scholarly journals Kariological indicators of buccal epitelia in newborns under sepsis, which parents have constantly lived in the conditions of various ecological conditions

2020 ◽  
Vol 19 (1) ◽  
pp. 13-19
Author(s):  
O. V. Vlasova
Keyword(s):  
High Risk ◽  
Neonatal Sepsis ◽  
Comparison Group ◽  
Main Group ◽  
The Body ◽  
Low Risk ◽  
Clinical Group ◽  
Average Risk ◽  
Buccal Epithelium ◽  
Group I

The generally accepted and accessible method of cytogenetic assessment of the mutagenic effect of factors of various nature is the micronucleus test. Now this test is one of the non-invasive methods of population survey, which are influenced by environmental pollution. Objective: to establish the characteristics of karyological indicators of buccal epithelium in children of patients with neonatal sepsis, whose parents constantly lived in different environmental conditions. Material and methods. To study this goal, a comprehensive examination of 260 newborns who underwent neonatal sepsis in 2015-2018 was carried out. A suggested feature of a comprehensive assessment of the long-term load on the body of parents of newborns of anthropogenic pollution of air, water and soil in the regions of the region was the proposed environmental risk coefficient (CER) taking into account the environmental situation in the regional centers. So, the first clinical group (the main one) included patients with neonatal sepsis, whose parents constantly lived for months with a CER of 2,0 or more and with an unfavorable ecological characterization of the regional center. The second group (comparisons) was formed by newborns with sepsis, whose parents lived permanently in areas with a low risk of adverse effects of these environmental factors on their bodies (CER<2,0). A micronuclear test of exfoliative buccal epithelium in patients with neonatal sepsis was performed and evaluated in the immunological laboratory of the Department of Pediatrics and Pediatric Infectious Diseases of the Bukovynian State Medical University according to the method of V.N. Kalaev. Results and its discussion. In the main group, children with a high risk of cytogenetic disorders significantly prevailed with a slight decrease in the quota of patients with low risk. So, in group I with a low risk of cytogenetic disorders there were 42,1 % of cases, with an average risk of 5,3 %, and with a high risk of 52,7 % of cases. In the comparison group, respectively, with a low risk of cytogenetic disorders there were 54,5 %, (P>0,05) cases, with an average risk of – 12,1 %, (P>0,05), and with a high risk of – 33,3 %, (P=0,05) cases. Conclusions. As a result of the karyological test of exfoliate buccal epithelium, it can be noted that in newborns of the main group, compared with children of the comparison group, cytogenetic disturbances and, in some cases, violation of cell kinetics in the form of proliferation and apoptosis were significantly more often detected. The accumulation index of cytogenetic disorders was also significantly higher in group I patients due to the predominance of patients with a high risk of cytogenetic disorders in them

scholarly journals CERTAIN PARACLINICAL INDICATORS IN NEWBORN PATIENTS WITH SEPSIS, WHOSE PARENTS HAVE CONSTANTLY LIVED UNDER DIFFERENT ECOLOGICAL CONDITIONS

2019 ◽  
Vol 18 (4) ◽  
pp. 118-125
Author(s):  
O. V. Vlasova
Keyword(s):  
Environmental Factors ◽  
Neonatal Sepsis ◽  
Interleukin 10 ◽  
The Body ◽  
Clinical Group ◽  
Environmental Situation ◽  
Group I ◽  
Anti Inflammatory ◽  
The Impact

Xenobiotics can have various effects on the human body, and especially on the course of fetal development. Numerous researchers point out that the nature of the external environment can negatively affect the course of certain diseases in both children and adults. Neonatal sepsis is one of the most serious diseases in neonatological practice and in our opinion is a completely unexplained topic of the impact of adverse environmental factors on the characteristics of sepsis in newborns, depending on the environmental situation of their parents. The aim of the study was to investigate the features of individual indicators of a pair of clinical trials in children with neonatal sepsis, whose parents lived permanently in different environmental conditions. Material and methods. To study this goal, a comprehensive survey of 260 newborns who in 2015-2018 suffered from neonatal sepsis. The proposed environmental risk factor (ERF) was a group-forming feature of a comprehensive assessment of the long-term load on the body of parents of newborns of anthropogenic pollution of air, water and soil in the regions, taking into account the environmental situation in regional centers. Thus, the first clinical group (main) included patients with neonatal sepsis, whose parents lived permanently in months with ERF 2.0 and more and with unfavorable environmental characteristics of the regional center. The second group (comparison) was formed by newborns with sepsis, whose parents lived permanently in areas with a low risk of adverse effects of these environmental factors on their body (ERF<2.0). Results and discussion. The content in the serum of patients with neonatal sepsis interleukins-6, -8.-10, Creactive protein, presepsin and procalcitonin reflected the activity of the systemic inflammatory response of the body to the infectious agent. It should be noted that patients of clinical group I were more likely to have a high serum content of interleukin-10, which has an anti-inflammatory effect. Thus, the content of this interleukin .35.0 pg / ml in the blood occurred in the newborn of the main group in 23.7 % of cases, and in children of the comparison group – in 18.1 % of cases. Along with a clearer definition of patients with group I high levels of anti-inflammatory interleukin-10, in newborns found a significant decrease in serum concentrations of immunoglobulins of classes A, G, M. Conclusions. The decrease in the level of these serum immunoglobulins is probably due to the immunosuppressive effect of xenobiotics on the fetus, whose mother was in the conditions of long-term action of xenobiotics. This, in turn, reduces the body's resistance of the newborn to infection and contributes to a more severe course of the infectious process. Probably, more severe manifestations of neonatal sepsis in neonates of the I clinical group are partly due to a combination of decreased immunoglobulin synthesis and increased production of interleukin-10.

scholarly journals Assessing the clinical utility of genetic risk scores for targeted cancer screening

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Carly A. Conran ◽  
Zhuqing Shi ◽  
William Kyle Resurreccion ◽  
Rong Na ◽  
Brian T. Helfand ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Primary Care ◽  
High Risk ◽  
Risk Score ◽  
Genetic Risk ◽  
Clinical Utility ◽  
Low Risk ◽  
Risk Scores ◽  
Average Risk ◽  
Genetic Risk Scores

Abstract Background Genome-wide association studies have identified thousands of disease-associated single nucleotide polymorphisms (SNPs). A subset of these SNPs may be additively combined to generate genetic risk scores (GRSs) that confer risk for a specific disease. Although the clinical validity of GRSs to predict risk of specific diseases has been well established, there is still a great need to determine their clinical utility by applying GRSs in primary care for cancer risk assessment and targeted intervention. Methods This clinical study involved 281 primary care patients without a personal history of breast, prostate or colorectal cancer who were 40–70 years old. DNA was obtained from a pre-existing biobank at NorthShore University HealthSystem. GRSs for colorectal cancer and breast or prostate cancer were calculated and shared with participants through their primary care provider. Additional data was gathered using questionnaires as well as electronic medical record information. A t-test or Chi-square test was applied for comparison of demographic and key clinical variables among different groups. Results The median age of the 281 participants was 58 years and the majority were female (66.6%). One hundred one (36.9%) participants received 2 low risk scores, 99 (35.2%) received 1 low risk and 1 average risk score, 37 (13.2%) received 1 low risk and 1 high risk score, 23 (8.2%) received 2 average risk scores, 21 (7.5%) received 1 average risk and 1 high risk score, and no one received 2 high risk scores. Before receiving GRSs, younger patients and women reported significantly more worry about risk of developing cancer. After receiving GRSs, those who received at least one high GRS reported significantly more worry about developing cancer. There were no significant differences found between gender, age, or GRS with regards to participants’ reported optimism about their future health neither before nor after receiving GRS results. Conclusions Genetic risk scores that quantify an individual’s risk of developing breast, prostate and colorectal cancers as compared with a race-defined population average risk have potential clinical utility as a tool for risk stratification and to guide cancer screening in a primary care setting.

PECULIARITY OF ADAPTATION OF BABIES ARE BORN PREMATURELY FROM MOTHERS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

2021 ◽  
Vol 74 (10) ◽  
pp. 2566-2568
Author(s):  
Tunzala V. Ibadova ◽  
Vitalii V. Maliar ◽  
Volodymyr V. Maliar ◽  
Vasyl V. Maliar
Keyword(s):  
Connective Tissue ◽  
Premature Infants ◽  
Distress Syndrome ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Main Group ◽  
Phenotypic Markers ◽  
Group I ◽  
Neonatal Respiratory Distress ◽  
Connective Tissue Dysplasia

The aim: To evaluate the peculiarity of clinical manifestations of neonatal respiratory distress syndrome (NRDS) in deeply premature infants from mothers with phenotypic markers of undifferentiated connective tissue dysplasia (UCTD). Materials and methods: The study represent the results of a retrospective clinical and statistical analysis of 268 premature birth report card and newborn report sheet. .The main (1 group) included 50 pregnants with obvious phenotypic markers of UCTD, the comparison group (group 2) consisted of 50 pregnant women without phenotypic markers of UDCTD. Results: According to the study, in 12 (24%) pregnant women of the main group at the time of admission to the clinic had contractions,which required specific therapy. Cervical cerclage was performed in 38 (76%) patients of the main group due to the presence of cervical insufficiency (CI). In these cases, the severity of the CI on the Steinber scale was 7.2 &#177; 0.4 points in the main group against 4.4 &#177; 0.2 points in the comparison group (p &#60;0.05). Group I patients were more likely to have complications of labor such as:premature rupture of membranes, uterine contraction abnormalities and fetal distress, which required in most cases cesarean delivery (7% and 2%), respectively (p &#60;0.05). The incidence of neonatal complications requiring respiratory support was 67% in group I and 48% in group II. According to our observations, the clinical manifestations of bronchopulmonary dysplasia were twice as high in infants of the main group (66%) against (44%) of the comparison group (p &#60;0.05). Conclusions:1.Neonatal respiratory distress syndrome in premature infants is more often associated from mothers with UDCTD. 2. The high importance of steroid prophylaxis of NRDS and antioxidant therapy in reducing the frequency of mechanical ventilation and the development of bronchopulmonary pathology, especially in infants from mothers with UDCTD syndrome, has been proven. 3. The possibility of diagnosing disorders of functional maturation of the lungs in the fetal period using a non-invasive method of ultrasonography has been confirmed.

Optimization of prevention measures of septic complications in women with high infectious risk

2018 ◽  
pp. 108-113
Author(s):  
Yu.R. Feyta ◽  
◽  
V.I. Pyrohova ◽  
Keyword(s):  
High Risk ◽  
Postpartum Period ◽  
Comparison Group ◽  
Infectious Complications ◽  
Main Group ◽  
Septic Complications ◽  
Effective Prevention ◽  
Vaginal Gel ◽  
Infectious Risk ◽  
Treatment Techniques

Despite the introduction of modern diagnostic technologies, prophylaxis and treatment techniques in obstetrical practice, the incidence of postpartum purulent-septic complications (PPSC) remains rather high and is an important medical and social problem, as they take one of the leading places in the structure of maternal morbidity and mortality. The objective: to improve the management of parturient womenwith a perineal birth injury in anamnesis, as part of an effective prevention of purulent-septic complications of puerperium. Materials and methods. The study included 77parturient women. Main and comparative groups were formed by women with a violation of the integrity of the perineum in the previous labor and with a high risk of developing infectious complications in puerperium. Women of the main group (n = 24) during each vaginal examination in labor (and an additional injection in 15-30 minutes after the rupture of the membranes) and twice a dayat a dose of 5 ml for 5 days postpartum, an antiseptic agent in the form of a vaginal gel, which consists of: 0.02% decamethoxin (antiseptic component), 0.5% hyaluronic acid (regenerating component) and lactate buffer (regulatory component). The comparison group included 27 women, without using vaginal gel in laborand using traditional wound treatment techniques in the postpartum period. The control group consisted of 26 women with uncomplicated somatic status, physiological course of pregnancy and labor. The evaluation of the effectiveness of the prescribed treatment was based on subjective symptoms (pain, discomfort, burning in the region of the perineal sutures), clinical data (swelling, hyperemia, nature of suturing healing), generally accepted indicators in dynamics (bacterioscopy of vaginal contents, pH-metry of the vaginal environment). Results. At the background of the use of three-component vaginal gel in the main group, the level of injury of soft tissues of the birth canal in these deliveries was lower by 19.9% than in the comparison group, prevalence of the 1st degreeperineumruptures, decreased the need for repeated episio- and perineotomy, which reduced the duration stay at hospital and improved postpartum rehabilitation in relation to the comparison group. On the third day of puerperium, hyperemia and edema of the wound area in women of the main group were observed almost three times less compared with the comparison group. On the fifth day of the puerperium in the main group the complaints were insignificant and appeared on the average 5 times less often, the healing was by the primary tension without infectious complications. The use of vaginal gel reduced the number of leukocytes in wound secretions by shortening the time of wound epithelization (1.5 times faster than in the parous from the comparison group). On the fifth day of using vaginal gel, 2/3 of the patients observed normalization of the vaginal microflora, the restoration of pH was observed. The results indicate the benefits of early onset of prophylactic measures and high effectiveness of topical antiseptic therapy in women with high infectious risk. Conclusions.In order to prevent antibiotic resistance tactics of prevention of PPSC in the group of high-risk septic complications provides one of the elements of anintegrated approach to use local antiseptics. Inclusion of the latter into a complex of prophylactic and treatment measures in the management of a high-riskwomen in puerperium contributes to the reduction of traumatic and infectious complications and provides more favorable course of labor and the postpartum period. Key words: labor traumatism, postpartum purulent-septic complications, local antiseptic.

scholarly journals The role of a balanced diet in the metabolism of nutrients

2021 ◽  
Vol 100 (4) ◽  
pp. 333-338
Author(s):  
Zoya I. Zholdakova ◽  
Rofail S. Rakhmanov ◽  
Elena S. Bogomolova ◽  
Rashid Sh. Khayrov ◽  
Ekaterina A. Olyushina
Keyword(s):  
Uric Acid ◽  
Total Cholesterol ◽  
Comparison Group ◽  
Density Lipoprotein ◽  
Food Products ◽  
Main Group ◽  
The Body ◽  
Metabolic Status ◽  
Low Density ◽  
Blood Indices

The purpose of the study was to assess the metabolic status of the body when correcting the diet with a concentrated natural product. Materials and methods. The diet of athletes was analyzed. The leading group (n = 15) received concentrated food products (CNP) for 20 days: No. 1 - 30.0 g and No. 2 - 20 g each. Blood indices including (total protein, uric acid, urea, creatinine, total cholesterol, high and low-density lipoprotein cholesterol, triglycerides, glucose, amylase) were assessed metabolic status: taken before, after, and in one month of taking CNP Results. The diet’s calorie content was 5953.2-6494.4 kcal/day in the main and the comparison group corresponding to this cohort’s physiological need. The proportions of protein and fat exceeded the recommended ones; deficiency of carbohydrates accounted for 8.7%. The inclusion of CNP increased the ratio of slow carbohydrates, vitamins, minerals, and minor food components. In the leading group, the increase in urea and uric acid was less significant in terms of average indices, and the proportion of such people increased. Creatinine was significantly higher than baseline within one month after CNP administration. The increase in the proportion of people with increased total cholesterol is 2.9 times less; the share with a borderline high level decreased by 15.5%, in the comparison group, it increased by 5.6%. The proportion with low-density lipoproteins exceeding the reference value decreased from 61.5% to 30.0% in the comparison group - without dynamics (55.6%) and signs of dyslipidemia increased. In the main group, within the normal range, 76.9% of individuals had an increase in glucose, amylase by 5.7% (p = 0.049). Conclusion. The diet is not macronutrient balanced. The use of CNP affected the metabolism of proteins, fats, and carbohydrates. It proved a more adequate energy supply for the activities of the persons of the main group. There has been shown the possibility of correcting the body’s metabolic processes with food products that reduces the risk of developing prenosological conditions during physical exertion, particularly fatigue and cardiovascular pathology.

scholarly journals Biochemical indices of urine in children with allergic diseases of airways

2020 ◽  
Vol 23 (4) ◽  
pp. 223-228
Author(s):  
Elena V. Tush ◽  
Anna N. Obuhova ◽  
Ivan I. Balabolkin ◽  
Olga V. Haletskaya ◽  
Andrey B. Stroganov ◽  
...  
Keyword(s):  
Comparison Group ◽  
Biochemical Study ◽  
Allergic Diseases ◽  
Main Group ◽  
The Body ◽  
Daily Urine ◽  
Daily Excretion ◽  
Biochemical Indices ◽  
Excretion Of Urates ◽  
Oxalate Metabolism

Currently, unsatisfactory control of the course of allergic diseases of airways (ADA) remains. There is data on the potential involvement of urate and oxalate metabolism in the pathogenesis of ADA, which determines the need to study the corresponding biomarkers. Aim of the work - to evaluate the daily urinary excretion of urates and oxalates in ADA children. Materials and methods. We examined 100 children aged 2 to 9 years, boys - 22, girls - 78, with symptoms of crystalluria. The children were divided into the main group (42 children) and the comparison group (58 people). The main group included patients with established diagnoses of ADA, and the comparison group included patients without ADA. A biochemical study of daily urine was performed in all cases. Results. It was found that the daily excretion of oxalates in ADA patients was significantly increased compared to the control, 26.5 [22.1; 32.6] mg/day and 23.3 [20.1; 27.6] mg/day, respectively. Daily urate excretion in patients of the main group was also significantly increased compared to the control, both in absolute numbers - 1.45 [1.13; 2.13] mmol/day and 1.17 [0.89; 1.5] mmol/day, respectively (p = 0.005), and in normalized to the body surface area units. Conclusion. A statistically significant increase in daily urate excretion was found in ADA children. The clinical and pathogenetic significance of this phenomenon in children with ADA requires further study.

scholarly journals Indicators of humoral immunity of patients with neonatal sepsis under different conditions of environmental pollution of parents' places of residence

2020 ◽  
pp. 66-69
Author(s):  
O.V. Vlasova ◽  
Keyword(s):  
Adverse Effects ◽  
Environmental Pollution ◽  
Humoral Immunity ◽  
Neonatal Sepsis ◽  
The Body ◽  
Group I ◽  
Regional Centers ◽  
Group Ii ◽  
Water And Soil Pollution

The aim is to determine the indicators of humoral immunity of patients with neonatal sepsis under different conditions of environmental pollution of their parents' places of residence. Materials and methods. 260 patients with neonatal sepsis born to parents who lived in different environmental conditions were examined. An environmental risk factor (CER) was proposed as a group-forming feature of a comprehensive assessment of the long+term load of anthropogenic air, water and soil pollution in the regions of the region on the body of parents of newborns, taking into account the environmental situation in regional centers. Results. The level of IgA in the serum of patients with neonatal sepsis in group I was 0.82±0.11 g/l against 1.54±0.23 g/l (p<0.05) in group II, the level of IgG in children I groups — 4.27±0.45 g/l against 6.67±0.77 g/l (p<0.05) of group II. The decrease in IgM content had no significant differences, but there was a tendency to reduce its level in children of group I. Conclusions. The constant residence of parents in areas with a high risk of adverse effects of these environmental factors on their body (ERF<2.0) contributed to a decrease in the level of immunoglobulins A, M, G in the serum of patients with neonatal sepsis, compared with newborns whose parents lived in areas with a low risk of adverse effects (ERF<2.0), and were more likely to have severe neonatal sepsis. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Key words: neonatal sepsis, pollution, immunoglobulins.

scholarly journals CLINICAL COURSE AND CONTROL OF BRONCHIAL ASTHMA INDICATORS IN OVERWEIGHT SCHOOLCHILDREN

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
L.A. Ivanova ◽  
M.N. Haras ◽  
I.B. Horbatiuk ◽  
A.O. Shkilnyuk
Keyword(s):  
Body Weight ◽  
Bronchial Asthma ◽  
The Body ◽  
Excess Body Weight ◽  
Clinical Group ◽  
Overweight Children ◽  
Group I ◽  
Negative Effect ◽  
And Control ◽  
Bodymass Index

The aim of the study - to study the clinical features and indicators for asthma control inoverweight children to optimize treatment strategies.Material and methods. 200 schoolchildren with asthma who were treated in the pulmoallergy department of the Chernivtsi Regional Children's Clinical Hospital have beenexamined. 52 patients with excess body weight (body mass index was greater than 25,0)belonged to group I, and children with body weight corresponding to the age norm (bodymass index from 18,0 to 24,9) were included into clinical group II under observation.Results. It has been found that the average number of points according to the ASTquestionnaire in patients of group I reached 14,0 ± 1,33 points, and in the comparisongroup – 16,3 ± 0,54 points (p˃0,05). At the same time, the share of patients withuncontrolled course of the disease among the overweight children reached 61,5% incomparison to 48,3% in the comparison group (p˃0,05).Indices of the risk of uncontrolled asthma (the sum of AST test scores <16) in childrenwith overweight have shown the following results: odds ratio = 1,6 (95% CI: 0,29-8,59),relative risk = 1,4 95% CI: 1,00-2,08) and attributive risk = 6,8%. Before treatment theindex of AKDNFG - 2,4 dinitrophenylhydrazones (AKDNFG) of the main character in thegroup of excess body weight children was 60,8 mmol /g of protein, and in group of normalbody weight children – 59,6 ± 9 mmol /g of protein. After the course of basic therapy,these indices gave next results – 47,2 ± 4,18 mmol/g of protein in group I and 4,3 ± 0,29mmol /g of protein (p> 0,05) in group II.Conclusions. Bronchial asthma in overweight children is more likely to debut at an earlyage and characterized by a persistent course. Predisposition to the body overweight inpatients with bronchial asthma has a negative effect on the indices of the disease controlachievement, although it is accompanied by an evidence decrease of the inflammatoryprocess of the respiratory tract in the course of treatment.

scholarly journals Modern approaches to treatment of superficial dermal burns

2020 ◽  
pp. 40-41
Author(s):  
O.M. Kovalenko ◽  
A.O. Kovalenko ◽  
O.I. Оsadcha ◽  
O.M. Lynnyk
Keyword(s):  
Comparison Group ◽  
Main Group ◽  
The Body ◽  
Water Soluble ◽  
Wound Dressings ◽  
Wound Management ◽  
Quantitative Composition ◽  
Closed Chamber ◽  
Microbial Association ◽  
Healing Wound

Objective. The aim of the study is improving the treatment’s effectiveness in patients with superficial dermal burns due to the usage of modern wound dressings. Materials and methods. Under observation were 150 patients with superficial dermal thermal lesions with an area of 5-30 % of the body surface aged 10-64 years, who were treated at the Kyiv City Clinical Hospital № 2 during 2016-2019. The main group consisted of 120 patients, whose burn’s treatment provided under wound dressings in a humid environment (hydrogel, spongy polyurethane foam, film coatings). Comparison group – 30 patients whose wounds were treated by applying wet-drying bandages or bandages with water-soluble antibacterial ointments. Results and discussion. At the beginning of the treatment, the pH of the wound content of dermal burns was 7.9-8.1. On the 3rd day of treatment in patients of the main group, the pH of wounds under wound dressings was defined as acidic (5.7). In patients of the comparison group on the 3rd and 4th day the pH of the wounds was determined as alkaline, and only on the 6th day it became slightly acidic. As the pH of the wounds increased, the rate of healing decreased. In the phase of acute inflammation and exudation, the pH of superficial dermal burns was alkaline 7.8-8.2, in the proliferation phase, under the wound coverings – acidic (5.5-4.1). The use of wound dressings led to a decrease in the number of microbial association in patients to 1.1±0.4 on 9-11th days after injury, the colonization of wound surfaces changed slightly to 3×102 per 1 g. In contrast, in patients of the comparison group in the sequestration period of superficial necrotic scab increased the number of microbial associates to 2.8±0.7, wound colonization increased to 105 per 1 g of tissue. The time of epithelialization with the use of wound dressings was 13.8±1.7 days, in patients of another group – 19.4±2.5 days. Conclusions. Wound dressings that keep the wound moist are an effective way to influence the wound process, which can be regulated. In the treatment of superficial dermal burns under wound dressings there is a change of the alkaline reaction to acidy, which stimulates wound healing. Wound management in a wet closed chamber changes the qualitative and quantitative composition of the wound microflora, reduces the microbial contamination of burn wounds by two orders of magnitude. Superficial dermal burns heal under wound dressings for 13.8 days against 19.4 in traditional treatment.

scholarly journals CLINICAL ASSESSMENT OF THE EFFECTIVENESS APPLICATION "BIOCERULIN" IN THE COMPLEX TREATMENT OF THE PATIENTS WITH ONTOGENIC FLAGMONS OF THE MAXILLOFACIAL AREA

2019 ◽  
pp. 29-32
Author(s):  
D.V. Steblovskyi ◽  
V.V. Bondarenko ◽  
O.S. Ivanytska ◽  
V.M. Skrypnyk ◽  
I.O. Ivanytskyi
Keyword(s):  
General Condition ◽  
Inflammatory Process ◽  
New Technologies ◽  
Comparison Group ◽  
Main Group ◽  
The Body ◽  
Steady Increase ◽  
Complex Treatment ◽  
Maxillofacial Region ◽  
Traditional Therapy

Treatment of odontogenic phlegmon of the maxillofacial region remains an urgent problem of surgical dentistry due to the steady increase in their frequency, tendency to generalize the process and adverse effects. In this regard, there is a constant search for ways to improve the effectiveness of treatment of patients with odontogenic phlegmons of maxillofacial region. New technologies of drug treatment of this pathology are developed and put into practice. In recent years the attention of researchers in various conditions accompanied by the development of oxidative stress began to attract drugs that have antioxidant action, as it became known that the excess of reactive oxygen species in the regenerating wounds in the hearth of purulent inflammation affects the course of the course, wound healing. Interest in the treatment of various pathological conditions of the body is caused by the domestic antioxidant multifunctional enzyme "Bioceruline" which is composed of copper. In this regard, the purpose of our study was to evaluate the effectiveness of the use of "Biocerulin" in the complex treatment of patients with odontogenic phlegmon of maxillofacial region. The object of the clinical study was 45 patients with odontogenic phlegmons of the maxillofacial region from 18 to 55 years old, who were treated in the maxillofacial department of PU "Poltava M.V. Sklifosovskyi regional clinical hospital PRC». All patients were without somatic pathology in compensated clinical condition. Immediately after hospitalization, patients underwent an emergency opening of purulent lesion, revision and adequate drainage of the affected cellular spaces, removal of the "causal" tooth. The extent of surgery and the choice of optimal access depended on the location and prevalence of phlegmon. Depending on the treatment, patients were divided into comparison groups (22 patients) and the main group (23 patients). The traditional therapy was used in the comparison group. "Biocerulin"was prescribed for the patients of the main group in addition to the traditional therapy. Analysis of obtained data in the treatment of patients with phlegmon revealed that both groups of patients had clear differences in the clinical course of purulent-inflammatory process. On the 2nd day after the opening of the phlegmon theweakness, headache, and sleep disorders were noted in the most of the patients of the comparison group who received traditional therapy. Pain with varying degrees of intensity was present in all patients. Improvement of the general condition of patients of this group was noted not earlier than 3-5 days after surgery. The improvement of the general condition and reduction of pain, normalization or decrease in body temperature, the beginning of restoration of function of the jaw apparatuswere notedin patients of the main group on the background of the introduction of "Bioceruline" already on the 2-3rd day after surgery. Thus, on the basis of the conducted researches it is possible to conclude that the basic (traditional) conservative therapeutic measures used for patients of the comparison group are not effective enough for the relief of the local and general inflammatory process, which caused the prolonged nature of organ-specific and functional rehabilitation of patients as a whole. The use of "Bioceruline" in complex therapy of patients with odontogenicphlegmons of the maxillofacial regionprovides rapid and intensive recovery of the general condition of patients and accelerates reparative processes in the wound and shortens the treatment time via 1.4 bed-days.

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