A STUDY ON MATERNAL SERUM TOTAL THIOLS AND HIGHLY SENSITIVE C-REACTIVE PROTEIN AS INDICATORS OF OXIDATIVE STRESS AND INFLAMMATION IN PREECLAMPSIA AND THEIR CORRELATION WITH OPHTHALMIC MANIFESTATIONS

Information concerning the mechanisms underlying oxidative stress and low-grade inflammation in young healthy women predisposing eventually to future diseases is scarce. We investigated the relationship of oxidative stress and high-sensitivity C-reactive protein (hsCRP) in fertile-age women by oral combined contraceptive (OC) use. Caucasian Italian healthy non-obese women (n = 290; 100 OC-users; 190 non-OC-users; mean age 23.2 ± 4.7 years) were analyzed. Blood hydroperoxides, as oxidative stress biomarkers, were assessed by Free Oxygen Radical Test (FORT). Serum hsCRP was determined by an ultra-sensitive method (hsCRP). Markedly elevated oxidative stress (≥400 FORT Units) was found in 77.0% of OC-users and 1.6% of non-OC-users, odds ratio (OR) = 209, 95% CI = 60.9–715.4, p < 0.001. Elevated hsCRP levels ≥ 2.0 mg/L, considered risky for cardiovascular diseases (CVDs), were found in 41.0% of OC-users and 9.5% of non-OC-users, OR = 6.6, 95%CI 3.5–12.4, p < 0.001. Hydroperoxides were strongly positively correlated to hsCRP in all women (rs = 0.622, p < 0.001), in OC-users (rs = 0.442, p < 0.001), and in non-OC-users (rs = 0.426, p < 0.001). Women with hydroperoxides ≥ 400 FORT Units were eight times as likely to have hsCRP ≥ 2 mg/L. In non-OC-users only, hydroperoxides values were positively correlated with weight and body mass index, but negatively correlated with red meat, fish and chocolate consumption. Our research is the first finding a strong positive correlation of serum hydroperoxides with hsCRP, a marker of low-grade chronic inflammation, in young healthy women. Further research is needed to elucidate the potential role of these two biomarkers in OC-use associated side-effects, like thromboembolism and other CVDs.

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Reliability of biomarkers of iron status, blood lipids, oxidative stress, vitamin D, C-reactive protein and fructosamine in two Dutch cohorts

Biomarkers ◽

10.1080/13547500600799748 ◽

2006 ◽

Vol 11 (4) ◽

pp. 370-382 ◽

Cited By ~ 42

Author(s):

W. K. Al-Delaimy ◽

E. H. J. M. Jansen ◽

P. H. M. Peeters ◽

J. D. van der Laan ◽

P. A. H. van Noord ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin D ◽

Blood Lipids ◽

Iron Status ◽

C Reactive Protein ◽

Reactive Protein

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Factors associated with maternal serum C-reactive protein throughout pregnancy: A longitudinal study in women of Rio de Janeiro, Brazil

Nutrition ◽

10.1016/j.nut.2015.04.006 ◽

2015 ◽

Vol 31 (9) ◽

pp. 1103-1108 ◽

Cited By ~ 13

Author(s):

Livia Costa de Oliveira ◽

Ana Beatriz Franco-Sena ◽

Fernanda Rebelo ◽

Dayana Rodrigues Farias ◽

Jaqueline Lepsch ◽

...

Keyword(s):

Longitudinal Study ◽

Rio De Janeiro ◽

Maternal Serum ◽

C Reactive Protein ◽

Factors Associated ◽

Reactive Protein

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Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease

Atherosclerosis ◽

10.1016/j.atherosclerosis.2004.08.007 ◽

2005 ◽

Vol 178 (1) ◽

pp. 115-121 ◽

Cited By ~ 85

Author(s):

Jerome L. Abramson ◽

W. Craig Hooper ◽

Dean P. Jones ◽

Salman Ashfaq ◽

Steven D. Rhodes ◽

...

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Reactive Protein ◽

Stress Markers

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Abstract P096: Maternal Serum C-Reactive Protein Levels During Pregnancy and Risk for High C-Reactive Protein 7-13 Years Later

Circulation ◽

10.1161/circ.129.suppl_1.p096 ◽

2014 ◽

Vol 129 (suppl_1) ◽

Author(s):

Bonny Rockette-Wagner ◽

Claudia Holzman ◽

Bertha L Bullen ◽

Andrew D Althouse ◽

Janet M Catov

Keyword(s):

Relative Risk ◽

Weight Change ◽

Elevated Serum ◽

Maternal Serum ◽

Health Study ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Inflammatory Status

Introduction: Elevated serum C-reactive protein (CRP) can be a marker of disease activity involving inflammation, such as pregnancy complications and cardiovascular disease (CVD). Systemically high levels of CRP in women, including during pregnancy, may indicate higher risk for CVD. It is unknown if CRP measured during the pro-inflammatory state of pregnancy correlates with concentrations assessed 7-13 years after delivery. Hypothesis: Concentrations of CRP assessed during pregnancy will be related to CRP measured several years after pregnancy, independent of weight gain. Methods: We studied the first 252 women enrolled in the follow-up of the Pregnancy Outcomes and Community Health Study (POUCHmoms 2011-2013) with complete CRP data for the pregnancy (mean gestational age: 22.36 [2.22] weeks) and POUCHmoms visits (mean follow-up: 10.76 [1.38] years). The relative risk for high hsCRP (≥ 3.39 μg/ml) at the follow-up visit, related to quartiles of CRP during pregnancy, was examined using stepwise regression models. Results: Median (IQR) levels of pregnancy CRP and hsCRP at the follow-up visit were 5.68 [3.08, 9.76] and 3.39 [0.69, 9.73] μg/ml, respectively. Although absolute values of hsCRP at follow-up were generally lower than pregnancy CRP, 56% of women in the top and bottom quartiles of pregnancy CRP (71 of 126) were in the same quartile for hsCRP at follow-up (figure). The relative risk of having high hsCRP (≥ 3.39 μg/ml) at follow-up ranged from 2.7-5.2 for the 2 nd - 4 th quartiles of pregnancy CRP (vs. the 1st quartile). Controlling for pre-pregnancy BMI and follow-up weight change, the relative risk of having high hsCRP at follow-up was significantly higher for the 2 nd (1.15 [1.02-1.30]),3 rd (1.19 [1.05-1.35), and 4 th (1.22 [1.05-1.41]) quartiles of pregnancy CRP. Conclusions: Pregnancy CRP levels are related to hsCRP levels several years later in this cohort of women, even after adjusting for pre-pregnancy BMI and follow-up weight change. CRP assessed in pregnancy may reflect inflammatory status later in life.

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The role of systemic inflammation in heart failure

Kazan medical journal ◽

10.17816/kmj2021-510 ◽

2021 ◽

Vol 102 (4) ◽

pp. 510-517

Author(s):

E V Khazova ◽

O V Bulashova

Keyword(s):

Heart Failure ◽

Cardiovascular Diseases ◽

Systemic Inflammation ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

C Reactive Protein ◽

Ventricular Ejection Fraction ◽

Reactive Protein ◽

Highly Sensitive

The discussion continues about the role of systemic inflammation in the pathogenesis of cardiovascular diseases of ischemic etiology. This article reviews the information on the role of C-reactive protein in patients with atherosclerosis and heart failure in risk stratification for adverse cardiovascular events, including assessment of factors affecting the basal level of highly sensitive C-reactive protein. Research data (MRFIT, MONICA) have demonstrated a relationship between an increased level of C-reactive protein and the development of coronary heart disease. An increase in the serum level of highly sensitive C-reactive protein is observed in arterial hypertension, dyslipidemia, type 2 diabetes mellitus and insulin resistance, which indicates the involvement of systemic inflammation in these disorders. Currently, the assessment of highly sensitive C-reactive protein is used to determine the risk of developing myocardial infarction and stroke. It has been proven that heart failure patients have a high level of highly sensitive C-reactive protein compared with patients without heart failure. The level of C-reactive protein is referred to as modifiable risk factors for cardiovascular diseases of ischemic origin, since lifestyle changes or taking drugs such as statins, non-steroidal anti-inflammatory drugs, glucocorticoids, etc. reduce the level of highly sensitive C-reactive protein. In patients with heart failure with different left ventricular ejection fraction values, it was found that the regression of the inflammatory response is accompanied by an improvement in prognosis, which confirms the hypothesis of inflammation as a response to stress, which has negative consequences for the cardiovascular system.

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