scholarly journals Diabetic retinopathy: a tool for cardiovascular risk stratification

2020 ◽  
Vol 22 (5) ◽  
pp. 455-460
Author(s):  
Angelo Avogaro ◽  
Gian Paolo Fadini
Keyword(s):  
Diabetes Mellitus ◽  
Bone Marrow ◽  
Renal Failure ◽  
Diabetic Retinopathy ◽  
Cardiovascular Risk ◽  
Microvascular Complications ◽  
Cardiovascular Complications ◽  
Cross Sectional ◽  
Patients With Diabetes ◽  
Diabetic Microvascular Complications

Randomized, cross-sectional, and prospective studies have demonstrated that microvascular complications in patients with diabetes are not only the cause of blindness, renal failure and non-traumatic amputations, but also powerful predictors of cardiovascular complications. The pathophysiology of diabetic microvascular complications is determined by several factors including epigenetic modifications, and reduced release of circulating progenitor cells by the bone marrow. Identifying microvascular complications, in particular retinopathy, increases the ability to stratify patients in terms of cardiovascular risk. There may no longer be a rational to consider microangiopathy and macroangiopathy as entirely separate entities, but they should most likely be viewed as a continuum of the widespread vascular damage determined by diabetes mellitus.

scholarly journals Anxiety among patients with diabetes mellitus evaluated using generalized anxiety disorder 7-item scale

2016 ◽  
Vol 04 (02) ◽  
pp. 133-136 ◽  
Author(s):  
Amit Thour ◽  
Ramninder Nagra ◽  
Arunjeet Gosal ◽  
Tejasav Sehrawat ◽  
Subhash Das ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Tertiary Care Hospital ◽  
Microvascular Complications ◽  
Tertiary Care ◽  
Generalized Anxiety ◽  
Care Hospital ◽  
Cross Sectional ◽  
Patients With Diabetes

Abstract Background: Anxiety has been shown to be associated with poor outcomes in people with diabetes. However, there has been limited data, especially from India, which has specifically examined whether diabetes mellitus is associated with an increased likelihood of comorbid anxiety. Aim: The aim was to estimate the prevalence of anxiety in patients with diabetes and to determine the association of anxiety with age, sex, and other related parameters. Setting: Endocrine clinic, tertiary care hospital. Design: Cross-sectional. Materials and Methods: The study was cross-sectional carried out in endocrinology clinic of tertiary care hospital in North India. Cases were patients with type 2 diabetes mellitus above 30 years of age. Anxiety was assessed using the generalized anxiety disorders 7-item (GADs-7) scale. The relationship with a sociodemographic profile, duration of diabetes, hypertension, and microvascular complications was also analyzed. Results: Seventy-three subjects (42.5% females) with mean age 50.8 ± 9.2 years were evaluated. The prevalence of anxiety was 34%. Severe anxiety (GAD-7 score ≥15) was present in three (4%) subjects, moderate anxiety (GAD-7 score ≥10) was present in six (8%) subjects, and mild anxiety was present in 16 (22%) of subjects. Anxiety increased with fasting plasma glucose, hypertension, was more in women, but the differences were not statistically significant. Conclusions: Our study demonstrates a higher prevalence of anxiety in patients with type 2 diabetes. No factor was significantly associated with anxiety. Therefore, anxiety should be assessed in each and every patient, irrespective of other factors.

Mode of Ayurvedic intervention in Diabetic Retinopathy (Sannipathika Kacha) associated with Chronic Renal Failure - A Case Study

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Ratheesh P ◽  
Abhayadev A ◽  
Soumya M C ◽  
Sreenivasan M
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Diabetic Retinopathy ◽  
Chronic Renal Failure ◽  
Dietary Habits ◽  
Microvascular Complications ◽  
Fluid Collection ◽  
Herbal Medicines ◽  
Clinical Findings ◽  
Microvascular Damage

Diabetic retinopathy and nephropathy are microvascular complications of diabetes mellitus affecting eye and kidney respectively. The patient has reported gradual loss of vision (counting finger at a distance of 70cm) in both eyes for one month associated with history of Chronic Renal Failure. In Ayurvedic classics defective urination and diminution of vision are mentioned in the context of Prameha (Diabetes mellitus). Ophthalmoscopic examination revealed haemorrhages and fluid collection at the level of retina especially at macula due to microvascular damage. The derangement of Pittadosha (humor)by improper dietary habits and irregular lifestyle result in the vitiation of Raktha, which is more evident in eyes. The condition showing clinical similarity with Sannipathika Kacha, a disease affecting Dhrishtipatala of the eye. The logical interpretation on the basis of both subjective and objective clinical findings concluded the diagnosis as Pittadhika Sannipathika Kacha. The treatment principle adopted was Rakthasthambhana, Pittakaphasophahara, Abhisyandhahara and Srothovisodhana with good metabolic control. The treatment was planned without giving any internal herbal medicines except medicated porridge. After treatment his vision has improved as 6/24 (Rt. Eye) and 6/12 (Lt. eye). The study discusses about the Ayurvedic management of diabetic retinopathy associated with chronic renal failure.

scholarly journals ALBUMIN AND HEMOGLOBIN VALUE IN CHRONIC RENAL FAILURE (CRF) PATIENTS WITH DIABETES AND NON-DIABETES

2018 ◽  
Vol 2 (2) ◽  
pp. 253
Author(s):  
Diyah Candra Anita
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Nutritional Status ◽  
Sampling Method ◽  
Historical Background ◽  
Measuring Instruments ◽  
Cross Sectional ◽  
Patients With Diabetes ◽  
Larger Sample

Introduction. Malnutrition is a common problem in patients with chronic renal failure (CRF) with Diabetes Mellitus and Non-Diabetes Mellitus. Assessments of nutritional status in CRF patients are required to measure some important parameters including serum albumin and hemoglobin. This study aimed to fi gure out the differences of nutritional status between CRF patients with diabetes mellitus and without diabetes mellitus in the inpatient unit of PKU Muhammadiyah Hospital Yogyakarta, by examining the levels of albumin and hemoglobin serum. Methods. This study applied cross sectional method of which measuring instruments were patients’ medical records of laboratory tests. This research used accidental sampling method involving 30 patients as samples. Result. The results of independent t-test showed that there was no signifi cant differences between the levels of albumin (p = 0.917) and hemoglobin (p = 0.168) between the group of non DM CRF patients and CRF patients with  M. Discussion. Therefore, further research should be performed by using a larger sample size as well as considering patients’ historical background of hemodialysis treatment.Keywords: Diabetes Mellitus (DM), Chronic Renal Failure (CRF), albumin, hemoglobin

scholarly journals Application of artificial intelligence in prediction of cardiovascular complications in patients with diabetes mellitus type 2: A protocol of systematic review

2021 ◽  
Author(s):  
Hengameh Ferdosian ◽  
◽  
Hadi Zamanian ◽  
Sayed Ali Emami ◽  
Elahe Sedighi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Microvascular Complications ◽  
Cardiovascular Complications ◽  
Diabetic Patients ◽  
Increased Risk ◽  
Patients With Diabetes ◽  
Review Question

Review question / Objective: The aim of this systematic review is to evaluate AI-based models in identifying predictors of cardiovascular events and risk predtion in patients with diabetes mellitus type2. Condition being studied: T2DM patients have an increased risk of macrovascular and microvascular complications, lead to decreased quality of life and mortality. Considering the significance of cardiovascular complications in these patients, prediction of such events would be important. Different traditional statistical methods(such as regression) and new AI-besed algorithms are used to predict these complications in diabetic patients.

scholarly journals Control of cardiovascular risk in patients with diabetes

2016 ◽  
Vol 13 (3) ◽  
pp. 42-47
Author(s):  
Yu V Zhernakova ◽  
I E Chazova
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Risk ◽  
Cardiovascular Complications ◽  
Point Of View ◽  
Modifiable Risk Factors ◽  
Complex Approach ◽  
Antihyperglycemic Therapy ◽  
Patients With Diabetes ◽  
Prevalence Of Diabetes Mellitus ◽  
Successful Prevention

Prevalence of diabetes mellitus (DM) is a version of pandemic, in Russia as well, nowadays. Mortality of patients suffering from DM is associated with the development of macrovascular complications and successful prevention of these complications depends on the complex approach to identify and to correct all modifiable risk factors, included in risk indexes. According to many experts’ point of view, key moments in reducing the risk of cardiovascular complications in patients with DM are to achieve target blood pressure and target levels of lipid metabolism, including the application of non-drug therapies. However, the appearance of new data concerning the possibility of antihyperglycemic therapy, no doubt, will change our point of view on managing cardiovascular risk in patients with DM, in particular empagliflozin, which can influence on cardiovascular outcomes.

scholarly journals Awareness of Diabetic Retinopathy among patients with Diabetes Mellitus in Ilorin, Nigeria

2017 ◽  
Vol 12 (2) ◽  
pp. 89
Author(s):  
Olokoba L B ◽  
Mahmud O A ◽  
Adepoju F G ◽  
Olokoba A B
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Clinical Information ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Female Ratio ◽  
Patients With Diabetes ◽  
High Level ◽  
Male To Female

<p><strong>Background: </strong>Diabetic retinopathy is a major cause of blindness worldwide. The associated loss of productivity and quality of life of the patients with diabetic retinopathy will lead to additional socioeconomic burden. This study aims to determine the level of awareness of diabetic retinopathy among diabetic patients. <strong></strong></p><p><strong>Materials and Methods: </strong>This hospital-based cross sectional study, was carried out at the Diabetic and Ophthalmology clinics of University of Ilorin Teaching Hospital, Nigeria from November 2011 to July 2012. A total of 365<strong> </strong>patients had validated, semi-structured, and interviewer-administered questionnaires to obtain information on socio-demographic characteristics, clinical information and awareness of diabetic retinopathy. <strong></strong></p><p><strong>Results: </strong>A total of 365 patients were enrolled, with age between 19 and 90 years, and a mean of 45.8 ±16.3 years. The male to female ratio was 1: 2.2. Ninety-nine respondents (27.1%) had no education. The majority (30.4%) had only primary education; 21.1% had tertiary; 14.5% had secondary while 6.8% had Quranic education. The mean duration of diabetes mellitus was 14.1 ±13.09 years. Of the 365 patients with diabetes mellitus, 279(76.4%) had heard that diabetes mellitus affects the eyes, while 86(23.6%) had not. Of those who had heard, 221(79.2%) heard it from health personnel, 45(16.1%) from radio/television, 25(9.0%) from internet, 23(8.2%) from books/newspapers, while 16(5.7%) heard from other sources.<strong></strong></p><p><strong>Conclusion: </strong>There was a high level of awareness of diabetic retinopathy amongst the patients. However, the high level of awareness of the blinding complication of diabetes mellitus did not translate to a correspondingly high level of ocular examination for diabetic retinopathy.  <strong></strong></p>

Individual Case Safety Reports Analysis for Patients with Diabetes Mellitus on Insulin in Africa and the Middle East

2021 ◽  
Vol 16 ◽  
Author(s):  
Charity R.N. Mlotshwa ◽  
Johanita R. Burger ◽  
Martine Vorster ◽  
Dorcas M. Rakumakoe ◽  
Marike Cockeran
Keyword(s):  
Diabetes Mellitus ◽  
Middle East ◽  
Microvascular Complications ◽  
Individual Case ◽  
Cross Sectional Study ◽  
Patient Age ◽  
Cross Sectional ◽  
Patient Âgé ◽  
Patients With Diabetes ◽  
Insulin Use

Background: The growing numbers of patients with diabetes mellitus in Africa and the Middle East on antidiabetic therapies necessitate an understanding of adverse event (AE) reporting in these regions. Objective: To provide an AE reporting overview in patients using insulins in Africa and the Middle East by characterizing and comparing individual case safety reports (ICSRs) features. Method: The cross-sectional study analyzed ICSR data from a global pharmaceutical company’s pharmacovigilance database for January to December 2018 to describe and compare patient demographics, report sources, reporter types, ICSR seriousness, suspect products, indication for insulin use and AE preferred terms, by country. Results: Overall 7076 ICSRs were analyzed, 63.6% from the Middle East. Most ICSRs were non-serious (91.5%), from solicited sources (83.5%), and reported by consumers (70.7%). Patients from the Middle East were, on average, 34.2 years of age, had gestational diabetes mellitus as indication (64.3%), insulin detemir as suspect product (76.5%), and exposure during pregnancy as AE preferred term (89.1%). Patients from Africa were 48.1 years old on average, a higher proportion of type 2 diabetes mellitus was observed (52.2%), human insulins the suspect product (51.6%), and blood glucose increased the AE preferred term (23.1%). Few macrovascular and microvascular complications were reported (<1% in both regions). Associations between the region and patient age, gender, report sources, reporter types, indications for insulin use, suspect products, and AE preferred term were significant (p <0.001). Conclusion: ICSRs features were region-specific and dependent on patient age, gender, report sources, reporter types, suspect products, and AE preferred terms.

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