Homogeneous precipitation synthesis of BaCO3 powders with a needle-like morphology

2018 ◽  
Vol 7 (3) ◽  
pp. 225-230 ◽  
Author(s):  
Guo Chen ◽  
Jin Chen ◽  
Jinhui Peng
Keyword(s):  
Particle Size ◽  
Barium Carbonate ◽  
Barium Chloride ◽  
Precipitation Method ◽  
Homogeneous Precipitation ◽  
Powder Preparation ◽  
Scanning Calorimetry ◽  
Chloride Dihydrate ◽  
Particle Size Analyzer ◽  
Thermal Stability Of

Abstract Barium chloride dihydrate, sodium hydroxide and carbamide were used to prepare barium carbonate (BaCO3) powders using the homogeneous precipitation method. The effects of Ba2+ concentration, (NH2)2CO concentration, NaOH concentration, reaction temperature and reaction time on the particle size and yield of product were mainly researched. The structure and the thermal stability of BaCO3 powders prepared were analyzed using scanning electron microscopy (SEM) and thermogravimetry-differential scanning calorimetry (TG-DSC), respectively. The particle size distribution of BaCO3 powders was also characterized using a laser particle size analyzer. The results showed that the BaCO3 powder prepared has high purity with a needle-like morphology. Based on the results mentioned, this method can be applied in an effective and efficient way for BaCO3 powder preparation.

Syntheses of ultra-fine barium carbonate powders by homogeneous precipitation method

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Guo Chen ◽  
Jin Chen ◽  
Jinhui Peng
Keyword(s):  
Barium Carbonate ◽  
Barium Chloride ◽  
Precipitation Method ◽  
Homogeneous Precipitation ◽  
Chloride Dihydrate ◽  
Homogeneous Precipitation Method

AbstractUltra-fine barium carbonate powders were successfully synthesized using barium chloride dihydrate (BaCl

The Influence of Calcination Temperature on Quantitative Phase of Hematite from Iron Stone Tanah Laut

2015 ◽  
Vol 1112 ◽  
pp. 489-492
Author(s):  
Ali Mufid ◽  
M. Zainuri
Keyword(s):  
Particle Size ◽  
Calcination Temperature ◽  
Thermo Gravimetric Analysis ◽  
Precipitation Method ◽  
Gravimetric Analysis ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Particle Size Analyzer ◽  
Co Precipitation

This research aims to form particles of hematite (α-Fe2O3) with a basis of mineral iron ore Fe3O4 from Tanah Laut. Magnetite Fe3O4 was synthesized using co-precipitation method. Further characterization using X-ray fluorescence (XRF) to obtain the percentage of the elements, obtained an iron content of 98.51%. Then characterized using thermo-gravimetric analysis and differential scanning calorimetry (TGA-DSC) to determine the calcination temperature, that at a temperature of 445 °C mass decreased by 0.369% due to increase in temperature. Further Characterization of X-ray diffraction (XRD) to determine the phases formed at the calcination temperature variation of 400 °C, 445 °C, 500 °C and 600 °C with a holding time of 5 hours to form a single phase α-Fe2O3 hematite. Testing with a particle size analyzer (PSA) to determine the particle size distribution, where test results indicate that the α-Fe2O3 phase of each having a particle size of 269.7 nm, 332.2 nm, 357.9 nm, 412.2 nm. The best quantity is shown at a temperature of 500 °C to form the hematite phase. This result is used as the calcination procedure to obtain a source of Fe ions in the manufacture of Lithium Ferro Phosphate.

scholarly journals Preparation and Characterization of Nimesulide Nanoparticles For Dissolution Improvement

2018 ◽  
pp. 46-60
Keyword(s):  
Particle Size ◽  
Dissolution Rate ◽  
Precipitation Method ◽  
Scanning Calorimetry ◽  
Decrease Particle Size ◽  
Antisolvent Precipitation ◽  
Particle Size Analyzer ◽  
Particle Size Increase ◽  
Freeze Dried ◽  
Inflammatory Drugs

Nimesulide is one of the types of non-steroidal anti-inflammatory drugs, widely used as analgesic and antipyretic. It is classified as class II drugs according to BCS guidance because of low solubility in water that leads to decrease in dissolution rate. So, the objective of this study was to decrease particle size, increase solubility and dissolution rate of nimesulide by preparation of nimesulide nanoparticles using solvent/antisolvent precipitation method by addition of organic solution of drug onto the solution of stabilizer. The size of nimesulide nanoparticles were studied and considered by particle size analyzer, drug content and loading efficiency. The freeze-dried nanoparticles were characterized by field emission electron microscope, X-Ray powder diffraction, differential scanning calorimetry and saturated solubility measurement. Tablet was manufactured by direct compression. The tablets were evaluated for drug release to measure the effect of nanoparticles on the dissolution improvement of drug.

scholarly journals Preparation and Properties of Ginger Essential Oil β-Cyclodextrin/Chitosan Inclusion Complexes

Coatings ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 305 ◽  
Author(s):  
Yan Zhang ◽  
Hui Zhang ◽  
Fang Wang ◽  
Li-Xia Wang
Keyword(s):  
Particle Size ◽  
Essential Oil ◽  
Spray Drying ◽  
Small Particle Size ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Ft Ir ◽  
Thermal Stability Of ◽  
Scanning Electron

The ginger essential oil/β-cyclodextrin (GEO/β-CD) composite, ginger essential oil/β-cyclodextrin/chitosan (GEO/β-CD/CTS) particles and ginger essential oil/β-cyclodextrin/chitosan (GEO/β-CD/CTS) microsphere were prepared with the methods of inclusion, ionic gelation and spray drying. Their properties were studied by using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermo-gravimetry analysis (TGA), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). The results showed that the particle size of GEO/β-CD composite was smaller than that of β-CD and GEO/β-CD/CTS particles were loose and porous, while the microsphere obtained by spray drying had certain cohesiveness and small particle size. Besides, results also indicated that β-CD/CTS could modify properties and improve the thermal stability of GEO, which would improve its application value in food and medical industries.

FORMULATION AND EVALUATION OF STABILIZED EPROSARTAN NANOSUSPENSION

2020 ◽  
pp. 83-87
Author(s):  
M. SANTHOSH RAJA ◽  
K. VENKATARAMANA
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Polymeric Nanoparticles ◽  
Precipitation Method ◽  
Dissolution Testing ◽  
Potential Drug ◽  
Dsc Analysis ◽  
Scanning Calorimetry ◽  
Bcs Class Ii ◽  
Pvp K30

Objective: The objective of the current study is to enhance the solubility of Eprosartan mesylate a BCS Class II drug by employing the nanoprecipitation technique. Methods: Polymeric nanoparticles of Eprosartan mesylate were prepared by precipitation technique with various polymers like PVP K30, HPMC K15M, and Eudragit L100 in various ratios. The incompatibility issues which may arise between the drug and polymers were tested by differential scanning calorimetry (DSC). The formed nanosuspensions were evaluated for various parameters like particle size, zeta potential, drug content, and dissolution testing. Results: Among all the nanosuspension formulations, E12 formulation prepared with Eudragit L 100 showed better evaluation characteristics. SEM and DSC analysis showed no major interactions with the excipients. The maximum drug release was showed at 12h. The formulation E12 showed the particle size of 81.5±5.5 nm and zeta potential of-55.1mv. Conclusion: The nano-precipitation method improved the dissolution as well as the bioavailability of Eprosartan mesylate nanosuspension.

Formulation and Characterization of Nateglinide Nanosuspension by Precipitation Method

2014 ◽  
Vol 7 (4) ◽  
pp. 2685-2691
Author(s):  
Amruta Papdiwal ◽  
Kishor Sagar ◽  
Vishal Pande
Keyword(s):  
Particle Size ◽  
Dissolution Rate ◽  
Water Solubility ◽  
Average Particle Size ◽  
Biologically Active ◽  
In Vitro Dissolution ◽  
Precipitation Method ◽  
Average Particle ◽  
Scanning Calorimetry

Poor water solubility and slow dissolution rate are major issues for the majority of upcoming and existing biologically active pharmaceutical compounds. Nateglinide is Biopharmaceutical Classification System Class-II drug that has low solubility and high permeability. The purpose of the present study was to improve the solubility and dissolution rate of Nateglinide by the preparation of nanosuspension by the nanoprecipitation technique. Nateglinide nanosuspension was evaluated for its particle size, in vitro dissolution study, and characterized by differential scanning calorimetry and scanning electron microscopy. The optimized formulation showed an average particle size of 207 nm and zeta potential of -25.8 mV. The rate of dissolution of the optimized nanosuspension was enhanced by 83% in 50 min relative to micronized suspension of nateglinide (37% in 50 min). This improvement was mainly due to the formulation of nanosized particles of Nateglinide. Stability study revealed that nanosuspension was more stable at room temperature and refrigerator condition with no significant change in particle size distribution. These results indicate that the nateglinide loaded nanosuspension may significantly improve in vitro dissolution rate and thereby possibly enhance the onset of therapeutic effect.

Formulation and Evaluation of Benidipine Nano-suspension by Precipitation Method using Central Composite Design

2021 ◽  
Vol 14 (3) ◽  
pp. 5492-5500
Author(s):  
Sejal Patel ◽  
Anita P Patel
Keyword(s):  
Particle Size ◽  
Polymer Concentration ◽  
In Vitro Dissolution ◽  
Precipitation Method ◽  
Tween 20 ◽  
Dissolution Profile ◽  
Scanning Calorimetry ◽  
Rate Of Dissolution ◽  
Central Composite ◽  
Pvp K30

In the interest of administration of dosage form oral route is most desirable and preferred method. Poor solubility and slow dissolution rate major challenges in upcoming and existing therapeutically active compound. Water insoluble drug indicate insufficient bioavailability as well dissolution resulting in fluctuating plasma level. Benidipine (BND) is Biopharmaceutical Classification System Class-II drug having low solubility and high permeability, antihypertensive drug has lower bioavailability. The purpose of the present study was to improve solubility as well dissolution profile of Benidipine HCL. BND nanosuspension was formulated using precipitation technique. Various polymers were evaluated  viz. HPMC E15, Tween 20, PVP K30 in preliminary trial to stabilized nanosuspension but PVP K30 was selected among them. The solubility of BND was carried out using different solvents like Ethanol, Acetonitrile; Acetone. Ethanol was used as a preferred solvent as BND shows high solubility in it.  The effect of different important process parameters e.g. selection of polymer concentration X1(10 mg), solvent concentration X2 (0.2 ml) were investigated by Central Composite factorial design to accomplish desired particle size and rate of dissolution. Stirring speed and time of stirring was kept constant as 1000 rpm and 2h respectively. To achieve optimized batch, 9 formulations (F1-F9) were prepared.  The optimized batch had 237 nm particle size Y1, and showed in-vitro dissolution Y2 98±0.72 % in 30 mins related to pure BND (58±0.25%) and zeta potential was -15.3. None of interaction between drug and polymer was confirmed by Differential scanning calorimetry (DSC) and FT-IR analysis. The obtained results showed that issues related particle size (nm) and rate of dissolution of BND has been solved when nanosuspension can be prepared by precipitation method by considering optimized parameter due to formation of nanosized particles

Synthesis and characterization of TiO2 nanocrystalline powder prepared by homogeneous precipitation using urea

2003 ◽  
Vol 18 (3) ◽  
pp. 571-577 ◽  
Author(s):  
Dong Seok Seo ◽  
Hwan Kim ◽  
Hang Chul Jung ◽  
Jong Kook Lee
Keyword(s):  
Particle Size ◽  
Particle Shape ◽  
Elevated Temperatures ◽  
Treatment Temperature ◽  
Precipitation Method ◽  
Nanocrystalline Powder ◽  
Homogeneous Precipitation ◽  
Homogeneous Precipitation Method ◽  
Good Crystallinity

TiO2 nanocrystalline powder was synthesized by homogeneous precipitation method using urea, and its characteristics were investigated through comparison with the powder prepared by conventional precipitation using ammonia. The homogeneously precipitated powder was anatase-type TiO2 with a particle size of 4–5 nm and a uniform spherical particle shape. The fact that the transformation from anatase to rutile was prohibited at elevated temperatures in the homogeneously precipitated powder can be useful to prepare anatase-type TiO2 thin films by calcination at high temperatures. With increasing heat-treatment temperature, the particle size of the homogeneously precipitated powder was smaller than that of the conventionally precipitated powder, and the particle shape was more uniform. The homogeneously precipitated powder showed good photocatalytic activity for Ag ion photoadsorption because the powder had both good crystallinity and a large specific surface area of 280 m2/g.

Synthesis of Calcium Metaphosphates Fine Powders by Chemical Precipitation Methods

2010 ◽  
Vol 105-106 ◽  
pp. 532-535 ◽  
Author(s):  
Yin Zhang ◽  
De Shuang Kong ◽  
Ya Qiu Tao ◽  
Jian Ping Zhu ◽  
Neng Jian Yao
Keyword(s):  
Particle Size ◽  
Chemical Precipitation ◽  
Precipitation Method ◽  
Fine Powders ◽  
Heat Treated ◽  
Particle Size Analyzer ◽  
Powder Characteristics ◽  
Ft Ir ◽  
Phosphorus Precursor ◽  
Hydrolysis Of

Calcium metaphosphate (CMP) fine powders were produced by a chemical precipitation method. In order to produce the powders, CMP was prepared by the mixing of two precursors, such as calcium oxide (CaO) and phosphate acid (H3PO4). Sparingly soluble chemicals, the Ca/P ratio of the mixture was set to be 0.50 to produce stoichiometric CMP, were chemical agitated in phosphate acid solution. At least 3 hours of pre-hydrolysis of phosphorus precursor were required to obtain CMP phase. The CMP powders were dried in a drying oven at 60°C for 72 hours and then heat-treated at various temperatures at a ramp of 1°C /min in air for various hours. The obtained powder was analyzed using XRD, XRF, FT-IR, SEM, TG-DTA, Zeta Potential Meter, Specific Surface Area, and Particle Size Analyzer. The results showed that obtained CMP powders have a significantly powder characteristics.

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