scholarly journals Retinol deficiency in animals: Etiopathogenesis and consequences

2020 ◽  
Vol 11 (2) ◽  
pp. 162-169
Author(s):  
P. M. Skliarov ◽  
S. Y. Fedorenko ◽  
S. V. Naumenko ◽  
O. V. Onischenko ◽  
K. О. Holda
Keyword(s):  
Vitamin A ◽  
Sperm Quality ◽  
Vitamin A Deficiency ◽  
Reproductive Function ◽  
The Body ◽  
Economic Losses ◽  
High Concentration ◽  
Retinol Deficiency ◽  
Endocrine Organs ◽  
And Performance

Infertility is widespread for all species of animals and causes significant economic losses to livestock due to the loss and shortage of offspring, their reduced viability and, consequently, increased morbidity and mortality. Alimentary-deficiency factors are among the commonest causes of infertility, from which A-vitamin deficiency should be singled out. The precursor of vitamin A in the body is carotene, which is an unstable compound which is easily destroyed even under the influence of moderate factors of influence, in connection with which its deficiency is global, especially at the end of the winter – stall period of keeping animals. Accordingly it is the leading etiological factor of retinol deficiency infertility. As a result, the body has two negatives that act in parallel: carotene / vitamin A deficiency adversely affects the organs, the constituent and major functional unit of which is the secretory epithelial cell, and the free radical oxides formed in high concentration are extremely effective in destroying the cells, weakening antioxidant protection. Vitamin A has a significant effect on the reproductive function of animals both directly and indirectly. It is necessary to ensure the structure and functioning of the epithelial tissues of the organs of regulation and performance of sexual function, and therefore the physiological development of the fetus and the course of pregnancy, parturition and postpartum period, ovo- and spermiogenesis, the manifestation of sexual reflexes. Instead, its deficiency underlies the etiology and pathogenesis of retinol deficiency infertility of animals, causing changes in individual indices of homeostasis and prooxidate-antioxidant system, morphostructure of the reproductive and endocrine organs, hormonal status, sperm quality and reproductive function. The consequence is the emergence and development of gynecological, andrological, mammological and perinatal (ante-, intra-, post- and neo-) pathologies. At the same time, the addition of carotene or retinol to the diets of animals or their oral administration in cases of deficiency of vitamin A prevents impaired reproductive function. The study of the features of the etiopathogenesis of retinol deficiency infertility of animals allows programs of complex diagnostics, therapy and prevention to be developed which provide determination of carotene and vitamin A content and replenishment of the organism in cases of their deficiency.

scholarly journals Marker-assisted pyramiding of lycopene-ε-cyclase, β-carotene hydroxylase1 and opaque2 genes for development of biofortified maize hybrids

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jagveer Singh ◽  
Shikha Sharma ◽  
Amandeep Kaur ◽  
Yogesh Vikal ◽  
Amandeep Kaur Cheema ◽  
...  
Keyword(s):  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Protein Energy Malnutrition ◽  
Essential Amino Acids ◽  
Economic Losses ◽  
Recurrent Parent ◽  
High Concentration ◽  
Protein Energy ◽  
Normal Maize ◽  
Micronutrient Malnutrition

AbstractMalnutrition affects growth and development in humans and causes socio-economic losses. Normal maize is deficient in essential amino acids, lysine and tryptophan; and vitamin-A. Crop biofortification is a sustainable and economical approach to alleviate micronutrient malnutrition. We combined favorable alleles of crtRB1 and lcyE genes into opaque2 (o2)-based four inbreds viz. QLM11, QLM12, QLM13, and QLM14 using marker-assisted backcross breeding. These are parents of quality protein maize versions of two elite hybrids viz. Buland and PMH1, grown in India. Gene-based SSRs for o2 and InDel markers for crtRB1 and lcyE were successfully employed for foreground selection in BC1F1, BC2F1, and BC2F2 generations. The recurrent parent genome recovery ranged from 88.9 to 96.0% among introgressed progenies. Kernels of pyramided lines possessed a high concentration of proA (7.14–9.63 ppm), compared to 1.05 to 1.41 ppm in the recurrent parents, while lysine and tryptophan ranged from 0.28–0.44% and 0.07–0.09%, respectively. The reconstituted hybrids (RBuland and RPMH1) showed significant enhancement of endosperm proA (6.97–9.82 ppm), tryptophan (0.07–0.09%), and lysine (0.29–0.43%), while grain yield was at par with their original versions. The dissemination of reconstituted hybrids holds significant promise to alleviate vitamin-A deficiency and protein-energy malnutrition in developing countries.

Research Recommendations for Applying Vitamin A-Labelled Isotope Dilution Techniques to Improve Human Vitamin A Nutrition

2014 ◽  
Vol 84 (Supplement 1) ◽  
pp. 52-59 ◽  
Author(s):  
Sherry A. Tanumihardjo ◽  
Anura V. Kurpad ◽  
Janet R. Hunt
Keyword(s):  
Public Health ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Human Subjects ◽  
The Body ◽  
Pool Size ◽  
Serum Retinol ◽  
Vitamin A Status ◽  
Status Assessment ◽  
Total Body

The current use of serum retinol concentrations as a measurement of subclinical vitamin A deficiency is unsatisfactory for many reasons. The best technique available for vitamin A status assessment in humans is the measurement of total body pool size. Pool size is measured by the administration of retinol labelled with stable isotopes of carbon or hydrogen that are safe for human subjects, with subsequent measurement of the dilution of the labelled retinol within the body pool. However, the isotope techniques are time-consuming, technically challenging, and relatively expensive. There is also a need to assess different types of tracers and doses, and to establish clear guidelines for the use and interpretation of this method in different populations. Field-friendly improvements are desirable to encourage the application of this technique in developing countries where the need is greatest for monitoring the risk of vitamin A deficiency, the effectiveness of public health interventions, and the potential of hypervitaminosis due to combined supplement and fortification programs. These techniques should be applied to validate other less technical methods of assessing vitamin A deficiency. Another area of public health relevance for this technique is to understand the bioconversion of β-carotene to vitamin A, and its relation to existing vitamin A status, for future dietary diversification programs.

Vitamin A in pregnancy and breastfeeding

2015 ◽  
Author(s):  
Sir Peter Gluckman ◽  
Mark Hanson ◽  
Chong Yap Seng ◽  
Anne Bardsley
Keyword(s):  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Reproductive Function ◽  
Late Pregnancy ◽  
Multiple Organ ◽  
Nutritional Risk ◽  
Food Sources ◽  
Organ Systems ◽  
Resistance To Infection ◽  
In Pregnancy

Vitamin A is critical for visual and reproductive function, supports resistance to infection, and is required for the development of multiple organ systems. including the heart, lungs, kidneys, and skeleton. Both excess and deficiency of vitamin A in pregnancy are associated with birth defects. High intakes of vitamin A, either in the form of supplements or in concentrated food sources such as liver, should be avoided in pregnancy, particularly between day 15 and day 60 post conception. However, in areas with endemic vitamin A deficiency, supplementation in late pregnancy is recommended to prevent night blindness. Most women who are at low nutritional risk can meet their early pregnancy vitamin A requirement from food sources, but should increase their vitamin A intake from food during the third trimester and through lactation.

scholarly journals Bilateral Keratomalacia Secondary to Diet Induced Vitamin A Deficiency in an Ethiopian Young woman: A Case Report

1970 ◽  
Vol 29 (2) ◽  
Author(s):  
Kumale Tolesa Daba ◽  
Dagmawit Kifle ◽  
Jafer Kedir Ababora
Keyword(s):  
Vitamin A ◽  
Low Socioeconomic Status ◽  
Night Blindness ◽  
Early Recognition ◽  
Vitamin A Deficiency ◽  
The Body ◽  
Parotid Glands ◽  
Low Socioeconomic ◽  
Background Diet ◽  
University Department

BACKGROUND: Diet induced vitamin A deficiency is less commonly seen in otherwise healthy adults, due to large store of vitamin A in the body. Night blindness is the commonest manifestation of vitamin A deficiency in adults, whereas Keratomalacia is a rare manifestation.CASE REPORT: A 27 years old Ethiopian woman came to Jimma University Department of Ohthalmology with a compliant of protrusion of the globe content of both eyes within a week, after having redness and fear of light of both eyes for 2 months. She was a mother of twins and had low socioeconomic status. On general examination, she was cachectic with enlarged parotid glands. On ocular examination, she was bilaterally blind and had dry ocularsurface. There was bilaterally melted cornea with prolapsed uveal tissue. After several investigations she was diagnosed as bilateral Keratomalacia (stage X3B) secondary to diet induced vitamin A deficiency. She was supplemented with vitamin A and other nutritional supplementation. Topical lubricating drops and ointments were administered. Finally, conjunctival flap was done to preserve the globe.CONCLUSION: Although it is rare, treating physicians should be aware of the occurrence of Keratomalacia in adults which is potentially blinding. Early recognition and treatment of vitamin A deficiency at the stage of night blindness is essential in reducing blindness caused by Keratomalacia.

scholarly journals Efektivitas Program Fortifikasi Minyak Goreng dengan Vitamin A terhadap Status Gizi Anak Sekolah di Kota Makasar

2010 ◽  
Vol 4 (6) ◽  
pp. 255 ◽  
Author(s):  
Endang Achadi ◽  
Siti Arifah ◽  
Siti Muslimatun ◽  
Trisari Anggondowati ◽  
Asih Setiarini
Keyword(s):  
Vitamin A ◽  
School Children ◽  
Vitamin A Deficiency ◽  
Urban Slum ◽  
The Body ◽  
Slum Area ◽  
Serum Retinol ◽  
Significant Public Health ◽  
The Impact ◽  
Prevalence Of Anemia

Di Indonesia, kekurangan Vitamin A masih menjadi masalah kesehatan masyarakat yang penting seperti terlihat pada balita penderita vitamin A defisiensi subklinis yang tinggi (50%). Hal tersebut akan berpengaruh terhadap berbagai fungsi tubuh yang antara lain meliputi sistem imun, penglihatan, sistem reproduksi dan diferensiasi sel. Tujuan dari penelitian ini adalah untuk mengetahui kontribusi konsumsi minyak yang diperkaya vitamin A dalam memperbaiki status vitamin A dan hemoglobin balita. Penelitian dengan disain studi intervensi Before-After ini dilaksanakan pada anak sehat berusia 7-10 tahun yang diberi obat cacing sebelum intervensi dilakukan. Pengukuran serum retinol dan hemoglobin dilakukan sebelum dan 3 bulan setelah intervensi . Minyak yang difortifikasi vitamin A telah disediakan di warung/ toko di sekitar tempat tinggal responden. Untuk meningkatkan demand, penelitian ini dilengkapi dengan pendekatan pemasaran sosial yang dilakukan pihak lain. Secara umum tidak terlihat perubahan status gizi, tetapi prevalensi anemia turun dari 21,8% menjadi 11,6%. Sementara, prevalens vitamin A defisiensi ditemukan lebih rendah pada anak yang mengkonsumsi ³12 minggu (26,6%) daripada yang mengkonsumsi < 12 minggu (42%) . Hasil tersebut dapat dijadikan pertimbangan untuk merekomendasikan agar minyak difortifikasi vitamin A.Kata kunci: Defisiensi vitamin A, anak sekolah, minyak fortifikasiAbstractVitamin A deficiency (VAD) remains as one of significant public health problems in Indonesia. Around 50% of under five children are suffering from subclinical VAD. Deficiency of vitamin A will affect several important role in the body, such as immune system, vision, reproductive system and cell differentiation. Therefore, guarding Indonesian children to be free from VAD is crucial for their quality as Human Resources. We assessed the impact of the consumption of vitamin A fortified cooking oil on the improvement of vitamin A and hemoglobin status among school children in urban slum area in Makassar City. The study was an intervention design Before-After. Healthy school children 7-10 years were selected from schools and de-wormed before the intervention. Serum retinol and hemoglobin was measured at baseline and at 3 months after. Fortified oil was made available through distribution at shops and accompanied with social marketing. Eventhough overall there was no change in VAD prevalence, the VAD prevalence is lower among children who consumedfortified oil ³12 weeks (26.6%) compared to those who consumed <12 weeks (42%). Prevalence of anemia decreased from 21.8% to 11.6%. We recommended that fortified oil is made mandatory.Key words: Vitamin A deficiency, school children, fortified oil

scholarly journals Effects of dietary vitamin A intake on acrosin- and plasminogen-activator activity of ram spermatozoa

Reproduction ◽  
2005 ◽  
Vol 129 (6) ◽  
pp. 707-715 ◽  
Author(s):  
I A Zervos ◽  
M P Tsantarliotou ◽  
G Vatzias ◽  
P Goulas ◽  
N A Kokolis ◽  
...  
Keyword(s):  
Vitamin A ◽  
Plasminogen Activator ◽  
Proteolytic Enzymes ◽  
Vitamin A Deficiency ◽  
Plasminogen Activators ◽  
The Body ◽  
Dietary Vitamin ◽  
Retinyl Acetate ◽  
Plasminogen Activator Activity ◽  
Group B

Acrosin and plasminogen activators are proteolytic enzymes of ram spermatozoa that play an essential role in the induction of the acrosome reaction, as well as the binding of spermatozoa to the oocyte and their penetration through the layers that surround the oocyte. Since vitamin A can alter gene expression in various tissues, testis included, this study was undertaken to evaluate the possible effect of vitamin A intake on acrosin- and plasminogen-activator activity. During a 20-week experiment, 15 rams of the Greek breed Karagouniki, divided to three groups, received different amounts of vitamin Aper osin retinyl acetate capsules (group A, controls, 12 500 iu/animal per day; group B, 50 000 iu/animal per day; group C, 0 iu/animal per day up to the 13th week, then 150 000 iu/animal per day until the end of the experiment). Acrosin- and plasminogen-activator activity were determined by spectrophotometric methods. Vitamin A was determined in blood plasma by HPLC. No statistical differences were detected regarding the body weight of the rams or the qualitative and quantitative parameters of their ejaculate throughout the whole experiment. No statistically significant alterations of enzyme activity were detected in group B. In group C, both enzyme activities started declining in week 9. Compared with controls, maximum reduction for acrosin was 49% on week 11 and for plasminogen activators 51% in week 14. Activities returned to normal rates after vitamin A resupplementation. To date, the main result of vitamin A deficiency was known to be arrest of spermatogenesis and testicular degeneration. A new role for vitamin A may be suggested, since it can influence factors related to male reproductive ability before spermatogenesis is affected.

About early diagnosis of vitamin deficiency

1937 ◽  
Vol 33 (2) ◽  
pp. 121-126
Author(s):  
E. M. Lepsky
Keyword(s):  
Vitamin A ◽  
Clinical Symptoms ◽  
Vitamin A Deficiency ◽  
Physiological Role ◽  
Vitamin Deficiency ◽  
The Body ◽  
Vitamin Deficiencies ◽  
Complete Diet ◽  
Digestive Disorders

In the expressed form of avitaminosis, we are now observed less and less. Nevertheless, the problem of vitamin deficiencies remains relevant for the practitioner. As the physiological role of vitamins and their importance in pathology becomes more and more clear, the presence of light, "erased" forms, which are more correctly called hypovitaminosis, becomes more and more obvious. Experience shows that the generally accepted ideas about the conditions for the occurrence of avitaminosis should be revised. Not only in the absence or in the absence of one or another vitamin in food, vitamin deficiency can develop. More and more observations are accumulating showing that a weak or even strongly pronounced vitamin deficiency can appear in a person who receives a completely complete diet. This phenomenon, paradoxical at first glance, can take place under the following circumstances: with digestive disorders associated with impaired absorption; with liver diseases (the latter is especially important for vitamin A deficiency, since the conversion of carotene into vitamin A suffers); when the need for vitamins is increased against the norm, for example, in rapidly growing children or in lactating women who excrete significant amounts of vitamin C with milk; with increased destruction of vitamin stores in the body, which is observed with all kinds of infections and other febrile and debilitating diseases. To what has been said, it must also be added that very often our food turns out to be poor in vitamins, due to irrational preparation, improper storage of food, peculiar deviations of appetite, etc. In the earliest stages, when even mild clinical symptoms do not yet exist, modern methods of studying vitamins can the presence of latent hypovitaminosis. This is especially evident in the example of the scourge.

scholarly journals The Development of Phyto- and Tissue Origin Medicines for Veterinary Reproductive Issues

2021 ◽  
Vol 24 (8) ◽  
pp. 15-25
Author(s):  
Pavlo Skliarov ◽  
Serhiy Fedorenko ◽  
Svitlana Naumenko ◽  
Vsevolod Koshevoy ◽  
Kateryna Pelyh
Keyword(s):  
Veterinary Medicine ◽  
High Efficiency ◽  
Sperm Quality ◽  
Reproductive Function ◽  
The Body ◽  
Growth Potential ◽  
New Drugs ◽  
Reproductive Capacity ◽  
Treatment And Prevention ◽  
Tissue Origin

Modern conditions of practical veterinary medicine require the use of effective and safe drugs. Along with the already known and common medicines, the search for new drugs which are harmless for the body and have the physiological direction of action is still required. In recent years, the attention to the use of phyto- and tissue-derived drugs increased. However, the problem of their use is insufficiently studied – many aspects of their clinical use require further development, expansion of the spectrum of used medicinal plants, study, and implementation into veterinary practice. Therefore, the purpose of this work was to develop a comprehensive vitamin-hormone drugs based on phyto- and tissue medicines for the treatment and prevention of reproductive abnormalities in animals. Based on the information on the etiopathogenesis of disorders of reproductive function indicators: homeostasis, reducing of the concentration of hormones (estrogen or progesterone), changes in the morphofunctional state of endocrine (pituitary, thyroid, and adrenal gland) and reproductive (ovaries) organs, the application of vitamin-hormone drugs in veterinary medicine is scientifically sound. Drugs in terms of pathogenetic therapy can optimise homeostasis, hormone concentrations, stimulate rehabilitation processes in the regulatory organs of reproductive function (pituitary, adrenal, and thyroid) and reproductive organs (ovaries), which, in turn, contributes to the normalisation of follicles which are a prerequisite for the full reproductive capacity of females. Vitamin-hormonal medicines of herbal and tissue origin were developed, with high efficiency for the treatment and prevention of reproductive pathologies of various species of animals, providing the stimulation of reproductive function (estrus signs) for therapy of females with gonadopathies (“Carafest”, “Caplaestrol” and “Caplagonìn”) and males (display of sexual reflexes and sperm quality) for reproductive activity dysfunction (“Carafand”), increase in the viability of the newborn (increasing the number of lambs and goatlings with satisfactory clinical condition with a high-growth potential, reduce in their morbidity and lethality), preventing the incidence of ìntra- and postnatal (labor hypofunction, diseases of post-labor period) pathology (“Carafest”, and “Caplaestrol”)

scholarly journals Association of genetic variation with disproportionate vitamin A deficiency in pregnant women of certain ethnicities in the United States.

2020 ◽  
Author(s):  
Masako Suzuki ◽  
Tao Wang ◽  
Diana J Garretto ◽  
Carmen R. Isasi ◽  
Wellington V Cardoso ◽  
...  
Keyword(s):  
United States ◽  
Vitamin A ◽  
Pregnant Women ◽  
Ethnic Groups ◽  
Latin American ◽  
Vitamin A Deficiency ◽  
The United States ◽  
Genetic Variations ◽  
The Body ◽  
Serum Retinol

Abstract Vitamin A is an essential micronutrient that plays critical roles in many biological functions of the body. Limited access to vitamin A-rich food or supplements severely affects tissue and blood levels of vitamin A. Therefore, low serum vitamin A and poverty levels are strongly associated in vitamin A deficiency (VAD) studies that have focused mainly on developing countries. The current national prevalence rate of vitamin A deficiency in the United States is reported to be very low (<1%). However, several studies, including ours, have suggested that people from certain ethnic groups still face a higher proportion of vitamin A deficiency. We hypothesize that the genetic variations between ethnic groups may associate to the VAD proportional differences between women of different ancestries. To assess the associations, we re-analyzed two independent datasets of serum retinol levels of pregnant women in the United States and three datasets of genotypic information of different ancestries. We found that pregnant women with non-Hispanic Black and with Latin American/Afro-Caribbean ancestry have strikingly high proportions of VAD compared to non-Hispanic White and Latin American/Mexican ancestry. Genotypic analyses showed that the minor allele frequencis of genetic variants that associate to serum retinol levels have significantly higher variations between these different ancestries. Our study revealed that VAD rates in the pregnant women differ between different ancestries and that ancestry-dependent genetic variations might contribute to the differences.

scholarly journals Re-Defining the Population-Specific Cut-Off Mark for Vitamin A Deficiency in Pre-School Children of Malawi

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 849
Author(s):  
Blessings H. Likoswe ◽  
Edward J. M. Joy ◽  
Fanny Sandalinas ◽  
Suzanne Filteau ◽  
Kenneth Maleta ◽  
...  
Keyword(s):  
Vitamin A ◽  
School Children ◽  
Vitamin A Deficiency ◽  
Threshold Concentration ◽  
The Body ◽  
Retinol Binding Protein ◽  
World Health ◽  
Target Tissue ◽  
Serum Retinol ◽  
Health Organization

Retinol Binding Protein (RBP) is responsible for the transport of serum retinol (SR) to target tissue in the body. Since RBP is relatively easy and cheap to measure, it is widely used in national Micronutrient Surveys (MNS) as a proxy for SR to determine vitamin A status. By regressing RBP concentration against SR concentration measured in a subset of the survey population, one can define a population-specific threshold concentration of RBP that indicates vitamin A deficiency (VAD). However, the relationship between RBP and SR concentrations is affected by various factors including inflammation. This study, therefore, aimed to re-define the population-specific cut-off for VAD by examining the influence of inflammation on RBP and SR, among pre-school children (PSC) from the 2015–16 Malawi MNS. The initial association between RBP and SR concentrations was poor, and this remained the case despite applying various methods to correct for inflammation. The World Health Organization (WHO) recommends the threshold of 0.7 µmol/L to define VAD for SR concentrations. Applying this threshold to the RBP concentrations gave a VAD prevalence of 24%, which reduced to 10% after inflammation adjustments following methods developed by the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA). Further research is required to identify why SR and RBP were poorly associated in this population. Future MNS will need to account for the effect of inflammation on RBP to measure the prevalence of VAD in Malawi.

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