8 MPa), up to 2% of a yellow substance is extracted, which does not differ in appearance from a supercritical extract.

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