scholarly journals Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome

2019 ◽  
Vol 62 (1) ◽  
pp. 12-18 ◽  
Author(s):  
Ayca Tuzcu ◽  
Rabia Aydogan Baykara ◽  
Murat Alışık ◽  
Ahmet Omma ◽  
Gunseli Karaca Acet ◽  
...  
Keyword(s):  
Fibromyalgia Syndrome ◽  
Fibromyalgia Impact Questionnaire ◽  
Somatic Symptoms ◽  
Thiol Group ◽  
Control Group ◽  
Widespread Pain ◽  
Healthy Individuals ◽  
Total Thiol ◽  
Healthy Female ◽  
Rheumatological Disease

Background: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Thiol group is a very strong antioxidant. We aimed to investigate whether thiol/disulfide homeostasis in FMS is altered or not. Material and methods: A total of 80 female FMS patients and 64 healthy female control individuals were included in this study. Thiol and disulfide values were measured by Erel’s novel methods. Results: Native thiol (330.6 ± 46.1 vs. 356.8 ± 55.5 μmol/L, p = 0.005) and native thiol/total thiol (89.4 ± 3.2 vs. 93.3 ± 4.0, p < 0.001) levels of FMS patients were significantly lower when compared to the values of control group. However, disulfide (19.4 ± 6.3 vs. 12.2 ± 6.3 μmol/L, p < 0.001) levels of FMS patients were significantly higher than healthy individuals. A negative correlation was found between the native thiol/total thiol and fibromyalgia impact questionnaire (FIQ) score among the FMS patients. A positive correlation was found between disulfide values and FIQ score among the patients. Conclusions: In FMS patients, there was a significant correlation between the decrease in the thiol levels and an increase in the disulfide levels with the FIQ scores. We determined that thiol-disulfide rate was deteriorated in FMS patients and it increases in favor of disulfide amounts.

scholarly journals Thiol/Disulfide homeostasis in patients with rheumatoid arthritis

2019 ◽  
Vol 57 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Ayca Tuzcu ◽  
Rabia Aydogan Baykara ◽  
Ahmet Omma ◽  
Gunseli Karaca Acet ◽  
Erdal Dogan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Disease Activity ◽  
Negative Correlation ◽  
Disease Activity Score ◽  
Thiol Group ◽  
Activity Score ◽  
Control Group ◽  
Healthy Individuals ◽  
Healthy Female

Abstract Background. Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with RA by evaluating thiol/disulfide homeostasis. Material and methods. A total of 50 female RA patients and 50 healthy female controls were included in this study. Thiol and disulfide values were calculated utilizing novel methods. Results. Native thiol (p < 0.001) and total thiol (p < 0.001) levels of RA patients were significantly lower compared to values in the control group. However, the disulfide (p < 0.001) levels of RA patients were strongly higher than in healthy individuals. A negative correlation was found between thiol and disease activity score-28 among the patients, whereas a positive correlation was found between disulfide and disease activity score-28 among the patients. Conclusion. We found that the thiol–disulfide rate deteriorated in RA patients, with the proportion of disulfide increasing. There is a strong correlation between the decrease in thiol levels, increase in disulfide levels and the disease activity scores.

scholarly journals Effectiveness of a strength training program for patients with fibromyalgia syndrome: feasibility study

2017 ◽  
Vol 16 (2) ◽  
pp. 169-176
Author(s):  
Alexandro Andrade ◽  
Guilherme Torres Vilarino ◽  
Carla Maria de Liz ◽  
Ricardo De Azevedo Klumb Steffens
Keyword(s):  
Strength Training ◽  
Training Program ◽  
Fibromyalgia Syndrome ◽  
Fibromyalgia Impact Questionnaire ◽  
Training Group ◽  
Control Group ◽  
Stress Scale ◽  
Post Test ◽  
And Control ◽  
General Community

Introduction: Fibromyalgia is a disease characterized by chronic pain; it is a syndrome with an unknown cause and has no cure. Objective: Examine the feasibility of a strength training program in patients with FM. Methods: Fortyseven patients from general community were allocated into two groups: strength training group and control group. The patients underwent strength training performed three times per week for eight weeks. We used the Fibromyalgia Impact Questionnaire and Perceived Stress Scale to obtain data. Results: After eight weeks of strength training, there was a significant reduction in pain (p = 0.00) and stress (p = 0.02). No changes were found in the variables analyzed in the control group pre- and post-test. Conclusions: The practice of strength training is a safe and effective alternative for the treatment of fibromyalgia patients.

scholarly journals Social Cognition and Attachment Profiles of Fibromyalgia Syndrome Patients in Comparison with Healthy Subjects

2021 ◽  
Author(s):  
Beycan Gözde Ayhan ◽  
BASAR AYRIBAS ◽  
Canan Sanal ◽  
Pemra Cöbek Ünalan
Keyword(s):  
Social Cognition ◽  
Attachment Style ◽  
Attachment Styles ◽  
Fibromyalgia Syndrome ◽  
Social Cognitive ◽  
Fibromyalgia Impact Questionnaire ◽  
Attachment Anxiety ◽  
Control Group ◽  
Sociological Factors ◽  
Significant Difference

Background: Fibromyalgia syndrome (FMS) is a chronic syndrome primarily characterized by widespread musculoskeletal pain. Although its etiology is not fully understood, complex interactions between biological, genetic and psycho-sociological factors thought to be effective in the onset and maintenance of FMS. Psychological factors could be explained by social cognitive concepts, which include mentalizing other person’s intentions, beliefs, behaviors and attachment styles. Objectives: In this study we aimed to examine social cognitive and attachment profiles of FMS patients. Methods: The participants were recruited from Marmara University Pendik Training and Research Hospital. Sociodemographic data were questioned in both groups while FMS group was also administered Fibromyalgia Impact Questionnaire (FIQ) to determine disease severity. In order to evaluate social cognition profiles of the participants, Reading Mind in the Eyes Test (RMET), Empathy Quotient (EQ) and Experiences in Close Relationships-Revised were applied by the same researcher. Results: 41 women with FMS and 44 healthy women matched for education and age were involved in the study. There was no significant difference in sociodemographic parameters between FMS and control groups. FMS patients did not differ significantly from control subjects in means of RMET and EQ scores. Although no significant difference found between attachment anxiety, FMS patients were found to have more avoidant attachment style than control group. Conclusion: FMS patients may have no social cognition impairments, especially in lack of any psychiatric comorbidities. Moreover, these patients may suffer from avoidant type of insecure attachment and this attachment style may effect social support seeking behaviour of these patients.

Assessment of sleep quality in fibromyalgia syndrome and its effect on postural balance and functional status

2020 ◽  
pp. 1-8
Author(s):  
Yasemin Bolukbas ◽  
Berna Celik
Keyword(s):  
Sleep Quality ◽  
Functional Status ◽  
Fibromyalgia Syndrome ◽  
Rating Scale ◽  
Sleep Problems ◽  
Fibromyalgia Impact Questionnaire ◽  
Numeric Rating Scale ◽  
Control Group ◽  
Balance Disorders ◽  
Abc Scale

BACKGROUND: Patients with fibromyalgia syndrome (FMS) often have sleep problems and balance disorders. OBJECTIVE: The aim of the study was to examine sleep quality and balance disorders and the relationship between sleep quality and balance, functional status and the frequency of falls in patients with FMS. METHODS: Fifty women with FMS and 50 healthy women were included in the study. Sleep quality was assessed with the numeric rating scale (NRS) and the Pittsburgh Sleep Quality Index (PSQI) and balance and balance self-confidence were assessed with the Berg Balance Scale (BBS) and Activities-Specific Balance Confidence (ABC) Scale, respectively. Functional status and symptom severity of patients were assessed with the Fibromyalgia Impact Questionnaire (FIQ) and the Symptom Impact Questionnaire (SIQR). The number of falls in the last six months were recorded. RESULTS: In the patient group, sleep quality scores were significantly higher, and BBS and ABC scores were significantly lower than the control group. NRS scores were significantly correlated with the BBS, FIQ, and SIQR scores, and the PSQI scores were significantly correlated with the BBS and ABC scores and the number of falls in FMS. CONCLUSION: This study showed that the prevalence of sleep and balance disorders is higher in FMS patients. A relationship was reported between the sleep quality and balance and functional status and frequency of falls.

scholarly journals AB0327 SERUM IRISIN LEVELS IN HEALTHY WOMEN AND PATIENTS WITH RHEUMATOID ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1462.1-1462
Author(s):  
A. Yury ◽  
В. Zavodovsky ◽  
P. J ◽  
S. L ◽  
E. Papichev ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Normal Level ◽  
Normal Values ◽  
Reference Interval ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Individuals ◽  
Average Value ◽  
Healthy Female ◽  
Group 2

Objectives:to study serum irisin levels in healthy females and patients with rheumatoid arthritis.Methods:We examined 110 patients with a reliable diagnosis of rheumatoid arthritis (RA). The age of the examined was from 18 to 69 years, all patients were female. The diagnosis of RA was established on the basis of the 2010 EULAR diagnostic criteria. The group of patients included patients with a diagnosis at least one month before the planned screening. As a control group, as well as to create a representation of the normal values irisina level in the blood serum of healthy persons were examined 60 healthy volunteers (all women). In both groups, the level of serum irisin was determined using the enzyme-linked immunosorbent assay by the commercial Irisin ELISA kit.Results:As a result of measurements in the group of healthy individuals, the average value with the standard deviation used to assess the reliability of the average values was 20.49±4.82 μg/ml (μ±σ). By calculation, a reference interval of 10.85-30.13 μg/ml was determined, defined as μ±2σ. In patients with RA, the level of serum irisin was 14.52±6.99 μg / ml (μ±σ), which is significantly lower than in healthy individuals (p<0.01). Then we divided all patients into 2 groups: group 1 with normal values (66 people), group 2 (44 patients) - with a reduced (less than 10.85 μg/ml) level of irisin. In both groups, the dynamics of the level of serum irisin was studied depending on the duration of the disease. Among patients with a disease RA duration of less than 4 years, 16 (24.24%) patients had a normal level of irisin, and 14 (31.82%) had a reduced level (less than 10.85 μg/ml). Among patients with a disease duration of more than 10 years, 36 (54.55%) patients had a normal level of serum irisin, and a low level was determined in 16 (36.36%) patients (χ2=3.568, p=0.168).Conclusion:According to the data obtained, the normal level of serum irisin in healthy female individuals was 10.85-30.13 μg/ml. In patients with RA, the average level of irisin is significantly lower, however, with an increase in the duration of the disease, it tends to normalize.Disclosure of Interests:None declared

scholarly journals Could Ferritin, Vitamin B12, and Vitamin D Play a Role in the Etiopathogenesis of Fibromyalgia syndrome?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Adem Kucuk ◽  
Rabia Aydogan Baykara ◽  
Ayca Tuzcu ◽  
Ahmet Omma ◽  
Medine Cumhur Cure ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Sleep Disturbances ◽  
Fibromyalgia Syndrome ◽  
Short Form ◽  
Fibromyalgia Impact Questionnaire ◽  
Vital Role ◽  
Control Group ◽  
Tender Points ◽  
And Control

Abstract Introduction: Fibromyalgia syndrome (FS) comprises general body pain, sleep disturbances, and fatigue. Vitamin B12 (VB), Vitamin D (VD), and iron deficiencies lead to similar complaints. First, this study aimed to evaluate the VB, VD, and ferritin levels of patients with FS. Second, it aimed to investigate whether there was a relationship between these parameters and FS severity. Material and Methods: The study included 58 female patients with FS and 58 healthy females as a control group. The patients completed the Fibromyalgia Impact Questionnaire (FIQ), Visual Analog Scale (VAS), fatigue questionnaire, Pittsburgh sleep quality scale, and the Short Form-36 (SF-36). This study examined the VD, VB, and ferritin levels of the patient and control groups. Results: The VB (240.0 [110.0-394.0] vs 291.0 [210.0-609.0] pg/ml, p<0.001), VD (12.5 [3.0-45.0] vs 20.0 [5.0-54.0] ng/ml, p=0.013), and ferritin levels (21.2 [4.0-86.0] vs 32.0 [7.1-120.0], ng/ml, p=0.009) of the FS patients were determined to be significantly lower than those of the control group. A negative correlation was determined between the number of tender points and VB, VD, and ferritin levels. In the regression analysis, we found low ferritin levels (odds ratio [OR] 1.036, 95% confidence interval [CI] 1.015-1.058, p<0.001) and VB (OR 1.010, CI 1.002-1.018, p=0.010) to be an independent risk factor for FS. Conclusions: There may be a relationship between VB, VD, and ferritin levels and the number of tender points in patients with FS. Levels of iron and VB may play a vital role in FS etiopathogenesis. However, VD levels may not risk factor for FS etiopathogenesis.

The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus

2018 ◽  
Vol 128 (02) ◽  
pp. 77-81 ◽  
Author(s):  
Merve Ergin ◽  
Cevdet Aydin ◽  
Emine Feyza Yurt ◽  
Bekir Cakir ◽  
Ozcan Erel
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gradual Increase ◽  
Control Group ◽  
Newly Diagnosed ◽  
Healthy Individuals ◽  
Total Thiol

Abstract Aim The purpose of this study was to examine thiol-disulfide balance in patients with type 2 diabetes mellitus. Methods This study included 32 subjects with known type 2 diabetes mellitus without complications, 30 patients with type 2 diabetes mellitus with complications, 28 newly diagnosed patients with type 2 diabetes mellitus, and 45 healthy individuals. Thiol-disulfide profile tests were quantified in all groups. Results Compared to the control group, patients in each of the diabetic groups had significantly lower native and total thiol levels, higher disulfide levels, and higher disulfide/native thiol and disulfide/total thiol ratios (p<0.05 for all). Disulfide levels were significantly lower in the newly diagnosed group than in other diabetic groups (p<0.05). There were significant associations between glycemic parameters and thiol-disulfide tests (p<0.05). Conclusions A disequilibrium between thiol-disulfide pairs occurs in patients with type 2 diabetes mellitus, and a gradual increase to disulfide levels may contribute to the disease’s severity. Deteriorated thiol-disulfide homeostasis may be relevant to the pathophysiology of type 2 diabetes mellitus.

The Impact of Acupuncture Treatment on dynamic thiol–disulphide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in Migraine Patients

2020 ◽  
Vol 44 (3) ◽  
pp. 229-240
Author(s):  
Yasemin Gündüztepe ◽  
Setenay Mit ◽  
Ersel Geçioglu ◽  
Neslihan Gurbuz ◽  
Salim Neşelioğlu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acupuncture Treatment ◽  
Disulphide Bond ◽  
Control Group ◽  
Healthy Individuals ◽  
Oxidative Stress Parameter ◽  
Blood Samples ◽  
Ischemia Modified Albumin ◽  
Total Thiol ◽  
The Impact

The aim of this study was to investigate the effect of acupuncture on dynamic thiol–disulphide homeostasis and ischemia-modified albumin (IMA) levels as a novel oxidative stress parameter in migraine patients. Acupuncture treatment was applied to the 22 volunteer migraine patients. The acupuncture treatment consists of 5 sessions with 2 sessions per week. Blood samples have been collected before performing acupuncture, after the 1st session and after the 5th session of the acupuncture. And for the control group blood samples were collected only once. A total of 44 participants were included in the study, and 24 of whom were diagnosed with migraine. The total thiol, native thiol and ischemia-modified albumin (IMA) levels in the serum were measured in all patients and healthy individuals. The dynamic disulphide bond and ischemia-modified albumin (IMA) levels were calculated from these values. The total and native thiol levels of migraine patients participating in the study were found to be significantly higher than the total and native thiol levels of healthy individuals. The total thiol, native thiol, and dynamic disulphide bond levels, and ischemia-modified albumin (IMA) were correlated with attack frequency, pain intensity, or migraine type. Thiol-disülfide homeostasis can play roles in the etiology and severity of Migraine.

scholarly journals Serum paraoxonase enzyme activity after balneotherapy in patients with fibromyalgia

2020 ◽  
Vol 7 (3) ◽  
pp. 429-432
Author(s):  
Ahmet Karadağ ◽  
Halef Okan Doğan
Keyword(s):  
Enzyme Activity ◽  
Venous Blood ◽  
Fibromyalgia Impact Questionnaire ◽  
Pon1 Activity ◽  
Control Group ◽  
Healthy Female ◽  
Before And After ◽  
Healthy Control ◽  
Pre Treatment ◽  
Serum Paraoxonase

Objective: The aim of this study was to compare the serum paraoxonase (PON 1) levels between patients with fibromyalgia syndrome (FMS) and healthy control subjects, and to investigate the possible effect of balneotherapy (BT) on PON 1 enzyme activity in FMS patients. Methods: The study included 45 female patients with FMS, and 35 healthy female volunteers. To measure PON 1 enzyme activity, venous blood samples were taken twice from the FMS group, before and after BT, and once from the control group. The Visual Analogue Scale (VAS) and Fibromyalgia Impact Questionnaire (FIQ) scales were applied to the FMS patients before and after BT. Results: There was no difference between the FMS group and healthy control group in terms of serum PON1 activity (p>0.05). The comparison of the serum PON 1 activity of the FMS group before and after BT revealed a statistically significant increase after BT (p=0.001). A statistically significant decrease was determined in the VAS and FIQ scores of the FMS group after BT compared to the pre-treatment values (p=0.002, p=0.001, respectively). Conclusion: BT is an effective non-pharmacologic method in the treatment of FMS. There was an increase in serum PON 1 activity in patients with FMS after BT. BT may have a regulatory effect on the antioxidant system of patients with FMS.

Prevalence of Toxoplasma gondii and Toxocara canis among Myositis Patients in Southwest of Iran

2019 ◽  
Vol 20 ◽  
Author(s):  
Jasem Saki ◽  
Karim Mowla ◽  
Reza Arjmand ◽  
Forough Kazemi ◽  
Somayeh Fallahizadeh
Keyword(s):  
Toxoplasma Gondii ◽  
Nested Pcr ◽  
Healthy Subjects ◽  
Toxocara Canis ◽  
Control Group ◽  
Igg Antibodies ◽  
Healthy Individuals ◽  
High Prevalence ◽  
Acute Toxoplasmosis ◽  
Southwest Of Iran

Introduction: Parasitic myositis is caused by some parasites such as T. gondii and T. canis. So, the aim of the study was to evaluate the prevalence T. gondii and T. canis in patients with myositis and healthy individuals. Methods: A total of 108 samples were randomly selected as the control (54 healthy individuals) and test (54 myositis patients) groups. IgG and IgM antibodies against T. gondii and IgG antibodies against T. canis were measured by the ELISA. The detection of chronic and acute toxoplasmosis was performed by the ELISA IgG avidity. The presence of T. gondii in blood was evaluated by the nested-PCR. Results: Of 108, 33 (30.6%) cases were detected positive for IgG against T. gondii that 19 (35.2%) and 14 (25.9%) were observed in myositis patients and healthy individuals, respectively (P=0.296). Of 19 positive cases, 12 (63.2%) and 7 (36.8%) cases were detected as chronic and acute toxoplasmosis, respectively, while, all positive cases in the control group had chronic toxoplasmosis (P=0.013). One (1.9%) sample was detected positive for anti- Toxoplasma gondii IgM and two (3.7%) samples were found positive for IgG against T. canis by the ELISA that these positive cases were observed only in myositis patients (P=1.000 P=0.495, respectively). B1 T. gondii gene was amplified in 12 (63.2%) and 1 (7.1%) in myositis patients and healthy subjects (P=0.001). Conclusions: Our findings showed that there was a relatively high prevalence of acute toxoplasmosis in myositis patients in comparison with the control subjects in southwest of Iran.

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