68Ga CdTe/CdS fluorescent quantum dots for detection of tumors: investigation on the effect of nanoparticle size on stability and in vivo pharmacokinetics

2020 ◽  
Vol 108 (7) ◽  
pp. 565-572 ◽  
Author(s):  
Yousef Fazaeli ◽  
Hakimeh Zare ◽  
Shokufeh Karimi ◽  
Shahzad Feizi
Keyword(s):  
Quantum Dots ◽  
Cadmium Telluride ◽  
Biomedical Applications ◽  
High Energy ◽  
Sprague Dawley ◽  
Liver Uptake ◽  
Cdte Qds ◽  
Cds Qds ◽  
Cdte Core

AbstractBackgroundQuantum dots (QDs)-based theranostics offer exciting new approaches to diagnose and therapy of cancer. To take advantage of the unique properties of these fluorescent QDs for different biomedical applications, their structures, size and/or surface chemistry need to be optimized, allowing their stability and functionalities to be tailored for different biomedical applications.MethodologyCadmium telluride/Cadmium sulfide QDs (CdTe/CdS QDs) were synthesized and their structure, size, photostability and functionalities as a bioprobe for detection of Fibrosarcoma tumors were studied and compared with Cadmium telluride (CdTe) QDs. Hence, CdTe/CdS QDs were labeled with 68Ga radionuclide for fast in vivo biological nuclear imaging. Using gamma paper chromatography (γ-PC), the physicochemical properties of the prepared labeled QDs were assessed. In vivo biodistribution and positron emission tomography (PET) imaging of the 68Ga@ CdTe/CdS QDs nanocrystals were investigated in Sprague Dawley® rats bearing Fibrosarcoma tumor.ResultsCdS shell on the surface of CdTe core increases the size and photostability against high energy radiations; therefore, CdTe/CdS QDs show prolonged fluorescence as compared to CdTe QDs.ConclusionExcellent accumulation in tumor was observed for core/shell quantum dots, but this study showed that small changes in the size of the QDs (+1 nm), after adding the CdS shell around CdTe core, greatly change their biodistribution (especially the liver uptake).

scholarly journals Liver Toxicity of Cadmium Telluride Quantum Dots (CdTe QDs) Due to Oxidative Stress in Vitro and in Vivo

2015 ◽  
Vol 16 (10) ◽  
pp. 23279-23299 ◽  
Author(s):  
Ting Zhang ◽  
Yuanyuan Hu ◽  
Meng Tang ◽  
Lu Kong ◽  
Jiali Ying ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Quantum Dots ◽  
Cadmium Telluride ◽  
Liver Toxicity ◽  
Cdte Qds ◽  
Cadmium Telluride Quantum Dots

scholarly journals Gene Expression and Transcriptome Profiling of Changes in a Cancer Cell Line Post-Exposure to Cadmium Telluride Quantum Dots: Possible Implications in Oncogenesis

Dose-Response ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 155932582110198
Author(s):  
Mohammed S. Aldughaim ◽  
Mashael R. Al-Anazi ◽  
Marie Fe F. Bohol ◽  
Dilek Colak ◽  
Hani Alothaid ◽  
...  
Keyword(s):  
Gene Expression ◽  
Quantum Dots ◽  
Cancer Cells ◽  
Cadmium Telluride ◽  
Cancer Progression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Dependent Manner ◽  
Cdte Qds ◽  
Cadmium Telluride Quantum Dots

Cadmium telluride quantum dots (CdTe-QDs) are acquiring great interest in terms of their applications in biomedical sciences. Despite earlier sporadic studies on possible oncogenic roles and anticancer properties of CdTe-QDs, there is limited information regarding the oncogenic potential of CdTe-QDs in cancer progression. Here, we investigated the oncogenic effects of CdTe-QDs on the gene expression profiles of Chang cancer cells. Chang cancer cells were treated with 2 different doses of CdTe-QDs (10 and 25 μg/ml) at different time intervals (6, 12, and 24 h). Functional annotations helped identify the gene expression profile in terms of its biological process, canonical pathways, and gene interaction networks activated. It was found that the gene expression profiles varied in a time and dose-dependent manner. Validation of transcriptional changes of several genes through quantitative PCR showed that several genes upregulated by CdTe-QD exposure were somewhat linked with oncogenesis. CdTe-QD-triggered functional pathways that appear to associate with gene expression, cell proliferation, migration, adhesion, cell-cycle progression, signal transduction, and metabolism. Overall, CdTe-QD exposure led to changes in the gene expression profiles of the Chang cancer cells, highlighting that this nanoparticle can further drive oncogenesis and cancer progression, a finding that indicates the merit of immediate in vivo investigation.

Heparin sodium-selective ‘on–off’ and lysine-selective ‘off–on’ fluorescence switching of cadmium telluride quantum dots and their analytical applications

2016 ◽  
Vol 8 (2) ◽  
pp. 453-459 ◽  
Author(s):  
Hong Zhi Zhang ◽  
Rong Sheng Li ◽  
Ni Wang ◽  
Li Qi ◽  
Cheng Zhi Huang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Hydrogen Bonding ◽  
Fluorescence Quenching ◽  
Cadmium Telluride ◽  
Electrostatic Interaction ◽  
Heparin Sodium ◽  
Strong Electrostatic Interaction ◽  
Cdte Qds ◽  
Fluorescence Switching ◽  
Cadmium Telluride Quantum Dots

The fluorescence quenching of CdTe QDs could be induced by heparin sodium via hydrogen bonding, which was then recovered by lysine through a strong electrostatic interaction.

scholarly journals Core-shell Semiconductor Nanocrystals: Effect of Composition, Size, Surface Coatings on their Optical Properties, Toxicity and Pharmacokinetics

2017 ◽  
Vol 23 (3) ◽  
pp. 340-349 ◽  
Author(s):  
Wafa' T. Al-Jamal
Keyword(s):  
Quantum Dots ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Biomedical Applications ◽  
Semiconductor Nanocrystals ◽  
Organic Dye ◽  
Surface Coatings ◽  
Core Shell ◽  
Biomedical Field

Quantum dots are semiconducting nanocrystals that exhibit extraordinary optical properties. QD have shown higher photostability compared to standard organic dye type probes. Therefore, they have been heavily explored in the biomedical field. This review will discuss the different approaches to synthesis, solubilise and functionalise QD. Their main biomedical applications in imaging and photodynamic therapy will be highlighted. Finally, QD biodistribution profile and in vivo toxicity will be discussed.

Poly(4-vinylpyridine) Coated CdTe Core/Shell Quantum Dots

2009 ◽  
Vol 60-61 ◽  
pp. 114-118 ◽  
Author(s):  
Zhao Dai ◽  
Ping Li ◽  
Ji Mei Zhang ◽  
Shi Chao Xu ◽  
Ning Guo ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Freeze Drying ◽  
Core Shell ◽  
Solution System ◽  
Dna Biosensors ◽  
Potassium Persulphate ◽  
Fluorescent Intensity ◽  
Reflux Time ◽  
Cdte Qds ◽  
Cdte Core

A kind of novel quantum dots (QDs) with poly(4-vinylpyridine) (PVPy) as shell and CdTe QDs as core was presented in this work. This core/shell ODs can conjugate DNA easily because the surface pyridyl exist on QDs, and which has potential application in DNA biosensors field. CdTe QDs were prepared in aqueous solution with 3-mercaptopropionic acid (MPA) as stabilizer. It was found that the fluorescent intensity of QDs was depended the reflux time. Following the increase of reflux time, the fluorescent intensity of QDs reached the maximum at 10 h with about 10 nm in diameters. And the fluorescent intensity of QDs was also increased. When the reflux time was 10 h, the diameter of QDs would increase to about 10 nm. After adjusted the pH of QDs solution system to 7.0, the MPA stabled QDs were purified by ultracentrifugation and freeze-drying respectively. The polymerization was performed in water when 4-vinylpyridine (VPy) used as monomer, N,N’-methylene-bisacrylamide (MBAAm) as crosslinker, potassium persulphate (PPS) as initiator and MPA stabled QDs as seeds. The surface carboxyl of MPA on QDs could promote the form of PVPy coated CdTe QDs. It was shown that the fluorescent intension of core/shell QDs was decreased following the polymerization and the diameter of QDs could increase to 20-30 nm.

Initiation and perpetuation of obesity and obesity resistance in rats

1989 ◽  
Vol 256 (3) ◽  
pp. R766-R771 ◽  
Author(s):  
B. E. Levin ◽  
S. Hogan ◽  
A. C. Sullivan
Keyword(s):  
High Energy ◽  
The Body ◽  
Sprague Dawley ◽  
Fat Pad ◽  
Intravenous Glucose ◽  
Insulin Resistant ◽  
Diet Induced Obesity ◽  
Sprague Dawley Rats ◽  
Fat Pads

A search was made for predisposing factors and sequelae of diet-induced obesity (DIO) or resistance to DIO (DR). During 3 mo on a high-energy (CM) diet, two-thirds of the male Sprague-Dawley rats ate 16% more calories over the first 30 days and developed DIO. The remaining one-third were DR, gaining the same amount of weight as chow-fed controls. Basal and norepinephrine (NE)-stimulated in vivo O2 consumption, performed before rats were placed on the CM diet, was the same in those rats that later became DR or DIO after 3 mo on the CM diet. DR rats were 4% lighter, whereas DIO rats were equal to chow-fed rats before their exposure to the CM diet. When CM-fed rats were switched to chow, DIO rats took 14 wk to reduce their body and retroperitoneal fat pad weights to those of chow-fed controls, whereas DR rats gained only 40% of the body weight, and fat pads were 34% lighter than controls. After 14 wk, DIO rats were neither hyperinsulinemic nor insulin resistant, whereas DR rats had 64% reduced areas under their insulin curves after intravenous glucose (1 g/kg) compared with controls. Unlike younger rats, animals here had inconsistent plasma NE responses to intravenous glucose. Therefore the CM diet produces DR and DIO states that tend to become self-perpetuating once established.

Antibacterial potential of rutin conjugated with thioglycolic acid capped cadmium telluride quantum dots (TGA-CdTe QDs)

2015 ◽  
Vol 138 ◽  
pp. 684-692 ◽  
Author(s):  
Devanesan Arul Ananth ◽  
Angappan Rameshkumar ◽  
Ramachandran Jeyadevi ◽  
Sivanadanam Jagadeeswari ◽  
Natarajan Nagarajan ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cadmium Telluride ◽  
Thioglycolic Acid ◽  
Cdte Qds ◽  
Cadmium Telluride Quantum Dots ◽  
Antibacterial Potential

Luminescent CdTe quantum dots incarcerated in a columnar matrix of discotic liquid crystals for optoelectronic applications

RSC Advances ◽  
2015 ◽  
Vol 5 (2) ◽  
pp. 1262-1267 ◽  
Author(s):  
Manish Kumar ◽  
Sandeep Kumar
Keyword(s):  
Quantum Dots ◽  
Thermal Properties ◽  
Liquid Crystal ◽  
Liquid Crystals ◽  
Cadmium Telluride ◽  
Cdte Quantum Dots ◽  
Discotic Liquid Crystals ◽  
Discotic Liquid Crystal ◽  
Cdte Qds ◽  
Cadmium Telluride Quantum Dots

The effects of highly luminescent alkylamine-capped semiconductor cadmium telluride quantum dots (CdTe QDs) dispersion on the optical, electrical, thermal properties and supramolecular order of a discotic liquid crystal were studied.

Pharmacokinetics of bio-shell-silver-core nanoparticles (AgNP) in Sprague-Dawley Rats – In vivo study

2021 ◽  
Vol 09 ◽  
Author(s):  
Asra Parveen ◽  
Vijay kumar B. Malashetty ◽  
Sushruta Marla ◽  
Shanth Reddy ◽  
Sidramappa Sirsand ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Body Weight ◽  
Biomedical Applications ◽  
Female Rats ◽  
Control Group ◽  
Sprague Dawley ◽  
Potential Toxicity ◽  
Target Organs ◽  
Sprague Dawley Rats

Background: Silver nanoparticles have been widely used in the field of nanomedicine. A comprehensive understanding of their pharmacokinetics is crucial for proper risk assessment and safe biomedical applications. Objectives: The purpose of this study was to investigate the safety of silver nanoparticles by determining its potential toxicity following 28 days administration in Sprague Dawley rats. Method: The silver nanoparticles were administered by intravenous injection at the doses of 100, 200 and 500 µg/kg body weight for 28 consecutive days. Animals in the control group were received sterile water for injection. Each group consists of 10 male and 10 female rats. Results: No treatment related effects were seen in any of the parameters monitored in rats given 100, 200 and 500 µg/kg body weight/day of silver nanoparticles. Conclusion: The study proved that the use of up to 500 µg/kg body weight biosynthesized silver nanoparticles have no toxic effect in the target organs and found safe. However, the safety of the nanoparticles might be attributed to the covering of biological moieties on nanoparticles. Hence, the biofunctionalized nanoparticles can be safely used by selecting the required size and dose in medicines and drug delivery systems.

Sign in / Sign up

Export Citation Format

Share Document