scholarly journals The association of adiponectin with risk of pre-diabetes and diabetes in different subgroups: a cluster analysis of general population in south China

2021 ◽  
Author(s):  
Xun Gong ◽  
Lili You ◽  
Feng Li ◽  
Qingyu Chen ◽  
Chaogang Chen ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
South China ◽  
Protective Factor ◽  
Adiponectin Level ◽  
Glycosylated Hemoglobin ◽  
Multivariate Logistic Regression Analysis ◽  
Obese Group ◽  
Healthy Population ◽  
Healthy Group ◽  
Fourth Quartile

Objective: Adiponectin is an adipocyte-derived hormone with an important role in glucose metabolism. The present study explored the effect of adiponectin in diverse population groups on pre-diabetes and newly diagnosed diabetes. Methods: A total of 3300 individuals were enrolled and their data were collected in the analyses dataset from December 2018 to October 2019. Cluster analysis was conducted based on age, body mass index, waistline, body-fat, systolic blood pressure, triglycerides and glycosylated hemoglobin 1c. Cluster analysis divided the participants into four groups: a young-healthy group, an elderly-hypertension group, a high glucose-lipid group, and an obese group. Odds ratio and 95% confidence intervals were calculated using multivariate logistic regression analysis. Results: Compared with the first quartile of adiponectin, the risk of pre-diabetes of fourth quartile was decreased 61% (aOR=0.39, 95%CI [0.20-0.73]) in the young-healthy group; and the risk of diabetes of fourth quartile was decreased 85% (aOR=0.15, 95%CI [0.02-0.67]) in the obese group. There were no significant correlations between the adiponectin level and diabetes/pre-diabetes in the other two groups. Additionally, receiver operating characteristic curve analysis indicated that adiponectin could significantly improve the diagnosis based on models in the young-healthy group (from 0.640 to 0.675) and the obese group (from 0.714 to 0.761). Conclusions: Increased adiponectin levels were associated with decreased risk of pre-diabetes in the young-healthy population, and with a decreased the risk of diabetes in the obese population. An increased adiponectin level is an independent protective factor for pre-diabetes and diabetes in specific population in south China.

Social and individual factors associated with condom use among single youths: an analysis of the 2018 Cameroon Demographic and Health Survey

2021 ◽  
pp. 1-27
Author(s):  
Jean-Robert Mburano Rwenge ◽  
Franklin Bouba Djourdebbe ◽  
Emmanuel Ekambi Ekambi
Keyword(s):  
Risk Factor ◽  
Condom Use ◽  
Sexual Intercourse ◽  
Health Survey ◽  
Protective Factor ◽  
Multivariate Logistic Regression Analysis ◽  
Demographic And Health Survey ◽  
Main Risk Factor ◽  
Factors Associated ◽  
Service Sectors

Abstract In Cameroon, two-fifths of the population is between the age of 15 and 24. Adolescents and youths are an important social group for the development of the country and the realization of the demographic dividend. The promotion of sexual and reproductive health will enable youth to transform their potential into development. This study aimed to identify the determinants of condom use at last sexual intercourse among single youths, highlight gender differences in the factors associated with condom use and identify the characteristics of youths who were less likely to use condoms. Data were taken from the 2018 Cameroon Demographic and Health Survey. The study sample comprised 1464 single females and 989 single males age 15–24. Multivariate logistic regression analysis was used to test the study hypotheses. Overall, 51% of the female and 66% of the male youths reported using condoms at last sexual intercourse. For both sexes, the protective factor was not having children. Among the females, belonging to the Bamileke or Mbo ethnic groups and delaying first sexual intercourse were also protective, while working in the modern or service sectors was the main risk factor. Among male youths, residing in households whose heads had a higher educational level was protective and household poverty was the main risk factor. These findings support Cameroon’s multi-sectoral approach to HIV/AIDS prevention among youths, and emphasize the importance of involving parents, teachers and youths in prevention strategies.

scholarly journals High-level Exposure of Uric Acid in Asymptomatic Hyperuricemia Could Be An Isolated Risk Factors of Cardio-Cerebrovascular Diseases: A Prospective Cohort Study

2021 ◽  
Author(s):  
Zhiyuan Cheng ◽  
Tongzhang Zheng ◽  
Desheng Zhang ◽  
Jingli Yang ◽  
Xiaobin Hu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Uric Acid ◽  
Cox Regression ◽  
Cerebrovascular Diseases ◽  
Healthy Population ◽  
Incidence Risk ◽  
High Level ◽  
Age Range ◽  
Fourth Quartile

Abstract Background: Whether the asymptomatic hyperuricemia (AH) raises the risk of cardiovascular disease with or without hyperuricemia-related comorbidities still remains contentious. Our study was aimed to quantitatively access the incidence risk of coronary heart disease (CHD) and stroke associated with AH.Methods: Multivariate-adjusted Cox regression models were applied to evaluate the risk of cardiovascular disease (CVD). Serum uric acid beyond normouricemia was quarterly stratified based on the distribution of healthy population without CVD onset.Results: 1,062 CVD first attack cases were collected among the 48,001 cohort participants (age range: 18-92, mean age: 47.2±13.9 years-old) with a mean follow-up duration of 5.78±0.83 years. 14,464 baseline population with comorbidities were excluded to further study the association between AH and CVD incidence. The AH showed overall non-association with CVD incident. However, significantly increased adjusted hazard ratio (HR) of CVD with 95% confidence interval (CI) were observed when the fourth quartile compared with normouricemia stratum in the total cohort population (CHD: 1.70, 1.34-2.16; stroke: 1.55, 1.13-2.13), male (CHD: 1.94, 1.47-2.56), female (CHD: 1.71, 1.03-2.35; stroke: 2.02, 1.14-3.58) and aged over 50 years-old population. Meanwhile, the age-standardized incidence rate of CVD in the fourth quartile was 2 to 3 time higher than the normouricemia population. Consistent results were also observed in the AH population in absence of comorbidities (CHD: 2.40, 1.39-4.14; stroke: 1.85, 1.12-3.59).Conclusion: Asymptomatic hyperuricemia patients exposed to higher level of uric acid (male>487 mmol/L, female>422 mmol/L) could significantly increase the incidence risk of CHD and stroke, with or without hyperuricemia-related comorbidities.

scholarly journals A First Step towards a Comprehensive Approach to Harmonic Analysis of Synchronous Peripheral Volume Pulses: A Proof-of-Concept Study

2021 ◽  
Vol 11 (12) ◽  
pp. 1263
Author(s):  
Hsien-Tsai Wu ◽  
Bagus Haryadi ◽  
Jian-Jung Chen
Keyword(s):  
Type 2 Diabetes ◽  
Waist Circumference ◽  
Confidence Interval ◽  
Harmonic Analysis ◽  
Protective Factor ◽  
Glycosylated Hemoglobin ◽  
Clinical Applications ◽  
Elderly Subjects ◽  
Short Period

The harmonic analysis (HA) of arterial radial pulses in humans has been widely investigated in recent years for clinical applications of traditional Chinese medicine. This study aimed at establishing the validity of carrying out HA on synchronous peripheral volume pulses for predicting diabetes-induced subtle changes in heart energy. In this study, 141 subjects (Group 1: 63 healthy elderly subjects; Group 2: 78 diabetic subjects) were enrolled at the same hospital. After routine blood sampling, all synchronous electrocardiogram (ECG) and photoplethysmography (PPG) measurements (i.e., at the six locations) were acquired in the morning. HA of synchronous peripheral volume pulses and radial pulse waves was performed and analyzed after a short period of an ensemble averaging process based on the R-wave peak location. This study utilized HA for the peripheral volume pulses and found that the averaged total pulse energy (i.e., the C0 of the DTFS) was identical in the same subject. A logistic regression model with C0 and a waist circumference variable showed a graded association with the risk of developing type 2 diabetes. The adjusted odds ratio for C0 and the waist circumference were 0.986 (95% confidence interval: 0.977, 0.994) and 1.130 (95% confidence interval: 1.045, 1.222), respectively. C0 also showed significant negative correlations with risk factors for type 2 diabetes mellitus, including glycosylated hemoglobin and fasting plasma glucose (r = −0.438, p < 0.001; r = −0.358, p < 0.001, respectively). This study established a new application of harmonic analysis in synchronous peripheral volume pulses for clinical applications. The findings showed that the C0 could be used as a prognostic indicator of a protective factor for predicting type 2 diabetes.

scholarly journals Prognostic value of early glycosylated hemoglobin and blood glucose levels in patients with basal ganglia cerebral hemorrhage

2019 ◽  
pp. 030006051987203
Author(s):  
Wentao Sun ◽  
Qunliang Hu ◽  
Juan Wang ◽  
Ning Zheng ◽  
Kai Chen ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Basal Ganglia ◽  
Cerebral Hemorrhage ◽  
Glycosylated Hemoglobin ◽  
Multivariate Logistic Regression Analysis ◽  
Neurological Impairment ◽  
Glucose Levels ◽  
Bleeding Volume ◽  
Consciousness Disorder ◽  
Ich Score

Objective This study was performed to analyze the relationships of the early glycosylated hemoglobin (GHb) level and blood glucose level (BGL) with prognosis in patients with basal ganglia cerebral hemorrhage (BGCH). Methods In total, 186 patients with BGCH were included in this prospective study. The GHb level, fasting BGL, bleeding volume, degree of consciousness disorder, intracerebral hemorrhage (ICH) score, functional outcome in patients with primary ICH (FUNC) score, ICH grading scale (ICH-GS) score, and neurological impairment were recorded during a 30-day observation period. Results The mean BGCH volume was 58.42 mL. The 30-day mortality rate was 22.32%. The ICH-GS score [odds ratio (OR) = 0.815, 95% confidence interval (95% CI) = 0.504–0.688, R = 0.624] and bleeding volume (OR = 0.882, 95% CI = 0.785–0.918, R = 0.784) were significant predictors of 30-day mortality. The GHb level (OR = 6.138, R = 0.705) and BGL (OR = 1.055, R = 0.418) were independent predictors of 30-day mortality according to the multivariate logistic regression analysis. Conclusion The GHb level and BGL are strong predictors of 30-day mortality in patients with BGCH and accurately predict the prognosis in these patients.

Middle Ordovician actinocerid nautiloids (Cephalopoda) from Xainza County, Tibet, western China, and their paleogeographic implications

2018 ◽  
Vol 92 (3) ◽  
pp. 398-411 ◽  
Author(s):  
Xiang Fang ◽  
Tingen Chen ◽  
Clive Burrett ◽  
Yongsheng Wang ◽  
Yonggui Qu ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
New Species ◽  
North America ◽  
South China ◽  
North China ◽  
Western China ◽  
Middle Ordovician ◽  
Lhasa Terrane ◽  
First Time ◽  
The Himalaya

AbstractActinocerid nautiloids from the Lhasai Formation in the Xainza region are studied systematically for the first time. The nautiloids are identified as Middle Ordovician in age based on stratigraphic correlations with those from North China, Sibumasu, North Australia (northern Gondwana), and North America (Laurentia). A cluster analysis shows strong affinities between the actinocerid nautiloids of the Lhasa Terrane and those of the Himalaya, North China, and Sibumasu terranes. Our results support Middle Ordovician paleogeographic reconstructions that place North China rather than South China much closer to Australia. Nine species assigned to six genera of Meitanoceratidae, Wutinoceratidae, Armenoceratidae, Ormoceratidae, and Discoactinoceratidae are described in detail:Pomphoceras nyalamense(Chen, 1975),Pomphoceras yaliense(Chen, 1975),Wutinocerascf.W.foerstei(Endo, 1930),Mesowutinoceras giganteumChen in Chen and Zou, 1984,Armenoceras tani(Grabau, 1922),Armenoceras teichertiEndo, 1932,Armenoceras xizangensenew species,Deiroceras globosomZou and Shen in Chen and Zou, 1984, andDiscoactinocerascf.D.multiplexumKobayashi, 1927.UUID:http://zoobank.org/ba851fea-e107-4754-a0f4-a70744e325ab

scholarly journals Development and validation of a nomogram risk prediction model for malignancy in dermatomyositis patients: a retrospective study

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12626
Author(s):  
Jiaojiao Zhong ◽  
Yunan He ◽  
Jianchi Ma ◽  
Siyao Lu ◽  
Yushi Wu ◽  
...  
Keyword(s):  
Protective Factor ◽  
Validation Cohort ◽  
Malignant Tumors ◽  
Univariate Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Area Under The Curve ◽  
Poor Prognostic Factor ◽  
Training Cohort ◽  
Discrimination Ability ◽  
Logistic Analysis

Background Dermatomyositis accompanied with malignancy is a common poor prognostic factor of dermatomyositis. Thus, the early prediction of the risk of malignancy in patients with dermatomyositis can significantly improve the prognosis of patients. However, the identification of antibodies related to malignancy in dermatomyositis patients has not been widely implemented in clinical practice. Herein, we established a predictive nomogram model for the diagnosis of dermatomyositis associated with malignancy. Methods We retrospectively analyzed 240 cases of dermatomyositis patients admitted to Sun Yat-sen Memorial Hospital, Sun Yat-sen University from January 2002 to December 2019. According to the year of admission, the first 70% of the patients were used to establish a training cohort, and the remaining 30% were assigned to the validation cohort. Univariate analysis was performed on all variables, and statistically relevant variables were further included in a multivariate logistic regression analysis to screen for independent predictors. Finally, a nomogram was constructed based on these independent predictors. Bootstrap repeated sampling calculation C-index was used to evaluate the model’s calibration, and area under the curve (AUC) was used to evaluate the model discrimination ability. Results Multivariate logistic analysis showed that patients older than 50-year-old, dysphagia, refractory itching, and elevated creatine kinase were independent risk factors for dermatomyositis associated with malignancy, while interstitial lung disease was a protective factor. Based on this, we constructed a nomogram using the above-mentioned five factors. The C-index was 0.780 (95% CI [0.690–0.870]) in the training cohort and 0.756 (95% CI [0.618–0.893]) in the validation cohort, while the AUC value was 0.756 (95% CI [0.600–0.833]). Taken together, our nomogram showed good calibration and was effective in predicting which dermatomyositis patients were at a higher risk of developing malignant tumors.

scholarly journals Prevalence and influencing risk factors of eczema among preschool children in Urumqi city: a cross-sectional survey

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Haonan Shi ◽  
Guangsheng Wan ◽  
Tingting Wang ◽  
Jia Zhu ◽  
Lan Jiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preschool Children ◽  
Protective Factor ◽  
Multivariate Logistic Regression Analysis ◽  
Chronic Inflammatory Disease ◽  
Han Chinese ◽  
Living Environment ◽  
Cluster Sampling ◽  
Cross Sectional Survey ◽  
Cross Sectional

Abstract Background Eczema is a chronic inflammatory disease associated with impaired quality of life. We identified indoor environmental risk factors, to provide strong evidence for the prevention and control of eczema in preschool children. Methods Using a cross-sectional study with stratified random cluster sampling, we conducted a self-administered questionnaire survey among 8153 parents of children aged 2–8 years in 60 kindergartens in six districts of Urumqi city during August 2019. Results Among 8153 preschool children, 12.0% of the children have been diagnosed with eczema. Multivariate logistic regression analysis showed that caesarean section (odds ratio [OR] = 1.18, 95% confidence interval [CI]: 1.03–1.36), being an only child (OR = 1.36, 95% CI: 1.18–1.57), presence of mould or moisture in the mother’s home before pregnancy (OR = 1.53, 95% CI: 1.17–2.00), presence of flies or mosquitoes in the dwelling currently (OR = 1.31, 95% CI: 1.10–1.55), pets kept in the child’s home currently (OR = 1.23, 95% CI: 1.01–1.51), presence of pets during child’s first year (OR = 1.45, 95% CI: 1.14–1.85), and family history of eczema (OR = 3.53, 95% CI: 2.98–4.19) are the risk factors for the development of eczema, whereas ethnicity other than the Han Chinese (OR = 0.77, 95% CI: 0.61–0.96) is a protective factor for eczema. Conclusion Preschool children in Urumqi are at a high risk of eczema, particularly those of the Han Chinese ethnicity. Parents should be attentive to the indoor living environment of children and take actions to reduce indoor humidity, pest control and elimination, and avoid raising pets to reduce the risk of development of eczema in children.

scholarly journals Risk factors for tuberculous empyema in pleural tuberculosis patients

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Peng Wen ◽  
Min Wei ◽  
Chao Han ◽  
Yu He ◽  
Mao-Shui Wang
Keyword(s):  
Risk Factors ◽  
Protective Factor ◽  
Significant Risk ◽  
Multivariate Logistic Regression Analysis ◽  
Epidemiological Data ◽  
Significant Risk Factor ◽  
Multidrug Resistant ◽  
Mortality And Morbidity ◽  
Pulmonary Tb ◽  
Pleural Tuberculosis

AbstractTuberculous empyema (TE) is associated with high mortality and morbidity. In the retrospective cohort study, we aimed to find risk factors for TE among pleural tuberculosis (TB) patients. Between July 2011 and September 2015, all culture-confirmed pleural TB patients (474 cases) were enrolled in our study. Empyema was defined as grossly purulent pleural fluid. Demographic and epidemiological data were collected for further analysis. Multivariate logistic regression analysis was used to evaluate risk factors of TE in pleural TB, age–adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated to show the risk. The mean age was 35.7 ± 18.1 years old, males comprised 79.1% of the participants (375 cases). Forty-seven patients (9.9%) were multidrug-resistant TB (MDR-TB), 29 (6.1%) had retreatment TB, 26 (5.5%) had diabetes mellitus. The percentage of empyema patients was 8.9% (42 cases). Multivariate analysis revealed that male (adjusted OR = 4.431, 95% CI: 1.411, 13.919), pleural adenosine deaminase (ADA, >88 U/L) (adjusted OR = 3.367, 95% CI: 1.533, 7.395) and white blood cell (WBC, >9.52 109/L) (adjusted OR = 5.763, 95% CI: 2.473, 13.431) were significant risk factors for empyema in pleural TB, while pulmonary TB (adjusted OR = 0.155, 95% CI: 0.072, 0.336) was the protective factor for the patients. TE remains a serious threat to public health in China. Male sex is a significant risk factor for TE while the presence of pulmonary TB is protective, and high levels of pleural ADA and WBC count could aid in early diagnosis of TE. This finding would help towards reducing the mortality and morbidity associated with TE.

Elevated Serum Homocysteine Associated with Distal Type of Single Small Subcortical Infarction

2020 ◽  
Vol 17 ◽  
Author(s):  
Conghui Liu ◽  
Yuan Gao ◽  
Bo Song ◽  
Yunchao Wang ◽  
Lulu Pei ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Multivariate Logistic Regression Analysis ◽  
Final Analysis ◽  
Lowering Therapy ◽  
Serum Homocysteine ◽  
Standard Template ◽  
Lenticulostriate Artery ◽  
Baseline Characteristics ◽  
Fourth Quartile ◽  
Subcortical Infarction

Objective: The aim of this investigation was to examine the association between the serum homocysteine (Hcy) level and the distal single small subcortical infarction (dSSSI). Methods: Consecutive patients were prospectively recruited in a registered hospital-based ischemic stroke database. Baseline characteristics and risk factors of single small subcortical infarction (SSSI), including the serum Hcy level, were assessed. The SSSI located in the lenticulostriate artery (LSA) territory was divided into proximal single small subcortical infarction (pSSSI) and dSSSI based on a standard template on axial diffusion-weighted imaging (DWI). The association between the serum Hcy level and dSSSI was analysed by multivariate logistic regression analysis. Results: Out of 3,247 patients, a total of 572 patients were included in the final analysis. We found that dSSSI had a higher serum Hcy level than pSSSI. Elevated Hcy level was independently correlated with dSSSI. Compared with the lowest quartile, the upper quartiles of Hcy level were independently associated with dSSSI, the odds ratio for the second quartile was 1.748 (95%CI 1.019 to 3.000), 1.824 (95% CI 1.060 to 3.140) for the third quartile, and 2.010 (95% CI 1.155 to 3.497) for the fourth quartile. The restricted cubic spline showed that the higher level of Hcy, the greater risk of developing dSSSI. Conclusion: The dSSSI shows higher serum Hcy level than pSSSI. Elevated serum Hcy is more closely related to dSSSI. In the future, the effectiveness of Hcy-lowering therapy for dSSSI needs to be explored by further clinical studies.

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