scholarly journals Implantomics: A Paradigm Shift in Implantology

2019 ◽  
Vol 5 (1) ◽  
pp. 131-136
Author(s):  
H. P. Jennissen

AbstractImplantomics is the science of the implantome. The implantome is a blend of the two terms implant and proteome. The proteome is defined as the protein complement of the genome. The term proteome also implies the mass screening of proteins for the determination of all proteins - and indirectly of all genes - involved in a certain tissue or organ response. In this sense the term proteome is employed here in a new way to specify the totality of proteins associated with a foreign body inserted into the human body. It will be addressed, why the determination of the implanttome is important and which role the implantome may play in the bone-implant interface.

2018 ◽  
Vol 69 (4) ◽  
pp. 875-880
Author(s):  
Oana Roxana Chivu ◽  
Ovidiu Mederle ◽  
Augustin Semenescu ◽  
Ileana Mates ◽  
Claudiu Babis ◽  
...  

The paper describes how to determine the noise in a production hall where there are production machines and equipment. The chosen plant is a production unit where filling of the polyurethane foam tubes is performed. The main activity is the production of professional insulators and wholesale of other products from the same range enumerating the following: wholesale chemical products; production of professional insulators; trade in chemicals and chemical industry. The recommended maximum admissible value for a normal 8h work program is 85 dB (A). The objective is to determine the level of noise in the factory and how it acts as a physical professional risk factor and its effects on the human body. The way in which the proposed objective was achieved was to determine the value of the noise level with the specialized equipment. Following the determinations that will be presented in the following chapters, appropriate protective measures have been taken.


2020 ◽  
Vol 16 ◽  
Author(s):  
Ramazan Akçan ◽  
Halit Canberk Aydogan ◽  
Mahmut Şerif Yıldırım ◽  
Burak Taştekin ◽  
Necdet Sağlam

Background/aim: Use of nanomaterials in the healthcare applications increases in parallel to technological developments. It is frequently utilized in diagnostic procedures, medications and in therapeutic implementations. Nanomaterials take place among key components of medical implants, which might be responsible for certain toxic effects on human health at nano-level. In this review, nanotoxicological effects, toxicity determination of nanobiomaterials used in human body and their effects on human health are discussed. Material and Method: A detailed review of related literature was performed and evaluated as per nanomaterials and medical implants. Results and Conclusion: The nanotoxic effects of the materials applied to human body and the determination of its toxicity are important. Determination of toxicity for each nanomaterial requires a detailed and multifactorial assessment considering the properties of these materials. There are limited studies in the literature regarding the toxic effects of nanomaterials used in medical implants. Although these implants are potentially biocompatible and biodegradable, it is highly important to discuss nanotoxicological characteristics of medical implant.


2010 ◽  
Vol 79 (4) ◽  
pp. 613-620 ◽  
Author(s):  
Lucie Urbanová ◽  
Robert Srnec ◽  
Pavel Proks ◽  
Ladislav Stehlík ◽  
Zdeněk Florian ◽  
...  

The study deals with the determination of mechanical properties, namely resistance to bending forces, of flexible buttress osteosynthesis using two different bone-implant constructs stabilizing experimental segmental femoral bone defects (segmental ostectomy) in a miniature pig ex vivo model using 4.5 mm titanium LCP and a 3 mm intramedullary pin (“plate and rod” construct) (PR-LCP), versus the 4.5 mm titanium LCP alone (A-LCP). The “plate and rod” fixation (PR-LCP) of the segmental femoral defect is significantly more resistant (p < 0.05) to bending forces (200 N, 300 N, and 500 N) than LCP alone (A-LCP). Stabilisation of experimental segmental lesions of the femoral diaphysis in miniature pigs by flexible bridging osteosynthesis 4.5 mm LCP in combination with the “plate and rod” construct appears to be a suitable fixation of non-reducible fractures where considerable strain of the implants by bending forces can be assumed. These findings will be used in upcoming in vivo experiments in the miniature pig to investigate bone defect healing after transplantation of mesenchymal stem cells in combination with biocompatible scaffolds.


Author(s):  
Mojtaba Arjomandi ◽  
*Hamid Shirkhanloo

Heavy metals are vital and necessary in our daily lives. Moreover, if the amounts of heavy metals are more than the acceptable amounts (mentioned by WHO) in soil, water, and air, indeed, they cause a lot of diseases in human bodies. Therefore, monitoring and measuring the amounts of heavy metals that are arduous and difficult are so important. In this review paper, a lot of studies that have been carried out on the determination and quantification of heavy metals in human bodies, soil, and water are considered. Moreover, the effect of toxicity of each heavy metal on human health is assessed. According to WHO, EPA, NIOSH, ACGIH, and clinical chemistry, the determination of heavy metals such as Cd, Pb, Zn, Hg, Cu, Mn is very important in the human body and Environmental matrixes. 


Author(s):  
Cristóbal Pera

ABSTRACTIf the human body is really a fabric, should surgeons be considered architects, as some surgeons describe themselves today? The author raises and analyzes this question, and he concludes that vsurgeons cannot be considered as such: the architect is the creator of his work —fabric or building—, but the surgeon is not the creator of this complex biological fabric —vulnerable and subject to deterioration and with an expiration date— which is the human body. This body is the object upon which his hands and instruments operate. The surgeon cures and heals wounds, immobilizes and aligns fractured bones in order to facilitate their good and timely repair, and cuts open the body’s surface in order to reach its internal organs. He also explores the body with his hands or instruments, destroys and reconstructs its ailing parts, substitutes vital organs taken from a donor’s foreign body, designs devices or prostheses, and replaces body parts, such as arteries and joints, that are damaged or worn out. In today’s culture, dominated by the desire to perfect the body, other surgeons keep retouching its aging façade, looking for an iconic and timeless beauty. This longing can drive, sometimes, to surgical madness. The surgeon is not capable of putting into motion, from scratch, a biological fabric such as the human body. Thus, he can’t create the subject of his work in the way that an architect can create a building. In contrast, the surgeon restores the body’s deteriorated or damaged parts and modifies the appearance of the body’s façade.RESUMEN¿Si el cuerpo humano fuera realmente una fábrica, podría el cirujano ser considerado su arquitecto, como algunos se pregonan en estos tiempos? Esta es la cuestión planteada por el autor y, a tenor de lo discurrido, su respuesta es negativa: porque así como el arquitecto es el artífice de su obra —fábrica o edificio— el cirujano no es el artífice de la complejísima fábrica biológica —vulnerable, deteriorable y caducable— que es el cuerpo humano, la cual le es dada como objeto de las acciones de sus manos y de sus instrumentos. El cirujano cura y restaña sus heridas, alinea e inmoviliza sus huesos fracturados para que su reparación llegue a buen término, penetra por sus orificios naturales o dibuja sobre la superficie corporal incisiones que le permitan llegar a sus entrañas, las explora con sus manos o mediante instrumentos, destruye y reconstruye sus partes enfermas, sustituye órganos vitales que no le ayudan a vivir por los extraídos de cuerpos donantes, y concibe, diseña y hace fabricar artefactos o prótesis, como recambio fragmentos corporales deteriorados o desgastados, como arterias o articulaciones. Otros cirujanos, en la predominante cultura de la modificación del cuerpo, retocan una y otra vez su fachada envejecida ineludiblemente por el paso del tiempo, empeñados en la búsqueda incesante de una belleza icónica y mediática e intemporal, una pretensión que puede conducir, y a veces conduce, al desvarío quirúrgico. En definitiva, el cirujano es incapaz de poner de pie, ex novo, una fábrica biológica como la del cuerpo humano y, por lo tanto, no puede ser su artífice, como lo es el arquitecto de su edificio. A lo sumo, es el restaurador de sus entrañas deterioradas y el modificador de su fachada, de su apariencia.


2013 ◽  
Vol 664 ◽  
pp. 1186-1190
Author(s):  
Maria Kapustova

Working conditions in engineering operations are often characterized by a complex of negative factors, which at every moment load the human body during the active work with various intensity. Determination of the intensity of the workload is important for creation of workplace comfort, which is closely connected to workers’ contentment. The contribution presents a description and application of a mathematical model for determination of the workers´ complex loading at forging press workplace. It's a new and human way of evaluating work comfort, which can take into account the summary effect of all the negative factors at the workplace.


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