scholarly journals Are We Ready For Covid – 19 Vaccines? – A General Side Effects Overview

2021 ◽  
Vol 4 (02) ◽  
Author(s):  
Dr. Lipika Das ◽  
Dr. Meghana A ◽  
Dr. Prolay Paul ◽  
Dr. Sayantan Ghosh
Keyword(s):  
Side Effects ◽  
Vaccine Development ◽  
Vaccination Strategy ◽  
Personal Hygiene ◽  
Effective Vaccine ◽  
Family Welfare ◽  
Public And Private ◽  
The People ◽  
Life Threatening ◽  
History Of

A vaccine is considered to be one of the best options in public health safety, specifically when there is no effective vaccine available against that infectious disease.6 Classic vaccine development often takes years, but developing a vaccine for the prevention of Covid- 19 has turned out to be a race between viruses and humans, and along with the identification of other similar strains has made it more difficult. COVID- 19 has serious and life-threatening complications and no one knows how COVID- 19 is affecting.13 Firstly vaccines are given to health care workers in public and private. The vaccine is first given to one crore healthcare workers around India working in both government and private hospitals according to the recommendation by NEGVAC. It is mandatory to monitor the patient for the next 15 minutes after taking the Covid 19 Vaccine shot. Most of the side effects occur within the next 3 days after vaccination. If someone has a history of allergic reactions which is not related to vaccines or injectable medications, they can still take Covid 19 Vaccine. If someone getting an immediate allergic reaction after getting the first dose of Covid 19 Vaccine, then he/she should not take the second dose of the vaccine. Even though the vaccination strategy throughout the globe is in peak, the people are asked to follow the similar guidelines to prevent the transmission of corona virus. Therefore throughout the world, several ministries of health and family welfare have asked people to maintain social distancing, wearing facemasks in public, using hand sanitizers, washing hands, avoid crowded places and maintain personal hygiene.

Systems Biology-Based Approaches Applied to Vaccine Development

Data Mining ◽  
2013 ◽  
pp. 1131-1148
Author(s):  
Patricio A. Manque ◽  
Ute Woehlbier
Keyword(s):  
Gene Expression ◽  
Systems Biology ◽  
Vaccine Development ◽  
Cost Effective ◽  
Host Responses ◽  
Effective Vaccine ◽  
Antigen Discovery ◽  
Genomic Technologies ◽  
History Of ◽  
Genomic Revolution

Vaccines represent one of the most cost-effective ways to prevent and treat diseases. The use of vaccines in the control of viral diseases represents an important milestone in the history of medicine. The genomic revolution brought us the possibility to scan genomes in the search of new and more effective vaccine candidates and the advancement of bioinformatics provided the framework for the application of strategies that were focused not only on antigen discovery but also on comparative genomics, and pathogenic factor identification and data mining. In addition, the progress in post-genomic technologies including gene expression technologies such as microarray and proteomics gave us the opportunity to explore the host responses to vaccines leading to a better understanding of immune responses to pathogens and/or to vaccines, assisting in the development of new and better vaccines and adjuvants. This chapter will review how systems biology-based approaches including genomics, gene expression technologies, and bioinformatics have changed the way of thinking about antigen discovery and vaccine development. In addition, the chapter will discuss how the study of the host responses in combination with “in silico” approaches could help predict immunogenicity and improve the efficacy of vaccines.

Risperidone-Induced Neuroleptic Malignant Syndrome: A Case Report and Review

1996 ◽  
Vol 41 (1) ◽  
pp. 52-54 ◽  
Author(s):  
Gb Meterissian
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Neuroleptic Malignant Syndrome ◽  
Clinical Features ◽  
Prior History ◽  
Extrapyramidal Side Effects ◽  
Life Threatening ◽  
History Of ◽  
Life Threatening Complication ◽  
The One

Objectives: 1. To report the case of a 53-year-old patient who developed neuroleptic malignant syndrome (NMS) — a rare but potentially life-threatening complication of neuroleptic therapy — 4 days after treatment with risperidone was initiated. 2. To review previously reported cases of NMS associated with risperidone. Methods: A computerized search of several databases, including MEDLINE, was conducted to find all previously reported cases of NMS with risperidone. Results: Five reported cases of risperidone-induced NMS were found in the literature. All cases including the one reported here displayed typical clinical features of NMS and all 6 patients had a prior history of extrapyramidal side effects and/or NMS. Age and duration of exposure to risperidone did not seem to be of significance. Conclusions: These cases illustrate that clinicians should be on the lookout for risperidone-induced NMS.

scholarly journals COVID-19: The Disease, the Immunological Challenges, the Treatment with Pharmaceuticals and Low-Dose Ionizing Radiation

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2212
Author(s):  
Jihang Yu ◽  
Edouard I. Azzam ◽  
Ashok B. Jadhav ◽  
Yi Wang
Keyword(s):  
Low Dose ◽  
Vaccine Development ◽  
Health Workers ◽  
Low Dose Radiation ◽  
Effective Strategies ◽  
Advantages And Disadvantages ◽  
Life Threatening ◽  
History Of ◽  
History Books ◽  
Dose Radiation

The year 2020 will be carved in the history books—with the proliferation of COVID-19 over the globe and with frontline health workers and basic scientists worldwide diligently fighting to alleviate life-threatening symptoms and curb the spread of the disease. Behind the shocking prevalence of death are countless families who lost loved ones. To these families and to humanity as a whole, the tallies are not irrelevant digits, but a motivation to develop effective strategies to save lives. However, at the onset of the pandemic, not many therapeutic choices were available besides supportive oxygen, anti-inflammatory dexamethasone, and antiviral remdesivir. Low-dose radiation (LDR), at a much lower dosage than applied in cancer treatment, re-emerged after a 75-year silence in its use in unresolved pneumonia, as a scientific interest with surprising effects in soothing the cytokine storm and other symptoms in severe COVID-19 patients. Here, we review the epidemiology, symptoms, immunological alterations, mutations, pharmaceuticals, and vaccine development of COVID-19, summarizing the history of X-ray irradiation in non-COVID diseases (especially pneumonia) and the currently registered clinical trials that apply LDR in treating COVID-19 patients. We discuss concerns, advantages, and disadvantages of LDR treatment and potential avenues that may provide empirical evidence supporting its potential use in defending against the pandemic.

scholarly journals Revolutionary Socialist Internationalism: Rank-and-File Reaction in the USPD

1977 ◽  
Vol 22 (3) ◽  
pp. 329-349 ◽  
Author(s):  
Robert F. Wheeler
Keyword(s):  
Working Class ◽  
International Meeting ◽  
Top Down ◽  
Bottom Up ◽  
Public And Private ◽  
The Public ◽  
The People ◽  
History Of ◽  
Per Se ◽  
Historical Accounts

Historical accounts of the First, Second and Third Internationals, i.e., those organizations that attempted to realize some sort of supranational working-class solidarity, have traditionally been presented in terms of congresses, programs and personalities. Invariably scholars have focused on the public and private debates at this or that international meeting and/or how Marx, Engels, Lenin or some other leading figure influenced or reacted to some specific development. In short, the history of the International has been looked at almost exclusively from the “top down”. There is not anything wrong with this approach per se, but it might be of some value to consider, occasionally at least, the people whom the various Internationals were supposed to be serving, in other words to examine the International not only from the “top down” but also from the “bottom up”.

scholarly journals AN OVERVIEW OF RECOMBINANT VACCINE TECHNOLOGY, ADJUVANTS AND VACCINE DELIVERY METHODS

2016 ◽  
Vol 8 (11) ◽  
pp. 19 ◽  
Author(s):  
Shuaibu Abdullahi Hudu ◽  
Saadatu Haruna Shinkafi ◽  
Shuaibu Umar
Keyword(s):  
Viral Infections ◽  
Vaccine Development ◽  
Journal Article ◽  
Vaccine Delivery ◽  
Recombinant Vaccine ◽  
Effective Vaccine ◽  
Routes Of Administration ◽  
Life Threatening ◽  
New Generation ◽  
And Control

Development of an effective vaccine is of paramount important in disease prevention and control. As such, recombinant technology can serve as a gateway for the development of safe and effective vaccines that can be delivered effectively with an appropriate adjuvant. Therefore, this paper aimed to review the role of recombinant vaccine technology, new adjuvants and the challenge of vaccine delivery. Related peer-reviewed journal article searches were conducted using a subscribed database at the Universiti Putra Malaysia library, involving areas of Health Sciences and Medicine via Medline, SCOPUS and Google Scholar. New generation vaccines include highly purified synthetic or recombinant antigens that stimulate effective cell-mediated immune and mucosal immunity. In order to enhance their efficacy, a number of adjuvants are used. Efforts have also been made to explore the usage of non-invasive routes of administration, devices and equipment for optimized antigen and immune-potentiator delivery of the immune system. Recombinant vaccine technology is rapid, compared to the traditional method of vaccine development and does not require the handling of live viruses. It is, therefore, a promising technology for developing a future vaccine to curb emerging and re-emerging viral infections that may be life-threatening or teratogenic.

The Ottoman Archives as a Source for the History of the Arab Lands

1951 ◽  
Vol 83 (3-4) ◽  
pp. 139-155 ◽  
Author(s):  
Bernard Lewis
Keyword(s):  
Public And Private ◽  
Islamic Period ◽  
The Public ◽  
The People ◽  
Large Numbers ◽  
Literary Sources ◽  
History Of ◽  
Early Islamic Period ◽  
Early Islamic ◽  
Archive Material

One of the classical difficulties of the student of the history of the Islamic Middle East, as contrasted with his colleagues in the European field, is the lack of archive material. While the western medievalist, for example, has at his disposal a mass of records, central and local, public and private, political, administrative, judicial, and ecclesiastical, the orientalist has to rely for the most part on literary and archæological sources. In many fields of history his findings are in consequence often vague and general; they are in the main limited to the public and external life of the communities and individuals he studies. Only the events and personalities important enough to achieve literary mention are known to him, and then only through the reflecting medium of literary sources. Even the great figures, with few exceptions, remain dim and formalized outlines, while for the life of the people he has to rely mainly on occasional hints and scraps of evidence. Large numbers of individual documents survive in isolation—some in the form of inscriptions, others quoted in the texts of the chronicles; but only for one period after the rise of Islam is any important body of original documents available—and the light they have shed on the period from which they derive has deepened the surrounding darkness. The Egyptian papyri of the early Islamic period have imposed a rewriting of much of the history of the early Caliphate, as recorded by the chroniclers and jurists. Yet even the papyri are not archives in the true sense of the word.

scholarly journals A brief note on the scope of RNA interference(RNAi) therapy in mitigating COVID-19

2021 ◽  
Vol 6 (2) ◽  
pp. 94-95
Author(s):  
Sanzida Islam Bristi
Keyword(s):  
Rna Interference ◽  
Side Effects ◽  
Vaccine Development ◽  
Host Immunity ◽  
Effective Vaccine ◽  
Immunomodulatory Agents ◽  
Viral Rnas ◽  
Respiratory Coronavirus ◽  
Consistent Application ◽  
Rnai Therapy

Together with the use of number of repurposed/ repositioned antiviral drugs and immunomodulatory agents against the severe acute respiratory coronavirus 2 (SARS-CoV-2) infection, currently several vaccines are under human trials to mitigate the COVID-19 worldwide. Although the drugs and vaccines appear to be effective in maximum cases or trials; however, the associated side effects, the required induction of the long-lasting immunity, and finally, the safety concerns are of significance in terms of their consistent application/ administration. A vast research on the SARS-CoV-2 genomics and on its similarities with SARS-CoV-1 and with the Middle East Respiratory Syndrome coronavirus (MERS-CoV) have unraveled the viral avoidance of the host immunity which creates a challenge in course of effective vaccine development although several COVID-19 vaccines are currently being used commercially worldwide. Such an unsteady circumstance led the scientists also to think on a new remedial approach i.e., the RNA interference (RNAi) therapy to inhibit the SARS-CoV-2 proliferation by degrading the viral RNAs. Present review discussed such strategy and its effectiveness during the ongoing COVID-19 pandemic.

scholarly journals Viruses, Vaccines and the Race for a Covid-19 Vaccine: A Tutorial

2020 ◽  
Author(s):  
Subramani Mani
Keyword(s):  
Clinical Trials ◽  
Vaccine Development ◽  
Effective Vaccine ◽  
History Of ◽  
Development Methods

This tutorial is organized into three major sections—viruses, vaccines and the race for a Covid-19 vaccine. The goal is to provide enough background on viruses, history of vaccines, and the science of vaccinology founded on the principles of immunity. The hope is that this will enable us to understand the challenges, methods and prospects for developing a safe and effective vaccine against SARS-CoV-2. Many important viruses such as smallpox, HIV, HCV and SARS-CoV-2 which is responsible for causing the Coronavirus disease 2019 (Covid-19) are presented in detail, which is then followed by a description of different vaccine development methods and strategies. The tutorial then discusses different candidate SARS-CoV-2 vaccines and provides specific details of many of the prospective vaccines on the leader-board which are undergoing clinical trials. The tutorial concludes with a realistic projection for a safe and effective vaccine against SARS-CoV-2 based on the historical scientific record.

Agricultural Involution and Bureaucratic Involution: Types, Concepts, Empirical Generalizations, and Theoretical Mechanisms

Rural China ◽  
2021 ◽  
Vol 18 (2) ◽  
pp. 169-191
Author(s):  
Philip C. C. Huang (黄宗智)
Keyword(s):  
Education System ◽  
Agricultural Development ◽  
Enterprise Management ◽  
State Party ◽  
Reform Era ◽  
Public And Private ◽  
The People ◽  
History Of ◽  
Chinese Agriculture ◽  
Empirical Generalizations

Abstract The article reviews the history of the word “involution,” the empirical basis of the concept of “agricultural involution,” and the mechanisms operating behind that phenomenon. It then considers the very different empirical bases and mechanisms of “bureaucratic involution.” State and peasant might interact in a positive way that leads to development – as when the state in the Reform era gave peasants the power and right to respond to market stimuli and develop the “labor and capital dual intensifying” “new agriculture” that has led to genuine development, demonstrating how small peasants have been the true primary subjects of Chinese agriculture and the true key to genuine agricultural development. By contrast, if bureaucratic involution should force on peasants policies that run counter to realities, it can lead to malignant “ultra-involution.” Similar consequences can be seen in spheres with scarce opportunities relative to the number of people seeking them, once they are placed under the forces of bureaucratic involution, as in the “examinations-above-all-else education system” as well as in similar (public and private) enterprise management. That is why the word “involution” has recently triggered such widespread resonance among so very many people. What is needed is state-party policies that truly accord with the interests of the people and draw their active participation. That kind of combination is what can check tendencies toward ultra-involution.

Systems Biology-Based Approaches Applied to Vaccine Development

2011 ◽  
pp. 61-78
Author(s):  
Patricio A. Manque ◽  
Ute Woehlbier
Keyword(s):  
Gene Expression ◽  
Systems Biology ◽  
Vaccine Development ◽  
Cost Effective ◽  
Host Responses ◽  
Effective Vaccine ◽  
Antigen Discovery ◽  
Genomic Technologies ◽  
History Of ◽  
Genomic Revolution

Vaccines represent one of the most cost-effective ways to prevent and treat diseases. The use of vaccines in the control of viral diseases represents an important milestone in the history of medicine. The genomic revolution brought us the possibility to scan genomes in the search of new and more effective vaccine candidates and the advancement of bioinformatics provided the framework for the application of strategies that were focused not only on antigen discovery but also on comparative genomics, and pathogenic factor identification and data mining. In addition, the progress in post-genomic technologies including gene expression technologies such as microarray and proteomics gave us the opportunity to explore the host responses to vaccines leading to a better understanding of immune responses to pathogens and/or to vaccines, assisting in the development of new and better vaccines and adjuvants. This chapter will review how systems biology-based approaches including genomics, gene expression technologies, and bioinformatics have changed the way of thinking about antigen discovery and vaccine development. In addition, the chapter will discuss how the study of the host responses in combination with “in silico” approaches could help predict immunogenicity and improve the efficacy of vaccines.

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