Allergy in Childhood

PEDIATRICS ◽  
1956 ◽  
Vol 18 (4) ◽  
pp. 687-687
Author(s):  
WILLIAM C. DEAMER

Most pediatricians will find this book, written by one with many years of experience in allergy, to be of helpful and practical aid in the management of allergic children. It gives, in great detail, information on the diagnosis and practical management of the most common allergic disorders: asthma, eczema and contact dermatitis, allergic rhinitis, and pollinosis. Practically all of the other proven or suspected manifestations of allergy are also commented upon in one or another of its 67 chapters.

2018 ◽  
Vol 36 (3) ◽  
pp. 139-145 ◽  
Author(s):  
Daniela Adam ◽  
Linus Grabenhenrich ◽  
Miriam Ortiz ◽  
Sylvia Binting ◽  
Thomas Reinhold ◽  
...  

Background Seasonal allergic rhinitis (SAR) is a common disease that has detrimental effects on the quality of life (QoL) of affected individuals. Approximately 18% of patients try to alleviate their symptoms through acupuncture. The ACUSAR (ACUpuncture in Seasonal Allergic Rhinitis) study (ClinicalTrials.gov registration no. NCT00610584) assessed the impact of acupuncture on SAR, showing significant improvements in rhinitis-specific QoL (RQoL) and in rescue medication (RM) use. Objective A secondary analysis of SAR patients’ use of antihistamine. Methods Patients were randomised into three study groups: acupuncture plus RM, sham acupuncture plus RM, and RM alone. The patients documented their medication use before and during the intervention period (8 weeks). The main outcome was the number of days with antihistamine use. Statistical analyses were conducted using parametric and non-parametric tests. The robustness of the results was tested by sensitivity analyses using non-parametric bootstrapping. Results The data from 414 patients were analysed. The acupuncture group used antihistamines significantly less often compared with the other groups (acupuncture vs sham acupuncture: mean difference −4.49 days, p=0.01; acupuncture vs RM: mean difference −9.15 days, p<0.001). Approximately 38% of the acupuncture group did not use any antihistamine in contrast to only 16% in the RM group. The pre-post comparison suggested that the acupuncture patients did not need to increase the days of antihistamine use to alleviate their symptoms, unlike the other groups. Conclusions Acupuncture appeared to significantly reduce the number of days of antihistamine use while improving RQoL and SAR symptoms; it can therefore be considered a valuable, additional treatment option for patients with SAR. Trial Registration Number NCT00610584; Post-results.


2019 ◽  
Vol 40 (3) ◽  
pp. 138-145 ◽  
Author(s):  
M. Asghar Pasha ◽  
Gargi Patel ◽  
Russell Hopp ◽  
Qi Yang

Background: Over the past decade, there has been increasing interest and research into understanding the type 2 immune responses by the epithelium-derived cytokines interleukin (IL) 33, IL-25, and thymic stromal lymphopoietin. Innate lymphoid cells (ILC) are a unique family of effector immune cells that functionally resemble T cells but lack clonal distributed antigen receptors. Group 2 ILCs, ILC2s, are known for their capability to secrete proallergic cytokines, including IL-5 and IL-13. ILC2s are enriched at mucosal barriers in lung, gut, and skin, and their activation has been associated with a variety of allergic disorders. Objective: To study the role of ILC2 in different allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Methods: A MEDLINE search was performed for articles that reported on ILC2 in allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Results: A review of the literature revealed an important role of ILC2 in various allergic disorders. Conclusion: Identification of ILC2s in patients with allergic rhinitis, asthma, and atopic dermatitis indicates that these cells may represent a new therapeutic target. In this review, we discussed the current understanding of ILC2 biology and its function and regulation in various allergic diseases.


2021 ◽  
Vol 16 (5) ◽  
pp. 2100-2114
Author(s):  
Abdallatif Khalaf Sliman Al-Ramamneh

This study aimed to assess the distance-education services provided to students with learning difficulties during the Coronavirus pandemic. To achieve the objectives of the study, the researcher built two scales to assess distance education services that are offered to students with learning difficulties; one is from the teachers’ viewpoint and the other is from the parent's perspective. The findings showed that the degree of assessment of distance education services for students with learning difficulties during the Corona pandemic was moderate at the overall level among teachers and low among parents. There were no statistically significant differences in the teachers’ responses attributed to the variables: gender, academic qualification, and years of experience. Moeover, there were no statistically significant differences in parents’ responses attributed to the variables: the child's gender, the educational qualification of the parents and the child's age.    Keywords: Corona pandemic, students with learning disabilities, distance education.


2021 ◽  
Vol 8 (1) ◽  
pp. 01-02
Author(s):  
Hilary Solomons

There is ample evidence that allergic disorders such as asthma, rhinitis and atopic dermatitis are mediated by oxidative stress. Excessive exposure to reactive oxygen and nitrogen species is the hallmark of oxidative stress and leads to damage of proteins, lipids and DNA. Oxidative stress occurs not only as a result of inflammation but also from environmental exposure to air pollution and cigarette smoke.


2016 ◽  
Vol 4 (4) ◽  
pp. 619-623 ◽  
Author(s):  
Daniel Zamanfar ◽  
Javad Ghaffari ◽  
Salar Behzadnia ◽  
Jamshid Yazdani-charati ◽  
Sahar Tavakoli

BACKGROUND: Eczema, allergic rhinitis and asthma are common chronic allergic disorders in childhood.AIM: The aim of this study was to determine the prevalence of common allergic disorders among Iranian guidance schools students in Mazandaran Province, northern Iran.METHODS: This analytical cross-sectional study was performed on 3000 children aged 11‐14 years old during 2012‐13 according to ISAAC study. Of 3000 recruited children 1576 (52.54%) were female and 1424 (47.46%) were male. Data gathered by ISAAC first phase questionnaire analysed by SPSS software 20.RESULTS: The prevalence of wheezing, allergic rhinitis symptoms (sneezing and pruritus) and atopic dermatitis symptoms (pruritus skin lesion) were 30.5%, 30% and 15% respectively. History of pets contact and smoking was positive 6.6% and 36 % respectively. About 52% was born with caesarian section. There was wheezing in 32.5% during sport. The diagnosis of asthma, allergic rhinitis and eczema were 12.2%, 28.5% and 15% respectively. Eczema, asthma and allergic rhinitis were significantly more common in boys students (p < 0.05).CONCLUSIONS: The results of this study showed that asthma, allergic rhinitis and eczema have a high prevalence and they are more common in boys.


2016 ◽  
Vol 4 (1) ◽  
pp. 215
Author(s):  
Dillip Kumar Dash ◽  
Mrutunjaya Dash ◽  
Bibhudatta Dash ◽  
Mamata Devi Mohanty ◽  
Swarup Kumar Bisoi

Background: Asthma is an increasing global health burden, especially in the western world but now a day not uncommon in developing countries like India. With rapid changes in diet being one of the hallmarks of westernization, nutrition may play a key role in affecting the complex genetics and developmental pathophysiology of asthma. People consume a combination of foods from various groups that form a dietary pattern. Studying the role of dietary patterns in asthma is an important emerging area of research. The aim of this study was to review dietary patterns and asthma outcomes in children, also to maternal diet and child asthma. With all the studies that have been undertaken, some clearly state the protective effects/adverse effects of certain foods, while others deepen the dilemma. The objective of this study was to establish association between dietary habits and Asthma (and allergic disorders) in children.Methods: A questionnaire obtained from the International study for Asthma and Allergy in Children questionnaire was used to evaluate the dietary habits and disease status of the 834 children attending to pediatrics OPD/IPD for varying disease condition of eastern Odisha region over a period of 2 years. Children aged 4 to14 years with diagnosis of asthma were eligible for the study. The clinical criteria for diagnosis of asthma were based on the recommendations of the British Thoracic Society Guidelines, October 2014. The diagnosis of asthma was made if all the following criteria were met: (i) recurrent episodes (>3) of one or more of the following symptoms - wheeze, cough, breathing difficulties and chest tightness, particularly at night or in the early hours of the morning; (ii) respiratory symptoms improve spontaneously or after treatment (bronchodilators with or without corticosteroids); (iii) presence of triggers or aggravating factors such as exposure to allergens or irritants, physical exercise, weather changes or emotional stress; and (iv) personal history of atopy (allergic rhinitis or eczema) and/or family history of atopy (asthma, allergic rhinitis or eczema) in first-degree relatives. The children/ parental had to fill the questionnaire under teachers’ guidance.Results: Present study reveals asthma and allergic disorders were more prevalent in those consuming a lacto ovo vegetarian diet. Other significant association was seen with Junk food {significantly correlated (OR: 1.643, P   <0.005)}, positive family history (P < 0.005) and as well as with obesity (P < 0.005).Conclusions: Although it is common belief that vegetarians are less affected by asthma and other allergic disorder which is backed up by numerous previous studies which reveals a vegetarian diet to be protective against asthma. But our study shows a different picture. The school of thought that considers vegetarian diet tobe protective may lay its basis on the high antioxidant levels in the blood, which according to a new hypothesis, on the contrary may be related to increased risk of allergies too.  


Children ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. 24 ◽  
Author(s):  
Helen T. Wang ◽  
Sara Anvari ◽  
Katherine Anagnostou

The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has been an increased interest in the role of probiotics for the prevention and treatment of allergic disorders, given the recent evidence that atopy risk may be associated with a dysbiosis of the gut microbiome. Research in this area is ongoing with some studies showing possible benefits of probiotics, with seemingly little to no risk. While these studies suggest that there may be a promise in probiotic use for the prevention or treatment of allergy, further evidence is needed to determine its efficacy, optimal dosing, and strains needed for treatment. In this review, we discuss recently published studies examining the benefits, risks, and role of probiotics in preventing atopic dermatitis, asthma, allergic rhinitis, and food allergy.


Author(s):  
Pengsheng Fan ◽  
Mengjie Sun ◽  
Di Qin ◽  
Yuan Congshan ◽  
Xiguang Chen ◽  
...  

Allergy, IgE-mediated inflammatory disorders involving allergic rhinitis, asthma, conjunctivitis, etc., affects billions of people worldwide. Conventional means of allergy managements include allergen avoidance, pharmacotherapy, emerging therapies, etc. Among them, chemotherapeutant...


2020 ◽  
pp. 014556132092633
Author(s):  
Ayse E. Göker ◽  
Maide H. Alagöz ◽  
Tolgar L. Kumral ◽  
Semih Karaketir ◽  
Ayça B. Yilmazer ◽  
...  

Background: We evaluated the efficacy of medical treatment on thiol–disulfide balance despite ongoing allergic stimulation. Methods: The research design was a prospective observational study that included 35 persistent allergic rhinitis (AR) patients. All patients who were diagnosed with persistent AR were included. A skin prick test was applied to all patients, and the Sino-nasal Outcome Test-22 was used to evaluate sinonasal symptoms. Thiol/disulfide homeostasis balance parameters were measured using a novel automatic and spectrophotometric method and compared statistically. Serum total thiol (TT), native thiol (SH), disulphide (SS), disulphide/native thiol (SS/SH), disulphide/total thiol (SS/TT), and native thiol/total thiol (SH/TT) ratios were measured after the second month of the treatment. Results: The 35 patients included 20 (58%) females and 15 (42%) males. The mean age of the patients was 33.17 ± 9.9 years. Disulphide, SS/SH, and SS/TT ratios decreased significantly after the treatment ( P < .05), while SH and SH/TT increased significantly ( P < .05). The mean SH measurement increased significantly in the second month ( P = .001), but TT mean measurements showed no difference after the treatment ( P = .058). The mean SS measurements, on the other hand, decreased significantly in the second month ( P = .003). Conclusion: Thiol/disulfide homeostasis may be used as a marker to evaluate the efficacy of persistent AR treatments. After the treatment, the increase in SH levels suggested the decrease in oxidative stress, even though allergen exposure continued.


1992 ◽  
Vol 44 ◽  
pp. 401-496
Author(s):  
D. Paul ◽  
R. B. Simler

We both started working in Spain at the end of 1991: one of us in a joint venture life company between a Spanish health insurer and a U.K. life office, and the other in an international actuarial consultancy.At the time of writing this paper we can only claim in the region of “4 man years” of experience of Spain. Therefore we do not pretend to offer an authoritative view of Spanish insurance or pensions, or of its actuarial profession. Clearly such a text would be better prepared by Spanish actuaries, or other long-standing practitioners of the Spanish market.


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