Criterion validity and discriminatory ability of the central sensitization inventory short form in individuals with inflammatory bowel diseases

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Carrie Falling ◽  
Simon Stebbings ◽  
G. David Baxter ◽  
Richard B. Gearry ◽  
Ramakrishnan Mani
Keyword(s):  
Central Sensitization ◽  
Online Survey ◽  
Short Form ◽  
Characteristic Curve ◽  
Intraclass Correlation ◽  
Criterion Validity ◽  
Discriminative Ability ◽  
Cross Sectional ◽  
Inflammatory Bowel ◽  
Central Sensitization Inventory

Abstract Objectives Increased symptoms related to central sensitization have previously been reported in inflammatory bowel disease (IBD) patients, identified by the original central sensitization inventory (CSI-25). However, the recently developed CSI short form (CSI-9) may be more clinically useful. The aim of the present study was to evaluate the performance of CSI-9 compared to the original CSI-25 in individuals with IBD. Study objectives were to investigate the criterion validity of the CSI-9 to the CSI-25, assess individual association of the CSI measures with clinical features of IBD and pain presentations, and to establish disease-specific CSI-9 and CSI-25 cut-off scores for discriminating the presence of self-reported pain in individuals with IBD. Methods Cross-sectional online survey was performed on adults with IBD exploring self-reported demographics, comorbidity, and clinical IBD and pain features. Criterion validity of the CSI-9 was investigated using intraclass correlation coefficient (ICC)3,1. Area under the receiver operating characteristic curve (AUC-ROC) analysis was conducted to investigate the discriminative ability of both versions of CSI. Results Of the 320 participants, 260 reported the presence of abdominal and/or musculoskeletal pain. CSI-9 and CSI-25 demonstrated substantial agreement (ICC3,1=0.64, 95% CI [0.58, 0.69]). AUC (95% CI) indicated that CSI-9 (0.788 (0.725, 0.851), p<0.001) and CSI-25 (0.808 (0.750, 0.867), p<0.001) were able to adequately discriminate the presence of pain using cut-offs scores of ≥17 (CSI-9) and ≥40 (CSI-25). Abdominal pain severity was the only feature to differ in significant association to CSI-25 (p=0.002) compared to CSI-9 (p=0.236). All other features demonstrated significant associations to both CSI versions, except age (p=0.291 and 0.643) and IBD subtype (p=0.115 and 0.675). Conclusions This is the first study to explore and validate the use of CSI-9 in IBD patients. Results demonstrated concurrent validity of the CSI-9 to CSI-25, with similar significant association to multiple patient features, and a suggested cut-off value of 17 on CSI-9 to screen for individuals with pain experiences. Study findings suggest that CSI-9 is suitable to use as a brief tool in IBD patients.

scholarly journals Assessment of Central Sensitization in Breast Cancer Survivors: Convergent Validity and Use of the Central Sensitization Inventory (CSI) and Its Short-Form as a Clustering Tool

2021 ◽  
Vol 11 (3) ◽  
pp. 607-618
Author(s):  
Alban Hurth ◽  
Jessica Nijzink-Ter Steege ◽  
Pauline Scheepbouwer ◽  
Eva Roose ◽  
Astrid Lahousse ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Internal Consistency ◽  
Central Sensitization ◽  
Convergent Validity ◽  
Breast Cancer Survivors ◽  
Short Form ◽  
Measurement Properties ◽  
Cross Sectional ◽  
Central Sensitization Inventory

The Central Sensitization Inventory (CSI) measurement properties in patients having nonspecific, noncancer pain are well-established. However, studies examining the reliability and validity of either the CSI or the Central Sensitization Inventory short-form version (CSI-9) in breast cancer survivors (BCS) are scarce. The purpose was to evaluate convergent validity and internal consistency of the CSI and CSI-9. Additionally, the relevance of a new cluster calculator using the CSI was explored. The cross-sectional multi-center study included 65 BCS and 37 healthy volunteers. Patients filled out multiple questionnaires assessing pain, number of painful areas, anxiety, depression and quality of life. The relevance of a cluster calculator was explored by known-group comparisons and boxplot description. All hypotheses were formulated before data analysis. The majority of hypotheses on the correlations between the CSI or CSI-9 and other health outcomes were confirmed (22 out of 27). The CSI and CSI-9 have excellent (α = 0.92) and good (α = 0.86) internal consistency, respectively. The CSI cluster calculator might be an interesting tool to use to have a patient’s overall condition snapshot. Generally, the study findings support the construct validity and internal consistency of the CSI, which underline the use of this self-reported instrument in BCS. The CSI-9 shows promising results, but should be further evaluated.

scholarly journals Mental Health, Sense of Coherence, and Interpersonal Violence during the COVID-19 Pandemic Lockdown in Germany

2020 ◽  
Vol 9 (11) ◽  
pp. 3708
Author(s):  
Stefanie Jung ◽  
Jonas Kneer ◽  
Tillmann H. C. Krüger
Keyword(s):  
Mental Health ◽  
Sense Of Coherence ◽  
Interpersonal Violence ◽  
Online Survey ◽  
Short Form ◽  
Well Being ◽  
Western Country ◽  
Cross Sectional ◽  
Substantial Impact ◽  
Patient Health

Preliminary data indicates that the Coronavirus SARS-CoV-2 disease (COVID-19) pandemic may have a substantial impact on mental health and well-being. We assessed mental health in response to the lockdown in Germany between 1 April 2020 and 15 April 2020 using a cross-sectional online survey (n = 3545) with a mixed-methods approach. We found increased levels of psychosocial distress (Patient Health Questionnaire (PHQ) stress module), anxiety, depressive symptoms (PHQ-4), irritability, and a decrease in overall well-being (WHO-Five Well-Being Index (WHO-5)), sense of coherence (Short Form of the Sense of Coherence Scale (SOC-L9)), sexual contentment, and sleep quality. The four-week-prevalence of interpersonal violence was yet at 5% and included verbal, physical, and sexual violence. Participants reported finding comfort in family, friends, conversation, exercise, and activity. Findings are also in line with research showing that women seem to have more trouble coping with the pandemic and lockdown measures. Our observations demonstrate that the COVID-19 pandemic and related measures lead to a mental health burden even in a highly developed Western country and should, therefore, be taken seriously. The findings for interpersonal violence are alarming. Thus, we should sharpen our focus on the matter and activate and enhance supporting systems to help protect those affected.

scholarly journals The ability of clinical balance measures to identify falls risk in multiple sclerosis: a systematic review and meta-analysis

2017 ◽  
Vol 32 (5) ◽  
pp. 571-582 ◽  
Author(s):  
Gillian Quinn ◽  
Laura Comber ◽  
Rose Galvin ◽  
Susan Coote
Keyword(s):  
Multiple Sclerosis ◽  
Quality Assessment ◽  
Meta Analysis ◽  
Characteristic Curve ◽  
Predictive Ability ◽  
Timed Up And Go ◽  
Discriminative Ability ◽  
Cross Sectional ◽  
Falls Risk ◽  
Clinical Measures

Objective: To determine the ability of clinical measures of balance to distinguish fallers from non-fallers and to determine their predictive validity in identifying those at risk of falls. Data sources: AMED, CINAHL, Medline, Scopus, PubMed Central and Google Scholar. First search: July 2015. Final search: October 2017. Review methods: Inclusion criteria were studies of adults with a definite multiple sclerosis diagnosis, a clinical balance assessment and method of falls recording. Data were extracted independently by two reviewers. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 scale and the modified Newcastle–Ottawa Quality Assessment Scale. Statistical analysis was conducted for the cross-sectional studies using Review Manager 5. The mean difference with 95% confidence interval in balance outcomes between fallers and non-fallers was used as the mode of analysis. Results: We included 33 studies (19 cross-sectional, 5 randomised controlled trials, 9 prospective) with a total of 3901 participants, of which 1917 (49%) were classified as fallers. The balance measures most commonly reported were the Berg Balance Scale, Timed Up and Go and Falls Efficacy Scale International. Meta-analysis demonstrated fallers perform significantly worse than non-fallers on all measures analysed except the Timed Up and Go Cognitive ( p < 0.05), but discriminative ability of the measures is commonly not reported. Of those reported, the Activities-specific Balance Confidence Scale had the highest area under the receiver operating characteristic curve value (0.92), but without reporting corresponding measures of clinical utility. Conclusion: Clinical measures of balance differ significantly between fallers and non-fallers but have poor predictive ability for falls risk in people with multiple sclerosis.

scholarly journals Insufficient Physical Activity and Sedentary Behaviors among Medical Students during the COVID-19 Lockdown: Findings from a Cross-Sectional Study in Pakistan

2021 ◽  
Vol 18 (19) ◽  
pp. 10257
Author(s):  
Irfan Ullah ◽  
Md. Saiful Islam ◽  
Sajjad Ali ◽  
Hashaam Jamil ◽  
Muhammad Junaid Tahir ◽  
...  
Keyword(s):  
Physical Activity ◽  
Medical Students ◽  
Online Survey ◽  
Short Form ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Sedentary Behaviors ◽  
Cross Sectional ◽  
Insufficient Physical Activity ◽  
Policies And Programs

Background: The unprecedented COVID-19 pandemic has resulted in social distancing and isolation which leads to insufficient physical activity and thereby increases sedentary behaviors. Hence, this study aimed to assess the prevalence of insufficient physical activity and sedentary behaviors among medical students during the COVID-19 lockdown in Pakistan, and to determine their associated factors. Methods: A cross-sectional online survey was carried out among 407 medical students from the Punjab and Sindh provinces between May and June 2020. To collect data, an e-questionnaire was sent to obtain informed consent along with questions concerning socio-demographics as well as an International Physical Activity Questionnaires–Short Form (IPAQ–SF). Results: As per the IPAQ, almost five in ten participants were physically inactive (48.2%), and 45.2% reported sedentary behaviors. Participants with insufficient physical activity were more likely to report sedentary behaviors than their counterparts (AOR = 2.53; 95% CI = 1.66–3.85, p < 0.001). The odds of insufficient physical activity were higher among the participants who did not strictly follow the COVID-19 preventive measures (AOR = 2.51; 95% CI = 1.35–4.69, p = 0.004); similarly, there were increased odds of sedentary behaviors observed among participants within a normal weight range compared to those who were underweight (AOR = 2.69; 95% CI = 1.76–4.11, p < 0.001). Conclusions: Insufficient physical activity and sedentary behavior are prevalent among medical students in Pakistan during the COVID-19 pandemic. These findings indicate the importance of establishing tailored policies and programs to encourage young adults to engage in physical activity.

scholarly journals Development of the 8-Item Phlegm Pattern Questionnaire (PPQ-8) Using Rasch Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Young-Jae Park
Keyword(s):  
Rasch Analysis ◽  
Item Difficulty ◽  
Short Form ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Clinical Severity ◽  
Mean Square ◽  
Discriminative Ability ◽  
Item Functioning ◽  
Dysfunctional Breathing

The 25-item Phlegm Pattern Questionnaire (PPQ) has been widely used to examine the relationship between the phlegm pattern (PP), quality of life, tongue colour, vocal qualities, and dysfunctional breathing. However, the concerns of response burden and differences in the respondent’s abilities or item difficulty for the original version of the PPQ have not been sufficiently addressed. This study aimed to develop a short-form PPQ using Rasch analysis, an item response theory. Based on the retrospective data, the response order, differential item functioning (DIF), dimensionality, reliability, concurrent validity, and fitting errors were examined for 291 normal participants and 61 inpatients. The discriminative ability of the short-form PPQ was examined using receiver operating characteristic curve analysis. Along with Rasch analysis, another short-form PPQ was developed using equidiscriminative item-total correlation (EITC) analysis and the results between the two short-form PPQs were compared accordingly. Rasch analysis results suggested a 6-point response category for the PPQ, and finally, 8 items without fitting errors or DIF variability were selected for the PPQ (PPQ-8). The PPQ-8 had satisfactory reliability (person separation index = 2.23), unidimensionality (unexplained variance in the first contrast = 1.598), fitting levels (infit mean square, 0.80–1.39; outfit mean square, 0.79–1.34), sensitivity (70.5%), and specificity (76.5%). The PPQ-8 had a moderate discriminative ability of the PP (area under the curve = 0.759), and the cut-off point was 23. Although the 8-item PPQ developed using EITC analysis showed similar levels of reliability, validity, and discriminative ability of the PP to the PPQ-8, it could not present the information of item hierarchy and differences in the respondents’ abilities. In conclusion, the PPQ-8 by Rasch analysis is recommended for future use to evaluate the clinical severity of PP.

scholarly journals Physical Activity Levels and Related Energy Expenditure during COVID-19 Quarantine among the Sicilian Active Population: A Cross-Sectional Online Survey Study

2020 ◽  
Vol 12 (11) ◽  
pp. 4356 ◽  
Author(s):  
Valerio Giustino ◽  
Anna Maria Parroco ◽  
Antonio Gennaro ◽  
Giuseppe Musumeci ◽  
Antonio Palma ◽  
...  
Keyword(s):  
Physical Activity ◽  
Energy Expenditure ◽  
Online Survey ◽  
Short Form ◽  
The Elderly ◽  
Survey Study ◽  
Rank Test ◽  
Cross Sectional ◽  
Physically Active ◽  
Significant Difference

Background: During the coronavirus disease 2019 (COVID-19) pandemic, the Italian government has adopted containment measures to control the virus’s spread, including limitations to the practice of physical activity (PA). The aim of this study was to estimate the levels of PA, expressed as energy expenditure (MET–minute/week), among the physically active Sicilian population before and during the last seven days of the COVID-19 quarantine. Furthermore, the relation between this parameter and specific demographic and anthropometric variables was analyzed. Methods: 802 Sicilian physically active participants (mean age: 32.27 ± 12.81 years; BMI: 23.44 ± 3.33 kg/m2) were included in the study and grouped based on gender, age and BMI. An adapted version of the International Physical Activity Questionnaire—short form (IPAQ-SF) was administered to the participants through an online survey. The Wilcoxon signed-rank test and the Kruskal-Wallis rank-sum test were used for statistical analyses. Results: As expected, we observed a significant decrease of the total weekly energy expenditure during the COVID-19 quarantine (p < 0.001). A significant variation in the MET–min/wk in the before quarantine condition (p = 0.046) and in the difference between before and during quarantine (p = 0.009) was found for males and females. The male group decreased the PA level more than the female one. Moreover, a significant difference in the MET–min/wk was found among groups distributions of BMI (p < 0.001, during quarantine) and of age (p < 0.001, both before and during quarantine). In particular, the highest and the lowest levels of PA were reported by the young and the elderly, respectively, both before and during quarantine. Finally, the overweight group showed the lowest level of PA during quarantine. Conclusion: Based on our outcomes, we can determine that the current quarantine has negatively affected the practice of PA, with greater impacts among males and overweight subjects. In regards to different age groups, the young, young adults and adults were more affected than senior adults and the elderly.

scholarly journals SF-12 or SF-36 in pituitary disease? Toward concise and comprehensive patient-reported outcomes measurements

Endocrine ◽  
2020 ◽  
Vol 70 (1) ◽  
pp. 123-133 ◽  
Author(s):  
Merel van der Meulen ◽  
Amir H. Zamanipoor Najafabadi ◽  
Daniel J. Lobatto ◽  
Cornelie D. Andela ◽  
Thea P. M. Vliet Vlieland ◽  
...  
Keyword(s):  
Short Form ◽  
Outcome Measurement ◽  
Intraclass Correlation ◽  
Fair Agreement ◽  
Substantial Agreement ◽  
Cross Sectional ◽  
Pituitary Diseases ◽  
Sf 36 ◽  
Patient Reported ◽  
Mean Differences

Abstract Purpose Pituitary diseases severely affect patients’ health-related quality of life (HRQoL). The most frequently used generic HRQoL questionnaire is the Short Form-36 (SF-36). The shorter 12-item version (SF-12) can improve efficiency of patient monitoring. This study aimed to determine whether SF-12 can replace SF-36 in pituitary care. Methods In a longitudinal cohort study (August 2016 to December 2018) among 103 endoscopically operated adult pituitary tumor patients, physical and mental component scores (PCS and MCS) of SF-36 and SF-12 were measured preoperatively, and 6 weeks and 6 months postoperatively. Chronic care was assessed with a cross-sectional study (N = 431). Mean differences and agreement between SF-36 and SF-12 change in scores (preoperative vs. 6 months) were assessed with intraclass correlation coefficients (ICC) and limits of agreement, depicting 95% of individual patients. Results In the longitudinal study, mean differences between change in SF-36 and SF-12 scores were 1.4 (PCS) and 0.4 (MCS) with fair agreement for PCS (ICC = 0.546) and substantial agreement for MCS (ICC = 0.931). For 95% of individual patients, the difference between change in SF-36 and SF-12 scores varied between −14.0 and 16.9 for PCS and between −7.8 and 8.7 for MCS. Cross-sectional results showed fair agreement for PCS (ICC = 0.597) and substantial agreement for MCS (ICC = 0.943). Conclusions On a group level, SF-12 can reliably reproduce MCS in pituitary patients, although PCS is less well correlated. However, individual differences between SF-36 and SF-12 can be large. For pituitary diseases, alternative strategies are needed for concise, but comprehensive patient-reported outcome measurement.

Validation of the Tunisian version of the patient health questionnaire (PHQ-9)

2017 ◽  
Vol 41 (S1) ◽  
pp. S523-S523
Author(s):  
H. Belhadj ◽  
R. Jomli ◽  
U. Ouali ◽  
Y. Zgueb ◽  
F. Nacef
Keyword(s):  
General Population ◽  
Correlation Coefficient ◽  
Intraclass Correlation ◽  
Positive Association ◽  
Criterion Validity ◽  
Internal Reliability ◽  
Cross Sectional ◽  
Patient Health ◽  
Competing Interest ◽  
Test Retest Reliability

IntroductionThe PHQ-9 has been recommended as the best available screening and case-finding instrument for primary care based on its brevity, and ability to inform the clinicians on both depression severity and diagnostic criteria.ObjectiveOur study evaluated the reliability and the validity of the Tunisian version of the PHQ-9 in detecting major depression in general population.MethodWe undertook a cross-sectional and analytical study. A total of 134 participants, representative of the Tunisian general population, were enrolled. The PHQ-9 was validated against the HAD reference standard. The types of validity determined for the PHQ-9 in this study were: translation validity, internal reliability and criterion validity.ResultsTest-Retest reliability was determined by intraclass correlation. This scale is stable over 2 weeks (ICC = 0.97). The Tunisian version of the PHQ-9 was found to have good internal reliability (Cronbach's alpha = 0.84). As for criterion validity of the PHQ-9, the Pearson's correlation coefficient between the PHQ-9 and HAD was 0.94 and the Spearman's correlation coefficient was 0.81. This indicated a positive association of good strength between the two instruments. A cut-off score of 10 or higher on the PHQ-9 had a sensitivity of 86.2 and a specificity of 83.8. The VPP was 0.6 and the VPN was 0.9.ConclusionThe Tunisan version of the PHQ-9 has several potential advantages. It was found to be a valid and reliable casefinding instrument for detecting depression in general population.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Factors associated with fear of hypoglycaemia among the T1D Exchange Glu population in a cross-sectional online survey

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e038462
Author(s):  
Jingwen Liu ◽  
Jeoffrey Bispham ◽  
Ludi Fan ◽  
Jiat-Ling Poon ◽  
Allyson Hughes ◽  
...  
Keyword(s):  
Online Community ◽  
Online Survey ◽  
Diabetes Management ◽  
Insulin Pump ◽  
Short Form ◽  
Glycosylated Hemoglobin ◽  
Improve Patient Care ◽  
Diabetes Distress ◽  
Cross Sectional ◽  
Factors Associated

ObjectivesFear of hypoglycaemia (FoH) has been associated with suboptimal diabetes management and health outcomes. This study investigated factors associated with behavioural and emotional aspects of FoH among adults living with type 1 diabetes (T1D) mellitus.DesignCross-sectional study.SettingOnline survey hosted on T1D Exchange Glu, an online community for patients living with T1D mellitus.MeasuresThe Hypoglycaemia Fear Survey II-short form and the Hypoglycaemic Attitudes and Behaviour Scale were used to assess FoH. Multivariable regressions were performed on assessment scores.ResultsThe study included 494 participants (mean±SD age 43.9±12.2 years, duration of T1D mellitus 16.6±16.8 years, self-reported glycosylated hemoglobin (HbA1c) 6.9%±0.8% (52±9 mmol/mol)), 63% men, 89% on insulin pump, 25% experienced a severe hypoglycaemic event in the last 6 months. Multivariable regression analyses showed higher anxiety, depression severity and diabetes distress were independently associated with FoH (all p<0.01). Longer diabetes duration was associated with lower FoH (p<0.01). Past experience with severe hypoglycaemia was associated with higher worry of hypoglycaemia (p<0.01) but not avoidance behaviour (ns).ConclusionsThese results highlighted the multifaceted nature of FoH, which warrants further discussion between providers and patients to uncover drivers of and actions required to reduce FoH and improve patient care and outcomes.

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