scholarly journals The role of probiotics in combination therapy of depressive disorders

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Sevilla R. Arifdjanova ◽  
Zera Z. Abrurakhmanova ◽  
Ekaterina S. Bizulya ◽  
Lesya N. Gumenyuk ◽  
Leya E. Sorokina ◽  
...  
Keyword(s):  
Depressive Episode ◽  
Standard Therapy ◽  
Depressive Disorders ◽  
Control Group ◽  
Depression Symptoms ◽  
Laboratory Methods ◽  
Health Group ◽  
Pronounced Reduction ◽  
Monoaminergic Neurotransmitter

Our objective was to investigate the effect of probiotic therapy on the profile of a psycho-emotional state and nature of neuro-immune-endocrine changes among patients with depressive disorders. Material and methods — The study involved 119 patients, diagnosed with a mild depressive episode (F32.0) or a moderate depressive episode (F32.1). The patients were split among two groups: Main Group, in which subjects were taking a probiotic medicine in addition to the standard therapy (Cipralex + Bac-Set Forte), and Comparison Group in which subjects were taking a placebo pill in addition to the standard therapy (Cipralex). The Control Group consisted of 30 subjects belonging to the health group 1 sensu the Order of the Ministry of Health care of the Russian Federation No. 869an of January 1, 2018. The examination included clinical and psychopathological, psychometric, and laboratory methods. Results — Patients with depressive disorders had dysfunction of cortisol and monoaminergic neurotransmitter systems, along with an increased content of proinflammatory cytokines and nitric oxide in their blood. As a result of the therapy with a probiotic medicine, in combination with an antidepressant, patients with depressive disorders had a statistically significant decrease in the levels of cortisol, dopamine, IL-6, TNF-, and NO, as well as a more pronounced reduction of depression symptoms, in comparison with the indicators of the patients who underwent standard therapy. Conclusion — Use of probiotics resulted in a more pronounced improvement of neuro-immune-endocrine indicators in study subjects, with subsequent improvement of their mental state – particularly, due to less obvious symptoms of depressive disorders.

scholarly journals Effect of Probiotics on Allergic Rhinitis: A Randomized, Controlled, Clinical Trial

2020 ◽  
Vol 9 ◽  
pp. 1918 ◽  
Author(s):  
Mahnaz Sadeghi-Shabestari ◽  
Yalda Jabbari Moghaddam ◽  
Hasan Rezapoor ◽  
Mojataba Sohrabpour
Keyword(s):  
Clinical Trial ◽  
Allergic Rhinitis ◽  
Standard Therapy ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
P Value ◽  
Nasal Discharge ◽  
Oral Corticosteroids ◽  
And Control

Background: Allergic rhinitis (AR) is one of the most common diseases in the world and affects about 10-50% of the general population. Probiotics are live microorganisms that help the normal state of the intestine, and if prescribed correctly, they can stimulate the mucosal immune system to prevent inflammatory symptoms of allergy and atopy. The present study aims to investigate the role of probiotics in the treatment of AR when added to standard therapy as adjuvant agents. Materials and Methods: In this clinical trial study, 28 patients older than 15 years with AR randomly divided into probiotics and control groups. The probiotics group received standard therapy for AR accompanied by probiotic capsules every 12 hours for eight weeks, whereas the control group received standard therapy for AR with placebo capsules as the same protocol. Data were analyzed using SPSS Version 23 (IBM Corporation, Armonk, NY, USA) and, the P-value less than 0.05 was considered statistically significant. Results: In the probiotics group, 14.3% of patients had sneezing at the baseline, which significantly decreased to 4.6% (P<0.01). Also, the necessity for nasal and oral corticosteroids after treatment with probiotics in the probiotics group was less than the control group (P<0.01). Although cough, nasal discharge, conchae hypertrophy, and night sleep disorders reduced after treatment with probiotics, this reduction was not statistically significant between the two groups. Conclusion: Based on the results of this clinical trial, the use of probiotics had no significant effect on the outcome of patients with AR. [GMJ.2020;9:e1918] 

scholarly journals Kriya Yoga in Patients with Depressive Disorders: A Pilot Study

2021 ◽  
Vol 12 (02) ◽  
pp. 362-367
Author(s):  
Ananya Srivastava ◽  
Pooja P. Kuppili ◽  
Tanu Gupta ◽  
Naresh Nebhinani ◽  
Ambika Chandani
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorders ◽  
Rating Scale ◽  
Remission Rate ◽  
Intervention Group ◽  
Control Group ◽  
Major Depressive ◽  
Yoga Intervention ◽  
Severity Of Depression

Abstract Background and Objectives Despite the easy acceptability and holistic nature of Kriya yoga, there are no studies evaluating the role of Kriya yoga intervention on depression. The objective of the current study was to assess the feasibility and effect of adjunctive Kriya yoga on depression. Methods Patients with major depressive disorder who opted for Kriya yoga were recruited into the intervention group (adjunctive Kriya yoga) and those on psychotropic medication alone were enrolled into the control group. The Hamilton Depression Rating Scale (HDRS) measurements were recorded at baseline, end of 2, 4, and 8 weeks. Results HDRS scores of the intervention group (n = 29) were found to be significantly lesser than that of the control group (n = 52) by the end of 2, 4, and 8 weeks. The remission rate was also significantly greater in the intervention group. Conclusion Kriya yoga intervention was found to be feasible, as well as improved the severity of depression.

scholarly journals Emotions as a state and as a trait in people with depressive disorders*

2019 ◽  
Vol 73 ◽  
pp. 721-728
Author(s):  
Aleksandra Skiba ◽  
Paulina Maruszewska ◽  
Monika Talarowska ◽  
Piotr Gałecki
Keyword(s):  
Psychosocial Functioning ◽  
Depressive Episode ◽  
Positive Emotions ◽  
Depressive Disorders ◽  
Rating Scale ◽  
Negative Emotions ◽  
Healthy People ◽  
Control Group ◽  
The People ◽  
Positive And Negative Emotions

Depression is a disorder involving a number of changes in human psychosocial functioning. The aim of this study is to evaluate the intensity of positive and negative emotions understood both as a state and a permanent personality trait in people with depressive disorders and to determine whether the intensity of positive and negative emotions differentiates healthy people from people suffering from depressive disorders. The study was conducted on 107 individuals – 67 people from the experimental group suffering from depressive disorders and 40 people from the control group with a negative interview in terms of mental and somatic disorders. The following tools were used: Hamilton Depression Rating Scale (evaluation of severity of depressive symptoms), STAI Questionnaire (evaluation of anxiety severity as a state and trait) and PANAS Questionnaire (intensity of negative and positive emotions as a state and trait). A significantly higher intensity of positive emotions understood both as a state and a trait was observed in the people not suffering from depression, while the opposite results were obtained with regard to negative emotions, i.e. the individuals suffering from depression recorded lower scores than the healthy persons. It was also shown that the people with depression had higher scores in terms of the level of anxiety as a state and trait. The intensity of positive emotions as a state was significantly higher among the people with the first depressive episode in comparison to the people with recurrent depressive disorders. The severity of depression correlated positively with the intensity of negative emotions as a state both at the time of inclusion in the study and after obtaining a response to the applied pharmacological treatment. Experienced positive and negative emotions, understood both as a state and as a trait, differentiate not only individuals with depression from healthy people, but also patients with the first depressive episode and those with recurrent depressive disorders.

scholarly journals Is NRXN1 Gene Expression an Important Marker of Treatment of Depressive Disorders? A Pilot Study

2021 ◽  
Vol 11 (7) ◽  
pp. 637
Author(s):  
Aleksandra Skiba ◽  
Monika Talarowska ◽  
Janusz Szemraj ◽  
Piotr Gałecki
Keyword(s):  
Gene Expression ◽  
Protein Level ◽  
Depressive Disorders ◽  
Depression Scale ◽  
Healthy People ◽  
Expression Level ◽  
Control Group ◽  
Depression Symptoms ◽  
Hamilton Depression Scale ◽  
Experimental Group

Aim: Due to the fact that NRXN1 is associated with neurodevelopmental disorders, the aim of this study was to investigate the role of the NRXN1 gene in the etiology and epigenetics of depression by comparison of NRXN1 mRNA expression and NRXN1 protein level expression in patients suffering from depression versus healthy controls, as well as to search for clinical variables related to expression of the analyzed gene. Material and Methods: A total of 180 people aged 19–64 qualified for the study. The experimental group consisted of 97 people who were psychiatrically hospitalized, diagnosed with recurrent depressive disorders (F33) or who met the diagnostic criteria of a depressive episode (F32) according to ICD-10. The control group included 83 healthy people who volunteered to participate in the study. A sample of peripheral blood was obtained from people who were positively qualified to participate in the study—twice in the experimental group and once in the control group for genetic testing. Sociodemographic variables and data on the course of the disorder were also gathered. Patients were examined on study entry and at the end of the hospitalization with the Hamilton Depression Scale. Obtained data were analyzed statistically. The study was approved by the University’s Bioethics Committee. Results: The gene expression of NRXN1 at both mRNA and protein level significantly differs and it is lower in the experimental group compared to expression in healthy people. The difference in gene expression of NRXN1 at both the mRNA and protein levels between the first and second measurement in the experimental group is also significant. The result demonstrates a higher expression level in the first measurement and lower expression level in the second measurement when reported depression symptoms are less severe. Conclusions: Results concerning expression of NRXN1 may play an important role in further researches about the etiopathogenesis of depressive disorders such as looking for depression biomarkers and identifying evidence which may be relevant to personalize treatment for depression.

scholarly journals Household pesticide exposure and depression syndromes: evidence from NHANES, 2005-2014

2020 ◽  
Author(s):  
Haiyan Chen ◽  
Guang Hao
Keyword(s):  
General Population ◽  
Pesticide Exposure ◽  
Control Group ◽  
Depression Symptoms ◽  
Health And Nutrition ◽  
Adult Participants ◽  
Prevalence Of Depression ◽  
Patient Health ◽  
First Time

Abstract Background The effect of household pesticide exposure on depression symptoms in general population is underexplored, and the role of exercise in the association between pesticide exposure and depression symptoms is unclear. The goals of this study are to examine whether the association of household pesticide exposure and depression symptoms exist in general population, and, if so, whether exercise can attenuate the effect of household pesticide on depression symptoms.Methods We used data from the 2005-2014 NHANES (National Health and Nutrition Examination Surveys), including a total of 14 708 US adult participants ≥ 20 years old. Depression symptoms was assessed using the Patient Health Questionnaire (PHQ-9).Results The prevalence of depression symptoms was significantly higher in participants who exposed to household pesticide compared to those not (28.9% vs. 21.1%, P <0.001). Household pesticide exposure was significantly associated with risk of depression symptoms. A significant interaction between exercise and pesticide exposure on depression symptoms was observed ( P =0.038). The prevalence of depression symptoms was significantly higher in pesticide exposure group compared to the control group (35.0% vs. 24.9%, P <0.001) in the population with light physical activity. However, we did not find a significant association in the group with moderate + vigorous physical activity.Conclusion This study further confirmed that household pesticide exposure is associated with a high risk of depression symptoms in the general population. More importantly, we for the first time reported that exercise tends to attenuate the effect of household pesticide exposure on depression symptoms.

Tryptophan-Niacin Metabolism in Rat with Puromycin Aminonucleoside-Induced Nephrosis

2006 ◽  
Vol 76 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Yukari Egashira ◽  
Shin Nagaki ◽  
Hiroo Sanada
Keyword(s):  
Body Weight ◽  
Urinary Excretion ◽  
Enzyme Activities ◽  
Treated Group ◽  
Control Group ◽  
Puromycin Aminonucleoside ◽  
Low Level ◽  
Key Enzyme

We investigated the change of tryptophan-niacin metabolism in rats with puromycin aminonucleoside PAN-induced nephrosis, the mechanisms responsible for their change of urinary excretion of nicotinamide and its metabolites, and the role of the kidney in tryptophan-niacin conversion. PAN-treated rats were intraperitoneally injected once with a 1.0% (w/v) solution of PAN at a dose of 100 mg/kg body weight. The collection of 24-hour urine was conducted 8 days after PAN injection. Daily urinary excretion of nicotinamide and its metabolites, liver and blood NAD, and key enzyme activities of tryptophan-niacin metabolism were determined. In PAN-treated rats, the sum of urinary excretion of nicotinamide and its metabolites was significantly lower compared with controls. The kidneyα-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) activity in the PAN-treated group was significantly decreased by 50%, compared with the control group. Although kidney ACMSD activity was reduced, the conversion of tryptophan to niacin tended to be lower in the PAN-treated rats. A decrease in urinary excretion of niacin and the conversion of tryptophan to niacin in nephrotic rats may contribute to a low level of blood tryptophan. The role of kidney ACMSD activity may be minimal concerning tryptophan-niacin conversion under this experimental condition.

Are Three Items Sufficient to Measure Sense of Coherence?

2018 ◽  
Vol 34 (4) ◽  
pp. 229-237 ◽  
Author(s):  
Francesca Chiesi ◽  
Andrea Bonacchi ◽  
Caterina Primi ◽  
Alessandro Toccafondi ◽  
Guido Miccinesi
Keyword(s):  
Sense Of Coherence ◽  
Convergent Validity ◽  
Clinical Sample ◽  
Clinical Samples ◽  
Depression Symptoms ◽  
Time Saving ◽  
Positive Role ◽  
Patients With Cancer ◽  
Measure Sense

Abstract. The present study aimed at evaluating if the three-item sense of coherence (SOC) scale developed by Lundberg and Nystrom Peck (1995) can be effectively used for research purpose in both nonclinical and clinical samples. To provide evidence that it represents adequately the measured construct we tested its validity in a nonclinical (N = 658) and clinical sample (N = 764 patients with cancer). Results obtained in the nonclinical sample attested a positive relation of SOC – as measured by the three-item SOC scale – with Antonovsky’s 13-item and 29-item SOC scales (convergent validity), and with dispositional optimism, sense of mastery, anxiety, and depression symptoms (concurrent validity). Results obtained in the clinical sample confirmed the criterion validity of the scale attesting the positive role of SOC – as measured by the three-item SOC scale – on the person’s capacity to respond to illness and treatment. The current study provides evidence that the three-item SOC scale is a valid, low-loading, and time-saving instrument for research purposes on large sample.

The role of companionship for support and relationship satisfaction: Evidence using diary and laboratory methods

2011 ◽  
Author(s):  
Gertraud Stadler ◽  
Niall Bolger ◽  
Kenzie A. Snyder ◽  
Elizabeth A. Pitula ◽  
Patrick E. Shrout
Keyword(s):  
Relationship Satisfaction ◽  
Laboratory Methods

The Use of Posterior Pericardiotomy Technique to Prevent Postoperative Pericardial Effusion in Cardiac Surgery

2012 ◽  
Vol 15 (2) ◽  
pp. 84 ◽  
Author(s):  
Canturk Cakalagaoglu ◽  
Cengiz Koksal ◽  
Ayse Baysal ◽  
Gokhan Alici ◽  
Birol Ozkan ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Heart Surgery ◽  
Artery Bypass ◽  
Pericardial Tamponade ◽  
Anxiety Level ◽  
Control Group ◽  
Echocardiographic Study ◽  
Number Of Patients ◽  
Hospital Stays

<p><b>Aim:</b> The goal was to determine the effectiveness of the posterior pericardiotomy technique in preventing the development of early and late pericardial effusions (PEs) and to determine the role of anxiety level for the detection of late pericardial tamponade (PT).</p><p><b>Materials and Methods:</b> We divided 100 patients randomly into 2 groups, the posterior pericardiotomy group (n = 50) and the control group (n = 50). All patients undergoing coronary artery bypass grafting surgery (CABG), valvular heart surgery, or combined valvular and CABG surgeries were included. The posterior pericardiotomy technique was performed in the first group of 50 patients. Evaluations completed preoperatively, postoperatively on day 1, before discharge, and on postoperative days 5 and 30 included electrocardiographic study, chest radiography, echocardiographic study, and evaluation of the patient's anxiety level. Postoperative causes of morbidity and durations of intensive care unit and hospital stays were recorded.</p><p><b>Results:</b> The 2 groups were not significantly different with respect to demographic and operative data (<i>P</i> > .05). Echocardiography evaluations revealed no significant differences between the groups preoperatively; however, before discharge the control group had a significantly higher number of patients with moderate, large, and very large PEs compared with the pericardiotomy group (<i>P</i> < .01). There were 6 cases of late PT in the control group, whereas there were none in the pericardiotomy group (<i>P</i> < .05). Before discharge and on postoperative day 15, the patients in the pericardiotomy group showed significant improvement in anxiety levels (<i>P</i> = .03 and .004, respectively). No differences in postoperative complications were observed between the 2 groups.</p><p><b>Conclusion:</b> Pericardiotomy is a simple, safe, and effective method for reducing the incidence of PE and late PT after cardiac surgery. It also has the potential to provide a better quality of life.</p>

The Estimation of prostate specific antigen (PSA) concentrations in patients with prostatitis by fully automated ELISA technique.

2020 ◽  
Vol 3 (11) ◽  
pp. 1100-1104
Author(s):  
Hussein Naeem Aldhaheri ◽  
Ihsan Edan AlSaimary ◽  
Murtadha Mohammed ALMusafer
Keyword(s):  
Personal Information ◽  
Receptor Gene ◽  
Specific Antigen ◽  
Gene Clusters ◽  
Control Group ◽  
P Value ◽  
Group Data ◽  
Elisa Technique ◽  
And Control

      The Aim of this study was to determine Immunogenetic expression of  Toll-like receptor gene clusters related to prostatitis, to give acknowledge about Role of TLR in prostatitis immunity in men from Basrah and Maysan provinces. A case–control study included 135 confirmed prostatitis patients And 50 persons as a control group. Data about age, marital status, working, infertility, family history and personal information like (Infection, Allergy, Steroid therapy, Residency, Smoking, Alcohol Drinking, Blood group, Body max index (BMI) and the clinical finding for all patients of Prostatitis were collected. This study shows the effect of PSA level in patients with prostatitis and control group, with P-value <0.0001 therefore the study shows a positive significant between elevated PSA levels and Prostatitis.

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