scholarly journals Effect of Intraoperative Propofol-Induced Sedation on the Neurotransmitter Levels (Pilot Study)

2021 ◽  
Vol 17 (6) ◽  
pp. 15-19
Author(s):  
V. O. Churakov ◽  
A. Yu. Zaitsev ◽  
O. V. Dymova ◽  
K. V. Dubrovin ◽  
S. G. Zhukova ◽  
...  
Keyword(s):  
Stress Hormone ◽  
Norepinephrine Level ◽  
Moderate Sedation ◽  
Initial Concentration ◽  
Main Stress ◽  
Blinded Study ◽  
Stabilizing Effect ◽  
Group 2 ◽  
Stage 1 ◽  
Group 1

The aim of the study was to determine the changes in the levels of various neurotransmitters depending on the depth of propofol-induced sedation.Material and methods. Twenty-four patients were included in a prospective, simple blinded study. All patients underwent elective orthopedic intervention with subarachnoid anesthesia and moderate (group 1, n=12) or deep (group 2, n=12) propofol-induced sedation. Peripheral blood sampling for measurement of neurotransmitter levels was performed before regional blockade (Stage 1), 35–40 min after the start of sedation (Stage 2), and 10–15 min after sedation was terminated and consciousness was recovered (Stage 3).Results. Deep propofol-induced sedation resulted in a decrease in norepinephrine level at stages 2 and 3. Under moderate sedation, its level decreased at Stage 2 and returned to baseline after restoration of consciousness. The initial concentration of norepinephrine (Stage 1) was higher in Group 2.Conclusion. Propofol-induced sedation resulted in reduced level of the main stress hormone, which suggests its stabilizing effect on autonomic nervous system.

scholarly journals Comparative analysis of physical development parameters of children with stages 1 to 3 of chronic kidney disease

2017 ◽  
Vol 98 (1) ◽  
pp. 5-9
Author(s):  
T L Nastausheva ◽  
O A Zhdanova ◽  
N S Nastausheva ◽  
L I Stahurlova ◽  
I V Grebennikova
Keyword(s):  
Chronic Kidney Disease ◽  
Comparative Analysis ◽  
Kidney Disease ◽  
Physical Development ◽  
Average Height ◽  
Time Period ◽  
Ckd Stage ◽  
Group 2 ◽  
Stage 1 ◽  
Group 1

Aim. To conduct comparative analysis of height, weight and body mass index in children with stages 1 to 3 of chronic kidney disease (CKD) caused by recurrent urinary tract infection due to congenital anomalies of kidney and urinary tract.Methods. The study was performed on 210 children: 110 patients examined in 2001-2002 (group 1) and 100 children examined in 2011-2012 (group 2). Stage 1 of CKD was observed in 94 (85.4%) children in group 1 and in 93 (93%) in group 2, stage 2 - in 16 (14.6%) and 7 (7%) patients, respectively. From both groups patients matched by sex, age, diagnosis and social status were selected: 20 patients with stage 1, 19 children with stage 2; in addition, 6 children with stage 3 were examined.Results. Nowadays children with CKD stage 1 are taller compared to patients of the beginning of the XXI century (Z-score: -0.14±1.43 and 0.20±0.98 respectively, p=0.01). Significant differences in weight were found in children with stage 1 in 2011-2012 compared to the patients in 2001-2002 (0.18±0.46 and 0.78±1.19 for groups 1 and 2, respectively, р=0.026). A tendency towards decrease of average height in children with stage 3 is observed compared to patients with stage 1, i.e. due to the progression of the disease.Conclusion. The data obtained reflect modern tendencies towards increase of children height and weight. No significant differences were found in physical development parameters of children with stages of chronic kidney disease 1 and 2 examined at the same time period but a tendency towards children’s height decrease from stages 1 to 3 of CKD of non-glomerular etiology was revealed.

Solitaire stents deployment may reduce ischemic events in staged angioplasty for severe carotid stenosis

Vascular ◽  
2020 ◽  
pp. 170853812096530
Author(s):  
Chunmei You ◽  
Xiaomang Zhang ◽  
Yina Wu ◽  
Wenjing Sun ◽  
Jianan Li ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Cerebral Infarction ◽  
Cerebral Hyperperfusion Syndrome ◽  
Hyperperfusion Syndrome ◽  
Cerebral Hyperperfusion ◽  
Group 2 ◽  
Antegrade Flow ◽  
Stage 1 ◽  
Group 1

Objectives Cerebral hyperperfusion syndrome is a fatal complication that can occur after stent angioplasty in patients with severe carotid artery stenosis. Staged angioplasty can prevent cerebral hyperperfusion syndrome. Conventional staged angioplasty consists of small balloon angioplasty in the first stage and carotid artery stenting in the second stage two to four weeks later. Sometimes, antegrade flow during stage 1 could hardly be maintained and stent will be needed. Solitaire stents were used in some patients in our center. This study aimed to examine the safety and effectiveness of Solitaire stents in staged angioplasty. Methods A retrospective analysis was performed on patients with severe carotid artery stenosis and preoperative computed tomography perfusion indicating risk of cerebral hyperperfusion syndrome from 2011 to 2018. Small balloon angioplasty (<3 mm in diameter) only was performed in stage 1 (group 1). If antegrade flow during stage 1 is compromised, then a solitaire stent is deployed (group 2). After two to four weeks, cerebral angiography was undertaken in both groups to determine whether to perform stage 2. If the residual stenosis was more than 50%, carotid artery stenting was deployed. Angiographic results, clinical results, and follow-up results were collected and analyzed. Results Twenty-five patients were included in the study (group 1, n = 19; group 2, n = 6). After stage 1, no patient in group 2 and two patients in group 1 developed new symptomatic cerebral infarction (0.0% vs. 10.5%, p =  1.000). One patient in group 2 and three patients in group 1 (16.7% vs. 15.8%, p =  1.000) developed symptomatic cerebral hyperperfusion syndrome. One patient in group 2 ( n = 4) and three patients in group 1 ( n = 12) (25% vs. 25%, p =  1.000) developed hyperperfusion phenomenon. Two patients in group 2 and five patients in group 1 (33.3% vs. 26.3%, p =  1.000) developed symptomatic cerebral hyperperfusion syndrome or hyperperfusion phenomenon. One patient in group 1 developed symptomatic cerebral hyperperfusion syndrome and hyperperfusion phenomenon. After stage 2, no new cerebral infarction occurred in both groups. No patient in group 2 ( n = 3) and one patient in group 1 ( n = 17) developed symptomatic cerebral hyperperfusion syndrome (0.0% vs. 5.9%, p =  1.000). In the combined analysis of both stages, two patients (10.5%) developed new symptomatic cerebral infarction and four patients (21.1%) developed symptomatic cerebral hyperperfusion syndrome in group 1, no patient (0.0%) developed symptomatic cerebral infarction and one patient (16.7%) developed symptomatic cerebral hyperperfusion syndrome in group 2. There was no significant difference in symptomatic cerebral infarction and symptomatic cerebral hyperperfusion syndrome between the two groups ( p = 1.000; p = 1.000). Three patients in group 2 and 17 patients in group 1 (50% vs. 89.5%, p =  0.070) underwent stage 2 angioplasty. No cerebral hemorrhage or cerebral infarction occurred in the Solitaire group during the one-year follow-up period. Conclusions Solitaire stents deployment may reduce ischemic events in staged angioplasty for severe carotid stenosis.

scholarly journals Sustained Attention and Types of Dynamics of Cardiovascular Reactivity during a Short-Term, Human Whole-Body Exposure to Cold Air

2020 ◽  
Vol 10 (4) ◽  
pp. 407-411
Author(s):  
Olga Krivonogova ◽  
Elena Krivonogova ◽  
Liliya Poskotinova
Keyword(s):  
Processing Speed ◽  
The Body ◽  
Whole Body ◽  
Short Term ◽  
Cold Air ◽  
Group I ◽  
Baseline Values ◽  
Group 2 ◽  
Stage 1 ◽  
Group 1

Background: Despite global warming and the improvement of personal protective equipment against unfavorable climatic factors, cold remains an important environmental challenge for humans. The aim of the work was to reveal the peculiarities of the dynamics of cardiovascular parameters in humans with short-term, whole-body exposure to cold air, depending on the parameters of voluntary attention. Methods and Results: The study involved 28 healthy male volunteers aged between18 and 21 years, born and living in Arkhangelsk. Testing to assess sustained attention parameters using the Toulouse-Pierón Attention Test with the measurement of the index of accuracy (C, units) (the ability to voluntary concentration) and processing speed (V, units), had been previously performed. Subsequent stages of the study included recording the studied parameters before (Stage 1), during 10-minute exposure to the cold air (Stage 2), and 5 minutes after cold exposure (Stage 3). The registration of indicators in Stages 1 and 3 was carried out indoors at an air temperature of +20 °C. The registration of indicators in Stage 2 was carried out in a cold chamber at -20 °C. Determining the body temperature in the ear canal (Tear, °C) and on the skin of the dorsum of the right hand (Tskin, °C) was performed using a B.Well WF-1000 medical electronic infrared thermometer. Parameters of blood pressure (SBP and DBP) and heart rate variability (HRV) were evaluated. As a result of cluster analysis, 2 groups were identified: Group 1 (n=14) and Group 2 (n=14). In Group 2, the index V was significantly lower than in Group 1(P=0.02). In Group I, Tskin in Stage 1 was significantly higher than in Group 2 (P=0.03). In Stage 2, Tskin decreased in both groups, but lower Tskin values (P=0.001) were recorded in Group 2 than in Group I. In Stage 2, there was a statistically significant increase in SBP in Group 2 (P=0.01). In Group 1, initial SDNN and all HRV spectral indices were significantly higher than in Group 2. In Stage 2, there was a significant increase in SDNN in both groups. However, in Group 2, we found a statistically significant increase in VLF in Stage 2 (P=0.01), while in Group I this indicator remained unchanged. In Stage 3, HRV parameters in Group 1 recovered to baseline values, while in Group 2, HRV parameters remained elevated relative to baseline values. Conclusion: Individuals with high processing speed and preserved attention span have higher vagal activity and skin temperature. When such individuals are exposed to cold, they experience a moderate increase in BP and baroreflex response. In persons with a reduced speed of information processing but with sufficient accuracy of attention, there is a more pronounced mobilization of regulation resources on the part of the cardiovascular, neurovegetative systems to maintain the core temperature of the body.

scholarly journals Matrix metalloproteinase-8 and osteoprotegerin in saliva of children with chronic kidney disease

2021 ◽  
pp. 62-68
Author(s):  
Н.С. Морозова ◽  
Н.Б. Захарова ◽  
Д.Ю. Лакомова ◽  
Л.Д. Мальцева ◽  
О.Л. Морозова
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Transplantation ◽  
Kidney Disease ◽  
Comparison Group ◽  
Group 3 ◽  
Group 2 ◽  
One Year ◽  
End Stage ◽  
Stage 1 ◽  
Group 1

Изменения минерального гомеостаза являются причиной костных нарушений зубочелюстной системы (ЗЧС) при хронической болезни почек (ХБП) у детей и могут развиваться задолго до появления клинических проявлений уремической токсинемии на 2-й стадии ХБП. В последние годы большое внимание уделяется неинвазивным методам диагностики патологии полости рта у детей. Наиболее известными индикаторами нарушения костного метаболизма считают матриксную металлопротеиназу 8 (ММР-8) и остеопротогерин (OPG). Цель исследования - установить закономерности изменения содержания ММР-8 и OPG в слюне детей с различной тяжестью ХБП. Объект и методы. Проведено исследование содержания ММР-8 и OPG в слюне у 76 детей, которые были разделены на равные группы по 19 человек: 1 группа - дети с ХБП 1-2 степени, получающие медикаментозное лечение; 2 группа - дети с терминальной стадией ХБП, получающие заместительную почечную терапию в объёме гемодиализа; 3 группа - дети через год после перенесённой трансплантации почки; 4 группа (группа сравнения) - дети с малой хирургической патологией, не имеющие патологии почек. Сбор слюны осуществлялся абсорбционным методом до медикаментозной коррекции основного заболевания утром до приема пищи. Исследование ММР-8 и OPG проводили методом твердофазного иммуноферментного анализа. Результаты. Установлено, что содержание ММР-8 и OPG в слюне у детей с различной степенью ХБП было значительно выше по отношению к группе сравнения. Максимальные значения ММР-8 регистрировались во 2-й группе у детей с терминальной ХБП, находящихся на гемодиализе. Повышение содержания OPG в слюне отмечалось в 1 группе детей с ХБП 1-2-й степени и 3-й группе пациентов, через год после перенесённой трансплантации почки. Заключение. Полученные результаты показывают возможность использования слюны в качестве биологической жидкости для диагностики доклинических этапов нарушения костного метаболизма у детей с ХБП, а ММР-8 и OPG в слюне могут рассматриваться в качестве предиктивных и прогностических маркеров. Changes in mineral homeostasis cause bone disorders of the dentition in children with chronic kidney disease (CKD) and may develop long before the onset of clinical manifestations of uremic toxemia in stage 2 CKD. In recent years, much attention has been paid to noninvasive methods for diagnosing oral pathology in children. The most common indicators of metabolic bone disorders are matrix metalloproteinase-8 (MMP-8) and osteoprotogerin (OPG). The aim of the study was to establish the patterns of changes in salivary concentrations of MMP-8 and OPG in children with various severity of CKD. Subject and methods. Salivary levels of MMP-8 and OPG were studied in 76 children divided into four equal groups: group 1, children with stage 1-2 CKD receiving a drug treatment; group 2, children with end-stage CKD receiving renal replacement therapy with hemodialysis; group 3, children one year after the kidney transplantation; and group 4 (comparison group), children with a minor surgical pathology without a kidney pathology. Saliva samples were collected by the absorption method before administration of drugs for the underlying disease, one hour before the morning meal. Salivary concentrations of MMP-8 and OPG were measured by enzyme-linked immunosorbent assay. Results. Salivary levels of MMP-8 and OPG were significantly higher in children with various severity of CKD than in the comparison group. The highest values of MMP-8 were observed in group 2 children with end-stage CKD on hemodialysis. Increased salivary OPG was noted in group 1 children with stage 1-2 CKD and in group 3 patients one year after the kidney transplantation. Conclusion. Saliva can be used as a biological fluid for diagnosis of preclinical stages of bone metabolism disorders in children with CKD, and salivary MMP-8 and OPG can be considered as predictive and prognostic markers.

Plasma Citrulline as a Biomarker for Early Diagnosis of Necrotizing Enterocolitis in Preterm Infants

2020 ◽  
Author(s):  
Nilima Jawale ◽  
Mallory Prideaux ◽  
Malavika Prasad ◽  
Malki Miller ◽  
Shantanu Rastogi
Keyword(s):  
Necrotizing Enterocolitis ◽  
Clinical Characteristics ◽  
Signs And Symptoms ◽  
Plasma Citrulline ◽  
Key Points ◽  
Group 3 ◽  
Group 2 ◽  
A Prospective Study ◽  
Stage 1 ◽  
Group 1

Objective Citrulline synthesized by healthy enterocytes and decreases with injury. This work aimed to study plasma citrulline concentrations (CITs) as a biomarker to differentiate among infants presenting with early nonspecific signs and symptoms of necrotizing enterocolitis (NEC) with those who will develop NEC. Further to study the correlation between posttreatment CIT with time to full feeds (TTFF) and length of stay (LOS). Study Design This is a prospective study which included infants < 32 weeks gestational age (GA) with 9 infants each in Group 1 (stage 2/3 NEC), Group 2 (with stage 1 NEC-like presentation), and Group 3 (healthy GA-matched infants). CIT was measured in Groups 1 and 2 within 24 hours of presentation and again in Group 1 after treatment. Results The three groups were similar in clinical characteristics. Median CIT (µmol/L) in Group 1 (15.4 [interquartile range, IQR: 7.3–18.0]) was lower than Group 2 (22.2 [IQR: 18.3–27.3], p = 0.02) and Group 3 (24.9 [IQR: 19.8–31.9], p = 0.009). Posttreatment CIT in Group 1 did not correlate with TTFF (r = 0.15; p = 0.69) and LOS (r =  − 0.33; p = 0.38). Conclusion CIT was lower in infants with NEC as compared with healthy controls and those infants with nonspecific signs of NEC. CIT after treatment does not correlate with TTFF and LOS. Key Points

scholarly journals The Effect of Resveratrol on Surgery-Induced Epidural Fibrosis in Laminectomy Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Peifeng Sun ◽  
Bo Miao ◽  
Hongmei Xin ◽  
Jinzhu Zhao ◽  
Guofeng Xia ◽  
...  
Keyword(s):  
Treatment Group ◽  
Inflammatory Factors ◽  
Epidural Fibrosis ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Blinded Study ◽  
Group 3 ◽  
Group 2 ◽  
Double Blinded ◽  
Group 1

Epidural fibrosis (EF) is a common complication for the patients who underwent laminectomy. Recently, EF is thought to cause recurrent postoperative pain after laminectomy. Resveratrol has been shown to exert its anti-inflammatory, antifibrotic, and antiproliferative multifaceted properties. The object of this study was to investigate the effects of resveratrol on the prevention of postlaminectomy EF formation in laminectomy rats. A controlled double-blinded study was performed on 60 healthy adult Sprague-Dawley rats that underwent lumbar laminectomy at the L1-L2 levels. They were divided randomly into 3 groups (1, 2, and 3) of 20 rats each—group 1: resveratrol treatment group; group 2: resveratrol dilution saline treatment group; group 3: sham group (rats underwent laminectomy without treatment). All rats were killed 4 weeks after operation. The Rydell score, hydroxyproline content, vimentin cells density, fibroblasts density, and inflammatory factors expressional levels all suggested better results in resveratrol group than the other two groups. Resveratrol is able to inhibit fibroblasts proliferation, and TGF-β1 and IL-6 expressions and prevent epidural fibrosis in postlaminectomy rat.

scholarly journals A prospective, randomized controlled, double-blinded study comparing dexmedetomidine and clonidine as an adjuvant to ropivacaine in femoral nerve block for postoperative analgesia in patients undergoing total knee arthroplasty

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Aathira Suresh ◽  
Gajanan Fultambkar ◽  
B. Vijayanand ◽  
Abhijit Nair
Keyword(s):  
Patient Satisfaction ◽  
Femoral Nerve Block ◽  
Femoral Nerve ◽  
Randomized Controlled ◽  
Pain Scores ◽  
Blinded Study ◽  
Total Knee ◽  
Group 2 ◽  
Double Blinded ◽  
Group 1

Abstract Background Total knee arthroplasty (TKA) causes significant postoperative pain, imposing a limitation on postoperative mobilization crucial in regaining joint function. Ultrasound (US)-guided femoral nerve block (FNB) in complex knee surgeries is associated with better pain scores and fewer hospital admissions. Alpha-2 (α2) adrenoreceptor agonists have been the recent focus of interest as additives to local anesthetic. We aimed to compare the equivalent dose of dexmedetomidine and clonidine as an adjuvant to ropivacaine in US-guided FNB in TKA. A prospective, randomized, controlled, double-blinded study was conducted involving 80 American Society of Anesthesiologists’ physical status (ASA-PS) I, II, and III patients scheduled to undergo TKA under subarachnoid block. Group 1 (n = 40) patients received 1 μg/kg dexmedetomidine and group 2 (n = 40) patients with 1 μg/kg clonidine as adjuvants added to 20 ml of 0.75% ropivacaine. Duration of postoperative analgesia, pain scores, sedation scores, hemodynamics, rescue analgesia requirement, complications, and patient satisfaction were compared. Results The total duration of analgesia in group 1 was better compared to group 2 (p < 0.001). The patients were better sedated and the mean NRS scores were significantly lower (p < 0.05) in group 1 up to 24 h postoperatively. Total analgesic consumption was reduced in group 1, with a p value < 0.001. Patient satisfaction was significantly better (p < 0.001) in group 1 compared to group 2. Conclusion We conclude that dexmedetomidine added as an adjuvant in FNB increased the duration of analgesia when compared to clonidine with decreased NRS scores, reduced postoperative tramadol requirement, and better sedation and patient satisfaction. Trial registration Researchregistry6709, “Retrospectively registered” on 31 March 2021.

scholarly journals Hypertension and its correlation with renal lesions in dogs with leishmaniosis

2015 ◽  
Vol 24 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Eveline Tozzi Braga ◽  
João Henrique Artero de Carvalho Leite ◽  
Fernando Azadinho Rosa ◽  
Patrícia Tivelli ◽  
Amanda Mariano Araújo ◽  
...  
Keyword(s):  
Renal Damage ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
Renal Lesions ◽  
Arterial Blood ◽  
Glomerular Lesions ◽  
The Mean ◽  
Group 2 ◽  
Stage 1 ◽  
Group 1

To evaluate the prevalence of hypertension and its correlation with the severity of renal injury and proteinuria in dogs with leishmaniosis, sixty-six dogs were divided into two groups. Group 1 (G1) was composed of 54 dogs included in stage 1 of chronic kidney disease (CKD), and group 2 (G2) of twelve dogs in stages 2 and 3 of CKD. Prevalence of hypertension was 28.8%, comprising 22.2% of the dogs from G1 and 58.3% from G2 (P=0.011). The mean arterial blood pressure (BP) of dogs from G1 (135.7 ± 20.5) was lower than from G2 (170.0 ± 26.3) (P <0.001). Urine protein-creatinine ratio (UP/C) revealed values above 0.5 in 75.7% of the dogs, with 34% presenting hypertension. All dogs with hypertension had histopathological and laboratory evidence of glomerular disease. Although there was no statistically significant correlation between elevated BP and the severity of glomerular lesions (P=0.408), there was a statistically significant correlation between elevated BP and increased UP/C in the studied population (P=0.002). Thus, dogs with leishmaniosis and renal disease must be screened for the presence of hypertension so that treatment may be instituted as early as possible, in countries where treatment is allowed, to prevent the progression of renal damage.

Abstract 2601: Staged Left Ventricular Recruitment in Patients with Hypoplastic Left Heart Disease and Borderline Left Ventricle

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Sitaram M Emani ◽  
Wayne Tworetzky ◽  
Doff B McElhinney ◽  
Brian Schroeder ◽  
David Zurakowski ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Multivariable Analysis ◽  
Left Ventricular ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Entire Cohort ◽  
Z Scores ◽  
Group 2 ◽  
Stage 1 ◽  
Group 1

Although hypoplastic left heart (LH) disease occurs as a spectrum, the initial management in neonates with hypoplastic LH syndrome and a borderline left ventricle (LV) is dichotomous: single ventricle palliation (SVP) or biventricular (BiV) repair. Once SVP is pursued, rarely are attempts made to salvage the LH or achieve subsequent BiV conversion. Staged LV recruitment may be achieved in selected patients following SVP by a surgical strategy consisting of relief of inflow and outflow tract obstructions, resection of endocardial fibroelastosis (EFE), and promotion of flow through the LV. All patients with hypoplastic LH and borderline LV (LV end diastolic volume [LVEDV] z scores between −5 and −0.5) who underwent stage 1 procedure between 1995 and 2007 were retrospectively analyzed. Patients with ventricular septal defects and valvular atresia were excluded. Those who underwent LV recruitment (Group 1, n=27) were compared to those who did not (Group 2, n=30). LV recruitment consisted of one or more procedures for EFE resection (27/27), mitral (MV) valvuloplasty (16/27), aortic (AoV) valvulo-plasty (21/27), atrial septal defect restriction (13/27), and augmentation of pulmonary blood flow (12/27). Predictors of increase in LVEDV were determined by multivariable analysis. Mean initial z scores for LVEDV, AoV, and MV for the entire cohort were −2.8 ± 1.2, −2.9 ± 1.0, and −2.0 ± 1.3 respectively, with no significant differences between groups. Stage 1 mortality was 2/27 in Group 1 and 2/30 in Group 2. LVEDV, AoV, and MV z scores increased significantly over time in Group 1, whereas they declined in Group 2 (slope of LVEDV z score regression = 0.76/yr vs. −0.06/yr, P <0.001), with restriction of the atrial septum at any stage being the strongest independent predictor of increase in LVEDV ( P <0.001). To date, BiV conversion has been achieved in 5/27 Group 1 patients and none in Group 2 ( P =0.015). In patients with borderline LH disease who undergo a stage I procedure during the neonatal period, it is possible to increase LH dimensions using a strategy of AoV and MV valvuloplasty, EFE resection, and modulation of LV filling. In a subset of patients, this strategy has allowed establishment of biventricular circulation.

scholarly journals Radiologic Evaluation of Compressive Osseointegration for the Fixation of Reconstruction Prostheses after Tumor Resection

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Manol Lazarov ◽  
Thomas De Bo ◽  
Bart Poffyn ◽  
Gwen Sys
Keyword(s):  
Initial Rate ◽  
Tumor Resection ◽  
Metal Interface ◽  
Future Studies ◽  
Radiologic Evaluation ◽  
Radiological Changes ◽  
Group 2 ◽  
Compressive Osseointegration ◽  
Stage 1 ◽  
Group 1

Objective. In pursuance of thoroughly understanding and facilitating the evaluation of the radiological changes in the preloaded bone by Compliant Pre-Stress osseointegration (Compress Biomet, Warsaw, Indiana) a new staging method was created depicting four stages.Methods. Two cohorts (10 and 17 patients resp., not-receiving and receiving chemotherapy) were compared in terms of progression of osseointegration. Based on the changes at the bone-metal interface seen on röntgenorgrams four stages were defined: stage 0: immediate postoperative status, no ingrowth, or noncalcified callus; stage 1: early mineralization, calcified callus; stage 2: mature mineralization; and stage 3: hypertrophy at the level of the pins.Results. There were no significant differences between the two cohorts. Group 2, which was significantly younger than group 1 (p<0.001), presented a delayed initial rate of bone formation and reached stage 1 at 6 months instead of 3 months like group 1. The children from the group 2 demonstrated a visible rebound ingrowth.Conclusion. Despite the fact that the staging fails to demonstrate a statistical difference, it is rather simple and can be used for future studies.

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