scholarly journals MEDITERRANEAN-DASH INTERVENTION FOR NEURODEGENERATIVE DELAY (MIND) DIET SLOWS COGNITIVE DECLINE AFTER STROKE

2019 ◽  
pp. 1-7
Author(s):  
L. Cherian ◽  
Y. Wang ◽  
K. Fakuda ◽  
S. Leurgans ◽  
N. Aggarwal ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Sex Education ◽  
Caloric Intake ◽  
Clinical History ◽  
Cognitive Assessments ◽  
Cognitive Domains ◽  
Fried Foods ◽  
Diet Assessment ◽  
The Mind ◽  
Mind Diet

Objective: This study sought to determine if the MIND diet (a hybrid of the Mediterranean and Dash diets, with modifications based on the science of nutrition and the brain), is effective in preventing cognitive decline after stroke. Design: We analyzed 106 participants of a community cohort study who had completed a diet assessment and two or more annual cognitive assessments and who also had a clinical history of stroke. Cognition in five cognitive domains was assessed using structured clinical evaluations that included a battery of 19 cognitive tests. MIND diet scores were computed using a valid food frequency questionnaire (FFQ). Dietary components of the MIND diet included whole grains, leafy greens and other vegetables, berries, beans, nuts, lean meats, fish, poultry, and olive oil and reduced consumption of cheese, butter, fried foods, and sweets. MIND diet scores were modeled in tertiles. The influence of baseline MIND score on change in a global cognitive function measure and in the five cognitive domains was assessed using linear mixed models adjusted for age and other potential confounders. Results: With adjustment for age, sex, education, APOE-ε4, caloric intake, smoking, and participation in cognitive and physical activities, the top vs lowest tertiles of MIND diet scores had a slower rate of global cognitive decline (β = .08; CI = 0.0074, 0.156) over an average of 5.9 years of follow-up. Conclusions: High adherence to the MIND diet was associated with a slower rate of cognitive decline after stroke.

scholarly journals Cross cultural “behavioural diagnosis” examining the uptake of the MIND diet, using the COM-B model to inform an intervention.

2020 ◽  
Author(s):  
Deirdre Timlin ◽  
Barbara Giannantoni ◽  
Jacqueline McCormack ◽  
Angela Polito Polito ◽  
Donatella Ciarapica Ciarapica ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Behaviour Change ◽  
Theoretical Domains Framework ◽  
Later Life ◽  
Behaviour Change Techniques ◽  
Valuable Insight ◽  
Two Samples ◽  
The Mind ◽  
Italian Sample ◽  
Mind Diet

Abstract Background: The aim of this study was to develop a “behavioural diagnosis” of factors influencing the uptake of the MIND diet in 40-55-year olds according to the COM-B model, in order to reduce the risk of cognitive decline in later life. Comparing a Mediterranean (Italy) and non-Mediterranean (Northern Ireland) country to inform an intervention. This study also sought to identify intervention functions and behaviour change techniques (BCTs) that are likely to be effective in changing MIND diet behaviour. Methods: This was a qualitative study that was used to elicit beliefs surrounding Capability, Opportunity, Motivation and Behaviour (COM-B) with adhering to a diet associated with a reduced risk of cognitive decline, the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND diet). This study further elaborated the COM-B components into the 14 domains of the Theoretical Domains Framework (TDF) to further understand behaviour. Twenty-five Northern Irish (NI) and Italian participants were recruited onto the study, to take part in either a focus group or an interview. Participants were both male and female aged between 40-55 years. Results: Thematic analysis revealed that the main barriers to the uptake of the MIND diet were; time, work environment (opportunity), taste preference and convenience (motivation). Culture (motivation), seasonal foods and lack of family support (opportunity) to be a barrier to the Italian sample only. The main facilitators reported were; improved health, memory, planning and organisation (motivation) and access to good quality food (opportunity). Cooking skills, knowledge (capability) and heathy work lunch (opportunity) being a facilitator to the Italian sample only. Five intervention functions and fifteen BCTs were identified for possible inclusion in intervention development. Conclusions: The “behavioural diagnosis” provides comparisons and valuable insight into the personal, social and environmental factors that participants report as barriers and facilitators to the uptake of the MIND diet in the two samples. More barriers to healthy dietary change were found than facilitators. There is a need for interventions that increase capability, opportunity and motivation to aid behaviour change. The “behavioural diagnosis” from this study will be used to design a behaviour change intervention using the subsequent steps from the Behaviour Change Wheel (BCW).

scholarly journals Higher circulating α-carotene was associated with better cognitive function: an evaluation among the MIND trial participants

2021 ◽  
Vol 10 ◽  
Author(s):  
Xiaoran Liu ◽  
Klodian Dhana ◽  
Jeremy D. Furtado ◽  
Puja Agarwal ◽  
Neelum T. Aggarwal ◽  
...  
Keyword(s):  
At Risk ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Semantic Memory ◽  
Sex Education ◽  
Dietary Intervention ◽  
Vegetable Consumption ◽  
Population At Risk ◽  
Global Cognition ◽  
The Mind

Abstract There is emerging evidence linking fruit and vegetable consumption and cognitive function. However, studies focusing on the nutrients underlying this relationship are lacking. We aim to examine the association between plasma nutrients and cognition in a population at risk for cognitive decline with a suboptimal diet. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) trial is a randomized controlled intervention that examines the effects of the MIND diet to prevent cognitive decline. The primary outcome is global cognition. A multivariate linear model was used to investigate the association between blood nutrients and global and/or domain-specific cognition. The model was adjusted for age, sex, education, study site, smoking status, cognitive activities and physical activities. High plasma α-carotene was associated with better global cognition. Participants in the highest tertile of plasma α-carotene had a higher global cognition z score of 0⋅17 when compared with individuals in the lowest tertile (P 0⋅002). Circulating α-carotene levels were also associated with higher semantic memory scores (P for trend 0⋅007). Lutein and zeaxanthin (combined) was positively associated with higher semantic memory scores (P for trend 0⋅009). Our study demonstrated that higher α-carotene levels in blood were associated with higher global cognition scores in a US population at risk for cognitive decline. The higher α-carotene levels in blood reflected greater intakes of fruits, other types of vegetables and lesser intakes of butter and margarine and meat. The higher circulating levels of lutein plus zeaxanthin reflected a dietary pattern with high intakes of fruits, green leafy, other vegetables and cheese, and low consumption of fried foods. Objective nutrient markers in the blood can better characterize dietary intake, which may facilitate the implementation of a tailored dietary intervention for the prevention of cognitive decline.

scholarly journals The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer's Disease—A Review

2019 ◽  
Vol 10 (6) ◽  
pp. 1040-1065 ◽  
Author(s):  
Annelien C van den Brink ◽  
Elske M Brouwer-Brolsma ◽  
Agnes A M Berendsen ◽  
Ondine van de Rest
Keyword(s):  
Cognitive Decline ◽  
Longitudinal Studies ◽  
Dietary Patterns ◽  
Lower Risk ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mediterranean ◽  
The Mind ◽  
Mind Diet

ABSTRACT As there is currently no cure for dementia, there is an urgent need for preventive strategies. The current review provides an overview of the existing evidence examining the associations of the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets and their dietary components with cognitive decline, dementia, and Alzheimer's disease (AD). A systematic search was conducted within Ovid Medline for studies published up to 27 March 2019 and reference lists from existing reviews and select articles were examined to supplement the electronic search results. In total, 56 articles were included. Higher adherence to the Mediterranean diet was associated with better cognitive scores in 9 of 12 cross-sectional studies, 17 of 25 longitudinal studies, and 1 of 3 trials. Higher adherence to the DASH diet was associated with better cognitive function in 1 cross-sectional study, 2 of 5 longitudinal studies, and 1 trial. Higher adherence to the MIND diet was associated with better cognitive scores in 1 cross-sectional study and 2 of 3 longitudinal studies. Evidence on the association of these dietary patterns with dementia in general was limited. However, higher adherence to the Mediterranean diet was associated with a lower risk of AD in 1 case-control study and 6 of 8 longitudinal studies. Moreover, higher adherence to the DASH or MIND diets was associated with a lower AD risk in 1 longitudinal study. With respect to the components of these dietary patterns, olive oil may be associated with less cognitive decline. In conclusion, current scientific evidence suggests that higher adherence to the Mediterranean, DASH, or MIND diets is associated with less cognitive decline and a lower risk of AD, where the strongest associations are observed for the MIND diet.

scholarly journals Effects of the MIND diet and physical activity on cognitive domains in the elderly

2021 ◽  
Vol 17 (S10) ◽  
Author(s):  
Thomas Monroe Holland ◽  
Puja Agarwal ◽  
Klodian Dhana ◽  
Shannon Halloway ◽  
Pankaja Desai ◽  
...  
Keyword(s):  
Physical Activity ◽  
The Elderly ◽  
Cognitive Domains ◽  
Diet And Physical Activity ◽  
The Mind ◽  
Mind Diet

Properties of the Cognitive Function Battery for the MIND Diet Intervention to Prevent Alzheimer’s Disease

2021 ◽  
pp. 1-8
Author(s):  
Kristin R. Krueger ◽  
Klodian Dhana ◽  
Neelum T. Aggarwal ◽  
Konstantinos Arfanakis ◽  
Vincent J. Carey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Cognitive Function ◽  
Cognitive Activity ◽  
Principal Component ◽  
Late Life ◽  
Cognitive Domains ◽  
Diet Intervention ◽  
The Mind ◽  
Mind Diet

Abstract Objective: To evaluate the properties of the cognitive battery used in the MIND Diet Intervention to Prevent Alzheimer’s Disease. The MIND Diet Intervention is a randomized control trial to determine the relative effectiveness of the MIND diet in slowing cognitive decline and reducing brain atrophy in older adults at risk for Alzheimer’s dementia. Methods: The MIND cognitive function battery was administered at baseline to 604 participants of an average age of 70 years, who agreed to participate in the diet intervention study, and was designed to measure change over time. The battery included 12 cognitive tests, measuring the 4 cognitive domains of executive function, perceptual speed, episodic memory, and semantic memory. We conducted a principal component analysis to examine the consistency between our theoretical domains and the statistical performance of participants in each domain. To further establish the validity of each domain, we regressed the domain scores against a late-life cognitive activity score, controlling for age, race, sex, and years of education. Results: Four factors emerged in the principal component analyses that were similar to the theoretical domains. In regression equations, we found the expected associations with age, education, and late-life cognitive activity with each of the four cognitive domains. Conclusions: These results indicate that the MIND cognitive battery is a comprehensive and valid battery of four separate domains of cognitive function that can be used in diet intervention trials for older adults.

scholarly journals Dietary Patterns and Self-reported Incident Disability in Older Adults

2018 ◽  
Vol 74 (8) ◽  
pp. 1331-1337 ◽  
Author(s):  
Puja Agarwal ◽  
Yamin Wang ◽  
Aron S Buchman ◽  
David A Bennett ◽  
Martha C Morris
Keyword(s):  
Older Adults ◽  
Sex Education ◽  
Functional Disability ◽  
Cox Proportional Hazards ◽  
Hazard Ratio ◽  
Mobility Disability ◽  
The Mediterranean ◽  
Adl Disability ◽  
The Mind ◽  
Mind Diet

Abstract Background or Objectives Disability in older adults is associated with low quality of life and higher mortality. Diet may be a potentially important public health strategy for disability prevention in aging. We examined the relations of the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean–DASH Intervention for Neurodegenerative Delay (MIND) diets to functional disability in the Rush Memory and Aging Project. Methods A total of 809 participants (mean age = 80.7 ± 7.2 years, 74% female) without functional disability at baseline were followed for an average of 5.3 years. Standardized measures for self-reported disability including, activities of daily living ADL), instrumental ADL, and mobility disability were assessed annually. The diet scores were computed based on a validated food frequency questionnaire administered at baseline. Results In Cox proportional hazards models adjusted for age, sex, education, smoking, physical activity, and total calories, the second (hazard ratio = 0.75, 95% CI: 0.60–0.95) and third tertiles (hazard ratio = 0.67, 95% CI: 0.53–0.86) of MIND diet scores had lower rates of ADL disability compared to the lowest tertile (p for trend = .001), whereas only the third tertiles of the Mediterranean (hazard ratio = 0.73, 95% CI: 0.57–0.94) and DASH (hazard ratio = 0.75, 95% CI: 0.59–0.95) diets were significantly associated with ADL disability. Instrumental ADL disability was inversely and linearly associated with the MIND diet score only (p for trend = .04). Mobility disability was associated with the MIND (p for trend = .02), Mediterranean (p for trend = .05) and DASH (p for trend = .02) diet scores. Conclusion These findings are encouraging that diet may be an effective strategy for the prevention of functional disability in older adults.

scholarly journals Racial Differences in the Association of Mediterranean Diet with Cognitive Decline (P14-002-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Puja Agarwal ◽  
Yamin Wang ◽  
Lisa Barnes ◽  
Thomas Holland ◽  
Denis Evans ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Racial Differences ◽  
Mediterranean Diet ◽  
Sex Education ◽  
Cognitive Assessments ◽  
Funding Sources ◽  
The Us ◽  
Education Participation ◽  
The Mediterranean ◽  
The Impact

Abstract Objectives The US older population is on the rise and projected to be 42% minority by 2050. Cognitive impairment is one of the major public health concerns of an aging population, and diet is one possible modifiable risk factor. However, we have limited knowledge of diet associations with cognition in minorities as most of the findings are either not reported by race or the data is not available for non-white populations. In a previous study, we found Mediterranean diet associated with slower cognitive decline in the biracial population of Chicago Health and Aging Project (CHAP). In this study, we examined this association in CHAP separately by race (Blacks and Whites). Methods Analyses included 4985 participants of the Chicago Health and Aging Project (63% African American, mean age = 75 ± 6.0 years, mean education = 12.6 ± 3.6 years) who completed a food frequency questionnaire and at least two cognitive assessments (a composite of 4 cognitive tests) over an average follow-up of 6.3 years. Computed scores of adherence to the Mediterranean diet were analyzed in tertiles of intake. We used mixed models adjusted for age, sex, education, participation in cognitive activities, physical activity, and total calories. Results Among Whites, both the middle (β = 0.014, P = 0.06) and highest tertiles of Mediterranean scores (β = 0.022, P = 0.003) were associated with slower cognitive decline compared to the lowest tertile of scores. Among Blacks, only the highest tertile of Mediterranean scores was associated with slower cognitive decline (T3 vs. T1: β = 0.014, P = 0.016; T2 vs. T1: β = −0.004, P = 0.92). The associations remained similar when further adjusted for cardiovascular conditions. Conclusions The Mediterranean diet associations with cognition may vary by race. Further study is required to understand these potential racial differences for the impact of diet on cognition. Funding Sources RFAG054057.

Association of long-term adherence to the mind diet with cognitive function and cognitive decline in American women

2017 ◽  
Vol 22 (2) ◽  
pp. 222-229 ◽  
Author(s):  
Agnes M. Berendsen ◽  
J. H. Kang ◽  
E. J. M. Feskens ◽  
C. P. G. M. de Groot ◽  
F. Grodstein ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
American Women ◽  
The Mind ◽  
Mind Diet

Plasma homocysteine and cognitive decline in older hypertensive subjects

2011 ◽  
Vol 23 (10) ◽  
pp. 1607-1615 ◽  
Author(s):  
Sunil K. Narayan ◽  
Brian K. Saxby ◽  
Michael J. Firbank ◽  
John T. O'Brien ◽  
Frances Harrington ◽  
...  
Keyword(s):  
Executive Function ◽  
Cognitive Decline ◽  
The Elderly ◽  
Plasma Homocysteine ◽  
Cognitive Assessments ◽  
Computerized Assessment ◽  
Cognitive Domains ◽  
Memory And Attention ◽  
Independent Association ◽  
The Relationship

ABSTRACTBackground:Elevated plasma homocysteine concentrations have been associated with both cognitive impairment and dementia. However, it is unclear whether some cognitive domains are more affected than others, or if this relationship is independent of B12 and folate levels, which can also affect cognition. We examined the relationship between plasma homocysteine and cognitive decline in an older hypertensive population.Methods:182 older people (mean age 80 years) with hypertension and without dementia, were studied at one center participating in the Study on COgnition and Prognosis in the Elderly (SCOPE). Annual cognitive assessments were performed using a computerized assessment battery and executive function tests, over a 3–5 year period (mean 44 months). Individual rates of decline on five cognitive domains were calculated for each patient. End of study plasma homocysteine, folate and B12 concentrations were measured. The relationship between homocysteine levels and cognitive decline was studied using multivariate regression models, and by comparing high versus low homocysteine quartile groups.Results:Higher homocysteine showed an independent association with greater cognitive decline in three domains: speed of cognition (β = −27.33, p = 0.001), episodic memory (β = −1.25, p = 0.02) and executive function (β = −0.05, p = 0.04). The association with executive function was no longer significant after inclusion of folate in the regression model (β = −0.032, p = 0.22). Change in working memory and attention were not associated with plasma homocysteine, folate or B12. High homocysteine was associated with greater decline with a Cohen's d effect size of approximately 0.7 compared to low homocysteine.Conclusions:In a population of older hypertensive patients, higher plasma homocysteine was associated with cognitive decline.

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