Heuristic theory in corpus compilation

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
John Patkin

AbstractBuilding the Asian Corpus of English (ACE, 2014) involved complex interactions between researchers, participants, transcription conventions, software and hardware. The gathering and transcribing of naturally occurring conversations of English among Asian multilinguals was undertaken by a team of more than twenty researchers in nine locations across Asia. Modelled on the Vienna Oxford Corpus of English (VOICE), ACE faced unique challenges due to linguistic, cultural and geographical differences. These problems were solved through procedures and tools known as heuristics which were built on prior experience and also trial and error. The process of developing and categorising these skills are presented with experiences shared by ACE researchers and the author along with examples from the corpus.

eLife ◽  
2013 ◽  
Vol 2 ◽  
Author(s):  
Xing Zhang ◽  
Huatao Guo ◽  
Lei Jin ◽  
Elizabeth Czornyj ◽  
Asher Hodes ◽  
...  

Bacteriophage BPP-1 infects and kills Bordetella species that cause whooping cough. Its diversity-generating retroelement (DGR) provides a naturally occurring phage-display system, but engineering efforts are hampered without atomic structures. Here, we report a cryo electron microscopy structure of the BPP-1 head at 3.5 Å resolution. Our atomic model shows two of the three protein folds representing major viral lineages: jellyroll for its cement protein (CP) and HK97-like (‘Johnson’) for its major capsid protein (MCP). Strikingly, the fold topology of MCP is permuted non-circularly from the Johnson fold topology previously seen in viral and cellular proteins. We illustrate that the new topology is likely the only feasible alternative of the old topology. β-sheet augmentation and electrostatic interactions contribute to the formation of non-covalent chainmail in BPP-1, unlike covalent inter-protein linkages of the HK97 chainmail. Despite these complex interactions, the termini of both CP and MCP are ideally positioned for DGR-based phage-display engineering.


1996 ◽  
Vol 07 (01) ◽  
pp. 101-108 ◽  
Author(s):  
ICHIRO OBANA ◽  
YASUHIRO FUKUI

One role of chaotic neural activity is illustrated by means of computer simulations of an imaginary agent’s goal-oriented behavior. The agent has a simplified neural network with seven neurons and three legs. The neural network consists of one photosensory neuron and three pairs of inter- and motor neurons. The three legs whose movements are governed by the three motor neurons allow the agent to walk in six concentric radial directions on a plane. It is intended that the neural network causes the agent to walk in a direction of greater brightness, to reach finally the most brightly lit place on the plane. The presence of only one sensory neuron has an important meaning. That is, no immediate information on directions of greater brightness is sensed by the agent. In other words, random walking in the manner of trial-and-error problem solving must be involved in the agent’s walking. Chaotic firing of the motor neurons is intended to play a crucial role in generating the random walking. Brief random walking and rapid straight walking in a direction of greater brightness were observed to occur alternately in the computer simulation. Controlled chaos in naturally occurring neural networks may play a similar role.


1982 ◽  
Vol 54 (3_suppl) ◽  
pp. 1123-1134 ◽  
Author(s):  
James M. Driscoll

This research examined whether persons high or low in naturally occurring aggression differ in attributions made to others engaged in an aggressive interaction. All participants were shown a videotaped aggressive exchange after which they completed a standard person-perception questionnaire and a self-report used to separate them into groups of persons high and low in aggression. The salience of the more aggressive stimulus person was manipulated as a means of relating results to existing findings and theory in person perception. Five of the seven dependent measures show effects of level of aggression consistent with prediction of more negative perceptions by persons high in aggression than by persons low in aggression. Level of aggression often interacts with salience and stimulus person, and some of these complex interactions are not easily interpretable. However, persons high in aggression perceive greater injury, negative reactions, and domineering in such situations and make greater causal distinction among stimulus persons.


Author(s):  
Jonathan M. Rhodes

The health benefits of fruit, vegetables and dietary fibre have been promoted for many years. Much of the supporting evidence is circumstantial or even contradictory and mechanisms underlying health benefits of specific foods are poorly understood. Colorectal cancer shows marked geographical differences in incidence, probably linked with diet, and explanations for this require knowledge of the complex interactions between diet, microbiota and the gut epithelium. Dietary fibres can act as prebiotics, encouraging growth of saccharolytic bacteria, but other mechanisms are also important. Some but not all soluble fibres have a ‘contrabiotic’ effect inhibiting bacterial adherence to the epithelium. This is particularly a property of pectins (galacturonans) whereas dietary fructans, previously regarded as beneficial prebiotics, can have a proinflammatory effect mediated via toxic effects of high butyrate concentrations. This also suggests that ulcerative colitis could in part result from potentially toxic faecal butyrate concentrations in the presence of a damaged mucus layer. Epithelial adherence of lectins, either dietary lectins as found in legumes, or bacterial lectins such as the galactose-binding lectin expressed by colon cancer-associated Fusobacterium nucleatum, may also be important and could be inhibitable by specific dietary glycans. Conversely, emulsifiers in processed foods may increase bacterial translocation and alter the microbiota thus promoting inflammation or cancer. Focusing on one condition is of limited value although in developing public health messages and growing evidence for impacts of dietary components on all-cause mortality is gaining more attention. We are only just starting to understand the complex interactions between food, the microbiota and health.


2021 ◽  
Vol 9 (19) ◽  
pp. 109-117
Author(s):  
Omar Nieva García ◽  
Patricia Luna González ◽  
Jesús Arellano Pimentel

The use of 360 virtual tours has become a technology that allows viewing from different angles, places, or spaces that, due to various circumstances, it is not possible to visit physically. Due to different restrictions existing today; of a physical, economic or health type, virtual visits to museums, archaeological sites, parks, and facilities of various kinds have become an alternative to disseminate, promote, or bring users closer to places, that through 360 panoramic images, make them feel immersed in them. Currently, creating a 360 virtual tour is available to more people, as the software and hardware tools used are increasingly accessible. However, deciding on the most appropriate software platform to publish virtual tours on the web can be a trial-and-error process, delaying obtaining these virtual products.


Author(s):  
A. W. Fetter ◽  
C. C. Capen

Atrophic rhinitis in swine is a disease of uncertain etiology in which infectious agents, hereditary predisposition, and metabolic disturbances have been reported to be of primary etiologic importance. It shares many similarities, both clinically and pathologically, with ozena in man. The disease is characterized by deformity and reduction in volume of the nasal turbinates. The fundamental cause for the localized lesion of bone in the nasal turbinates has not been established. Reduced osteogenesis, increased resorption related to inflammation of the nasal mucous membrane, and excessive resorption due to osteocytic osteolysis stimulated by hyperparathyroidism have been suggested as possible pathogenetic mechanisms.The objectives of this investigation were to evaluate ultrastructurally bone cells in the nasal turbinates of pigs with experimentally induced atrophic rhinitis, and to compare these findings to those in control pigs of the same age and pigs with the naturally occurring disease, in order to define the fundamental lesion responsible for the progressive reduction in volume of the osseous core.


Author(s):  
W. W. Barker ◽  
W. E. Rigsby ◽  
V. J. Hurst ◽  
W. J. Humphreys

Experimental clay mineral-organic molecule complexes long have been known and some of them have been extensively studied by X-ray diffraction methods. The organic molecules are adsorbed onto the surfaces of the clay minerals, or intercalated between the silicate layers. Natural organo-clays also are widely recognized but generally have not been well characterized. Widely used techniques for clay mineral identification involve treatment of the sample with H2 O2 or other oxidant to destroy any associated organics. This generally simplifies and intensifies the XRD pattern of the clay residue, but helps little with the characterization of the original organoclay. Adequate techniques for the direct observation of synthetic and naturally occurring organoclays are yet to be developed.


Author(s):  
G. M. Hutchins ◽  
J. S. Gardner

Cytokinins are plant hormones that play a large and incompletely understood role in the life-cycle of plants. The goal of this study was to determine what roles cytokinins play in the morphological development of wheat. To achieve any real success in altering the development and growth of wheat, the cytokinins must be applied directly to the apical meristem, or spike of the plant. It is in this region that the plant cells are actively undergoing mitosis. Kinetin and Zeatin were the two cytokinins chosen for this experiment. Kinetin is an artificial hormone that was originally extracted from old or heated DNA. Kinetin is easily made from the reaction of adenine and furfuryl alcohol. Zeatin is a naturally occurring hormone found in corn, wheat, and many other plants.Chinese Spring Wheat (Triticum aestivum L.) was used for this experiment. Prior to planting, the seeds were germinated in a moist environment for 72 hours.


Author(s):  
J. M. Paque ◽  
R. Browning ◽  
P. L. King ◽  
P. Pianetta

Geological samples typically contain many minerals (phases) with multiple element compositions. A complete analytical description should give the number of phases present, the volume occupied by each phase in the bulk sample, the average and range of composition of each phase, and the bulk composition of the sample. A practical approach to providing such a complete description is from quantitative analysis of multi-elemental x-ray images.With the advances in recent years in the speed and storage capabilities of laboratory computers, large quantities of data can be efficiently manipulated. Commercial software and hardware presently available allow simultaneous collection of multiple x-ray images from a sample (up to 16 for the Kevex Delta system). Thus, high resolution x-ray images of the majority of the detectable elements in a sample can be collected. The use of statistical techniques, including principal component analysis (PCA), can provide insight into mineral phase composition and the distribution of minerals within a sample.


Author(s):  
Jean Fincher

An important trend in the food industry today is reduction in the amount of fat in manufactured foods. Often fat reduction is accomplished by replacing part of the natural fat with carbohydrates which serve to bind water and increase viscosity. It is in understanding the roles of these two major components of food, fats and carbohydrates, that freeze-fracture is so important. It is well known that conventional fixation procedures are inadequate for many food products, in particular, foods with carbohydrates as a predominant structural feature. For some food science applications the advantages of freeze-fracture preparation procedures include not only the avoidance of chemical fixatives, but also the opportunity to control the temperature of the sample just prior to rapid freezing.In conventional foods freeze-fracture has been used most successfully in analysis of milk and milk products. Milk gels depend on interactions between lipid droplets and proteins. Whipped emulsions, either whipped cream or ice cream, involve complex interactions between lipid, protein, air cell surfaces, and added emulsifiers.


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