The Creation of the International Thymic Malignancies Interest Group as a Model for Rare Diseases

2012 ◽  
pp. 471-474
Author(s):  
Frank C. Detterbeck
Keyword(s):  
Rare Disease ◽  
Interest Group ◽  
Scientific Collaboration ◽  
Rare Condition ◽  
Orphan Diseases ◽  
Rapid Progress ◽  
International Database ◽  
The Past ◽  
Novel Approaches ◽  
Made In

Overview: Similar to other orphan diseases, little progress has been made in the past decades in thymic malignancies. A determination to make a difference, despite the challenges facing a rare disease, led to the formation of the International Thymic Malignancies Interest Group (ITMIG) in 2010. This organization has brought together the majority of those focused on the management of thymic malignancies and has built a foundation for scientific collaboration, including consistent use of terms, an international database, and multidisciplinary engagement of clinicians and researchers from around the world. ITMIG has embarked on the development of novel approaches to research particularly suited to a rare condition. ITMIG has gained substantial recognition for the rapid progress that has been made and serves as a model for the advancement of knowledge in a rare disease.

Managing Aviation Technologies

1959 ◽  
Vol 63 (583) ◽  
pp. 381-393
Author(s):  
Charles J. McCarthy
Keyword(s):  
New York ◽  
Memorial Lecture ◽  
Rapid Progress ◽  
The Past ◽  
Anglo American ◽  
Wilbur Wright ◽  
Made In

It is a great distinction and a highly esteemed honour to be privileged to read the forty-seventh Wilbur Wright Memorial Lecture. It is also a distinct personal pleasure to be here. Over the past 15 years I have made periodic trips to England to visit the aircraft companies, to witness the spectacular Farnborough displays of the S.B.A.C. and to attend the Anglo-American Conferences of the Royal Aeronautical Society and the Institute of the Aeronautical Sciences. This has afforded opportunities to observe and admire the rapid progress you have made in aeronautics, the brilliant achievements of British engineers and scientists and, more importantly, the chance to make and deepen warm and valued friendships. The joint meetings of the Society and the Institute are proving to be fruitful ground for the exchange of ideas and for becoming better acquainted. May I express the sincere wish that I shall have the pleasure of welcoming many of you to the Seventh Anglo-American Conference which will be held in October 1959 in New York.

Quantitative x-ray microfluorescence analysis of small areas and individual particles

1992 ◽  
Vol 50 (2) ◽  
pp. 1754-1755
Author(s):  
P. A. Pella ◽  
M. Lankosz ◽  
B. Holynska
Keyword(s):  
Gaussian Function ◽  
Normal Incidence ◽  
Video Camera ◽  
Rapid Progress ◽  
X Ray ◽  
Small Areas ◽  
The Past ◽  
Source Sample ◽  
Individual Particles ◽  
Made In

During the past few years, rapid progress has been made in the development of collimated x-ray sources which permit energy-dispersive x-ray analysis of small areas with dimensions below 100 μm. An x-ray microfluorescence spectrometer developed at NIST employs a commercial low-power (50 WATTS) x-ray tube providing a small focused x-ray beam (0.25 × 0.25 mm). The x-ray beam size was further reduced with a Mo collimator tipped with a Pt foil having a 70μm hole in the center. The x-ray beam profile was measured by step scanning across Cu wires 50 μm in diameter in both X and Y directions. The cross section of the beam was approximated by a Gaussian function with a FWHM of 43 μm. A schematic diagram of the spectrometer which is capable of operation in vacuum is shown in Figure 1.Other features include a close coupled source-sample-detector for optimum count rate, a motorized x-y stage, and a color video camera for continuous viewing of the sample at normal incidence.

scholarly journals The changing face of a rare disease: lymphangioleiomyomatosis

2015 ◽  
Vol 46 (5) ◽  
pp. 1471-1485 ◽  
Author(s):  
Sergio Harari ◽  
Olga Torre ◽  
Roberto Cassandro ◽  
Joel Moss
Keyword(s):  
Rare Disease ◽  
Tuberous Sclerosis Complex ◽  
Therapeutic Approach ◽  
Clinical Manifestations ◽  
Therapeutic Strategies ◽  
The Past ◽  
Lymphatic Abnormalities ◽  
Abdominal Tumours ◽  
Remarkable Progress ◽  
Made In

Lymphangioleiomyomatosis is a rare disease characterised by cystic destruction of the lung, lymphatic abnormalities and abdominal tumours. It affects almost exclusively females and can occur sporadically or in patients with tuberous sclerosis complex.In the past decade remarkable progress has been made in understanding of the pathogenesis of this disease leading to a new therapeutic approach. This review summarises recent advances regarding pathogenic mechanisms and clinical manifestations, and highlights the current and the most promising future therapeutic strategies.

scholarly journals Intracarotid Delivery of Drugs

2008 ◽  
Vol 109 (3) ◽  
pp. 543-564 ◽  
Author(s):  
Shailendra Joshi ◽  
Phillip M. Meyers ◽  
Eugene Ornstein
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Endovascular Procedures ◽  
Molecular Techniques ◽  
Rapid Progress ◽  
The Past ◽  
Risk Patients ◽  
Kinetics Of ◽  
The Brain ◽  
Made In

The major efforts to selectively deliver drugs to the brain in the past decade have relied on smart molecular techniques to penetrate the blood-brain barrier, whereas intraarterial drug delivery has drawn relatively little attention. Meanwhile, rapid progress has been made in the field of endovascular surgery. Modern endovascular procedures can permit highly targeted drug delivery by the intracarotid route. Intracarotid drug delivery can be the primary route of drug delivery or it could be used to facilitate the delivery of smart neuropharmaceuticals. There have been few attempts to systematically understand the kinetics of intracarotid drugs. Anecdotal data suggest that intracarotid drug delivery is effective in the treatment of cerebral vasospasm, thromboembolic strokes, and neoplasms. Neuroanesthesiologists are frequently involved in the care of such high-risk patients. Therefore, it is necessary to understand the applications of intracarotid drug delivery and the unusual kinetics of intracarotid drugs.

scholarly journals A new era for research into aging

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Matt Kaeberlein ◽  
Jessica K Tyler
Keyword(s):  
Clinical Impact ◽  
Rapid Progress ◽  
Special Issue ◽  
New Era ◽  
The Past ◽  
Age Related ◽  
Mechanistic Understanding ◽  
Made In

eLife is publishing a special issue on aging, geroscience and longevity to mark the rapid progress made in this field over the past decade, both in terms of mechanistic understanding and translational approaches that are poised to have clinical impact on age-related diseases.

scholarly journals Dark Matter in Clusters of Galaxies

1995 ◽  
Vol 164 ◽  
pp. 227-235
Author(s):  
Claude R. Canizares
Keyword(s):  
Dark Matter ◽  
Galaxy Clusters ◽  
Gravitational Lensing ◽  
Clusters Of Galaxies ◽  
Rapid Progress ◽  
X Ray ◽  
Mass Distributions ◽  
The Past ◽  
Accurate Picture ◽  
Made In

An appropriate subtitle for this talk might be “Newton meets Einstein.” For many decades, the prime tool for studying the amount and distribution of matter in galaxy clusters was decidedly Newtonian, involving at first the measurements of the dynamics of the galaxies themselves and, for the past 15 years or so, the imputed dynamics of the hot, X-ray emitting intra-cluster gas. Einstein enters more recently with the introduction of gravitational lensing as a tool for studying cluster mass distributions. Rapid progress is being made in each of these areas, and there are now attempts to bring them together to give a consistent and more accurate picture of clusters.

1989 göçü sonrası Bulgaristan göçmenlerinin yemek kültüründeki değişim

2017 ◽  
Vol 4 (2) ◽  
pp. 227-245
Author(s):  
Cahit Kahraman ◽  
İlhan Güneş ◽  
Nanae Kahraman
Keyword(s):  
Eating Habits ◽  
Supply And Demand ◽  
Food Culture ◽  
Rapid Progress ◽  
Canned Food ◽  
Product Range ◽  
The World ◽  
Before And After ◽  
Day By Day ◽  
Made In

1989 göçü öncesi, dünyada eşzamanlı olarak gittikçe gelişen ve zenginleşen mutfak kültürü, Bulgaristan Türklerini de etkilemiştir. Pazardaki çeşitlilik arttıkça, yemek alışkanlıkları da değişime uğramıştır. Büyük göçten sadece 30-40 sene evvel kısıtlı imkânlar ile sınırlı sayıda yemek çeşidi üretilirken, alım gücünün artmasıyla yemek kültüründe de hızlı gelişmeler olmuştur. Artan ürün çeşitliliği yemeklere de yansımış, farklı lezzetler mutfaklara girmiştir. Göçmen yemekleri denilince hamur işleri, börek ve pideler akla gelir. Ayrıca, göçmenlerin çok zengin turşu, komposto ve konserve kültürüne sahip oldukları da bilinir. Bu çalışma, 1989 öncesi Bulgaristan’ın farklı bölgelerinde yaşayan Türklerin yemek alışkanlıklarına ışık tutmakla birlikte, göç sonrasında göçmen mutfak kültüründe bir değişiklik oluşup oluşmadığını konu almaktadır. Bu amaçla, 1989 yılında Türkiye’ye göç etmiş 50 kişiye 8 sorudan oluşan anket düzenlenmiştir. Bu verilerden yola çıkarak oluşan bulgular derlenmiş ve yeni tespitler yapılmıştır. Ayrıca, Türkiye’nin farklı bölgelerine yerleşen göçmenler, kendi göçmen pazarlarını kurmuşlardır. Bulgaristan’dan getirilen ürünlerin bu pazarlarda satılması böyle bir arz talebin hala devam ettiğine işaret etmektedir.ABSTRACT IN ENGLISHThe Diversity in Cuisine Culture of the Immigrants from Bulgaria After 1989 MigrationThe Cuisine culture that has been developing and getting rich day by day contemporaneously in the world before 1989 migration has also had an impact on Bulgarian Turks. By the increase in diversity in the market, eating habits have changed. While producing a limited number of food types with limited opportunities just some 30 or 40 years before the ‘Big Migration’, there has been a rapid progress in food culture by the help of the increase in purchase power. Enhancing product range has been reflected in food, and different tastes have entered the cuisines. When we say immigrant, the first things that come to our mind are pastry, flan and pitta bread. Moreover, it is also known that immigrants have a very rich cuisine culture of pickle, stewed fruit, and canned food. This study aims both to disclose the eating habits of Turks living in different regions of Bulgaria before 1989 and to determine whether there has been a difference in immigrant cuisine culture before and after the migration. For this purpose, a questionnaire consisting of 8 questions has been administered to 50 people who migrated to Turkey in 1989. The results gathered from these data have been compiled and new determinations have been made. In addition, immigrants that settled in different regions of Turkey have set their own immigrant markets. The fact that the products brought from Bulgaria are being sold in these markets shows that this kind of supply and demand still continues.

South Asian Developmental Crisis (Review Article)

1973 ◽  
Vol 12 (2) ◽  
pp. 181-188
Author(s):  
Rafiq Ahmad
Keyword(s):  
Second World War ◽  
World War ◽  
The Past ◽  
The Great Depression ◽  
Political Independence ◽  
Integrated Theory ◽  
Pass Through ◽  
Developed World ◽  
Second World ◽  
Made In

Like nations and civilizations, sciences also pass through period of crises when established theories are overthrown by the unpredictable behaviour of events. Economics is passing through such a crisis. The challenge thrown by the Great Depression of early 1930s took a decade before Keynes re-established the supremacy of economics. But this supremacy has again been upset by the crisis of poverty in the vast under-developed world which attained political independence after the Second World War. Poverty had always existed but never before had it been of such concern to economists as during the past twenty five years or so. Economic literature dealing with this problem has piled up but so have the agonies of poverty. No plausible and well-integrated theory of economic development or under-development has emerged so far, though brilliant advances have been made in isolated directions.

Mass Spectrometry Techniques: Principles and Practices for Quantitative Proteomics

2020 ◽  
Vol 21 ◽  
Author(s):  
Rocco J. Rotello ◽  
Timothy D. Veenstra
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Proteomics ◽  
Protein Identification ◽  
Dynamic Nature ◽  
Complete Coverage ◽  
The Past ◽  
Proteome Level ◽  
A Cell ◽  
Quantitative Changes ◽  
Made In

: In the current omics-age of research, major developments have been made in technologies that attempt to survey the entire repertoire of genes, transcripts, proteins, and metabolites present within a cell. While genomics has led to a dramatic increase in our understanding of such things as disease morphology and how organisms respond to medications, it is critical to obtain information at the proteome level since proteins carry out most of the functions within the cell. The primary tool for obtaining proteome-wide information on proteins within the cell is mass spectrometry (MS). While it has historically been associated with the protein identification, developments over the past couple of decades have made MS a robust technology for protein quantitation as well. Identifying quantitative changes in proteomes is complicated by its dynamic nature and the inability of any technique to guarantee complete coverage of every protein within a proteome sample. Fortunately, the combined development of sample preparation and MS methods have made it capable to quantitatively compare many thousands of proteins obtained from cells and organisms.

Evidence-based Assessment

2010 ◽  
pp. 76-98
Author(s):  
John Hunsley ◽  
Eric J. Mash
Keyword(s):  
Decision Making ◽  
Clinical Assessment ◽  
Assessment Process ◽  
Evidence Based ◽  
The Past ◽  
Specific Assessment ◽  
The Many ◽  
Selection Of ◽  
Made In

Evidence-based assessment relies on research and theory to inform the selection of constructs to be assessed for a specific assessment purpose, the methods and measures to be used in the assessment, and the manner in which the assessment process unfolds. An evidence-based approach to clinical assessment necessitates the recognition that, even when evidence-based instruments are used, the assessment process is a decision-making task in which hypotheses must be iteratively formulated and tested. In this chapter, we review (a) the progress that has been made in developing an evidence-based approach to clinical assessment in the past decade and (b) the many challenges that lie ahead if clinical assessment is to be truly evidence-based.

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