scholarly journals BIOMARKERS OF INFLAMMATION AT BRONCHIAL ASTHMA IN CHILDREN WITH ALTERNATIVE DEBUT OF THE DISEASE

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
O.K. Koloskova ◽  
Т.М. Bilous ◽  
О.P. Korotun ◽  
F.V. Herman ◽  
V.V. Bilous ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Inflammatory Process ◽  
Community Acquired Pneumonia ◽  
Clinical Group ◽  
Group Iii ◽  
The Third ◽  
Group I ◽  
Comparison Groups ◽  
Discrete Nature ◽  
Personalized Approach

Objectives - to analyze the activity of the inflammatory process in the airways of childrenwith bronchial asthma depending on different onset of the disease.Material and methods. Keeping to the principles of bioethics a comprehensiveretrospective examination of 319 children suffering from BA was performed. In 257children (clinical group I) bronchial asthma developed against a background of chronicobstructive bronchitis. The second clinical group included 43 children, in whom asthmadebuted after community-acquired pneumonia. The third (III) clinical group consistedof 19 children in whom asthma was first verified after inpatient treatment for asthmaticstatus.Results. According to the severity of bronchial asthma, it was found that the representativesof the III clinical group, compared with other patients, significantly more often had a severecourse of the disease. For patients of the I clinical group in the debut it is characterizedby increased eosinophils and decreased neutrophil counts in sputum, for patients ofgroup II - increased eosinophils and epitheliocytes, but a decrease in lymphocytes, andfor children of clinical group III - low eosinophils sputum with a simultaneous increasein neutrophils. In particular, a statistically significant increase in the content of VEGF,a decrease in the content of cationic proteins, MMP-9, and interleukins-6, and -13 inthe sputum indicates the predominance of neoangiogenesis in children of clinical groupIII. Instead, in the representatives of the II clinical group the remodeling processes weremainly caused by the inflammatory process with the release of intracellular eosinophiliccationic proteins.Conclusion. These data indicate the discrete nature of the type and severity of theinflammatory process of the respiratory tract in the dynamics of observation in childrenof clinical comparison groups, which suggests the presence of certain phenotypicdifferences due to the alternative onset of the disease, which in its turn was determinedby different triggers. Such deviations of the inflammatory process indicate that patientswith asthma require a personalized approach to differentiated diagnostic monitoring andtargeted anti-inflammatory treatment, taking into account the peculiarities of the onsetof the disease.

The Third Intergroup Rhabdomyosarcoma Study.

1995 ◽  
Vol 13 (3) ◽  
pp. 610-630 ◽  
Author(s):  
W Crist ◽  
E A Gehan ◽  
A H Ragab ◽  
P S Dickman ◽  
S S Donaldson ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Progression Free Survival ◽  
Residual Tumor ◽  
Clinical Group ◽  
Comparable Group ◽  
Group Iii ◽  
The Third ◽  
Favorable Histology ◽  
Group I ◽  
Multiagent Chemotherapy

PURPOSE The ultimate goal of the Third Intergroup Rhabdomyosarcoma Study (IRS-III, 1984 to 1991) was to improve treatment outcome in children with rhabdomyosarcoma through clinical trials comparing risk-based protocols of surgery and multiagent chemotherapy, with or without irradiation. PATIENTS AND METHODS One thousand sixty-two previously untreated, eligible patients who were entered onto the study after surgery were randomized or assigned to treatment by clinical group (I through IV), histology (unfavorable or favorable), and site of the primary tumor. Initial responses, progression-free survival (PFS), and survival (S) were the end points used in comparisons between randomized groups and between patients treated in IRS-III and IRS-II (1978 to 1984). RESULTS The overall outcome of therapy in IRS-III was significantly better than in IRS-II (5-year PFS, 65% +/- 2% v 55% +/- 2%; P < .001 by stratified testing). Patients with group I favorable-histology tumors fared as well on a 1-year regimen of vincristine and dactinomycin (VA), as did a comparable group treated with VA plus cyclophosphamide (C) (5-year PFS, 83% +/- 3% v 76% +/- 4%; P = .18). Results for patients with group II favorable-histology tumors, excluding orbit, head, and paratesticular sites, were inconclusive regarding the benefit from addition of doxorubicin (ADR) to VA. Patients with group III tumors, excluding those in special pelvic, orbit, and other selected nonparameningeal head sites, fared much better on the more intensive regimens of IRS-III than on pulsed VAC or VAC-VADRC in IRS-II (5-year PFS estimates, 62% +/- 3% v 52% +/- 3%; P < .01); however, there were no significant differences in outcome among the groups treated in IRS-III. Patients with metastatic disease at diagnosis (clinical group IV) did not benefit significantly from the more complex therapies evaluated in IRS-III. CONCLUSION Intensification of therapy for most patients in IRS-III, using a risk-based study design, significantly improved treatment outcome overall. The largest gain from this strategy was realized in patients with gross residual tumor after biopsy (clinical group III). It was also possible to decrease therapy for selected patient subsets without compromising survival.

CLINICAL AND SPIROGRAPHIC FEATURES OF BRONCHIAL ASTHMA IN SCHOOLCHILDREN DEPENDING ON THE DIFFERENT REGIMENS OF BASIC ANTI-INFLAMMATORY THERAPY

2020 ◽  
Vol 73 (1) ◽  
Author(s):  
Olena Koloskova ◽  
Tetiana Bilous ◽  
Galyna Bilyk ◽  
Kristina Buryniuk-Glovyak ◽  
Olena Korotun ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
High Specificity ◽  
Clinical Feature ◽  
Clinical Group ◽  
Comparison Groups ◽  
Anti Inflammatory ◽  
High Doses ◽  
Persistent Bronchial Asthma

The aim: To study the clinical and spirographic features persistence of the bronchial asthma in schoolchildren against the background of the alternative daily doses of inhaled corticosteroids to increase the effectiveness of anti-inflammatory therapy for this disease. Materials and methods: A complete comprehensive clinical-paraclinical examination of 65 schoolchildren with persistent asthma was conducted. According to the average daily dose of inhaled corticosteroids (ICS) the patients were divided into two clinical groups. The first (I) group consisted of 46 children who received ICS in the regimen of low-to-medium equipotent doses (253.95±9.98 μg per day), and the second (II) comparison group was formed of 19 patients who controlled the pBA using high doses of ICS (494.74±5.56 μg per day). Results: The patients of the І clinical group compared to patients of the ІІ group have a higher risk of the mild bronchial obstructive syndrome during asthma attacks. In assessing the level of control of persistent bronchial asthma using the CIA-scale, it was found that in II group cases of the controlled course of the disease were observed almost two times less than in children of the I group of comparison. In conducting spirography in children of comparison groups, it was shown that the ratio of indices of bronchospasm (FEV1/ FVC) was worse in patients receiving high doses of ICS. Conclusions: So, сharacteristic clinical feature of asthma controlled by high doses of ICS is more severe nature of bronchial obstructive syndrome during the period of exacerbation (OR=1.9-3.0). In the management of persistent bronchial asthma, the Gensler index which has high specificity (94.4%) and accuracy (92.2%) should be used for disease control verification.

scholarly journals Etiology of community-acquired pneumonia and prevalence of comorbidities in elderly patient population

2020 ◽  
pp. 242-248
Author(s):  
Sergey K. Zyryanov ◽  
M.S. Chenkurov ◽  
Marina A. Ivzhits ◽  
Yu.A. Batechko ◽  
E.B. Ivanova ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Patient Population ◽  
Age Groups ◽  
Mortality Rates ◽  
Community Acquired Pneumonia ◽  
Gram Negative Bacteria ◽  
Old Patients ◽  
Group Iii ◽  
Group I ◽  
Enterococcus Spp

Objective. To investigate the mortality rate, comorbidity prevalence, and etiology of community-acquired pneumonia (CAP) in elderly patient population. Materials and Methods. Hospitalized elderly patients with CAP were distributed into the following age groups: 65–74 years (group I), 75–84 years (group II) and 85–94 years (group III). The patients’ medical records were used for determining comorbidities and mortality rate. In order to determine etiology of CAP, sputum or BAL samples were collected. A total of 171 isolates were identified using MALDI-TOF MS. Results. The mortality rates were 27.1%, 31.5% and 45.7% in age groups I, II, III, respectively. The most common concomitant diseases in all age groups were arterial hypertension (47.4%, 54.6%, and 62.8% for groups I, II, and III, respectively), chronic heart failure (45.7%, 50.9%, and 60.0%, respectively), and coronary heart disease (15.2%, 25.9%, and 24.3%, respectively). The most frequently isolated bacteria by age group were the following: group I – non-fermenting Gram-negative bacteria (NFGNB) (7.4%), Enterobacterales (6.6%), S. aureus (6.6%); group II – Enterobacterales (13.9%), S. aureus (5.6%), Enterococcus spp. (5.6%), NFGNB (2.8%); group III – NFGNB (15.4%), S. aureus (7.7%), Enterococcus spp. (7.7%), Enerobacterales (7.7%). Conclusions. The mortality rates in elderly patients with CAP were high and varied from 27.1% in 65–74 years old patients to 45.7% in 85–94 years old patients. The most common comorbidities in all age groups were arterial hypertension (up to 62.8%), chronic heart failure (up to 60%), and coronary heart disease (up to 25.9%). The main pathogens causing CAP in elderly patient population were Enterobacterales and non-fermenting Gram-negative bacteria.

Androgen secretion in women with threatened miscarriage

2020 ◽  
Vol 19 (5) ◽  
pp. 22-28
Author(s):  
М.М. Amiraslanova ◽  
◽  
I.V. Kuznetsova ◽  
E.P. Gitel ◽  
◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
First Trimester ◽  
Total Testosterone ◽  
Third Trimester ◽  
Group Iii ◽  
The Third ◽  
Threatened Miscarriage ◽  
Group I ◽  
Androgen Secretion ◽  
Group Ii

Objective. To assess androgen secretion and its possible effect on pregnancy in women with threatened miscarriage in the first trimester. Patients and methods. This prospective observational study included 120 pregnant women divided into four groups. Group I comprised 32 patients with threatened miscarriage and hyperandrogenism who received corticosteroids; Group II was composed of 28 patients with threatened miscarriage and hyperandrogenism who did not receive corticosteroids; Group III included 30 patients with threatened miscarriage and no hyperandrogenism; and Group IV comprised 30 women with normal pregnancy. Serum levels of dehydroepiandrosterone sulfate (DHEA-S), 17-hydroxyprogesterone (17-OHP), and total testosterone were measured on the following weeks of gestation: 5–8, 9–12, 13–18, 19–24, and 25–32. We also evaluated clinical outcomes of pregnancy. Results. We observed no significant differences in 17-ОНР and DHEA-S secretion between women from Group III and controls. Patients from Group II demonstrated higher hormone levels than controls; however, their dynamics of 17-ОНР and testosterone secretion was similar to that in women without hyperandrogenism, so their DHEA-S levels decreased and reached control values by the third trimester. Corticosteroids reduced 17-ONR secretion in the second and third trimesters and DHEA-S secretion in the third trimester. Women receiving corticosteroids demonstrated the poorest clinical pregnancy outcomes. Conclusion. Hyperandrogenism should be considered as one of the risk factors for poor pregnancy outcomes. Administration of corticosteroids to reduce androgen levels impairs normal dynamics of their secretion, does not improve pregnancy outcomes, and is potentially harmful; therefore, these drugs should not be used for such purposes. Key words: pregnancy, hyperandrogenism, corticosteroid therapy, pregnancy outcomes, pregnancy loss, androgen secretion, threatened miscarriage

THE EFFECTS OF THYROXINE AND THIOURACIL ON THE TUBERCULIN REACTIONS OF GUINEA-PIGS

1952 ◽  
Vol 8 (2) ◽  
pp. 96-101 ◽  
Author(s):  
F. B. LEECH ◽  
A. B. PATERSON
Keyword(s):  
Drug Treatment ◽  
Statistical Methods ◽  
Guinea Pigs ◽  
Adrenal Glands ◽  
Average Response ◽  
Group Iii ◽  
The Third ◽  
Group I ◽  
Live Culture

Three groups of twelve guinea-pigs were selected from a batch inoculated with a live culture of BCG. Two of these groups were selected for treatment with thyroxine and thiouracil. The third served as untreated controls. The experiment was divided into three periods; in the first, groups I and III received thyroxine and thiouracil respectively; in the second, all drug treatment was discontinued; in the third, the treatments were reversed, thiouracil being given to group I and thyroxine to group III. All guinea-pigs were injected intradermally with OT and PPD tuberculins at the end of the first and third periods; the diameters of the 24 hr. lesions were analysed by the appropriate statistical methods. Thyroxine and thiouracil had opposite effects on the reactions to PPD tuberculin, the former depressing the average response. Effects on the reactions to OT were irregular. There were no significant effects on the fresh weights of the adrenal glands.

scholarly journals THE EFFECT OF JAMU FORMULAS ON BODY WEIGHT, ANTIOXIDANT ACTIVITIES, AND ANTIBODY TITER IN CHICKEN / Pengaruh Jenis Jamu terhadap Bobot Badan, Aktivitas Antioksidan dan Titer Antibodi Ayam

2018 ◽  
Vol 24 (2) ◽  
pp. 65
Author(s):  
Bagem BR Sembiring ◽  
Ening Wiedosari ◽  
Sujianto Sujianto
Keyword(s):  
Body Weight ◽  
Medicinal Plants ◽  
Antibody Titer ◽  
Fermentation Time ◽  
Group Iii ◽  
The Third ◽  
Weight Increment ◽  
Group I ◽  
Ic50 Value ◽  
Functional Drink

<p>Medicinal plants are useful to increase body immunity, body weight, appetite, and improve health both for human and animal. The research aimed to obtain functional drink formula for chicken, called jamu, made with spices and medicinal plants. These trials consisted of 3 activities; first, raw materials preparation include fermentation and extraction, second, functional drink formulation in form liquid and powder with pH and IC50 value as parameters, third, efficacy test of formulas that had the strongest antioxidant. The treatments were categorized as group I (chicken were fed with jamu, without vaccination), group II (fed with jamu for two weeks then vaccinated), group III (jamu feeding complemented by vaccination), group IV (control, only vaccination). The third activity was arranged in a randomized block design with 6 replications. Parameters observed were body weight increment and antibody titer. The fermentation time and formula composition showed no significant effect on pH until the third day (4.31 - 4.68), but they indicated significant effect on pH from the fourth day, declined until the seventh day (3.65-4.26). The type and compositions of the formula significantly affected IC50 value. The smallest of IC50 value of liquid and powder formulas were 7796.25 ppm and 244.57 ppm, respectively. The incremental body weight regarding liquid, powder, and control formulas were 365.55 g / week, 351.22 g / week, and 326.66 g / week, respectively. The highest antibody titer was at group III that had 4.50 (log 2), whereas control was 3.30 (log2). The combination feeding, jamu formula and vaccine, was able to increase body weight increment and antibody titer on chicken.</p><p>Keywords: medicinal plants, functional drink, IC50, broilers, antibody titers</p><p> </p><p><strong>Abstrak</strong></p><p>Tanaman obat digunakan untuk meningkatkan daya tahan tubuh, bobot badan, nafsu makan, mencegah penyakit, serta pemulihan kesehatan manusia dan hewan. Penelitian bertujuan mendapatkan formula minuman fungsional untuk ayam berbasis tanaman rempah dan obat. Kegiatan meliputi 3 aktivitas (1) Penanganan bahan baku, fermentasi dan ekstraksi (2) Formulasi minuman fungsional (cair dan serbuk) dengan parameter pH dan nilai IC50. (3) Uji efikasi formula cair dan serbuk yang menghasilkan aktivitas antioksidan terkuat. Perlakuan: kelompok I, ayam hanya diberi formula jamu selama dua minggu, kelompok II, ayam diberi formula jamu selama dua minggu sebelum vaksinasi, kelompok III, ayam divaksin sebelum diberi formula jamu selama dua minggu, kelompok IV, ayam hanya divaksinasi. Kegiatan (3) menggunakan Rancangan Acak Kelompok dengan 6 ulangan dan parameter pengamatan yaitu penambahan bobot badan dan titer antibodi. Waktu fermentasi dan komposisi formula tidak menunjukkan efek yang signifikan pada pH sampai hari ketiga (4,31-4,68), namun signifikan pada hari keempat ditandai dengan penurunan pH sampai hari ketujuh (3,65-4,26). Jenis dan komposisi formula secara signifikan mempengaruhi nilai IC50. Nilai IC50 terkecil dari formula cair adalah 7796,25 ppm dan serbuk 244,57 ppm. Kenaikan berat badan dengan formula jamu cair yaitu 365,55 g / minggu, serbuk 351,22 g / minggu dan kontrol 326,66 g / minggu. Titer antibodi tertinggi adalah 4,50 (log2) yang ditunjukkan oleh kelompok III, sedangkan kontrol 3,30 (log2). Minuman fungsional (jamu) ditambah dengan vaksinasi mampu meningkatkan pertambahan berat badan dan titer antibodi ayam.</p><p>Kata kunci: Tanaman obat, minuman fungsional, IC50, ayam broiler, titer antibodi</p>

scholarly journals Optimalus vidinės miego arterijos endarterektomijos laikas sergant insultu ir didelio laipsnio vidinės miego arterijos stenoze

2006 ◽  
Vol 4 (1) ◽  
pp. 0-0
Author(s):  
Auksė Meškauskienė ◽  
Egidijus Barkauskas ◽  
Artūras Mackevičius
Keyword(s):  
Carotid Artery ◽  
Carotid Endarterectomy ◽  
Carotid Stenosis ◽  
Carotid Artery Stenosis ◽  
Group Iv ◽  
Operative Risk ◽  
Group Iii ◽  
The Third ◽  
Group I ◽  
Significant Difference

Optimalus vidinės miego arterijos endarterektomijos laikas sergant smegenų insultu ir didelio laipsnio vidinės miego arterijos stenoze Auksė Meškauskienė, Egidijus Barkauskas, Artūras MackevičiusVilniaus universiteto Neurologijos ir neurochirurgijos klinikosNeuroangiochirurgijos centras,Šiltnamių g. 26, LT-04130 VilniusEl paštas: [email protected] Įvadas / tikslas Miego arterijos endarterektomija yra veiksmingas gydymo būdas, padedantis išvengti insulto esant didelio laipsnio simptominei miego arterijos stenozei. Ankstyva, tuoj po insulto atlikta endarterektomija sukelia daug komplikacijų, todėl dauguma chirurgų siūlo operaciją atidėti 4–6 savaitėms. Tačiau operacijos atidėjimas didina insulto pasikartojimo riziką. Naujausios literatūros duomenimis, per 30 dienų nuo insulto pradžios atlikta endarterektomija nedidina komplikacijų skaičiaus, tačiau nėra vienodos nuomonės dėl tikslaus operacijos laiko. Darbo tikslas – nustatyti operacijos riziką ligoniams, kurie serga smegenų insultu ir didelio laipsnio vidinės miego arterijos stenoze, atsižvelgiant į atliekamos endarterektomijos laiką. Ligoniai ir metodai Į analizę įtraukti duomenys 243 ligonių (192 vyrų ir 51 moters, amžiaus vidurkis 65,4 metų), kurie sirgo išeminiu insultu ir jiems buvo operuota simptominė didelio laipsnio miego arterijos stenozė. Iki operacijos visų analizuotų ligonių neurologinė simptomatika buvo stabili arba gerėjanti. Atsižvelgdami į laiko trukmę nuo ligos pradžios iki operacijos, ligonius suskirstėme į keturias grupes: I grupę (n = 59) sudarė operuotieji pirmą savaitę, II grupę (n = 61) – antrą savaitę, III grupę (n = 67) trečią ar ketvirtą savaitę, IV grupę (n = 56) – po keturių savaičių nuo ligos pradžios. Rezultatai Po operacijos komplikacijų buvo 14 (5,6%) ligonių, pusei iš jų įvyko insultas ir tiek pat ligonių mirė. Komplikacijų pasireiškė 5 ir 59 (8,5%) pirmos grupės ligonių, 4 iš 61 (6,5%) – antros, 1 iš 67 (1,5%) – trečios ir 4 iš 56 (7,2%) – ketvirtos. Mažiausia komplikacijų ištiko ligonius, kuriems endarterektomija daryta trečią ar ketvirtą ligos savaitę, nors komplikacijų skirtumas tarp grupių nebuvo statistiškai reikšmingas. Išvados Mirties ir operacinio insulto rizika ligoniams, sergantiems insultu ir didelio laipsnio vidinės miego arterijos stenoze, tiesiogiai nepriklausė nuo endarterektomijos laiko, tačiau mažiausiai komplikacijų ištiko ligonius, operuotus trečią ar ketvirtą savaitę nuo insulto pradžios. Reikšminiai žodžiai: insultas, miego arterijos endarterektomija, laikas, operacinė rizika The optimal timing of carotid endarterectomy in patients with stroke and severe carotid artery stenosis Auksė Meškauskienė, Egidijus Barkauskas, Artūras MackevičiusVilnius University, Clinics of Neurology and Neurosurgery,Center of Neuroangiosurgery,Šiltnamių str. 26, LT-04130 Vilnius, LithuaniaE-mail: [email protected] Background / objective Carotid endarterectomy is highly effective in preventing stroke in patients with recentl symptomatic severe stenosis. Some studies showed early carotid endarterectomy to carry a high risk. Therefore, many surgeons delay carotid endarterectomy for 4 to 6 weeks after stroke, but any delay leads to reduced benefit because of the risk of stroke before surgery. Recent data have suggested that the operative risk is not increased in patients operated on within 30 days of stroke; however, controversy remains regarding the timing of this intervention. The purpose of the current work was to determine the operative risk of death and stroke in patients with stroke and severe carotid stenosis in relation to the time of carotid endarterectomy. Patients and methods A retrospective study of 243 patients undergoing carotid endarterectomy after stroke is presented. All patients had either stable or improving neurological examinations. The patients were divided into four groups: group I (n = 59) patients who had carotid endarterectomy between 2–7 days after stroke, group II (n = 61) patients who had carotid endarterectomy during the second week, group III (n = 67) patients who were operated during the third–fourth week after stroke and group IV (n = 56) patients who were operated on later than 4 weeks. Results Of the 192 men and 51 women who underwent surgery, there were 7 strokes and 7 deaths, with the total rate of complications 5.6%. Postoperative stroke and mortality was respectively: group I – 8.5%, group II – 6.5%, group III – 1.5%, group IV – 7.2%. There was no statistically significant difference in operative risk among the groups; however, a trend toward a decreased operative risk was noticed in patients operated on during the third–fourth week after stroke. Division to early (<2 weeks) and late (>2 weeks) endarterectomy also did not reveal any significant difference in the operative risk. Conclusions The perioperative risk of stroke and death was unrelated to the timing of carotid endarterectomy in patients with stroke and severe carotid stenosis. Carotid endarterectomy can be performed safely after 2 weeks of ischemic stroke in patients with severe carotid artery stenosis. Key words: stroke, carotid endarterectomy, time, operative risk

scholarly journals CLINICAL COURSE AND CONTROL OF BRONCHIAL ASTHMA INDICATORS IN OVERWEIGHT SCHOOLCHILDREN

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
L.A. Ivanova ◽  
M.N. Haras ◽  
I.B. Horbatiuk ◽  
A.O. Shkilnyuk
Keyword(s):  
Body Weight ◽  
Bronchial Asthma ◽  
The Body ◽  
Excess Body Weight ◽  
Clinical Group ◽  
Overweight Children ◽  
Group I ◽  
Negative Effect ◽  
And Control ◽  
Bodymass Index

The aim of the study - to study the clinical features and indicators for asthma control inoverweight children to optimize treatment strategies.Material and methods. 200 schoolchildren with asthma who were treated in the pulmoallergy department of the Chernivtsi Regional Children's Clinical Hospital have beenexamined. 52 patients with excess body weight (body mass index was greater than 25,0)belonged to group I, and children with body weight corresponding to the age norm (bodymass index from 18,0 to 24,9) were included into clinical group II under observation.Results. It has been found that the average number of points according to the ASTquestionnaire in patients of group I reached 14,0 ± 1,33 points, and in the comparisongroup – 16,3 ± 0,54 points (p˃0,05). At the same time, the share of patients withuncontrolled course of the disease among the overweight children reached 61,5% incomparison to 48,3% in the comparison group (p˃0,05).Indices of the risk of uncontrolled asthma (the sum of AST test scores <16) in childrenwith overweight have shown the following results: odds ratio = 1,6 (95% CI: 0,29-8,59),relative risk = 1,4 95% CI: 1,00-2,08) and attributive risk = 6,8%. Before treatment theindex of AKDNFG - 2,4 dinitrophenylhydrazones (AKDNFG) of the main character in thegroup of excess body weight children was 60,8 mmol /g of protein, and in group of normalbody weight children – 59,6 ± 9 mmol /g of protein. After the course of basic therapy,these indices gave next results – 47,2 ± 4,18 mmol/g of protein in group I and 4,3 ± 0,29mmol /g of protein (p> 0,05) in group II.Conclusions. Bronchial asthma in overweight children is more likely to debut at an earlyage and characterized by a persistent course. Predisposition to the body overweight inpatients with bronchial asthma has a negative effect on the indices of the disease controlachievement, although it is accompanied by an evidence decrease of the inflammatoryprocess of the respiratory tract in the course of treatment.

scholarly journals Efficiency of bronchial asthma control in children of school age depending on the features of the disease debut

2021 ◽  
Vol 25 (1(97)) ◽  
pp. 54-62
Author(s):  
O. Koloskova ◽  
T. Bilous ◽  
N. Shevchenko ◽  
G. Bilyk
Keyword(s):  
Asthma Control ◽  
Bronchial Asthma ◽  
Status Asthmaticus ◽  
Chronic Obstructive ◽  
Clinical Group ◽  
Chronic Obstructive Bronchitis ◽  
Group I ◽  
Asthma In Children ◽  
Anti Inflammatory ◽  
Basic Treatment

Objective. To assess the effectiveness of achieving and maintaining control of bronchial asthma in children during dynamic observation, depending on the characteristics of the onset of the disease. Material and methods. In order to study the peculiarities of the course and controllability of bronchial asthma in children, depending on the alternative onset of the disease, 319 children were comprehensively examined by the "experience-control" method in parallel groups using a simple random sample on the basis of the Regional Children's Clinical Hospital in Chernivtsi. In 257 patients (I clinical group), bronchial asthma developed on the background of chronic obstructive bronchitis, the II clinical group included 43 children in whom BA debuted after suffering community-acquired pneumonia, and the third (III) clinical group was formed by 19 children in whom BA was verified after inpatient treatment for status asthmaticus. Research results. It was shown that the representatives of the III clinical group, compared with other patients, probably more often had the phenotype of early asthma and severe disease, and the ratio of the chances of severe asthma in the future for these children compared with the cohort of group I was 6.8. According to the results of self-assessment of asthma control on standardized questionnaires GINA and AST, as well as using a clinical-instrumental assessment scale, it was found that the level of disease control in all groups was insufficient, and the distribution of children in clinical groups in group III relative to other patients with partially controlled and uncontrolled asthma predominated. The conducted standard anti-inflammatory basic treatment allowed to achieve certain positive changes in patients of clinical observation groups, and the representatives of the III clinical group required more active basic anti-inflammatory therapy, in particular, the volume of the 1st step in GINA compared to patients of the I group was prescribed twice less often, and the 4th - 6.9 times more often. Conclusion. Patients with the onset of bronchial asthma in the form of status asthmaticus further retain a worse level of control over the disease as compared to patients with chronic obstructive bronchitis or pneumonia in history. This cohort of patients requires a larger volume of basic treatment, as well as a personalized approach to prescribing therapy with the obligatory consideration of the characteristics of asthma onset.

scholarly journals Reactions of eosinophilic granulocytes in the sputum and peripheral blood of children suffering from bronchial asthma with signs of eosinophilic and non-eosinophilic inflammation of the bronchi

2017 ◽  
Vol 8 (1) ◽  
pp. 15-18
Author(s):  
O. K. Koloskova ◽  
T. M. Bilous ◽  
M. V. Dikal ◽  
U. V. Lomakina ◽  
T. G. Kopchuk ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Peripheral Blood ◽  
Comparison Group ◽  
Absolute Risk ◽  
Eosinophil Cationic Protein ◽  
Clinical Group ◽  
Group I ◽  
Bronchial Inflammation ◽  
Number Of Patients ◽  
Eosinophil Granulocytes

The aim of research was to improve the management of bronchial asthma in children by examining the peculiarities and diagnostic value of reaction markers of eosinophil granulocytes in the sputum and peripheral blood of patients with signs of eosinophil and non-eosinophil phenotypes of this disease. A cohort of 118 school-age children suffering from BA was examined during a period free from attacks. Group I (the main group ) included 61 schoolchildren with signs of eosinophil phenotype (EP) of asthma detected by the character of bronchial inflammation with eosinophil granulocytes present in the sputum at a level of >3%, group II (the comparison group) included 57 patients with a lower number of eosinophils in the sputum (non-eosinophil phenotype (NP) of BA). The average index of the relative content of eosinophils in the peripheral blood among the representatives of group I was 5.82 ± 0.63%, and in children with the signs of NPBA – 6.02 ± 0.74% (P > 0.05), and average indices in the groups of absolute eosinophil number in the blood were 0.37 ± 0.04 and 0.41 ± 0.05 respectively (P > 0.05). The negative reserve of NBT eosinophils in the sputum as a test to verify EPBA showed the following diagnostic values: specificity – 83.3%, predicted value of a positive result – 95.6%. IL-5 content in the blood serum of children with EPBA was 5.99 ± 1.74 ng/ml, in patients of group ІІ – only 1.99 ± 0.49 ng/ml (P < 0.05). Eosinophil cationic protein (ЕСР) in the sputum of patients of group I reached 2.72 ± 0.35 ng/ml, and in the comparison group – only 1.74 ± 0.34 ng/ml (P < 0.05), when the content of ECP in sputum was >1.0 ng/ml the risk of EPBA showed a statistically significant increase: OR = 4.13, RR = 2.02, and AR – 0.34. The efficacy of the standardized basic anti-inflammatory therapy in patients of clinical group I was higher as compared to the children with the signs of NPBA, which was illustrated by the reduced risk of inadequate control of the disease: the index of absolute risk decrease was 31.7%, relative risk – 57.1% with necessary minimal number of patients – 1.75. 

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