Role of vitamin D deficiency in the development obstetric and perinatal complications (Literature review)

2018 ◽  
pp. 93-96
Author(s):  
O.O. Korchinska ◽  
◽  
N.O. Loya ◽  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Birth Defects ◽  
Premature Birth ◽  
Geographical Location ◽  
Perinatal Complications ◽  
Adverse Health Outcomes ◽  
High Prevalence ◽  
Low Levels

The article gives an overview of the literature that shows the high prevalence of deficiency and insufficiency of vitamin D in pregnant women in countries irrespective of their geographical location, leading to adverse health outcomes, such as miscarriage, premature birth defects, preeclampsia, gestational diabetes, risk Caesarean section, low birth weight and an increase in the number of autoimmune diseases associated with low levels of vitamin D during pregnancy. Key words: vitamin D deficiency, pregnancy, obstetric complications, perinatal complications.

scholarly journals Vitamin D Deficiency: Consequence or Cause of Obesity?

Medicina ◽  
2019 ◽  
Vol 55 (9) ◽  
pp. 541 ◽  
Author(s):  
Luka Vranić ◽  
Ivana Mikolašević ◽  
Sandra Milić
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Treatment Option ◽  
Obese People ◽  
Diet And Exercise ◽  
High Prevalence ◽  
Excess Amount ◽  
Obese Subjects ◽  
Significant Health

Obesity is defined as an excess amount of body fat and represents a significant health problem worldwide. High prevalence of vitamin D (VD) deficiency in obese subjects is a well-documented finding, most probably due to volumetric dilution into the greater volumes of fat, serum, liver, and muscle, even though other mechanisms could not completely be excluded, as they may contribute concurrently. Low VD could not yet be excluded as a cause of obesity, due to its still incompletely explored effects through VD receptors found in adipose tissue (AT). VD deficiency in obese people does not seem to have consequences for bone tissue, but may affect other organs, even though studies have shown inconsistent results and VD supplementation has not yet been clearly shown to benefit the dysmetabolic state. Hence, more studies are needed to determine the actual role of VD deficiency in development of those disorders. Thus, targeting lifestyle through healthy diet and exercise should be the first treatment option that will affect both obesity-related dysmetabolic state and vitamin D deficiency, killing two birds with one stone. However, VD supplementation remains a treatment option in individuals with residual VD deficiency after weight loss.

scholarly journals The role of calcium and vitamin D in arterial hypertension

2020 ◽  
pp. 117-123
Author(s):  
И.А. Туйзарова ◽  
Т.С. Свеклина ◽  
В.А. Козлов ◽  
Р.Т. Сардинов
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Receptor Gene ◽  
Plasma Concentrations ◽  
Geographical Location ◽  
Renin Angiotensin System ◽  
The Elderly ◽  
Relationship Of

В ряде последних эпидемиологических и ретроспективных исследований представлены доказательства роли кальция и витамина D в развитие артериальной гипертензии и связанной с ней сердечной недостаточностью. Дефицит витамина D, который может встречаться у 82,5% населения, и связанное с ним нарушение обмена кальция, эпидемиологи расценивают как пандемию. Цель обзора - систематизация современных сведений о роли кальциевого гомеостаза и дефицита витамина D в формировании артериальной гипертензии. В обзоре литературы рассмотрены вопросы связи артериальной гипертензии с плазменными концентрациями кальция и холекальциферолов. Анализ данных литературы свидетельствует, что у молодых людей стойкое повышение артериального давления ассоциировано с высокими плазменными концентрациями Ca2+, а у пожилых, особенно лиц с остеопорозом - с низкими. Циркадианные колебания плазменных концентраций кальция совпадают с изменением величины артериального давления. Данные ряда проспективных исследований и метаанализов о связи артериальной гипертензии и низких концентраций холекальциферолов в крови подтверждены экспериментами на мышах с нокаутированным геном рецептора витамина D. Низкие концентрации витамина D в плазме крови сопровождаются уменьшением высвобождения оксида азота, поэтому предполагают, что витамин D является эндокринным регулятором ренин-ангиотензиновой системы. Дефицит витамина D осложняет течение заболеваний, ассоциированных с артериальной гипертензией (хроническая сердечная недостаточность, сахарный диабет второго типа, ожирение). Вне зависимости от географического места проживания у значительной части населения наблюдается дефицит холекальциферолов в крови. Уменьшение плазменных концентраций холекальциферолов у пожилых людей, особенно сочетанное с остеопорозом, ассоциируется с инсулинорезистентностью и АГ. Дефицит витамина D во время беременности и концентрации ниже 11 нг/мл при рождении и 25 нг/мл в раннем детстве увеличивают риск высокого систолического давления более чем в 1,5 раза. Заключение: результаты нескольких независимых метаанализов убедили авторов в необходимости включения активных форм витамина D в плановую терапию артериальной гипертензии. Several recent epidemiological and retrospective studies have provided evidence for the role of calcium and vitamin D in development of hypertension and related heart failure. Epidemiologists regard as a pandemic the vitamin D deficiency, which may occur in 82.5% of the population and be associated with calcium metabolism disorders. The aim of the review was to systematize current information about the role of calcium homeostasis and vitamin D deficiency in the development of hypertension. The review addresses the relationship of blood pressure (BP) with plasma concentrations of calcium and cholecalciferols. In young people, a persistent BP elevation correlates with high plasma concentrations of Ca2+ whereas in the elderly, particularly those with osteoporosis, high BP correlates with low Ca2+. Circadian fluctuations of plasma calcium parallel changes in BP. A number of prospective studies and meta-analyses has reported a relationship of hypertension and low blood cholecalciferols. These results were confirmed by experiments on knockout mice lacking the vitamin D receptor gene. Low plasma concentrations of vitamin D are associated with decreased release of nitric oxide, which suggests that vitamin D is an endocrine regulator of the renin-angiotensin system. Vitamin D deficiency complicates the course of diseases associated with hypertension (chronic heart failure, type 2 diabetes, obesity). Regardless of the geographical location of the residence, a significant part of the population has a shortage of cholecalciferols in the blood. Decreased plasma concentrations of cholecalciferols in the elderly, particularly in combination with osteoporosis, is associated with insulin resistance and hypertension. Vitamin D shortage during pregnancy and its concentrations <11 ng/ml at birth and <25 ng/ml in early childhood increase the risk of high systolic BP more than 1.5 times. Conclusion: Results of several independent metaanalyses warrant the inclusion of active forms of vitamin D into regimens of antihypertensive treatment.

Serum 25-OH Vitamin D Level in Psoriatic Patients and Comparison With Control Subjects

2015 ◽  
Vol 20 (3) ◽  
pp. 207-210 ◽  
Author(s):  
Masoud Maleki ◽  
Yalda Nahidi ◽  
Sahar Azizahari ◽  
Naser Tayyebi Meibodi ◽  
Ali Hadianfar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
High Prevalence ◽  
The Difference ◽  
25 Oh Vitamin D

Background: Vitamin D has been shown to have immunomodulatory effects, and previous studies have proposed a role of vitamin D deficiency in multiple autoimmune diseases, including psoriasis. Objectives: The aim of this study was to investigate serum vitamin D levels in psoriatic patients and compare them with levels in controls. Methods: This study was carried out in 50 psoriasis patients. Serum vitamin D was measured by enzyme-linked immunosorbent assay. Results: The mean serum vitamin D levels in psoriatic patients and controls were 14.92 ± 6.31 and 12.52 ± 4.54 ng/mL, respectively. The difference was not statistically significant ( P = .06). The prevalence of vitamin D deficiency (<20 ng/mL) was 84.0% in psoriatic patients and 93.0% in controls ( P = .21). Conclusions: Most of the patients with psoriasis had vitamin D deficiency, which may have contributed to the evolution of their psoriasis. However, considering the high prevalence of vitamin D deficiency in Iran, no difference was noted between the psoriatic patients and the controls.

scholarly journals Vitamin D and Demyelinating Diseases: Neuromyelitis Optica (NMO) and Multiple Sclerosis (MS)

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Cady Rodney ◽  
Sherriann Rodney ◽  
Richard M. Millis
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Neuromyelitis Optica ◽  
Geographical Location ◽  
Demyelinating Diseases ◽  
Future Research ◽  
Dietary Recommendations ◽  
Health Practitioners

Vitamin D deficiency is prevalent in all ages regardless of climate or geographical location and evidence is emerging that the incidence of autoimmune diseases is increasing worldwide. Women make up a large proportion of autoimmune disease diagnoses, underscoring the importance of fully elucidating the complex synergistic relationships between estrogens and vitamin D. Vitamin D receptor-activating drugs appear to enhance remyelination in patients diagnosed with multiple sclerosis (MS) and other demyelinating diseases such as neuromyelitis optica (NMO). This review is intended to update health practitioners about the potential role of vitamin D deficiency demyelination and to motivate future research on dietary recommendations for vitamin D in preventing and treating demyel1nating diseases.

scholarly journals Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1378
Author(s):  
Francesco Palmese ◽  
Rossella Del Toro ◽  
Giulia Di Marzio ◽  
Pierluigi Cataleta ◽  
Maria Giulia Sama ◽  
...  
Keyword(s):  
Vitamin D ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Nutrient Deficiencies ◽  
Pathological Conditions ◽  
High Prevalence ◽  
The Relationship

Sarcopenia is a prevalent condition in patients with Crohn’s disease (CD), representing an independent predictor factor for the development of major postoperative complications. Thus, a proper assessment of the muscle strength, by using different validated tools, should be deemed an important step of the clinical management of these patients. Patients with CD are frequently malnourished, presenting a high prevalence of different macro- and micro-nutrient deficiencies, including that of vitamin D. The available published studies indicate that vitamin D is involved in the regulation of proliferation, differentiation, and regeneration of muscle cells. The relationship between vitamin D deficiency and sarcopenia has been extensively studied in other populations, with interesting evidence in regards to a potential role of vitamin D supplementation as a means to prevent and treat sarcopenia. The aim of this review was to find studies that linked together these pathological conditions.

scholarly journals Prevalence of vitamin D deficiency in Indian women

2018 ◽  
Vol 7 (6) ◽  
pp. 2222 ◽  
Author(s):  
Ruchika Garg ◽  
Vishy Agarwal ◽  
Prabhat Agarwal ◽  
Saroj Singh ◽  
Neharika Malhotra
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Rural Areas ◽  
Nutritional Deficiency ◽  
Indian Women ◽  
The People ◽  
High Prevalence ◽  
Daily Allowance ◽  
Set Up

Background: Vitamin D is the widespread nutritional deficiency in India yet it has been widely undiagnosed and untreated. Nowadays its deficiency has become the widely investigational topic as the role of vitamin D deficiency has been identified in various disorders.Methods: In order to study the prevalence of vitamin d in our study (level <20 ng/ml) the 1052 women attending the clinic are taken into the consideration and the levels of vitamin d are done in them irrespective of the symptom.Results: In our study the 1052 women attending the clinic were taken and it was found that the prevalence of vitamin D level <20 ng/ml was 64.06% and the level of vitamin D <30 ng/ml was 98.75% and it was higher in younger (65.51%), illiterate (89.92%), housewife women (70%) and its prevalence was higher in women residing in rural areas (69.94%) and also having an income <10,000 (61.96%).Conclusions: Thus it was concluded the cut off level for the vitamin D deficiency level should be revised in according to the need of the people of India as the high prevalence of vitamin D deficiency in our study could be the result of our being over concerned and the internationally set up criteria for its deficiency and also ICMR should also revise the recommend daily allowance to include daily recommendation of vitamin D level.

Vitamin D Deficiency and Otosclerosis

1985 ◽  
Vol 93 (3) ◽  
pp. 313-321 ◽  
Author(s):  
Gerald B. Brookes
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Alkaline Phosphatase ◽  
Hearing Improvement ◽  
Duration Of Symptoms ◽  
Etiologic Role ◽  
The Mean ◽  
Low Levels ◽  
A Prospective Study

A prospective study of 47 patients with otosclerosis was undertaken to investigate the possible etiologic role of vitamin D undernutrition. The population comprised 27 women and 20 men, with a mean age of 46.4 years (range 21 to 79). The disease was bilateral in 43 patients, and cochlear involvement was present in 84.4%. The mean duration of symptoms was 17.1 years. Vitamin D status was evaluated by measuring the plasma 25-hydroxy vitamin D3 (25-OHD), which is the main storage metabolite. Abnormally low 25-OHD levels were found in 10 patients (21.7%) and borderline low levels in another two. Raised serum alkaline phosphatase levels were present in 32.6%, calcium in 6.5%, and inorganic phosphate in 4.3%. Calcium and vitamin D replacement therapy resulted in significant hearing improvement in 3 of 16 patients; these data support a causal correlation. Vitamin D deficiency is probably a factor in the etiology of some cases of otosclerosis and is important, since the deafness resulting from cochlear involvement may be reversible.

scholarly journals Role of stress in development of cardiovascular pathology in extreme professions

2019 ◽  
Vol 2 (27) ◽  
pp. 42-44
Author(s):  
N. V. Orlova ◽  
A. Ya. Starokozheva ◽  
A. V. Timoshchenko
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Stress Resistance ◽  
Stress Reactions ◽  
Stress Studies ◽  
Industrial Sectors ◽  
High Prevalence ◽  
High Level ◽  
The Impact

Psychoemotional stress is a risk factor for cardiovascular diseases, including arterial hypertension and coronary heart disease. Neurohumoral mechanisms are involved in the development of hypertensive reactions to stress. The severity of stress reactions depends on the stress resistance of people. The study of stress resistance is carried out in industrial sectors associated with the impact of professional psycho-emotional stress. Studies in locomotive drivers reveal a high level of cardiovascular disease. Stress helps to reduce vitamin D. Vitamin D deficiency helps reduce stress resistance. Studies conducted among locomotive drivers have revealed a high prevalence of vitamin D deficiency, requiring medical correction.

High Prevalence of Vitamin D Deficiency among LVAD Patients

2015 ◽  
Vol 63 (S 01) ◽  
Author(s):  
M. von Stumm ◽  
D. Knappe ◽  
M.J. Barten ◽  
A. Bernhardt ◽  
F. Wagner ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
High Prevalence
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