FURTHER OBSERVATIONS ON THE CORRECTED BROMIDE SPACE OF THE NEONATE AND INVESTIGATION OF WATER AND ELECTROLYTE STATUS IN INFANTS BORN OF DIABETIC MOTHERS

PEDIATRICS ◽  
1961 ◽  
Vol 28 (6) ◽  
pp. 861-869
Author(s):  
Donald B. Cheek ◽  
T. G. Maddison ◽  
M. Malinek ◽  
J. H. Coldbeck

The present study extends previous observation on the extracellular volume and total body chloride of infants in the neonatal period. It is shown that the decrease in the corrected bromide space is most rapid in postnatal life during the first 2 weeks when 40 ml/kg are lost. By the end of the second week, body weight approaches birth weight. Hence by that time there is a gain of 40 gm/kg, and mainly of protein and cell water. Growth processes are in full progress. The values obtained by other workers for the chloride space of muscle in premature, full-term and 6-month-old infants do not vary considerably from the corrected bromide space for the whole body at these age periods. Nine infants born around the thirty-sixth week of gestation, and of diabetic mothers, were investigated concerning composition and distribution of water and electrolytes, mainly on the third day of postnatal life. It was found that total water was reduced on a weight basis by 37 ml/kg, and this reduction can be explained on the basis of increased body fat, as demonstrated by other workers. The corrected bromide space (on the basis of weight, not age) was reduced by 50 ml/kg of weight, and it was considered that part of this reduction was not due to body fat increase. As much as 40 ml of water/kg of lean body weight probably shifts from the extracellular to the intracellular phase. There is a reduction of extracellular sodium and chloride in infants born of diabetic mothers. This finding was supported by muscle analysis of one infant who died of the respiratory distress syndrome. No change was found in the plasma osmotic pressure or in the concentrations of sodium and chlorides in plasma. The urea content of plasma was elevated, due perhaps to the reduction in extracellular volume.

1963 ◽  
Vol 41 (1) ◽  
pp. 2225-2235
Author(s):  
A. DesMarais ◽  
P. A. Lachance

The well known reduction in growth rate of cold-acclimated rats has been shown to depend on a decreased gain in total body fat, without change in the gain in lean body weight. This has been observed in rats fed Lab Chow or a high-fat diet ad libitum. In those groups fed a high-carbohydrate diet ad libitum or calorie-restricted high-fat or high-carbohydrate diets, exposure to cold had no effect on the gain in neither total body weight nor lean body weight, which were already reduced by the diet; in those animals, the significant decrease in the gain in total body fat upon exposure to cold was compensated by a slight but unsignificant increase in the gain in lean body weight, so that differences in gain in total body weight were not significant.


1975 ◽  
Vol 48 (5) ◽  
pp. 431-440 ◽  
Author(s):  
C. J. Edmonds ◽  
B. M. Jasani ◽  
T. Smith

1. Total body potassium was estimated by 40K measurement with a high-sensitivity whole-body counter in normal individuals over a wide age range and in patients who were obese or were grossly wasted as a result of various conditions which restricted food intake. 2. Potassium concentration (mmol/kg body weight) fell with increasing age over 30 years in both normal males and females, but when individuals of different age groups were matched for height, a significant fall in total body potassium with increasing age was observed only in males. Total body potassium of females was about 75% that of males of similar height when young, the sex difference decreasing with ageing. In the normal population, total body potassium was significantly correlated with height and with weight; regression equations for various relationships are given. 3. Fat-free mass was estimated from total body potassium, values of 65 and 56 mmol of potassium/kg fat-free mass being used for males and females respectively. Body fat estimated by this method correlated well with skinfold measurements over a wide range of body weight but in malnourished individuals having inadequate food intake there was considerable discrepancy and present formulae for estimating fat-free mass from total body potassium appear unsatisfactory in malnutrition. Considerable differences between expected and observed values of total body potassium were found in muscular individuals and in normal individuals who were thin but whose body weight was relatively constant. 4. The patients with malnutrition were low both in body fat as estimated by skinfold thickness and in total body potassium estimated on the basis of height. Plasma potassium was, however, normal and potassium supplements did not increase the total body potassium. 5. Total body potassium of obese individuals was not significantly different from that of normal weight individuals on the basis of height. Total body potassium fell on weight reduction with a very low energy diet of 1260 kJ (300 kcal.) daily but changed little with a 3300 kJ (800 kcal.) diet over several months' observation. 6. For overweight, obese individuals, total body potassium was best predicted from the individual's height. For those whose body weight was less than expected, the use of weight gave the best prediction but the error was considerable when the weight deviation was large.


2017 ◽  
Vol 11 (2) ◽  
pp. 15-27
Author(s):  
Tomáš Hadžega ◽  
Václav Bunc

The aim of our observation was to measure selected anthropometric characteristics and to analyze actual body composition in children of younger school age from elementary schools in Prague. The group consisted of a total of 222 probands, boys (n-117) and girls (n-105) aged 8–11 years (average boys age = 9.0 ± 1.0 years, body height = 139.9 ± 8.6 cm, body weight = 32 ± 7.5 kg, BMI = 16.3 ± 2.4 kg.m–2). Average age girls = 8.9 ± 0.9 years, body height = 137.3 ± 8.8 cm, body weight = 30.5 ± 7.3 kg, BMI = 15.9 ± 2.4 kg.m–2). The BIA 2000 M multi-frequency apparatus (whole-body bioimpedance analysis) was used to analyze the body composition. Children of younger school age showed higher TBW values – total body water (boys 65.5 ± 6.0%, girls 66.6 ± 6.5%), low body fat (boys 16.1 ± 2.4%, girls 16.5 ± 2.9%) and higher ECM/BCM coefficients (boys 1.0 ± 0.13, girls 1.02 ± 0.11). The authors draws, attention to the importance of monitoring other body composition parameters. The percentage of fat-free mass (FFM) and the share of segmental distribution of body fat and muscle mass on individual parts of the human body.


1981 ◽  
Vol 96 (1) ◽  
pp. 213-220 ◽  
Author(s):  
D. A. Little ◽  
R. W. McLean

SUMMARYFollowing the measurement of tritiated water (TOH) spaces, 31 cattle were slaughtered and chemically analysed in this study. They included several breeds, both females and castrate males, and were of varied nutritional history. Their body-fat content ranged from 4 to 21% of fasted live weight.Total body water (including the water in the gut contents) was reliably estimated from TOH space, measured after allowing an overnight 16 h waterless fast for TOH equilibration. Following this regime, residual D.M. in the gut contents amounted to 1·75% of fasted live weight. The relationships of body fat to body weight, and body fat to body water when both were expressed as percentages of body weight, were too variable to be used in any predictive fashion. Equations were derived, using fasted live weight, allowing the accurate estimation in vivo of the quantities of the chemical components in the whole body (i.e. total body minus D.M. in gut contents).It was demonstrated that the sum of total body water and total body fat constituted virtually 80% of total body tissues, and that total body protein closely approximated 80% of the fat-free dry matter, in cattle varying widely in body condition. These relationships constitute the physiological basis of the equations presented.Comparable principles appear to apply to sheep, and a range of other mammalian species.


1963 ◽  
Vol 41 (11) ◽  
pp. 2225-2235
Author(s):  
A. DesMarais ◽  
P. A. Lachance

The well known reduction in growth rate of cold-acclimated rats has been shown to depend on a decreased gain in total body fat, without change in the gain in lean body weight. This has been observed in rats fed Lab Chow or a high-fat diet ad libitum. In those groups fed a high-carbohydrate diet ad libitum or calorie-restricted high-fat or high-carbohydrate diets, exposure to cold had no effect on the gain in neither total body weight nor lean body weight, which were already reduced by the diet; in those animals, the significant decrease in the gain in total body fat upon exposure to cold was compensated by a slight but unsignificant increase in the gain in lean body weight, so that differences in gain in total body weight were not significant.


2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Moreno Zanardo ◽  
Fabio Martino Doniselli ◽  
Anastassia Esseridou ◽  
Massimiliano Agrò ◽  
Nicol Antonina Rita Panarisi ◽  
...  

Abstract Objectives Iodinated contrast media (ICM) could be more appropriately dosed on patient lean body weight (LBW) than on total body weight (TBW). Methods After Ethics Committee approval, trial registration NCT03384979, patients aged ≥ 18 years scheduled for multiphasic abdominal CT were randomised for ICM dose to LBW group (0.63 gI/kg of LBW) or TBW group (0.44 gI/kg of TBW). Abdominal 64-row CT was performed using 120 kVp, 100–200 mAs, rotation time 0.5 s, pitch 1, Iopamidol (370 mgI/mL), and flow rate 3 mL/s. Levene, Mann–Whitney U, and χ2 tests were used. The primary endpoint was liver contrast enhancement (LCE). Results Of 335 enrolled patients, 17 were screening failures; 44 dropped out after randomisation; 274 patients were analysed (133 LBW group, 141 TBW group). The median age of LBW group (66 years) was slightly lower than that of TBW group (70 years). Although the median ICM-injected volume was comparable between groups, its variability was larger in the former (interquartile range 27 mL versus 21 mL, p = 0.01). The same was for unenhanced liver density (IQR 10 versus 7 HU) (p = 0.02). Median LCE was 40 (35–46) HU in the LBW group and 40 (35–44) HU in the TBW group, without significant difference for median (p = 0.41) and variability (p = 0.23). Suboptimal LCE (< 40 HU) was found in 64/133 (48%) patients in the LBW group and 69/141 (49%) in the TBW group, but no examination needed repeating. Conclusions The calculation of the ICM volume to be administered for abdominal CT based on the LBW does not imply a more consistent LCE.


1995 ◽  
Vol 268 (4) ◽  
pp. E546-E550 ◽  
Author(s):  
C. N. Boozer ◽  
G. Schoenbach ◽  
R. L. Atkinson

This study examined the effects of increasing levels of dietary fat fed isocalorically on body weight, body composition, and adipose distribution. Adult male rats were weight matched into four groups. One group that was fed a low-fat diet (12%) served as reference controls. The other three groups were fed diets of 24, 36, or 48% fat in amounts to equal the energy intake of the control group. After 6 wk, body weights of the four groups were not significantly different. Intrascapular brown fat did not differ between groups. Total body fat and adipose depot weights, however, increased in proportion to the level of fat in the diet. Total body fat and retroperitoneal and mesenteric depot weights of the 48% fat group were greater than controls (P < 0.05). Mesenteric fat in this group was also significantly increased over all other groups (P < 0.05). These results show that high-fat diets fed to adult animals cause increased body fat in the absence of significant changes in body weight and that mesenteric fat is increased disproportionately.


2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 95-95
Author(s):  
Tylo J Kirkpatrick ◽  
Kaitlyn Wesley ◽  
Sierra L Pillmore ◽  
Kimberly Cooper ◽  
Travis Tennant ◽  
...  

Abstract This experiment was designed to quantify the empty body composition of Jersey steers administered an aggressive implant strategy. Jersey steers {n = 30; initial body weight (BW) 183 ± 43 kg} were randomly assigned to one of two implant strategies: negative control (CON), or implanted with Revalor 200 (200 mg trenbalone acetate / 20 mg estradiol 17-β; (REV) every 70 d (d 0, d 70, d 140, d 210, d 280, d 350) during a 420 d feeding period. Steers were harvested on d 421; 6 CON and 6 REV steers were randomly selected for collection of blood, hide, ground viscera, bone, and ground lean and fat to determine empty body composition. Proximate analysis was completed for each sample to determine total body percentages of moisture, crude protein, fat, and ash. Data were analyzed via independent t-test. Percentage empty body moisture (46.48% CON vs 49.69% REV) and empty body protein (15.32% CON vs 17.58% REV) were greater (P &lt; 0.01) in REV cattle. In contrast empty body fat (33.51% CON vs 26.93% REV) was greater (P &lt; 0.01) for CON cattle. Empty body ash did not differ (P &gt; 0.10; 4.69% CON vs 5.80% REV) between treatments. Negative control steers contained a total empty body protein to total empty body fat ratio of 0.44:1 compared to 0.62:1 for REV steers. These data suggest that an aggressive implant strategy alters composition of gain during the finishing of Jersey steers toward increased protein and decreased fat.


1978 ◽  
Vol 40 (2) ◽  
pp. 377-386 ◽  
Author(s):  
R. B. Williams ◽  
I. McDonald ◽  
I. Bremner

1. The amounts of copper and zinc in the foetuses of ewes carrying from one to four lambs were measured at different stages of gestation and estimates were made of the amounts of these metals in their livers.2. The accretion of Cu and Zn could be described by growth equations of the Gompertz form, from which could be derived estimates of the instantaneous and fractional rates of deposition of these metals in the foetal body.3. Between the 80th and 144th day of gestation the instantaneous rates of deposition of the metals increased exponentially, and at the end of pregnancy were calculated to be 0.24 and 2.0 mg Cu and Zn/d respectively in the triplet lamb foetus. The corresponding total accretions were estimated to be 10 and 69 mg respectively.4. The fractional rates of live-weight gain and of deposition of Cu were similar and decreased at similar rates; that of Zn deposition decreased much more slowly.5. The proportion of whole-body Cu estimated to be in the liver was always greater than 50 %. The amount of Zn in the liver remained constant and contributed 72 % of the total body Zn at 80 d but only 8 % at 144d.6. The relative amounts of Cu and of Zn accrued per unit body-weight gain were not constant during the development of the foetus. As foetal numbers increased the amounts of each metal deposited in the foetus decreased more rapidly than did foetal weight.7. The results are discussed in relation to the demands for Cu and Zn during pregnancy in sheep.


2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Alaa Sabry ◽  
Amir Basiony ◽  
Mohamed Kamal

Abstract Background and Aims Obesity is a potent risk factor for the development of kidney disease. The prevalence of abdominal obesity in Egyptians based upon the European cut-off points was 30.2% for men and 70.9% for women. To detect the best formula for estimation of glomerular filtration rates in morbidly obese individuals. Method: In this prospective study 82 morbidly obese patients were included, Age: 15 to 65 years, Morbidly obese patient (BMI &gt; 40 Kg/m2), Creatinine clearance calculated from a 24-h urine was done, Estimated glomerular filtration rate (eGFR): It was assessed to be correlated with creatinine clearance and detect the most suitable formula for morbidly obese patients. Cockcroft-Gault formula:  Cockcroft-Gault formula (for total body weight): ockcroft-Gault formula (for adjusted body weight): Cockcroft-Gault formula (for lean body weight), MDRD-eGFR (Modification of Diet in Renal Disease equation) (Shahbaz & Gupta, 2019), CKD-epidemiology (CKD-EPI): (Levey, et al, 2009) Results Demogrphic criteria of the studdied patients Conclusion: The equations that had the nearest values to creatinine clearance were CG-TBW-GFR and CGAjBW- GFR, both of them had a moderate reliability with more agreement for the CG-TBW-GFR equation . The CG-TBW-GFR formula was the most reliable one to measure GFR, followed by the CG-AjBW-GFR formula, while the CG-IBW, CG-LBW, MDRD-GFR and CKD-EPI-GFR formulae were not reliable at all .


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