scholarly journals Assessment of lung function in a large cohort of patients with acromegaly

2017 ◽  
Vol 177 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Sylvère Störmann ◽  
Bodo Gutt ◽  
Josefine Roemmler-Zehrer ◽  
Martin Bidlingmaier ◽  
Rudolf M Huber ◽  
...  
Keyword(s):  
Lung Function ◽  
Airway Obstruction ◽  
Vital Capacity ◽  
Large Cohort ◽  
Cross Sectional ◽  
Lung Volumes ◽  
Female Patients ◽  
Significant Difference ◽  
Active Acromegaly ◽  
Expiratory Flow

Objective Acromegaly is associated with increased mortality due to respiratory disease. To date, lung function in patients with acromegaly has only been assessed in small studies, with contradicting results. We assessed lung function parameters in a large cohort of patients with acromegaly. Design Lung function of acromegaly patients was prospectively assessed using spirometry, blood gas analysis and body plethysmography. Biochemical indicators of acromegaly were assessed through measurement of growth hormone and IGF-I levels. This study was performed at the endocrinology outpatient clinic of a tertiary referral center in Germany. Methods We prospectively tested lung function of 109 acromegaly patients (53 male, 56 female; aged 24–82 years; 80 with active acromegaly) without severe acute or chronic pulmonary disease. We compared lung volume, air flow, airway resistance and blood gases to normative data. Results Acromegaly patients had greater lung volumes (maximal vital capacity, intra-thoracic gas volume and residual volume: P < 0.001, total lung capacity: P = 0.006) and showed signs of small airway obstruction (reduced maximum expiratory flow when 75% of the forced vital capacity (FVC) has been exhaled: P < 0.001, lesser peak expiratory flow: P = 0.01). There was no significant difference between active and inactive acromegaly. Female patients had significantly altered lung function in terms of subclinical airway obstruction. Conclusions In our cross-sectional analysis of lung function in 109 patients with acromegaly, lung volumes were increased compared to healthy controls. Additionally, female patients showed signs of subclinical airway obstruction. There was no difference between patients with active acromegaly compared with patients biochemically in remission.

scholarly journals Forced vital capacity (FVC), peaked expiratory flow rate (PEFR), are additional parameters in the assessment of the reversibility test.

2018 ◽  
Vol 60 (1) ◽  
pp. 24-27
Author(s):  
Mustafa N. Abd Ali ◽  
Ahmed H. Jasim ◽  
Abdulrasool N. Nassr ◽  
Monqith A. Kaddish
Keyword(s):  
Pulmonary Function ◽  
Airway Obstruction ◽  
Flow Rate ◽  
Forced Vital Capacity ◽  
Social Order ◽  
Vital Capacity ◽  
Chronic Obstructive ◽  
P Value ◽  
Cross Sectional ◽  
Expiratory Flow

Background: Spirometry is an important test performed in patients expect to have airway obstruction, assessment of intense reaction to inhalers (the trial of reversibility of airway blockade) is a normally utilized technique in clinical and academic studies. The consequences of this test are utilized to take choices on treatment, consideration, exclusion from diagnosis and other research think about, and for analytic marking [asthma versus chronic obstructive airway disease (COPD)]. Usually, the (FEV1) or (FVC) standards before and after giving of the bronchodilator are compared and the adjustment is processed to distinguish variations from the norm in lung volumes and air flow.Objective: The aim of this study was to investigate the effectiveness of FVC and PEFR as further constraints to evaluate bronchodilator reaction in asthmatic peoples with severe or moderate airflow blockade.Patients and methods: This study is cross sectional study performed in Baghdad teaching hospital where one hundred patient were enrolled in this study patients were detected with asthma and confirm airway blockade according to (GINA) guide lines. The pulmonary function for all members was investigated with a convenient spirometer (spiro-lab3 Spirometer) as stated by those measures from claiming American thoracic particular social order, The mean and standard deviation results of the predicted% values pulmonary function test were also used for comparisons were measured by t-test. A p-value of ≤ 0.05 considered to be significant statistically.Results: The post bronchodilator (post –BD) results of FVC, PEFR are greater than pre- bronchodilator where are statistically significant P value = 0.00. the amount of the changes of FVC post (BD) was more than 400ml from pre (BD) and the amount of the changes of PEFR post (BD) more than 1000ml from the pre (BD) both were p-value = 0.00.Conclusion: The asthmatic patients with moderate and severe airway obstruction, we observed that FVC and PEFR is a valuable important limit to FEV1 to evaluate reversibility reactionKeyword: forced vital capacity(FVC), peaked expiratory flow rate (PEFR), spirometry and forced expiratory volume in 1st second (FEV1). السعة الحيويه القصوى ومعدل الجريان الزفيري الاعلى وصفات اضافية في تقييم اختبار المعاكسه القصبيه أ.د. مصطفى نعمه عبد علي  احمد حسين جاسم عبد الرسول نوري نصر منقذ عبد المحسن كاظم  الخلاصه : خلفية البحث : ان جهاز قياس التنفس هو وسيله لقياس تضيق المجاري الهوائية ومدى استجابتها لموسع القصبات عند التشخيص للحالات السريريه , وفي تحديد نوع العلاج , وفي التمييز بين الربو القصبي وانسداد القصبات المزمن . في هذا البحث تم قياس السعة الحيويه القصوى والحجم الزفيري الاعلى في الثانيه وذلك قبل وبعد اعطاء موسع القصبات وقياس الفرق في الحالات الطبيعيه لحجوم الرئه وجريان الهواء فيها . هدف البحث : استخدام عنصر السعة الحيويه القصوى وعنصر معدل الجريان الزفيري الاعلى كعوامل اضافية لتقييم اختبار توسع القصبات في مرضىالربو القصبي ذوي تضيق القصبات المتوسط والشديد. المرضى وطرق العمل:اجريت دراسه مقطعيه في مستشفى بغداد التعليمي على 100 مريض يعانون من الربو مع تضيق المجاري الهوائية حسب التصنيف العالمي (GINA) , وقد اجريت لهم وظائف الرئه  . تم استخدام اختبار - testt و    p – value على مستوى معنويه اقل او يساوي 0.05. النتائج : اظهرت نتائج السعة الحيويه ومعدل الجريان الزفيري الاعلى بعد اعطاء موسع القصبات هي اكبر من قبل اعطائه مع قيمة p- value  تساوي صفر .كما ان معدل التغيير للسعة الحيويه بعد اعطاء موسع القصبات كانت اكثر من 400ml من قبل اعطاء موسع القصبات . وقد بلغ  معدل التغيير في الجريان  الزفيري الاعلى بعد اعطاء موسع القصبات اكثر من 1000ml بالمقارنة ما قبل اعطاء موسع القصبات , وكانت p- value تساوي صفر . الاستنتاج : في هذا البحث ,كانت السعة الحيويه القصوى ومعدل الجريان الزفيري الاعلى لمرضى الربو  القصبي ذات قيمه مهمه لدعم الحجم الزفيري الاقصى في الثانية الاولى لتقييم تفاعل المعاكسة  لتوسع القصبات . مفتاح الكلمات : السعه الحيوية القصوى , معدل الجريان الزفيري الاعلى , جهاز قياس التنفس , لحجم الزفيري الاقصى في الثانية الاولى 

scholarly journals Socio-demographic profile and lung function status among tobacco wor

2017 ◽  
Vol 3 (2) ◽  
pp. 205-210
Author(s):  
Md Ekramul Haque ◽  
Md Shah Golam Nabi ◽  
Sumon Chandra Debnath ◽  
Irfan Nowroze Noor ◽  
Monalisa Monwar ◽  
...  
Keyword(s):  
Lung Function ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Tobacco Industry ◽  
Simple Random Sampling ◽  
Total Sample ◽  
Cross Sectional ◽  
Male And Female ◽  
Demographic Profile ◽  
Significant Difference

This cross-sectional study was conducted to assess the lung function status and socio-demographic profile of the tobacco workers. The study place was “Akij Tobacco Industry” which is situated in Sharsa Upazila under Jessore District of Bangladesh. The period of the study extending from January to December 2014. Tobacco worker who had worked in Akij Tobacco Industry, both male and female and working period more than one year. The total sample size was 203 and simple random sampling was done to select the workers on the basis of their identification number. Data were collected through face to face interviews using a semi-structured questionnaire and lung function status measured by the spirometer. About one-third (34.0%) of the workers was in the age group 40-60 years and mean age were35.8 ± 0.2 years. Of them the majority (54.1%) were male, 89.2% were married, and 48.3% were illiterate. More than half (53.2%) of the worker from the joint family and maximum (53.7%) respondents were in the income group 5000-10000 taka, 39.4% of the worker lived in katcha house and 95.5% were using the sanitary latrine. Approximately half (49.7%) of workers were working for more than 10 years and 66.5% of the workers were working daily for 6-8 hours. More than half (52.7%) of the workers were consuming tobacco product in which 62.3% used to smoke and 31.1% exposed to smokeless tobacco. The mean ± SD forced vital capacity in the 1st second (FEV1) was 2.25 ± 0.12 whereas forced vital capacity (FVC) was 2.59 ± 0.27 and the FEV1/FVC ratio was 87.16 ± 4.91.There was no significant (p>0.05) difference between male and female in their lung function status. There was a significant difference (p<0.05) was found between in mean score of FEV1/FVC ratio and the total working period. From the public health point of view, preventive measures need to be taken to control the dusty environment and wearing of personal protective masks.Asian J. Med. Biol. Res. June 2017, 3(2): 205-210

Maximal Expiratory Flow and Lung Volume Changes Associated with Exercise-Induced Asthma in Children and the Effect of Breathing a Low-Density Gas Mixture

1974 ◽  
Vol 46 (3) ◽  
pp. 317-329 ◽  
Author(s):  
S. R. Benatar ◽  
P. König
Keyword(s):  
Flow Rate ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Lung Volumes ◽  
Flow Rates ◽  
Before And After ◽  
Expiratory Flow

1. Lung volumes and maximum expiratory flow volume (MEFV) curves were measured before and after exercise and after a bronchodilator in eight asthmatic children. 2. Exercise produced significant changes in all volumes and flow rates measured, but the most sensitive measurement was of flow rate at an absolute volume in the terminal portion of the forced vital capacity. Of the more simply obtained measurements maximal flow at 50% of the exhaled vital capacity was the most sensitive, but reductions in forced expiratory volume at 1 s and peak flow rate were almost as marked. 3. The marked reductions in flow rates at low lung volumes after exercise were accompanied by large increases in residual volume and a reduction in the slope of the MEFV curve. These changes suggest functional closure of some lung units and an increase in the time-constant of emptying of other units. 4. The response of flow to breathing helium—oxygen (79:21, v/v) was assessed in the dilated state (before exercise or after bronchodilator) and the constricted state (after exercise) in five of the subjects. 5. An increase in density-dependence of flow rates at all lung volumes during constriction is evidence that, despite the reduction in flow rates, convective acceleration and turbulent flow constitute a greater proportion of the total upstream resistance after exercise than before exercise. The implication is that the cross-sectional area at equal pressure points (EPP) is smaller after exercise than before exercise. This could result from either bronchoconstriction with no change in the location of EPP, or from progression of the EPP further upstream to a region where loss of airways or reduction in their diameter has rendered the total cross-sectional area considerably smaller than under normal circumstances.

scholarly journals Effects of different sitting postures on forced vital capacity in healthy school children

2019 ◽  
Vol 45 (2) ◽  
pp. 117-121 ◽  
Author(s):  
Mohammad Fazlul Haque ◽  
Shahin Akhter ◽  
Nayeema Tasnim ◽  
Mahmudul Haque ◽  
Sujat Paul ◽  
...  
Keyword(s):  
Lung Function ◽  
School Children ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Mean Value ◽  
Body Posture ◽  
Repeated Measure ◽  
Cross Sectional ◽  
Sitting Posture ◽  
Significant Difference

Background: Lung function varies with the different body posture of normal individuals. Normal healthy school children adopt different body posture which influences their lung function. This cross sectional observational study was done to assess the effects of different sitting postures on lung function like forced vital capacity (FVC) in healthy school children. Methods: This study was conducted in the Department of Physiology, Chittagong Medical college, Chittagong and K S Nazu Miah High school, Khondokia, Younus Nagar, Hathazari, Chittagong during July 2015 to June 2016. A total of 88 subjects of which 42 male and 46 female students aged between 14-16 years studying in class eight to ten were included by purposive sampling method. FVC were recorded by portable digital spirometer (HI-101, Japan). Data were taken in normal upright sitting, kyphotic and at slumped sitting posture. Unpaired and paired t test and repeated measure ANOVA tests were done using SPSS for windows version 20. Results: The mean value of FVC were significantly (p<0.001) changed in different sitting posture. Kyphotic sitting posture showed no significant difference (p>0.05) comparing to normal upright sitting posture. Regarding slumped sitting posture comparing to normal upright showed significant low values (p<0.001). Female subjects showed significant low FVC (p<0.001) comparing to male subjects. Conclusion: The results of this study suggest that the lung function like FVC is significantly decreased in slumped sitting posture. Bangladesh Med Res Counc Bull 2019; 45: 117-121

No effect of artificial gravity on lung function with exercise training during head-down bed rest

2015 ◽  
pp. 1-7
Author(s):  
Longxiang Su ◽  
Yinghua Guo ◽  
Yajuan Wang ◽  
Delong Wang ◽  
Changting Liu
Keyword(s):  
Lung Function ◽  
Pulse Rate ◽  
Vital Capacity ◽  
Pulmonary Ventilation ◽  
Bed Rest ◽  
Forced Expiratory Volume ◽  
Observation Time ◽  
Artificial Gravity ◽  
Postural Changes ◽  
Expiratory Flow

AbstractTo explore the effectiveness of microgravity simulated by head-down bed rest (HDBR) and artificial gravity (AG) with exercise on lung function. Twenty-four volunteers were randomly divided into control and exercise countermeasure (CM) groups for 96 h of 6° HDBR. Comparisons of pulse rate, pulse oxygen saturation (SpO2) and lung function were made between these two groups at 0, 24, 48, 72, 96 h. Compared with the sitting position, inspiratory capacity and respiratory reserve volume were significantly higher than before HDBR (0° position) (P&lt; 0.05). Vital capacity, expiratory reserve volume, forced vital capacity, forced expiratory volume in 1 s, forced inspiratory vital capacity, forced inspiratory volume in 1 s, forced expiratory flow at 25, 50 and 75%, maximal mid-expiratory flow and peak expiratory flow were all significantly lower than those before HDBR (P&lt; 0.05). Neither control nor CM groups showed significant differences in the pulse rate, SpO2, pulmonary volume and pulmonary ventilation function over the HDBR observation time. Postural changes can lead to variation in lung volume and ventilation function, but a HDBR model induced no changes in pulmonary function and therefore should not be used to study AG CMs.

scholarly journals Does Ramadan Fasting Affect Spirometric Data of Healthy Adolescents?

2019 ◽  
Vol 13 ◽  
pp. 117955651986228
Author(s):  
Selma Ben Fraj ◽  
Amira Miladi ◽  
Fatma Guezguez ◽  
Mohamed Ben Rejeb ◽  
Jihène Bouguila ◽  
...  
Keyword(s):  
Experimental Study ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Healthy Male ◽  
Ramadan Fasting ◽  
Male Adolescents ◽  
Significant Difference ◽  
Quasi Experimental ◽  
Expiratory Flow ◽  
Healthy Males

Purpose: Several studies raised the effects of Ramadan fasting on healthy adults spirometric data, but none was performed in children. The aim of this study was to compare the spirometric data of a group of faster adolescents (n = 26) with an age-matched non-faster one (n = 10). Methods: This comparative quasi-experimental study, including 36 healthy males aged 12 to 15 years, was conducted during the summer 2015 (Ramadan: June 18 to July 16). Three sessions (Before-Ramadan [Before-R], Mid-Ramadan [Mid-R], After-Ramadan [After-R]) were selected for spirometry measurements. Spirometry was performed around 5.5 to 3.5 h before sunset and the spirometric data were expressed as percentages of local spirometric norms. Results: The two groups of fasters and non-fasters had similar ages and weights (13.35 ± 0.79 vs 12.96 ± 0.45 years, 46.8 ± 9.2 vs 41.7 ± 12.6 kg, respectively). There was no effect of Ramadan fasting on forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, peak expiratory flow, and maximal mid-expiratory flow. For example, during the Before-R, Mid-R, and After-R sessions, there was no significant difference between the fasters and non-fasters mean FVC (101 ± 11 vs 99 ± 14, 101 ± 12 vs 102 ± 14, 103 ± 11 vs 104 ± 13, respectively) or FEV1 (101 ± 13 vs 96 ± 16, 98 ± 11 vs 97 ± 16, 101 ± 10 vs 98 ± 16, respectively). Conclusions: Ramadan fasting had no interaction effect with the spirometric data of Tunisian healthy male adolescents.

scholarly journals The Role of Pressure and Duration of Dive on Lung Physiology in Professional and Non-Professional Divers

2020 ◽  
Vol 40 (2) ◽  
pp. 103-112
Author(s):  
Jerry Indra Setiawan ◽  
Suradi Suradi ◽  
Yusup Subagio Sutanto
Keyword(s):  
Vital Capacity ◽  
Cross Sectional Study ◽  
Professional Group ◽  
Sectional Study ◽  
Test Statistic ◽  
Cross Sectional ◽  
Lung Physiology ◽  
Significant Difference ◽  
Normally Distributed

Backgrounds: Professional divers have a greater lung volume than non-professional divers in higher force vital capacity (FVC) and force expiratory flow in 1 second (FEV1) values. The purpose of this study is to analyse the effect of pressure and duration of diving on changes in lung physiology in professional divers and non-professional divers. Methods: This is a cross sectional study on the personnel of the Indonesian Navy Dislambair Koarmada II Surabaya and RSAL personnel of dr. Ramelan Navy Hospital in Lakesla Surabaya in March-April 2019. Samples was collected with purposive sampling. This study used unpaired subjects with the independent t-test statistic analysis if the data is normally distributed and the Mann-Whitney U test if the data is not normally distributed Results: There was a significant difference in the professional divers group compared to non-professional divers group in the values of FVC (P=0.042) and FEV1 (P=0.040) at 1.3 ATA for 10 minutes and the FEV1 (P=0.049) for 20 minutes. No significant differences in FVC (P=0.092) at 1.3 ATA pressure for 20 minutes. There were no significant differences in FVC (P=0.865), FEV1 (P=0.659) at 1.5 ATA pressure for 10 minutes and FVC (P=0.858) and FEV1 (P=0.857) for 20 minutes. Conclusions: The different pressure in non-professional group could reduce the FEV1 value. There was a difference in the FVC value of the professional diver group and non-professional divers at a pressure of 1.5 ATA for 10 minutes. (J Respir Indo. 2020; 40(2): 103-12)

scholarly journals TO STUDY THE ONSET AND PROGRESSION OF AIRWAY ABNORMALITY IN TERMS OF ALTERATION IN PFT IN ASYMPTOMATIC SMOKERS.

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dr. Hitesh Kumar Solanki ◽  
Dr. Omnath P Yadav ◽  
Dr. Anita J Gojiya
Keyword(s):  
Lung Function ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Group I ◽  
Significant Difference ◽  
History Of ◽  
Young Smokers ◽  
The Mean ◽  
Group Ii

The study was conducted in department of physiology, B J Medical College, Ahmedabad from Mar. 2012 to Feb. 2013. This was a cross-sectional study to evaluate the effect of smoking on lung   function and serum lipids in asymptomatic smokers   and comparable non   smokers. The mean of the various spirometric parameters were calculated of the subjects for both the groups. The mean FVC in group I and group II was 2.60 ± 0.62 L and 4.10 ± 0.64L respectively. The mean FEV1 in group I was 1.91 ± 0.57L and     3.19 ± 0.77L in group II Group I had mean FEF25% - 75% and PEFR of 1.98 ± 0.67L/sec and 4.50 ± 1.57L/sec respectively. Group II had mean FEF25 – 75% of 4.22 ± 1.23L/sec and a mean PEFR of 7.22 ± 1.42L/sec. In young smokers and asymptomatic, still the spirometric values were significantly deranged as compared to controls. Even smokers with history of less pack years of smoking also had significant abnormalities of lung function. All he spirometric values in the two groups had statistically highly significant difference and were higher in non-smokers as compared to smokers. The spirometric values were reduced in smokers with history of smoking for as low as two pack years. Keywords: Progression, PFT, Asymptomatic & Smokers

scholarly journals Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study

Thorax ◽  
2018 ◽  
Vol 73 (6) ◽  
pp. 538-545 ◽  
Author(s):  
Sandra Ekström ◽  
Jenny Hallberg ◽  
Inger Kull ◽  
Jennifer L P Protudjer ◽  
Per Thunqvist ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lung Function ◽  
Airway Obstruction ◽  
Body Mass ◽  
Overweight And Obesity ◽  
School Age Children ◽  
Childhood And Adolescence ◽  
Small Airways ◽  
Cross Sectional ◽  
The Impact

BackgroundFew large prospective studies have investigated the impact of body mass index (BMI) on lung function during childhood.MethodsUsing data collected between 2002 and 2013, we analysed associations between BMI status and lung function (assessed by spirometry) from 8 to 16 years, as well as cross-sectional associations with small airway function (impulse oscillometry) at 16 years in the BAMSE cohort (n=2889). At 16 years, cross-sectional associations with local and systemic inflammation were investigated by analysing FENO, blood eosinophils and neutrophils.ResultsOverweight and obesity at 8 years were associated with higher FVC, but lower FEV1/FVC ratio at 8 and 16 years. In boys, but not girls, obesity at 8 years was associated with a further reduction in FEV1/FVC between 8 and 16 years. In cross-sectional analyses, overweight and obesity were associated with higher frequency dependence of resistance (R5–20) and larger area under the reactance curve (AX0.5) at 16 years. Increased blood neutrophil counts were seen in overweight and obese girls, but not in boys. No association was found between BMI status and FENO. Persistent, but not transient, overweight/obesity between 8 and 16 years was associated with higher R5–20 and AX0.5 and lower FEV1/FVC (−2.8% (95% CI −4.1 to −1.2) in girls and −2.7% (95% CI −4.4 to −1.1) in boys) at 16 years, compared with persistent normal weight.ConclusionIn childhood and adolescence, overweight and obesity, particularly persistent overweight, were associated with evidence of airway obstruction, including the small airways.

scholarly journals Impact of chronic khat (Catha edulis Forsk) chewing on pulmonary function test and oxygen saturation in humans: A comparative study

2019 ◽  
Vol 7 ◽  
pp. 205031211882461 ◽  
Author(s):  
Gashaw Garedew Woldeamanuel ◽  
Teshome Gensa Geta
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Oxygen Saturation ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Mean Values ◽  
Khat Chewing ◽  
Significant Difference ◽  
The Mean

Background: Chronic consumption of khat affects many organ systems and leads to various health disturbances in the chewers. Few studies examined the acute effects of khat ingestion on lung function parameters. However, studies which assessed the long-term effects of khat chewing on pulmonary function parameters and oxygen saturation are lacking. Objective: The aim of this study was to assess the impact of chronic Khat chewing on pulmonary function parameters and oxygen saturation among chronic Khat chewers in Wolkite, Ethiopia. Methods: A community-based comparative cross-sectional study was conducted in Wolkite, Ethiopia from 1 June 2018 to 15 August 2018. A total of 324 participants, 162 khat chewers and 162 non-chewers were included in the study. The data were collected through face-to-face interview by trained data collectors. British Medical Research Council respiratory questionnaire was used to assess respiratory symptoms. A spirometer was used to assess various lung function parameters. Moreover, oxygen saturation of hemoglobin was measured using pulse oximeter. Data were entered into CSPro version 6.2 and analyzed using SPSS version 23. Results: This study showed statistically significant (p < 0.05) reduction in the mean values of forced vital capacity, forced expiratory volume in first second and maximum ventilation volume among khat chewers as compared to non-chewers. There was no significant difference in the mean values of other lung function parameters between the two groups. Similarly, there was no significant difference (p = 0.642) in mean oxygen saturation of hemoglobin (SaO2) across the two groups. Conclusion: It is evident from this study that long-term khat consumption is associated with decreased mean forced vital capacity, forced expiratory volume in first second and maximum ventilation volume. Hence, there is a need for further study to strengthen the current findings and to explore the mechanisms of khat chewing effect on lung function parameters.

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