scholarly journals Grappling with the Future Use of Big Data for Translational Medicine and Clinical Care

2017 ◽  
Vol 26 (01) ◽  
pp. 96-102 ◽  
Author(s):  
S. Murphy ◽  
V. Castro ◽  
K. Mandl

Summary Objectives: Although patients may have a wealth of imaging, genomic, monitoring, and personal device data, it has yet to be fully integrated into clinical care. Methods: We identify three reasons for the lack of integration. The first is that “Big Data” is poorly managed by most Electronic Medical Record Systems (EMRS). The data is mostly available on “cloud-native” platforms that are outside the scope of most EMRs, and even checking if such data is available on a patient often must be done outside the EMRS. The second reason is that extracting features from the Big Data that are relevant to healthcare often requires complex machine learning algorithms, such as determining if a genomic variant is protein-altering. The third reason is that applications that present Big Data need to be modified constantly to reflect the current state of knowledge, such as instructing when to order a new set of genomic tests. In some cases, applications need to be updated nightly. Results: A new architecture for EMRS is evolving which could unite Big Data, machine learning, and clinical care through a microservice-based architecture which can host applications focused on quite specific aspects of clinical care, such as managing cancer immunotherapy. Conclusion: Informatics innovation, medical research, and clinical care go hand in hand as we look to infuse science-based practice into healthcare. Innovative methods will lead to a new ecosystem of applications (Apps) interacting with healthcare providers to fulfill a promise that is still to be determined.

2017 ◽  
Vol 26 (01) ◽  
pp. 96-102
Author(s):  
S. Murphy ◽  
V. Castro ◽  
K. Mandl

Summary Objectives: Although patients may have a wealth of imaging, genomic, monitoring, and personal device data, it has yet to be fully integrated into clinical care. Methods: We identify three reasons for the lack of integration. The first is that “Big Data” is poorly managed by most Electronic Medical Record Systems (EMRS). The data is mostly available on “cloud-native” platforms that are outside the scope of most EMRs, and even checking if such data is available on a patient often must be done outside the EMRS. The second reason is that extracting features from the Big Data that are relevant to healthcare often requires complex machine learning algorithms, such as determining if a genomic variant is protein-altering. The third reason is that applications that present Big Data need to be modified constantly to reflect the current state of knowledge, such as instructing when to order a new set of genomic tests. In some cases, applications need to be updated nightly. Results: A new architecture for EMRS is evolving which could unite Big Data, machine learning, and clinical care through a microservice-based architecture which can host applications focused on quite specific aspects of clinical care, such as managing cancer immunotherapy. Conclusion: Informatics innovation, medical research, and clinical care go hand in hand as we look to infuse science-based practice into healthcare. Innovative methods will lead to a new ecosystem of applications (Apps) interacting with healthcare providers to fulfill a promise that is still to be determined.


Author(s):  
Xabier Rodríguez-Martínez ◽  
Enrique Pascual-San-José ◽  
Mariano Campoy-Quiles

This review article presents the state-of-the-art in high-throughput computational and experimental screening routines with application in organic solar cells, including materials discovery, device optimization and machine-learning algorithms.


2017 ◽  
Vol 47 (10) ◽  
pp. 2625-2626 ◽  
Author(s):  
Fuchun Sun ◽  
Guang-Bin Huang ◽  
Q. M. Jonathan Wu ◽  
Shiji Song ◽  
Donald C. Wunsch II

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Yao Huimin

With the development of cloud computing and distributed cluster technology, the concept of big data has been expanded and extended in terms of capacity and value, and machine learning technology has also received unprecedented attention in recent years. Traditional machine learning algorithms cannot solve the problem of effective parallelization, so a parallelization support vector machine based on Spark big data platform is proposed. Firstly, the big data platform is designed with Lambda architecture, which is divided into three layers: Batch Layer, Serving Layer, and Speed Layer. Secondly, in order to improve the training efficiency of support vector machines on large-scale data, when merging two support vector machines, the “special points” other than support vectors are considered, that is, the points where the nonsupport vectors in one subset violate the training results of the other subset, and a cross-validation merging algorithm is proposed. Then, a parallelized support vector machine based on cross-validation is proposed, and the parallelization process of the support vector machine is realized on the Spark platform. Finally, experiments on different datasets verify the effectiveness and stability of the proposed method. Experimental results show that the proposed parallelized support vector machine has outstanding performance in speed-up ratio, training time, and prediction accuracy.


Author(s):  
C.S.R. Prabhu ◽  
Aneesh Sreevallabh Chivukula ◽  
Aditya Mogadala ◽  
Rohit Ghosh ◽  
L.M. Jenila Livingston

Author(s):  
Suriya Murugan ◽  
Sumithra M. G.

Cognitive radio has emerged as a promising candidate solution to improve spectrum utilization in next generation wireless networks. Spectrum sensing is one of the main challenges encountered by cognitive radio and the application of big data is a powerful way to solve various problems. However, for the increasingly tense spectrum resources, the prediction of cognitive radio based on big data is an inevitable trend. The signal data from various sources is analyzed using the big data cognitive radio framework and efficient data analytics can be performed using different types of machine learning techniques. This chapter analyses the process of spectrum sensing in cognitive radio, the challenges to process spectrum data and need for dynamic machine learning algorithms in decision making process.


Author(s):  
Fernando Enrique Lopez Martinez ◽  
Edward Rolando Núñez-Valdez

IoT, big data, and artificial intelligence are currently three of the most relevant and trending pieces for innovation and predictive analysis in healthcare. Many healthcare organizations are already working on developing their own home-centric data collection networks and intelligent big data analytics systems based on machine-learning principles. The benefit of using IoT, big data, and artificial intelligence for community and population health is better health outcomes for the population and communities. The new generation of machine-learning algorithms can use large standardized data sets generated in healthcare to improve the effectiveness of public health interventions. A lot of these data come from sensors, devices, electronic health records (EHR), data generated by public health nurses, mobile data, social media, and the internet. This chapter shows a high-level implementation of a complete solution of IoT, big data, and machine learning implemented in the city of Cartagena, Colombia for hypertensive patients by using an eHealth sensor and Amazon Web Services components.


Author(s):  
Kağan Okatan

All these types of analytics have been answering business questions for a long time about the principal methods of investigating data warehouses. Especially data mining and business intelligence systems support decision makers to reach the information they want. Many existing systems are trying to keep up with a phenomenon that has changed the rules of the game in recent years. This is undoubtedly the undeniable attraction of 'big data'. In particular, the issue of evaluating the big data generated especially by social media is among the most up-to-date issues of business analytics, and this issue demonstrates the importance of integrating machine learning into business analytics. This section introduces the prominent machine learning algorithms that are increasingly used for business analytics and emphasizes their application areas.


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