Comparative study of the efficacy of topical therapy of mixed vaginitis associated with cervicitis by combined medications

2018 ◽  
pp. 42-49
Author(s):  
V.I. Pyrohova ◽  
◽  
S.O. Shurpyak ◽  
Yu.R. Fayta ◽  
M.Y. Malachinska ◽  
...  
Keyword(s):  
Comparative Study ◽  
Comparison Group ◽  
Topical Therapy ◽  
Local Therapy ◽  
Main Group ◽  
Reproductive Age ◽  
Gardnerella Vaginalis ◽  
Pathogenic Microorganisms ◽  
Candida Spp ◽  
Vaginal Suppository

The objective: to increase the effectiveness of local therapy for recurrent nonspecific vaginitis associated with cervicitis in women of reproductive age on the basis of a comparative evaluation of combined drugs Terzhinan and Neo Penotran Forte. Materials and methods. A prospective, open comparative study included 56 women aged 27.5±2.8 years with recurrent nonspecific vaginitis and cervicitis who were randomized to the main group and comparison group. Patients of the main group (n=28) received the drug Terzhinan® (1 vaginal tablet in the evening, before bed, for 10 days). The comparison group included 28 patients who received Neo-Pentran Forte (1 vaginal suppository in the evening, before bedtime, for 10 days), one vaginal suppository containing 750 mg of metronidazole and 200 mg of miconazole nitrate. The complex clinical-paraclinical examination included the determination of the state of the vaginal microbiota using several methods in parallel: a bacterioscopy of vaginal smears stained by Gram, a bacteriological rapid method using AFGENITAL SYSTEM (Liofilchem®, Italy), real-time PCR (Florocenosis) with detection antigens of chlamydia, herpes simplex virus, human papillomavirus, trichomonads. Results. The main reason for the treatment of patients were abundant pathological discharge from the genital tract (73.2%), pruritus (37.5%) and burning (23.2%) in the vulva, pain during sexual intercourse (8.9%), while 33.9% of women expressed combined complaints. Attention was drawn to the significant frequency of dyshormonal pathology among women with recurrent cervico-vaginal infections. In the examined women, uterine leiomyoma was diagnosed (28.6%), genital endometriosis (19.6%), fibrocystic breast disease (37.5%), combined benign dyshormonal diseases of the genital organs (14.3%). About 21.4% of patients treatment of thyroid gland dysfunction (hypothyroidism). According to the comprehensive examination, in all patients of clinical groups, decompensated vaginal dysbiosis was diagnosed, which was manifested by a sharp decrease in the absence of Lactobacillus spp strains in 39.3% of patients and an increase in the number of isolated opportunistic and pathogenic microorganisms to 1011 CFU/ml with an increase in the number of microorganisms in microbial associations (from 2–3 to 5–6 conditionally pathogenic and pathogenic pathogens) in all the cases analyzed. When using the genital express system in vaginal contents, women of the main group identified Escherichia coli (17.9%), Pseudomonas spp. (10.7%), Gardnerella vaginalis (39.3%), Staphylococcus aureus (17 9%), Enterococcus faecalis (25.0%), Streptococcus Group B (10.7%), Candida spp. (46.4%), Mycoplasma spp./Ureaplasma ur. in the title > 105 (14.0%). In the comparison group, the spectrum of detected pathogenic and conditionally pathogenic microorganisms did not differ significantly from the data of the main group. 92.6% of patients in the main group had a pronounced positive clinical effect, and a positive microbiological effect was achieved in 96.4% of cases that persisted during the next two months of follow-up. Without additional prescription of antifungal agents, a positive effect was achieved in 84.6% of patients in the main group with mixed bacterial-candidiasis vaginitis at 54.5% in the comparison group. The independent recovery of the lactobacilli pool to a titer of 107–109 CFU/ml in 17.9% of patients with a lack of detection of lactobacilli before treatment. A similar effect was not observed in the comparison group. Сonclusion. In a comparative study of the results of the use of Terzhinan and Neo-Penotran Forte in monotherapy in patients with inflammatory diseases of the lower genitalia (nonspecific recurrent vaginitis and cervicitis), the high clinical and microbiological efficacy of Terzhinan has been demonstrated. Key words: mixed vaginitis, cervicitis, Terzhinan, Neo-Penotran Forte.

scholarly journals Bacterial vaginosis: evaluation of the effectiveness of simultaneous treatment of sexual partners

2020 ◽  
Vol 23 (6) ◽  
pp. 422-431
Author(s):  
V. A. Okhlopkov ◽  
S. V. Barinov ◽  
Yu. I. Tirskaya ◽  
Turan Shakhin kyzy Babaeva ◽  
L. B. Sinelnikova ◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Comparison Group ◽  
Clinical Symptoms ◽  
Sexual Partners ◽  
Main Group ◽  
Reproductive Age ◽  
Gardnerella Vaginalis ◽  
Male Partners ◽  
Associated Bacteria ◽  
Atopobium Vaginae

BACKGROUND: Bacterial vaginosis (BV) is one of the most common diseases affecting women of reproductive age. The main problem of BV is the low efficiency of traditional methods of treatment with a frequent recurrence of up to 50%. MATERIALS AND METHODS: A total of 59 patients were examined and treated with the diagnosis of BV, which was confirmed in accordance with the Amsel criteria. The main group included women with BV and their male partners, whereas the compared group included only women with BV. All women were treated with systemic metronidazole and topical clindamycin, and suppositories with lactic acid were prescribed at the second stage. The men partners were treated systemically with metronidazole and topically with clindamycin. RESULTS: Gardnerella vaginalis, Atopobium vaginae, and Prevotella were the most commonly identified bacteria in the vaginal discharge. In men, BV-associated bacteria were found in the foreskin of the glans penis and distal urethra. The similarity of the microflora of the genital organs of women and their male partners was determined. In women with sexual partners who were treated 6 months after the therapy, the number of BV-associated bacteria was detected two or more times less frequently than in patients in the comparison group. For the men, the number of complaints and clinical symptoms significantly decreased after the treatment. Significant decreases in Gardnerella vaginalis, Atopobium vaginae, Prevotella spp., Leptotrichia amnionii, and Mobiluncus were achieved in the foreskin and Gardnerella in the urethra. In the main group of women, the frequency of BV recurrences recorded was 2.3 times less than that in the comparison group. CONCLUSION: The treatment of partners of women with BV effectively reduces the growth of BV-associated bacteria and significantly decreases the frequency of recurrences.

scholarly journals Results of prevention of massive postural bleeding in women with preeclampsy

2020 ◽  
pp. 37-38
Author(s):  
M.Ya. Kamilova ◽  
N. Amin-Zade
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Comparison Group ◽  
Thrombus Formation ◽  
Laboratory Data ◽  
Massive Bleeding ◽  
Main Group ◽  
Severe Preeclampsia ◽  
Reproductive Age ◽  
Significant Difference

Objective. To evaluate the effectiveness of a tranexamic acid for the prevention of critical bleeding in women with preeclampsia. Materials and methods. 31 puerperas with postpartum hypotonic bleeding. Inclusion criteria: reproductive age, severe preeclampsia, postpartum hemorrhage, volume of blood loss – 700 ml, voluntary consent to the administration of the tranexamic acid. Exclusion criteria: delivery by the caesarean section. When providing emergency care, along with other standard measures, 14 women (the main group) were injected with the tranexamic acid when blood loss reached 700 ml, 17 women (the comparison group) did not receive the tranexamic acid. Research methods: measurement of the volume of blood loss (by the calculation method and by the method of measuring blood loss), statistical analysis – comparison of populations by qualitative characteristics. Results and discussion. A bleeding with a blood loss of 700-800 ml was registered in 7 women of the main group and in 6 women of the comparison group, with a blood loss of 800-900 ml – in 6 and 4 women, with the blood loss 900-1000 ml – in 1 and 7 women, respectively. There was a significant difference in outcomes (blood loss – 900-1000 ml) depending on the use of the tranexamic acid (Fisher’s exact test – 0.04537; p<0.05). Evaluation of the strength of the relationship between the frequency of aggravation of bleeding and the use of the tranexamic acid for the prevention of massive bleeding established a relationship of average strength (Cramer’s criterion – 0.387). Pregnant women with severe preeclampsia are at risk of the developing obstetric bleeding, which is associated with secondary changes in the hemostatic system in women with preeclampsia. With obstetric bleeding in women with preeclampsia, the balance between the coagulation, anti-coagulation and fibrinolytic systems is disturbed faster. Fibrinolysis is activated faster due to the limitation of thrombus formation due to the breakdown of fibrin in thrombi and the fibrinolytic properties of the fibrin breakdown products themselves. The use of the tranexamic acid in the obstetric bleeding is justified by the antifibrinolysis effect of the drug. Further research on the use of the tranexamic acid for the prevention of massive bleeding, confirmed by laboratory data, is highly relevant. Conclusions. The use of tranexamic acid with the onset of obstetric bleeding in women with risk factors for the secondary thrombocytopathy will prevent the aggravation of coagulopathy and reduce the incidence of massive obstetric bleeding caused by a disseminated intravascular coagulation.

scholarly journals Вплив лікувально-профілактичних заходів на показники ротової рідини та клінічний стан тканин пародонта у дітей 6–7 років, хворих на гінгівіт

2017 ◽  
Author(s):  
O. V. Avdeev ◽  
Y. K. Zmarko ◽  
A. B. Boykiv ◽  
R. O. Drevnitska
Keyword(s):  
Clinical Supervision ◽  
Oral Fluid ◽  
Urease Activity ◽  
Comparison Group ◽  
Local Therapy ◽  
Main Group ◽  
Control Group ◽  
Results Of Treatment ◽  
Comparative Group ◽  
Anti Inflammatory

The high prevalence of inflammatory processes in the periodontitis of children, the ineffective effectiveness of preventive and curative measures can contribute to the development of generalized periodontitis, therefore it remains urgent to develop pathogenetic effects in the treatment of chronic catarrhal gingivitis.The aim of the study – a comparative assessment of the traditional treatment of chronic catarrhal gingivitis in children aged 6–7 years with therapy using an anti-inflammatory gel with neovitin.Materials and Methods. 61 children aged 6–7 years, suffering from chronic catarrhal gingivitis, were taken under clinical supervision and divided into groups: the main (30 children) and the comparative (31 children). All children underwent conventional therapy in accordance with the protocols for the provision of medical care – basic therapy. In the main group, for a month, pathogenetic agents were used: an anti-inflammatory gel with neovitin, hygiene products were recommended. In the comparative group, 3 % hydrogen peroxide solution was used for local therapy, for rinsing of the mouth (during the first week of treatment) – Rotokan, a therapeutic and prophylactic toothpaste.Examination and control examinations were carried out with the hygienic state of the mouth determined by the hygienic index of Yu. A. Fedorov and V. V. Volodkina, prevalence and intensity of the inflammatory process in the gums with the help of the Schiller-Pisarev test and the PMA index, oral fluid index (lysozyme content, formation of oxydradicals, urease activity, degree of dysbiosis, pH and viscosity).Results and Discussion. After the treatment, elimination of gum inflammation in patients of the main group was accompanied by a decrease in the PMA index by 3.8 times; formation of oxyradicals decreased in children of the main group by 6.35 %; in the comparative group – by 6.15 %. Urease activity decreased in children of the main group by 16.37 % (p<0.05), the viscosity of the oral fluid of children decreased in 2.65 times in the main group and in 2.13 times in the comparative group (p<0.05). The lysozyme content increased in children of the main group by 15.61 % (p<0.05) in the comparison group – by 9.63% (p<0.05). The treatment after 0.5 years caused an increase in the lysozyme content in the oral fluid of the children of the main group to the level of the control group. The degree of dysbiosis decreased in the main group, in the comparison group tended to increase.Conclusions. The use of the proposed therapy with gel with neovitin contributed to the best results of treatment: reducing the degree of inflammation of the gums, the number of visits to the doctor, improving the indices of nonspecific protection in the oral fluid of 6-7 years-old children and, to a greater extent, six months after the treatment.

scholarly journals Microbial eczema: possibilities of correction at the present stage

2018 ◽  
Vol 94 (4) ◽  
pp. 60-67 ◽  
Author(s):  
M. M. Tlish ◽  
T. G. Kuznetsova ◽  
Z. Yu. Naatyzh ◽  
F. A. Psavok
Keyword(s):  
High Efficiency ◽  
Comparison Group ◽  
Topical Therapy ◽  
Bacterial Flora ◽  
The Body ◽  
Complete Suppression ◽  
Candida Spp ◽  
Drug Of Choice ◽  
Regulatory Systems ◽  
Before And After

Microbial eczema is a chronic recurrent dermatosis characterized by evolutionary polymorphism of the elements of the rash, sputum, itching, allergic reaction of the sensitized skin to the products of the decay of microorganisms and their toxins, developing against the background of a long-existing pyogenic focus in violation of the most important regulatory systems of the body.Purpose: to study the biocenosis of the skin in patients with microbial eczema and to evaluate the clinical efficacy and safety of the cream “Tetraderm” in such patients.Materials and methods. Patients with microbial eczema were observed, randomly selected into two groups. All patients studied biocenosis of the skin before and after treatment. Patients of the study group received topical therapy with the cream “Tetraderm”. External therapy for patients of the comparison group was carried out with cream of mometasone furoate in combination with erythromycin and clotrimazole ointments. The effectiveness of the therapy was evaluated taking into account the clinical dynamics of the skin process, bacteriological data on the content of pustules and detachable erosion, calculation of the EASI and DIJ indices.Results. A comparative analysis of the biocenosis of microbial eczema foci in patients of both groups at the end of therapy showed a higher severity of disbiotic changes in the comparison group. As a result of our study found that patients who used the cream “Tetraderm”, there was a more rapid regression of dermatosis, almost complete suppression of pathogenic bacterial flora, a significant improvement in the quality of life.Conclusion. The biocenosis of the skin of patients with microbial eczema was characterized by a high degree of contamination of Staphylococcus aureus and Staphylococcus epidermidis, against the background of the average verification of Streptococcus spp., Candida spp. The combination of pronounced anti-inflammatory, antibacterial, antimicotic and regenerating effects of the cream “Tetraderm” causes its high efficiency and prospects of use as a drug of choice of topical monotherapy of microbial eczema.

scholarly journals A complex approach to the diagnosis and treatment of pelvic pain in women: clinical and economic aspects

2012 ◽  
Vol 93 (1) ◽  
pp. 61-67 ◽  
Author(s):  
N V Moskovenko
Keyword(s):  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Comparison Group ◽  
Treatment Time ◽  
Economic Effect ◽  
Laboratory Data ◽  
Main Group ◽  
Diagnostic Methods ◽  
Reproductive Age ◽  
Doppler Flowmetry

Aim. To improve the results of treatment of chronic pelvic pain in women secondary to chronic nonspecific salpingoophoritis and chronic cystitis. Methods. Examined were 91 women of reproductive age suffering from pelvic pain. The patients comprised two groups. The first group included 68 women in the treatment of which physical exercise therapy, electromagnetic resonance radiation and laser treatment were used. The comparison group included 23 women who received conventional therapy. Used were the generally accepted clinical and special methods of investigation: determined was the content of gonadotropic and steroid hormones, conducted were sonographic, urodynamic studies, laser Doppler flowmetry, assessed was the heart rate variability by the R.M. Baevskiy technique. The medical and psychological examination of women included a study of a women’s personality traits with the help of classical psycho-diagnostic methods. Results. Chronic pelvic pain in women is accompanied by a disturbance of the autonomic balance, increase in the activity of the regulatory systems and psychoemotional disorders, in the structure of which anxiety and depression conditions dominate. The influence of these disturbances on the major categories of quality of life has been established. After treatment was completed marked improvement was observed in the women of the main group; herein the disappearance of major symptoms, normalization of laboratory data, ultrasound investigation data, indicators of microcirculation occurred in a shorter time; the duration of treatment decreased. In the long-time registered was a decrease of the frequency of exacerbations of the disease in the main group of women by 2.6 times relative to the comparison group of patients. The economic effectiveness of the proposed methods of treatment was 40.2%. Conclusion. The usage of physiotherapy techniques in the treatment of pelvic pain made it possible to reduce the treatment time, reduce the frequency of exacerbations of the disease, to establish an economic effect.

scholarly journals Medical-social risk factors of cervical cancer development among women of reproductive age

2019 ◽  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Comparison Group ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Social Risk ◽  
Social Risk Factors ◽  
Sociological Study ◽  
Female Population

Cervical cancer is one of the widespread diseases that have a negative impact on the reproductive health. However, medical-social risk factors which provoke this pathology aren't studied sufficiently yet. We have identified the most significant medical-social risk factors of cervical cancer's development and progression based on data analysis of a sociological study. Thus, it was found that cervical cancer can't be associated with predominantly late reproductive age of women in conditions of the Republic of Belarus: most of the patients with this pathology (more than 53%) were under the age of 35 years old. The group of patients suffered from cervical cancer was quite homogeneous in their social status, which was average and relatively stable in a large majority of them (more than 90%), despite employment in various sectors of the national economy. Social functioning of these patients wasn't significantly different from the main population of women in reproductive age. Thus, early sexual activity and random early sexual relations weren't characteristic for the majority of them: 86.1±4.46% (the control group – 87.3±5.51%, the comparison group – 78.2±3.96%) and 83.5±4.72% (the control group – 89.1±4.28%, the comparison group – 75.2±2.36%). Moreover, the married patients of the main group had the most ordered sexual behavior (p<0.01; tau=0.572) which determined the low prevalence of artificial abortions among them, including menstrual cycle regulation (less than 8%). However, the revealed different defects of health-saving behavior in the main group of patients (more than 70%), including an insufficient level of valeological knowledge, the presence of common harmful habits and low medical activity, indicate that there are significant reserves for improvement of the preventive activities of medical stuff in the field of primary medical care for the development of a healthy lifestyle among female population of reproductive age and providing clinical examination among this contingent of females in reproductive age with the purpose of cervical cancer prevention.

scholarly journals Risk of developing gestational diabetes in women after assisted reproductive technologies

2019 ◽  
Vol 68 (2) ◽  
pp. 17-22
Author(s):  
Olga N. Arzhanova ◽  
Anna V. Rulyova ◽  
Yulia M. Paykacheva ◽  
Alina O. Ivanova ◽  
Natalya G. Nichiporuk
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Gestational Diabetes ◽  
Comparison Group ◽  
Assisted Reproductive Technologies ◽  
Polycystic Ovary ◽  
Significant Risk ◽  
Reproductive Technologies ◽  
Main Group ◽  
Reproductive Age

Hypothesis/aims of study. Gestational diabetes mellitus (GDM) is one of the leading causes of perinatal morbidity and mortality. The use of assisted reproductive technologies (ART) is an independent risk factor for the development of GDM. Among other risk factors are overweight, diabetes burdened heredity, previous GDM, previous birth weight more than 4 kgs, stillbirth, miscarriage in history, glucosuria, polyhydramnios in this pregnancy, age over 30 years, polycystic ovary syndrome. The most significant risk factor for GDM is excess weight before pregnancy. The aim of this study was to investigate the risks of GDM in patients after ART. Study design, materials, and methods. 342 case histories of women with single pregnancy for the period 2014–2017 were studied on archival material. The main group consisted of 234 women with single pregnancy after ART. The comparison group comprised 108 medical records of fertile women with a history of single pregnancy that occurred spontaneously. The exclusion criteria in the comparison group were pregestational diabetes mellitus and severe extragenital pathology. Results. The incidence of GDM was significantly higher in the group of women in whom pregnancy occurred after ART compared to the comparison group (15.4 ± 0.4% and 5.5 ± 0.4% respectively). In the main group, patients were more likely to have overweight, extragenital pathology and pregnancy complications. Conclusion. The increase in the frequency of GDM among patients after ART is probably associated with late reproductive age, initially negative somatic background at the time of entry into the IVF protocols, as well as long-term hormone therapy during pregnancies after ART, starting from early terms.

scholarly journals NT-proBNP content in seminal plasma of ejaculate in normal conditions and in oligozooastenospermia

2020 ◽  
Vol 37 (4) ◽  
pp. 26-35
Author(s):  
Dmitriy Yu. Sosnin ◽  
Konstantin R. Galkovich ◽  
A. V. Krivtsov
Keyword(s):  
Seminal Plasma ◽  
Comparison Group ◽  
Solid Phase ◽  
Sperm Count ◽  
Test System ◽  
Mean Value ◽  
Main Group ◽  
Reproductive Age ◽  
System A ◽  
Human Fertility

Objective. To investigate the NT-proBNP concentration in ejaculate samples from healthy men and men with oligozooastenospermia. Materials and methods. The study included 52 men of reproductive age (34.4 3.9 years). The main group (n = 18) consisted of men with reduced ejaculate fertility, the comparison group (n = 34) consisted of men with normal levels of concentration and total sperm count. In seminal plasma, the concentration of NT-proBNP was investigated by solid-phase ELISA using the NT-proBNP-ELISA-BEST test system (A-9102) (Vector-Best, Russia). Results. The mean value of NT-proBNP content in the ejaculate (n = 52) was 29.498 pg / ml, the median concentration was 2.860 pg / ml and was characterized by high variability. In 62% (32 of 52) of the tested seminal plasma samples, the NT-proBNP value was below 20 pg / ml. The frequency of samples with such a low NT-proBNP content did not differ statistically significantly between the groups. In the main group, the number of such samples was 44 % (8 samples out of 18), and in the comparison group, 65 % (12 samples out of 34). Conclusions. When comparing the content of NT-proBNP in seminal plasma, no statistically significant differences were found between the groups. An analysis of the correlation between the concentration and the number of sperm in the ejaculate and the NT-proBNP content also did not reveal a statistically significant relationship. The possible role of natriuretic peptides in human fertility is discussed.

scholarly journals Ozonotherapy influence on hormonal status of pregnant women of older reproductive age

2019 ◽  
Vol 36 (4) ◽  
pp. 27-32
Author(s):  
R. B. Safarova
Keyword(s):  
Pregnant Women ◽  
Comparison Group ◽  
Preventive Therapy ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Hormonal Status ◽  
Group Iii ◽  
Group I ◽  
Medical Ozone

Aim. To study the hormonal status in pregnant women of older reproductive age and estimate the influence of administration of medical ozone on the course of pregnancy. Materials and methods. Ninety pregnant women aged 3544 years were examined over the period from 2013 to 2015. They were randomized by their age, social factors, associated gynecological and extragenital diseases. The main group (group I) joined 30 patients, the group of comparison (group II) 30 patients and the control (group III) 30 patients. All the patients underwent clinical and laboratory investigations according to the existing standards of obstetric examination. In the main group, complex treatment included therapy with medical ozone. In the comparison group, a standard medico-preventive therapy by the protocol №05 (20.02.2014 MH of AR) was implemented. In the control group, estrogen indices were studied in dynamics. Results. Pregnant women aged 35 years and older have an unfavorable background of extragenital and gynecological pathology that is confirmed by hormonal background. Conclusions. Planning of pregnancy, timely prevention and correction of clinicolaboratory indices permit to reduce the frequency and severity of pregnancy and delivery complications and improve the perinatal indices among patients of this age group.

scholarly journals Clinical characteristics of women with infertility and ovaricovaricocele

2018 ◽  
Vol 22 (1) ◽  
pp. 55-61
Author(s):  
O.V. Astakhova
Keyword(s):  
Clinical Characteristics ◽  
Structural Changes ◽  
Comparison Group ◽  
Inflammatory Diseases ◽  
Varicose Veins ◽  
Main Group ◽  
Reproductive Age ◽  
Ovarian Dysfunction ◽  
Significant Percentage

Despite numerous studies devoted to the etiological factors and pathogenetic aspects of infertility, the lack of a comprehensive analysis of the causes of ovarian dysfunction and the exact diagnosis leads to the polypharmacy of hormonal drugs and their low effectiveness. One of the less well known and poorly studied factors is pelvic venous complications, including varicose veins of the ovaries. Violation of venous circulation in the pelvic organs plays a significant role in the structure of gynecological pathology, particularly in the development of ovarian dysfunction. The purpose of our study was to analyze the clinical characteristics of women with functional infertility and ovaricovaricocele, namely the features of anamnesis of life, gynecological and somatic anamnesis, the study of which allows to assess and determine the risk factors, possible causes of ovarian dysfunction and the formation of varicose veins. To solve the goals and objectives, were prospectively examined and divided into 2 groups for the comparative analysis 117 pregnant women of reproductive age (21–44 years old) with functional infertility: the main group was 62 women with infertility and varicose veins in the ovaries; comparison group has 55 women with infertility without varicose veins. Patients were examined by a specially designed questionnaire, which included the results of gynecological and somatic anamnesis, anamnesis of life. In the main group of women there is an increased proportion of women with intellectual differentiation of labor and psycho-emotional and physical activity, which may be the basis for the formation of maladaptation syndrome with the subsequent occurrence of functional disorders of the reproductive system. In addition, conditions of work with considerable physical activity can indirectly have a negative effect on venous hemodynamics in the small pelvis. Women with functional infertility and ovaricovaricocele had a high incidence of infectious diseases in childhood — 83.9%. It is precisely at the stage of formation of reproductive function that the action of an infectious factor can be significant in the occurrence of violations of complete oogenesis in the subsequent reproductive life of patients. Attention is drawn to the large number of inflammatory diseases of the internal organs in women as the main group and the comparison group in the study of the somatic anamnesis: from the otolaryngologic organs — 48.3%, respiratory organs – 54.7%, genitourinary system — 43.5% and in the structure of gynecological diseases: inflammation of ovaries — 43.5%, vagina and cervix — 25.8%, suggesting that factors of violations of folliculogenesis in active reproductive age may be inflammatory diseases of the genitals. There is a significant percentage of dyshormonal abnormalities in the form of abnormal uterine bleeding in the structure of gynecological pathology in women with functional infertility and ovaricovaricocele (30.6%) against patients with infertility without structural changes in ovarian veins. Patients with infertility are more likely to point out dysgharmony of sexual life (58.1%), which in patients with varicose veins in the pelvic organs was accompanied by dyspareunia (32.2%), suggesting the role of chronic stress as a risk factor for ovarian dysfunction, which is also exacerbated by the presence pain of syndrome in the lower abdomen in women of the main group (77,4%). The more significant percentage of gynecological pathology of endocrine genesis in women with functional infertility and ovaricovaricocele and the presence of certain extragenital pathology, which affects the formation of pelvic pelvic flooring in comparison with patients with infertility without structural changes in ovarian veins, is established during the analysis of the clinical characteristics of the significant percentage of venous hemodynamics in the functional properties of the ovary and induces further investigation of the role of varicose veins of the pelvic reservoirs, in particular ovariсovariсocele, in the pathogenesis of ovarian dysfunction in order to further develop the methods of therapeutic correction.

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