scholarly journals Utilización de tallos femorales largos cementados en revisiones de cadera.

10.15417/74 ◽  
2012 ◽  
Vol 77 (2) ◽  
pp. 104 ◽  
Author(s):  
German Garabano ◽  
Fernando Lopreite ◽  
Diego Mana Pastrian ◽  
Javier Dal Lago ◽  
Hernan Del Sel
Keyword(s):  
Bone Graft ◽  
Treatment Options ◽  
Poor Quality ◽  
Reconstruction Technique ◽  
Femoral Stems ◽  
Long Stem ◽  
Distal Fixation ◽  
To Receive ◽  
Made In

<p><strong>Resumen</strong></p><p><strong>Introducción:</strong> existen diferentes opciones de tratamiento para realizar una revisión (RRTC) de un reemplazo total de cadera (RTC) fallido. El uso de tallos femorales largos cementados asociados a la utilización de injerto óseo molido representa una de estas modalidades para los RTC con mala calidad y pérdida de capital óseo. El objetivo de este trabajo fue evaluar una serie de pacientes tratados mediante esta modalidad.</p><p><strong>Materiales y Método:</strong> Analizamos retrospectivamente una serie de 33 RRTC, con un seguimiento promedio de 4 años. Las causas de la revisión fueron en 28 casos aflojamientos mecánicos, en 3 fracturas peri-protésicas y en 2 fallas de osteosíntesis. En todos los casos se utilizaron tallos largos cementados y en 30 (90%) casos se utilizo injerto óseo molido.</p><p><strong>Resultados:</strong> en cuanto al comportamiento de los tallos el hundimiento promedio fue de 4mm. Se observo osteintegración del injerto en 27 (90%) de los 30 casos, hubieron 3 fallas radiológicas donde los tallos se hundieron en 2 oportunidades 8mm y en el restante 12mm. Además hubieron 2 falsas vías (6%), 2 luxaciones (6%) y 2 pseudoartrosis de trocánter mayor (6%)</p><p><strong>Conclusión:</strong> la utilización de tallos largos femorales y cementados, asociados a injerto óseo molido e impactado, en los casos donde el fémur distal no es adecuado para recibir un tallo de fijación distal impresiona ser una técnica adecuada de reconstrucción para RRTC con déficit de capital óseo. Debe ser realizado en centros de referencia por manos experimentadas ya que es una técnica no exenta de complicaciones.</p><p><strong>Palabras claves</strong>: Tallos femorales largos cementados, injerto óseo molido, Ling, defecto óseo.</p><p><strong>Abstract </strong></p><p><strong>Introduction:</strong> currently, there are different treatment options to perform a revision of a failed total hip arthroplasty (RTHA). The use of cemented long femoral stems associated with the use of morcelled bone graft is one of these modalities for the RTC with poor quality and loss of bone capital.</p><p><strong>Methods:</strong> we analyze retrospectively 33 RTHA, with an average follow-up of 4 years. The causes of the review were in 28 cases mechanical losing, 3 peri-prosthetic fractures and 2 failures of osteosynthesis. Long stems cups and 30 were used in all cases (90%) cases I use ground bone graft.</p><p><strong>Results:</strong> with regard to the behaviour of the stems the average sinking was 4 mm. See the graft integration in 27(90%) of the 30 cases, had 3 radiological failures where the stems were sunk in two opportunities 8 mm and the remaining 12 mm. In addition there were 2 false tracks (6%), 2 dislocations (6%) and 2 pseudoarthrosis of major trochanter (6%)</p><p><strong>Conclusion:</strong> the use of cemented long femoral stems associated with impacted bone graft in cases where the distal femur is not suitable to receive a uncemented stem of distal fixation impresses be a proper reconstruction technique for RTHA with bone capital deficit. It must be made in centers of reference by experienced hands that it is not free of complications.</p><p><strong>Key words:</strong> RTHA, impacted bone graft, bone loss, cemented long stem, Ling, uncemented long stem.</p>

scholarly journals Side effects of the metacognitive training for depression compared to a cognitive remediation training in patients with depression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mona Dietrichkeit ◽  
Marion Hagemann-Goebel ◽  
Yvonne Nestoriuc ◽  
Steffen Moritz ◽  
Lena Jelinek
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Statistical Power ◽  
Controlled Trial ◽  
Treatment Options ◽  
Cognitive Remediation ◽  
Negative Effects ◽  
Metacognitive Training ◽  
To Receive

AbstractAlthough awareness of side effects over the course of psychotherapy is growing, side effects are still not always reported. The purpose of the present study was to examine side effects in a randomized controlled trial comparing Metacognitive Training for Depression (D-MCT) and a cognitive remediation training in patients with depression. 84 patients were randomized to receive either D-MCT or cognitive remediation training (MyBrainTraining) for 8 weeks. Side effects were assessed after the completion of each intervention (post) using the Short Inventory of the Assessment of Negative Effects (SIAN) and again 6 months later (follow-up) using the Negative Effects Questionnaire (NEQ). D-MCT and MyBrainTraining did not differ significantly in the number of side effects. At post assessment, 50% of the D-MCT group and 59% of the MyBrainTraining group reported at least one side effect in the SIAN. The most frequently reported side effect was disappointment in subjective benefit of study treatment. At follow-up, 52% reported at least one side effect related to MyBrainTraining, while 34% reported at least one side effect related to the D-MCT in the NEQ. The most frequently reported side effects fell into the categories of “symptoms” and “quality”. Our NEQ version was missing one item due to a technical error. Also, allegiance effects should be considered. The sample size resulted in low statistical power. The relatively tolerable number of side effects suggests D-MCT and MyBrainTraining are safe and well-received treatment options for people with depression. Future studies should also measure negative effects to corroborate our results.

Migration pattern of a short uncemented stem with or without collar: a randomised RSA-study with 2 years follow-up

2019 ◽  
pp. 112070001988847
Author(s):  
Erik Weber ◽  
Carl Flivik ◽  
Martin Sundberg ◽  
Gunnar Flivik
Keyword(s):  
Clinical Outcome ◽  
Conventional Radiography ◽  
Migration Pattern ◽  
Bone Stock ◽  
Design Features ◽  
Significant Difference ◽  
Femoral Stems ◽  
Stem Type ◽  
To Receive

Background: There is an increasing interest in shorter, proximally loading, uncemented femoral stems. The aim of this study was to evaluate a new short stem type, its design based on a well-proven precursor, but with several new design features to facilitate easier insertion and possible preservation of proximal bone stock. It is available with or without a collar. Methods: The study includes 50 patients with primary osteoarthritis, mean age 59 (range 36–75) years, randomised to receive either the collar-fitted or the collarless stem. The patients underwent repeated radiostereometry (RSA) examinations (0, 0.5, 3, 12, 24 months), conventional radiography and filled out both hip-specific (HOOS) and general health (EQ-5D) questionnaires. Results: There was no statistically significant difference between the collared and collarless stems regarding migration and clinical outcome. Both stem types exhibit a similar pattern of initial subsidence (collared 0.63 mm vs. collarless 0.75 mm [ p = 0.50]) and retroversion (collared 0.71° vs. collarless 0.97° [ p = 0.36]) up to 3 months followed by stabilisation, in similarity with its precursors, suggesting good osseointegration. No stem has been revised or considered loose. Conclusions: The new design features, including shortening the stem, do not compromise migration pattern or osseointegration, regardless collar or not.

Pemetrexed (P) in relapsed small cell lung cancer (SCLC): Preliminary results of a phase II trial

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 7716-7716 ◽  
Author(s):  
R. N. Raju ◽  
M. A. Neubauer ◽  
D. A. Smith ◽  
D. A. Richards ◽  
L. Asmar ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Treatment Options ◽  
Single Agent ◽  
Primary Outcome Measure ◽  
Stopping Rule ◽  
Stage Design ◽  
Extensive Stage ◽  
Dose Levels ◽  
To Receive

7716 Background: Pts with relapsed SCLC have a poor prognosis and few effective treatment options. P is a novel multitargeted antifolate that is active and well-tolerated as a single agent in lung cancer. We undertook a trial to assess the efficacy and safety of single- agent P in both chemosensitive (S) and chemorefractory (R) relapsed SCLC pts. Methods: Eligible pts had limited or extensive- stage SCLC, PS 0 to 2, and only 1 prior chemo regimen. S pts were defined as having had a prior response with disease progression >2 mos from end of 1st-line chemo. R pts were those who progressed while on 1st-line therapy, or had any response but progression <2 mos from end of 1st-line chemo. The initial P dose tested was 500 mg/m2 q 21 d. Planned sample sizes were 36 S pts in a 2-stage sequential fashion with potential early stopping for lack of efficacy or unacceptable toxicity, and 25 R pts in a single-stage design with no stopping rule. The stopping rule was invoked when <3 of 14 qualified S pts responded. The protocol was then amended to evaluate P at 900 mg/m2 in additional cohorts of 40 S and 40 R pts. Pts were to receive folic acid and Vitamin B12 prior to treatment with P. The primary outcome measure was response rate. Results: From 7/04 to 3/06, 121 pts were enrolled, with 116 pts treated. S and R pts were analyzed separately at both dose levels. S pts (n=56): M/F, 29/27; median age 65 (range 43–82); PS 0/1/2, 25/23/8. R pts (n=65): M/F, 31/34; median age 64 (range, 35–85); PS 0/1/2, 16/37/12. *3 S pts treated with P 900 mg/m2 remain with disease control after a minimum of 11 mos of follow-up. Conclusions: Preliminary clinical benefit rates (CR+PR+SD) of 20% and 17.4% achieved respectively in S and R pts treated with P 500 mg/m2 suggest modest activity of single-agent P in relapsed SCLC. P can be given at a dose of 900 mg/m2 without a significant increase in Grades 3–4 toxicities, although this does not appear to increase efficacy. [Table: see text] [Table: see text]

scholarly journals Microneedling in Combination with Topical Pimecrolimus 1% versus Topical Pimecrolimus 1% for the Treatment of Refractory Stable Vitiligo: A Randomized Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Fariba Iraji ◽  
Ali Asilian ◽  
Zahra Talebzadeh ◽  
Mina Saber ◽  
Fatemeh Mokhtari ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Treatment Options ◽  
Skin Irritation ◽  
Skin Lesions ◽  
The Other ◽  
Improvement Rate ◽  
Separate Treatment ◽  
Hospital Patients ◽  
To Receive

Objective. Vitiligo is a common, autoimmune disease that results in the destruction of the melanocytes and manifests as depigmented macules on various areas of the skin. Numerous treatment options have been proposed for vitiligo. The purpose of this study was to compare the efficacy of microneedling plus topical pimecrolimus 1% versus the sole use of topical pimecrolimus 1% for the treatment of vitiligo. Methods. This clinical trial was conducted on 30 skin lesions on 15 Al-Zahra hospital patients. Each patient had two similar lesions in the limb area, and each lesion was considered a separate treatment group. The left or right side of the patient’s lesion was randomly assigned to receive microneedling plus topical pimecrolimus for three months, while the other side received only topical pimecrolimus 1%. As part of the follow-up, digital photography was taken at the baseline and biweekly for three months after treatment and six months’ follow-up. The following methods were used to evaluate the results: DLQI questionnaires, patient satisfaction questionnaires, and two independent dermatologists comparing the improvement rate for each group. Results. Topical pimecrolimus 1% treatment led to unsatisfactory results, whereas the combination of microneedling and topical pimecrolimus1% treatment produced a more favorable overall outcome ( P < 0.001 ). Conclusion. This study established that combination therapy results in more significant patient improvement. Additionally, one patient experienced mild skin irritation as a side effect of topical pimecrolimus.

An Overview of Dementias

2012 ◽  
Vol 21 (3) ◽  
pp. 75-84
Author(s):  
Venkata Vijaya K. Dalai ◽  
Jason E. Childress ◽  
Paul E Schulz
Keyword(s):  
Clinical Presentation ◽  
Treatment Options ◽  
Current Treatment ◽  
Great Variability ◽  
Health Concern ◽  
Public Health Concern ◽  
Life Threatening ◽  
The Common ◽  
Neurodegenerative Dementias ◽  
Made In

Dementia is a major public health concern that afflicts an estimated 24.3 million people worldwide. Great strides are being made in order to better diagnose, prevent, and treat these disorders. Dementia is associated with multiple complications, some of which can be life-threatening, such as dysphagia. There is great variability between dementias in terms of when dysphagia and other swallowing disorders occur. In order to prepare the reader for the other articles in this publication discussing swallowing issues in depth, the authors of this article will provide a brief overview of the prevalence, risk factors, pathogenesis, clinical presentation, diagnosis, current treatment options, and implications for eating for the common forms of neurodegenerative dementias.

A Pilot Study of Mobile Telephone Message Interventions with Suicide Attempters in China

Crisis ◽  
2010 ◽  
Vol 31 (2) ◽  
pp. 109-112 ◽  
Author(s):  
Hui Chen ◽  
Brian L. Mishara ◽  
Xiao Xian Liu
Keyword(s):  
Pilot Study ◽  
Effective Means ◽  
Text Message ◽  
Text Messages ◽  
Mobile Telephone ◽  
Future Research ◽  
Quick Method ◽  
Suicide Attempters ◽  
To Receive

Background: In China, where follow-up with hospitalized attempters is generally lacking, there is a great need for inexpensive and effective means of maintaining contact and decreasing recidivism. Aims: Our objective was to test whether mobile telephone message contacts after discharge would be feasible and acceptable to suicide attempters in China. Methods: Fifteen participants were recruited from suicide attempters seen in the Emergency Department in Wuhan, China, to participate in a pilot study to receive mobile telephone messages after discharge. All participants have access to a mobile telephone, and there is no charge for the user to receive text messages. Results: Most participants (12) considered the text message contacts an acceptable and useful form of help and would like to continue to receive them for a longer period of time. Conclusions: This suggests that, as a low-cost and quick method of intervention in areas where more intensive follow-up is not practical or available, telephone messages contacts are accessible, feasible, and acceptable to suicide attempters. We hope that this will inspire future research on regular and long-term message interventions to prevent recidivism in suicide attempters.

Data Management in an Epidemiological Study : Experiences from the Iowa 500 Field Follow-up and Family Study

1980 ◽  
Vol 19 (01) ◽  
pp. 37-41
Author(s):  
R. F. Woolson ◽  
M. T. Tsuang ◽  
L. R. Urban
Keyword(s):  
Data Management ◽  
Epidemiological Study ◽  
Family Study ◽  
Data Sets ◽  
Data Handling ◽  
Management Decisions ◽  
Numerous Data ◽  
Made In

We are now conducting a forty-year follow-up and family study of 200 schizophrenics, 325 manic-depressives and 160 surgical controls. This study began in 1973 and has continued to the present date. Numerous data handling and data management decisions were made in the course of collecting the data for the project. In this report some of the practical difficulties in the data handling and computer management of such large and bulky data sets are enumerated.

Lesson Study dan Implikasinya Terhadap Pembelajaran Berbasis Kurikulum Tingkat Satuan Pendidikan

2016 ◽  
Vol 1 ◽  
pp. 189-196
Author(s):  
Vian Harsution
Keyword(s):  
Learning Environment ◽  
Learning Process ◽  
Lesson Study ◽  
Learning Difficulties ◽  
Learning Needs ◽  
Democratic Leadership ◽  
Entrepreneurial Spirit ◽  
To Receive

Lesson study is a systematic, collaborative, and sustainable method of improving the quality of learning. Lesson study emphasizes the exploration of students’ learning needs; teacher openness towards learning difficulties encountered; the willingness of teachers to receive and provide advice and solutions to the difficulties encountered; and the consistency of the various parties to follow up the suggestions and solutions. Implementation of lesson study involving teachers, principals, and experts in the field of education. Kurikulum tingkat satuan pendidikan or abbreviated KTSP is operational curriculum formulated and implemented by each educational unit. KTSP has the characteristics, namely: giving broad autonomy to the educational unit, involving the community and parent participation, involving the democratic leadership of the principal, and require the support of a working team that is synergistic and transparent. KTSP based on the learning process, needs to be supported by a conducive learning environment and fun to be created by teachers.Teachers and principals in a professional, systematic and collaborative create an atmosphere that fosters independence, tenacity, entrepreneurial spirit, adaptive and proactive nature of the learning process. Thus, the learning needs of students who fulfilled optimally and professional ability of teacher who have increased on an ongoing basis, may usher in success – based learning KTSP. It means that the lesson study provides positive implications for the KTSP – based learning.

Antiretroviral Treatment-Associated Labia Majora Lipohypertrophy: A Rare Case and Plastic Surgical Treatment Options

2017 ◽  
Vol 2 (1) ◽  
pp. 43
Author(s):  
Akmal Hisham ◽  
Devananthan Ilenghoven ◽  
Wan Syazli Wan Ahmad Kamal ◽  
Salina Ibrahim ◽  
Shah Jumaat Mohd Yussof
Keyword(s):  
Highly Active Antiretroviral Therapy ◽  
Daily Living ◽  
Treatment Options ◽  
Hiv Positive ◽  
Highly Active ◽  
Labia Majora ◽  
The Face ◽  
Central Fat

The emergence of highly active antiretroviral therapy (HAART) has revolutionized the prognosis of HIV-infected patients. However, the extended use of HAART is associated with a disfiguring complication termed lipodystrophy, a disorder of body fat maldistribution causing peripheral fat loss (lipoatrophy) and central fat accumulation (lipohypertrophy). Lipoatrophy commonly affects the face, legs, buttocks and arm, whilst lipohypertrophy frequently favours the abdomen, breast and dorsocervical region. To our knowledge, we present only the second documented case in the literature of a labia majora lipohypertrophy in a HIV-positive patient receiving long-term HAART. The severity of labial abnormality caused significant physical and functional morbidities. Labiaplasty with dermolipectomy of the labia majora and excisional lipectomy of the mons pubis was successfully performed. At a 6-month follow-up, patient had no recurrence with resolution of symptoms and resumption of normal activities of daily living (ADL).

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