scholarly journals Safety Assessement And Pharmacological Effect of Algal Oil Omega 3-6 Capsule Rich In Dha, Dpa, Epa From Oil of Heterotrophic Marine Microalga Schizochytrium mangrovei TB17 on the Experimental Animals

2018 ◽  
Vol 40 (2) ◽  
pp. 193-202
Author(s):  
Le Thi Thom ◽  
Nguyen Hoang Ngan ◽  
Dang Diem Hong
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Human Health ◽  
Pharmacological Effect ◽  
Learning Ability ◽  
Whole Body ◽  
Omega 3 ◽  
Experimental Animals ◽  
Marine Microalga ◽  
Algal Oil

Recently, heterotrophic marine microalga Schizochytrium mangrovei has been shown to be rich in omega 3-6 fatty acids, mainly docosahexaenoic acid (DHA), ecosapentanoic acid (EPA) and docosapentanoic acid (DPA). These fatty acids play an important role on human health. In this article, we presented results of safety assessment and pharmacological effect of Algal Oil Omega 3-6 (AOO-3-6) which made from oil of S. mangrovei TB17 on the experimental animals after 90 days of use. The results of acute toxicity study showed that by oral administration of the AOO-3-6 on white mice at the highest dose of 15.27 g total of DHA, EPA, DPA / kg of whole body of mice/ day (the dosage was 113.63 times higher than the mice dose), the LD50 was not determined. It means that AOO-3-6 capsules was no signs toxicity. At doses of 78.4 mg and 352.8 mg of total of DHA, EPA, DPA/ kg of whole bode of rat/ day (effec-tive dose znd 4.5 times higher than the expected dose) for 90 continuous days on the mice didn’t affect the normal increment of body weight, hematological indices, biochemical indicators; function of liver and kid-ney; histopathology of liver, kidney, spleen of white rats. At the same time, at doses of 134.4 and 403.2 mg total of DHA, EPA and DPA/kg of body weight/day improved the ability to learn, remember on the mice. In addition, it also allowed building its reflexes sustainability in finding food to be faster with shorter reflectance time. As a result, AOO-3-6 capsules are safe and have the ability to improve memory, learning ability on the mouse which can be used for functional food for human health.

Cultivation and extraction of omega 3-6 fatty acids from the heterotrophic marine microalga Schizochytrium mangrovei TB17 to make a functional food

2021 ◽  
Vol 16 (8) ◽  
pp. 22-32
Author(s):  
Thi Thom Le ◽  
Diem Hong Dang
Keyword(s):  
Fatty Acids ◽  
Functional Food ◽  
Learning Ability ◽  
Omega 3 ◽  
Oral Toxicity ◽  
Marine Microalga ◽  
Dry Cell Weight ◽  
Bio Oil ◽  
Omega 6 ◽  
Total Fatty Acids

The objective of this study was to investigate the different fermentation conditions for Schizochytrium mangrovei TB17 biomass production rich in omega-3 and omega-6 fatty acids to determine the optimal conditions for bio-oil extraction from the algal biomass and to study the pharmacological effects of this bio-oil in experimental animal models. After 108 h of fed-batch fermentation, the cell density, dry biomass, lipid contents and docosahexaenoic acid (DHA) contents reached 392.53±3.89×106 cells/mL, 100.41±3.17 g/L, 41.04±0.87% dry cell weight (DCW) and 33.33±1.96% total fatty acids (TFAs) respectively. The in situ transesterification producing bio-oil rich in omega 3-6 fatty acids from the biomass of the TB17 strain reached a yield of TFAs of 45.02±1.37% DCW. The yields of PUFAs and SFAs were 30.02±0.38% and 69.98±0.53% of TFA respectively. The bio-oil mainly contains DHA and EPA accounting for 74.04±0.25% and 10.97±0.43% of the TFAs respectively. The bio-oil met the Vietnam food safety standard. According to the results of the acute in mice and the subchronic oral toxicity in rats for 90 days, the bio-oil rich in omega 3-6 fatty acids is safe and has the ability to improve memory and learning ability in mice which can be made functional food oil capsules for human.

Evaluation of a New Preparation of Urokinase

1973 ◽  
Vol 30 (01) ◽  
pp. 114-122
Author(s):  
C.R.M Prentice ◽  
K.M Rogers ◽  
G.P McNicol
Keyword(s):  
Body Weight ◽  
Maintenance Therapy ◽  
Initial Dose ◽  
Fibrinolytic Activity ◽  
Pharmacological Effect ◽  
Whole Body ◽  
Fibrinolytic Agent ◽  
Thromboplastic Activity

SummaryThe pharmacological effect of a new preparation of urokinase (Leo) has been studied, both in vitro and in six patients suffering from thrombo-embolic disorders. It was a non-toxic, effective fibrinolytic agent if given in sufficient dosage. A regimen consisting of an initial dose of 7,200 ploug units per kg body weight, followed by hourly maintenance therapy with 3,600 ploug units per kg intravenously, gave satisfactory evidence of whole body fibrinolytic activity. The preparation had minor but insignificant thromboplastic activity both when assayed in the laboratory and when given to patients.

scholarly journals Milk Fatty Acid Profiles in Different Animal Species: Focus on the Potential Effect of Selected PUFAs on Metabolism and Brain Functions

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1111
Author(s):  
Maria P. Mollica ◽  
Giovanna Trinchese ◽  
Fabiano Cimmino ◽  
Eduardo Penna ◽  
Gina Cavaliere ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Human Health ◽  
Milk Fat ◽  
Animal Species ◽  
Essential Fatty Acids ◽  
In Vivo Studies ◽  
Omega 3 ◽  
Milk Fatty Acids ◽  
Brain Functions ◽  
The Impact

Milk contains several important nutrients that are beneficial for human health. This review considers the nutritional qualities of essential fatty acids (FAs), especially omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) present in milk from ruminant and non-ruminant species. In particular, the impact of milk fatty acids on metabolism is discussed, including its effects on the central nervous system. In addition, we presented data indicating how animal feeding—the main way to modify milk fat composition—may have a potential impact on human health, and how rearing and feeding systems strongly affect milk quality within the same animal species. Finally, we have presented the results of in vivo studies aimed at supporting the beneficial effects of milk FA intake in animal models, and the factors limiting their transferability to humans were discussed.

scholarly journals Polyunsaturated Fatty Acids Mediated Regulation of Membrane Biochemistry and Tumor Cell Membrane Integrity

Membranes ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 479
Author(s):  
Souvik Mukerjee ◽  
Abdulaziz S. Saeedan ◽  
Mohd. Nazam Ansari ◽  
Manjari Singh
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Human Health ◽  
Biological Membrane ◽  
Membrane Integrity ◽  
Dietary Fatty Acids ◽  
Body System ◽  
Omega 3 ◽  
Membrane Composition ◽  
Tumor Cell Membrane

Particular dramatic macromolecule proteins are responsible for various cellular events in our body system. Lipids have recently recognized a lot more attention of scientists for understanding the relationship between lipid and cellular function and human health However, a biological membrane is formed with a lipid bilayer, which is called a P–L–P design. Our body system is balanced through various communicative signaling pathways derived from biological membrane proteins and lipids. In the case of any fatal disease such as cancer, the biological membrane compositions are altered. To repair the biological membrane composition and prevent cancer, dietary fatty acids, such as omega-3 polyunsaturated fatty acids, are essential in human health but are not directly synthesized in our body system. In this review, we will discuss the alteration of the biological membrane composition in breast cancer. We will highlight the role of dietary fatty acids in altering cellular composition in the P–L–P bilayer. We will also address the importance of omega-3 polyunsaturated fatty acids to regulate the membrane fluidity of cancer cells.

scholarly journals Designer Eggs with an Increased Content of Omega-3 fatty Acids and Pigments — Production and Health Benefits of their Consumption

Poljoprivreda ◽  
2021 ◽  
Vol 27 (2) ◽  
pp. 67-74
Author(s):  
Zlata Kralik ◽  
Gordana Kralik ◽  
Manuela Grčević ◽  
Danica Hanžek ◽  
Ewa Biazik
Keyword(s):  
Fatty Acids ◽  
Human Health ◽  
Functional Foods ◽  
Health Benefits ◽  
Nutritional Composition ◽  
Poultry Production ◽  
Composition Change ◽  
Omega 3 ◽  
Research And Innovation ◽  
Positive Effect

Designed-enriched products have been recently one of the most interesting areas of research and innovation in the animal production and food industry. These products are considered functional foods and contain ingredients that have beneficial physiological effects on human health. Designed or enriched eggs are an important type of functional food in poultry production. Demand for functional foods in the market has been increasing in recent years. Due to the increased interest of people in buying designed products, there is a production adjustment in the poultry industry. Composition change of laying hens feed affects nutritional composition change of eggs as well as their quality preservation. This process can an effect of the change in the concentration of cholesterol and its fractions, fatty acids, and pigments in eggs. It is evident from the relevant scientific literature that designer eggs consumption can have a positive effect on human health. Therefore, the aim of this paper is to describe different concepts of designer eggs production and emphasize the health benefits of their consumption in humans.

scholarly journals Analysis of influence of omega-3-polyunsaturated fatty acids on biochemical values of the blood and adipokines content in patients with arterial hypertension, osteoarthritis and its combination with optimal and increased body weight

ScienceRise ◽  
2016 ◽  
Vol 2 (3 (19)) ◽  
pp. 44
Author(s):  
Тетяна Олександрівна Ілащук ◽  
Наталія Валентинівна Швець ◽  
Оксана Павлівна Микитюк
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Polyunsaturated Fatty Acids ◽  
Arterial Hypertension ◽  
Omega 3

scholarly journals Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1601 ◽  
Author(s):  
Hiroki Saito ◽  
Yu Toyoda ◽  
Tappei Takada ◽  
Hiroshi Hirata ◽  
Ami Ota-Kontani ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Human Health ◽  
Serum Urate ◽  
The Body ◽  
Omega 3 ◽  
Beneficial Effects ◽  
Uricosuric Agents ◽  
Transport Assay ◽  
The Impact

The beneficial effects of fatty acids (FAs) on human health have attracted widespread interest. However, little is known about the impact of FAs on the handling of urate, the end-product of human purine metabolism, in the body. Increased serum urate levels occur in hyperuricemia, a disease that can lead to gout. In humans, urate filtered by the glomerulus of the kidney is majorly re-absorbed from primary urine into the blood via the urate transporter 1 (URAT1)-mediated pathway. URAT1 inhibition, thus, contributes to decreasing serum urate concentration by increasing net renal urate excretion. Here, we investigated the URAT1-inhibitory effects of 25 FAs that are commonly contained in foods or produced in the body. For this purpose, we conducted an in vitro transport assay using cells transiently expressing URAT1. Our results showed that unsaturated FAs, especially long-chain unsaturated FAs, inhibited URAT1 more strongly than saturated FAs. Among the tested unsaturated FAs, eicosapentaenoic acid, α-linolenic acid, and docosahexaenoic acid exhibited substantial URAT1-inhibitory activities, with half maximal inhibitory concentration values of 6.0, 14.2, and 15.2 μM, respectively. Although further studies are required to investigate whether the ω-3 polyunsaturated FAs can be employed as uricosuric agents, our findings further confirm FAs as nutritionally important substances influencing human health.

scholarly journals Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 852
Author(s):  
Pauter ◽  
Fischer ◽  
Bengtsson ◽  
Asadi ◽  
Talamonti ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Adipose Tissue ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Synergistic Effects ◽  
Plasma Lipoproteins ◽  
Sucrose Content ◽  
Omega 3 ◽  
High Sucrose

The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) is implicated in theregulation of both lipid and carbohydrate metabolism. Thus, we questioned whether dietary DHAand low or high content of sucrose impact on metabolism in mice deficient for elongation of verylong-chain fatty acids 2 (ELOVL2), an enzyme involved in the endogenous DHA synthesis. Wefound that Elovl2 -/- mice fed a high-sucrose DHA-enriched diet followed by the high sucrose, highfat challenge significantly increased body weight. This diet affected the triglyceride rich lipoproteinfraction of plasma lipoproteins and changed the expression of several genes involved in lipidmetabolism in a white adipose tissue. Our findings suggest that lipogenesis in mammals issynergistically influenced by DHA dietary and sucrose content.

Omega-3 polyunsaturated fatty acids and human health outcomes

BioFactors ◽  
2009 ◽  
Vol 35 (3) ◽  
pp. 266-272 ◽  
Author(s):  
Philip C. Calder ◽  
Parveen Yaqoob
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Health Outcomes ◽  
Human Health ◽  
Omega 3

Effect of feeding different sources of fat during gestation and lactation on reproduction of beef cows and calf performance

2006 ◽  
Vol 86 (2) ◽  
pp. 235-243 ◽  
Author(s):  
H. V. Petit ◽  
R. Berthiaume
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Birth Weight ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Fat Supplementation ◽  
Grass Silage ◽  
Calf Mortality ◽  
Ad Libitum ◽  
Ad Libitum Intake

Experiment 1: Over a 2-yr period, a total of 231 Angus crossbred cows were assigned randomly to one of three gestation diets to evaluate the effects of fat sources on birth weight, weaning weight and average daily gain of calves, calf condition at birth, calf mortality, body weight of cows, gestation length, calving percentage, and the percentages of retained placenta and dystocia. Isonitrogenous and isoenergetic supplements were based on whole flaxseed (FLA), calcium salts of palm oil (Megalac®, MEG) or no fat (CON). All cows were fed grass silage (90% of ad libitum intake) until 1 mo before calving. Cows were then fed grass silage for ad libitum intake until they were put on pasture. Cows were offered 600 g of supplement per head per day starting 43 d before the first calving for a period averaging 78 d. Diet had no effect on body weight (BW) of cows at calving. Birth weights of calves were similar among treatments. However, calf mortality percentage at birth was almost four times higher (P = 0.03) for cows fed CON compared with those fed FLA and MEG. More than 90% of cows rejected placenta within 12 h of calving and treatment had no effect. Cows fed FLA and CON tended (P ≤ 0.10) to have higher cumulative pregnancy rates (92.9 and 91.9%, respectively) than those fed MEG (76.7%). Experiment 2: From 2000 Jan. 19 to 2000 Sep. 05, 41 heifers received 600 g per head per day of one of the three supplements used in exp. 1 to determine the effect of fat supplementation during pregnancy and breeding. Diet had no effect on calf birth weight, but contrasts indicated that heifers fed MEG tended (P = 0.09) to have a lower pregnancy rate than those fed CON. These data suggest that cows and heifers fed grass silage and/or on pasture would not be deficient in omega 3 fatty acids, thus would not benefit from a supplement rich in omega 3 fatty acids such as flaxseed. However, fat supplementation contributed to lower calf mortality at birth in cows, but not in heifers. Key words: Beef, flaxseed, reproduction, fatty acids

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