scholarly journals Transamination in syncytiotrophoblast of placenta villi in parturient women who suffered the acute form of cmvi at the third trimester of gestation

2015 ◽  
Vol 70 (6) ◽  
pp. 621-626
Author(s):  
Mikhail Timofeevich Lutsenko ◽  
Irina Anatol'evna Andrievskaya
Keyword(s):  
Pregnant Women ◽  
Peripheral Blood ◽  
Caspase 3 ◽  
Reaction Products ◽  
Cmv Infection ◽  
Third Trimester ◽  
The Usa ◽  
Acute Form ◽  
Metabolic Adjustment ◽  
Infection Recurrence

Aim: to study the process of proteins transamination in syncytiotrophoblast of placenta villi of women who suffered the acute form of cytomegalovirus (CMV) infection during pregnancy.Methods: 30 pregnant women with CMV infection recurrence at the 25–28th week of pregnancy were examined. The activity of γ-glutamyltransferase in the peripheral blood of pregnant women was determined by spectrophotometry at the device «Stat-Fax-2100» (The USA). Hsp-70 and caspase-3 in placenta homogenate were found out with serological methods. The activity of glutamatdehydrogenase and pyridoxal-5-phosphatase was studied with histochemical method of Z. Loyd at the placenta slice of parturient women. The apoptotic changes in syncytiotrophoblast nuclei were defined by ISEL-method.Results. The peripheral blood of CMV-seropositive parturient women showed a reduction of γ-glutamyltransferase in 1.30 times. Histochemically we identified the reduction of reaction products' concentration in response to pyridoxal-5-phosphate by 2.14 times, to glutamatdehydrogenase by 1,57 times. At the same time there was an increase of caspase-3 in 2,8 times and reduction of Hsp70 in 2.6 times in placenta homogenate. The number of apoptotic changes in syncytiotrophoblast nuclei increased by 4 times.Conclusion. Worsening of CMV infection in the period 25–28 weeks of pregnancy leads to disruption of amino acid metabolism in the placenta, causing structural and functional and metabolic adjustment, and is one of the reasons for slow growth and lack of development of the fetus. 

CHANGES IN THE COMPOSITION OF LIPIDS IN PREGNANT WOMEN WITH CYTOMEGALOVIRUS INFECTION IN THE THIRD TRIMESTER OF PREGNANCY DEPENDING ON ANTIBODY TITERS OF IMMUNOGLOBULIN G

2016 ◽  
Vol 1 (61) ◽  
pp. 69-74 ◽  
Author(s):  
Ишутина ◽  
Nataliya Ishutina
Keyword(s):  
Lipid Metabolism ◽  
Phospholipase A2 ◽  
Pregnant Women ◽  
Peripheral Blood ◽  
Pathological Process ◽  
Study Group ◽  
Igg Antibodies ◽  
Cmv Infection ◽  
Third Trimester ◽  
The Third

The work was carried out to study the processes of lipid peroxidation, antioxidant defense, the content of phospholipase A2, the main structural phospholipids (phosphatidylethanolamine, phosphatidylcholine and its lizoform) in the peripheral blood of women with reactivation of chronic cytomegalovirus (CMV) infection in the III trimester of gestation depending on the titer of IgG antibodies to CMV. The method of random sample was used to select 90 pregnant women. The study group consisted of 60 pregnant women with exacerbation of chronic CMV infection in the third trimester. It was divided into two subgroups: subgroup A (30 women with active CMV infection, the titer of IgG antibodies to CMV was 1:1600); subgroup B (30 women with latent CMV infection, the titer of IgG antibodies to CMV was 1:800). The control group consisted of 30 healthy pregnant women who matched the study group by the period of gestation and age. It was found out that lipid metabolism imbalance in plasma and erythrocytes of the peripheral blood was one of the reasons for progression of the pathological process of CMV infection in pregnant women. Changes in the composition of erythrocyte membrane phospholipids, i.e the reduction of phosphatidylethanolamine by 22% (p<0.001), of phosphatidylcholine by 23% (p<0.001), an increase in the content of lysophosphatidylcholine by 34% (p<0.001), are regarded as membrane destabilizing processes. Their development is caused by uncontrolled free radical reactions leading to the initiation of peroxidation of cell membrane lipid oxidation (the increase in the concentration of TBA-active products by 78% (p<0.001), and the activation of lipolytic enzymes (increased concentration of phospholipase A2 by 60% (p<0.001). These changes occur against the oppression of antioxidant protection (reducing the concentration of α-tocopherol by 26% (p<0.001). The rate of change of lipid metabolism in these structures as manifestations of membrane destructive phenomena depends on the titer of IgG antibodies to CMV and is most pronounced when there is the active form of CMV infection (titer IgG antibodies to CMV is 1:1600). The mentioned pathological processes taken together aggravate the condition of pregnant women with CMV infection and create a favorable background for further progression of the pathological process, which greatly burdens the prenatal period and childbirth. The results obtained allow us to establish the important role of lipid metabolism disorders in the pathogenesis of CMV infection, which can be the basis for the expansion of the diagnostic and therapeutic base for this pathology of pregnant women.

Features of the course and treatment of glaucoma during pregnancy

2020 ◽  
Vol 98 (3) ◽  
pp. 178-184
Author(s):  
T. V. Chernyakova ◽  
A. Yu. Brezhnev ◽  
I. R. Gazizova ◽  
A. V. Kuroyedov ◽  
A. V. Seleznev
Keyword(s):  
Pregnant Women ◽  
Laser Treatment ◽  
Progressive Disease ◽  
Clinical Course ◽  
The Other ◽  
Third Trimester ◽  
The Third ◽  
Chronic Progressive Disease ◽  
Hypotensive Therapy ◽  
Eye Pressure

In the review we have integrated all up-to-date knowledge concerning clinical course and treatment of glaucoma among pregnant women to help specialists choose a proper policy of treatment for such a complicated group of patients. Glaucoma is a chronic progressive disease. It rarely occurs among childbearing aged women. Nevertheless the probability to manage pregnant patients having glaucoma has been recently increasing. The situation is complicated by the fact that there are no recommendations on how to treat glaucoma among pregnant women. As we know, eye pressure is progressively going down from the first to the third trimester, so we often have to correct hypotensive therapy. Besides, it is necessary to take into account the effect of applied medicines on mother health and evaluate possible teratogenic complications for a fetus. The only medicine against glaucoma which belongs to category B according to FDA classification is brimonidine. Medicines of the other groups should be prescribed with care. Laser treatment or surgery may also be a relevant decision when monitoring patients who are planning pregnancy or just bearing a child. Such treatment should be also accompanied by medicines.

HUBUNGAN PENDIDIKAN DAN STATUS EKONOMI DENGAN STATUS GIZI IBU HAMIL TRIMESTER III DI PUSKESMAS SOSIAL PALEMBANG TAHUN 2012

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Tirta Anggraini Tirta Anggraini
Keyword(s):  
Nutritional Status ◽  
Pregnant Women ◽  
Health Center ◽  
Economic Status ◽  
Social Health ◽  
World Health ◽  
Third Trimester ◽  
Chi Square ◽  
Cross Sectional ◽  
Health Organization

ABSTRACT According to the World Health Organization (WHO), maternal nutritional status at the time of growth and during pregnancy can affect fetal growth and development. Based on (IDHS) survey of 2007 AKI Indonesia at 228 per 100,000 live births, although this figure is still the highest in Asia. Social health center in Palembang in 2011 the number of pregnant women with good nutritional status of 67 men (97.1%). factors that influence the nutritional status of pregnant women is the temperature of the environment, economic status, habits and views of women to food, age, education, and health status. The purpose of this study is a known relationship education and economic status with nutritional status of pregnant women in the third trimester of Social Health Center Palembang in 2012. This study uses analytic survey with cross sectional approach. The population in this study were all third trimester pregnant women who visit the health center Social Palembang in May 2012, with a sample of 30 respondents. Sampling in this study with non-random methods with techniques Accidental Sampling. Data analysis carried out univariate and bivariate statistics with Chi-Square test with significance level α = 0.05. The results showed than 30 respondents there (73.3%) of respondents that good nutritional status, higher education (76.7%), and high economic status (70.0%). The results of this study showed no significant association education and economic status with nutritional status of pregnant women in the third trimester of Social Health Center Palembang in 2012. From the results of this study, researchers hope to improve the health care workers, especially health services in Antenatal Care services pay more attention to maternal risk of poor nutritional status.   ABSTRAK Menurut World Health Organization (WHO), status gizi ibu hamil pada waktu pertumbuhan dan selama hamil dapat mempengaruhi pertumbuhan dan perkembangan janin. Berdasarkan (SDKI) survei terakhir tahun 2007 AKI Indonesia sebesar 228 per 100.000 Kelahiran Hidup, meskipun demikian angka tersebut masih tertinggi di Asia.  Di Puskesmas Sosial Palembang tahun 2011 jumlah ibu hamil yang berstatus gizi baik sebesar 67 orang (97,1%). faktor-faktor yang mempengaruhi status gizi ibu hamil adalah suhu lingkungan, status ekonomi, kebiasaan dan pandangan wanita terhadap makanan, usia, pendidikan, dan status kesehatan. Tujuan penelitian ini adalah diketahuinya hubungan pendidikan dan status ekonomi dengan status gizi ibu hamil trimester III di Puskesmas Sosial Palembang tahun 2012. Penelitian ini menggunakan metode survey analitik dengan pendekatan cross sectional. Populasi pada penelitian ini adalah semua ibu hamil trimester III yang berkunjung di Puskesmas Sosial Palembang pada bulan Mei tahun 2012, dengan jumlah sampel 30 responden. Pengambilan sampel pada penelitian ini dengan metode non random dengan teknik Accidental Sampling. Analisa data dilakukan secara univariat dan bivariat dengan uji statistik Chi-Square dengan tingkat kemaknaan α = 0,05. Hasil penelitian menunjukkan dari 30 responden terdapat (73,3%) responden yang berstatus gizi baik, pendidikan tinggi (76,7%), dan status ekonomi tinggi (70,0%). Hasil penelitian ini menunjukkan ada hubungan yang bermakna pendidikan dan status ekonomi dengan status gizi ibu hamil trimester III di Puskesmas Sosial Palembang tahun 2012. Dari hasil penelitian ini, peneliti berharap petugas pelayanan kesehatan dapat meningkatkan pelayanan kesehatan terutama dalam pelayanan Antenatal Care lebih memperhatikan kehamilan ibu yang berisiko status gizi buruk.

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KESEDIAAN IBU BERSALIN UNTUK PEMASANGAN IUD POST PLACENTA

2019 ◽  
Vol 1 (2) ◽  
pp. 28-34
Author(s):  
Saiful Batubara ◽  
Risqi Utami
Keyword(s):  
Maternal Mortality ◽  
Pregnant Women ◽  
Third Trimester ◽  
Chi Square ◽  
Purposive Sampling ◽  
Factors Associated ◽  
Analyze Data

Intra Uterine Device post placenta is the installation in the first 10 minutes to 48 hours after the birth placenta plays a role in reducing maternal mortality through prevention of pregnancy, delaying pregnancy, and spacing pregnancies, the effectiveness of use up to 99.4% can prevent 5-10 years of pregnancy. This study aims to determine the factors associated with maternal willingness to post Post Placenta IUD. The study used a questionnaire with a population of third trimester pregnant women who examined their pregnancies and a sample of 98 people by purposive sampling. Analyze data with Chi Square. The results showed that the majority of pregnant women were not willing to do post placenta IUD installation of 58.2% which was influenced by age, parity, knowledge and support of the husband.

Pengaruh Umur Ibu Hamil Dan Dukungan Keluarga Terhadap Kepatuhan Mengkonsumsi Tablet Besi (Fe) Dan Anemia Pada Ibu Hamil Di Puskesmas Kota Wilayah Selatan Kota Kediri

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Dina Dewi Anggraini
Keyword(s):  
Pregnant Women ◽  
Health Center ◽  
Family Support ◽  
Random Sampling ◽  
Maternal Age ◽  
Sampling Technique ◽  
Deficiency Anemia ◽  
Third Trimester ◽  
Regional Health ◽  
Cross Sectional

ABSTRAKPerdarahan merupakan prosentase tertinggi penyebab terjadinya kematian ibu. Dan anemia zat besi merupakan penyebab utama terjadinya perdarahan. Pencegahan anemia gizi besi dilakukan melalui pemberian tablet besi dengan dosis pemberian sebanyak 1 tablet berturut-turut minimal selama 90 hari selama kehamilan. Pada kecamatan dan Puskesmas Kota Kediri 2014, cakupan Fe1 dan Fe3 yang terendah adalah pada Kecamatan Kota, yaitu Puskesmas Kota Wilayah Selatan, dengan Fe1 sebesar 69,81% dan Fe3 sebesar 66,29%. Penelitian dilakukan untuk menganalisis pengaruh umur ibu hamil dan dukungan keluarga terhadap kepatuhan mengkonsumsi tablet besi dan anemia pada ibu hamil di Puskesmas Kota Wilayah Selatan Kota Kediri 2016. Metode pada penelitian ini dengan observasi analitik dan rancang bangun cross sectional. Populasi pada penelitian ini 63 orang ibu hamil trimester III dan sampelnya 34 orang ibu hamil trimester III yang telah mendapatkan 90 tablet besi (Fe), dengan teknik simpel random sampling. Data diperoleh dari kuesioner, buku Kesehatan Ibu dan Anak, dan wawancara yang mendalam. Analisis data yang dilakukan dengan menggunakan regresi ordinal dan regresi logistik. Hasil uji didapatkan nilai p = 0,000 0,05 untuk variabel umur ibu hamil 20 tahun terhadap kepatuhan mengkonsumsi tablet besi (Fe), nilai p = 0,238 0,05 untuk variabel dukungan keluarga terhadap kepatuhan mengkonsumsi tablet besi (Fe), dan nilai p = 0,012 0,05 untuk variabel kepatuhan yang cukup dalam mengkonsumsi tablet besi (Fe) terhadap anemia pada ibu hamil. Semakin tinggi faktor risiko umur pada ibu hamil, maka semakin cenderung ibu hamil untuk patuh mengkonsumsi tablet besi (Fe) pada masa kehamilan. Semakin tinggi tingkat kepatuhan ibu hamil dalam mengkonsumsi tablet besi (Fe), maka semakin tinggi pula kecenderungan ibu hamil untuk tidak terkena anemia pada masa kehamilan. Kata kunci: Umur, Dukungan Keluarga, Kepatuhan, Anemia.   ABSTRACTBleeding is the highest percentage of the causes of maternal mortality. And iron anemia is a major cause of bleeding. Prevention of iron deficiency anemia is done through the provision of iron tablets with doses as much as 1 tablet in a row for a minimum of 90 days during pregnancy. In the town of Kediri district and health center in 2014, Fe1 and Fe3 coverage is lowest in the City District, the Southern Regional Health Center, with Fe1 amounted to 69,81% and amounted to 66,29% Fe3. The study was conducted to analyze the effect of maternal age and family support for adherence to consume iron tablets and anemia in pregnant women in the South Regional Health Center of Kediri, 2016. The method in this study with analytic observation and cross sectional design. The population in this study 63 third trimester pregnant women and the sample 34 third trimester pregnant women who have received 90 tablets of iron (Fe), with a simple random sampling technique. Data obtained from questionnaires, books Maternal and Child Health, and in-depth interviews. Data analysis was performed using ordinal regression and logistic regression. The test results obtained value of p = 0,000 0,05 for the variable maternal age 20 years of adherence to consume tablets of iron (Fe), p = 0,238 0,05 for the variable of family support for adherence to consume tablets of iron (Fe), and p = 0,012 0,05 for the variable adherence sufficient to consume iron tablet (Fe) against anemia in pregnant women. The higher the risk factors of age in pregnant women, pregnant women, the more it tends to stick to consume tablets of iron (Fe) during pregnancy. The higher the level of adherence of pregnant women consume iron tablet (Fe), the higher the tendency of pregnant women not exposed to anemia during pregnancy. Keywords: Age, Family Support, Adherence, Anemia.

scholarly journals A systematic review and meta-analysis of prevalence of insomnia in the third trimester of pregnancy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nader Salari ◽  
Niloofar Darvishi ◽  
Behnam Khaledi-Paveh ◽  
Aliakbar Vaisi-Raygani ◽  
Rostam Jalali ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Meta Analysis ◽  
Physical And Mental Health ◽  
Third Trimester ◽  
Cross Sectional ◽  
The Third ◽  
Physical Problems ◽  
Meta Regression Analysis

Abstract Background Sleep disorders, which are among the foremost important medical care issues, are prevalent in pregnancy. The present study is a meta-analysis of the prevalence of insomnia in the third trimester of pregnancy. This study aims to systematically review the overall prevalence of insomnia in the third trimester of pregnancy through conducting a meta-analysis. Method The literature used in this meta-analysis for the topic discussed above were obtained through searching several databases, including SID, MagIran, IranDoc, Scopus, Embase, Web of Science (WoS), PubMed Science Direct and Google Scholar databases without time limitation until December 2020. Articles developed based on cross-sectional studies were included in the study. The heterogeneity of studies was investigated using the I2 index. Also, the possible effects of heterogeneity in the studied studies are investigated using meta-regression analysis. Result In 10 articles and 8798 participants aged between11–40, the overall prevalence of insomnia in the third trimester of pregnancy based on meta-analysis was 42.4% (95% CI: 32.9–52.5%). It was reported that as the sample size increases, the prevalence of insomnia in the third trimester of pregnancy increases. Conversely, as the year of research increases, the prevalence of insomnia in the third trimester of pregnancy decreases. Both of these differences were statistically significant (P < 0.05). Conclusion Insomnia was highly prevalent in the last trimester of pregnancy. Sleep disorders are neglected among pregnant women, and they are considered natural. While sleep disturbances can cause mental and physical problems in pregnant women, they can consequently cause problems for the fetus. As a result, maintaining the physical and mental health of pregnant mothers is very important. It is thus recommended that in addition to having regular visits during pregnancy, pregnant women should also be continuously monitored for sleep-related disorders.

The sFlt-1 to PlGF Ratio in Pregnant Women with Rheumatoid Arthritis: Impact of Disease Activity and Sulfasalazine Use

Rheumatology ◽  
2021 ◽  
Author(s):  
Rugina I Neuman ◽  
Hieronymus T W Smeele ◽  
A H Jan Danser ◽  
Radboud J E M Dolhain ◽  
Willy Visser
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Disease Activity ◽  
Pregnant Women ◽  
Gestational Age ◽  
Third Trimester ◽  
Low Disease Activity ◽  
The Third ◽  
Observational Prospective Cohort Study ◽  
Plgf Ratio

Abstract Objectives An elevated sFlt-1/PlGF-ratio has been validated as a significant predictor of preeclampsia, but has not been established in women with rheumatoid arthritis (RA). We explored whether the sFlt-1/PlGF-ratio could be altered due to disease activity in RA, and could be applied in this population to predict preeclampsia. Since sulfasalazine has been suggested to improve the angiogenic imbalance in preeclampsia, we also aimed to examine whether sulfasalazine could affect sFlt-1 or PlGF levels. Methods Making use of a nationwide, observational, prospective cohort study on pregnant women with RA, sFlt-1 and PlGF were measured in the third trimester. A total of 221 women, aged 21–42 years, were included, with a median gestational age of 30 + 3 weeks. Results No differences in sFlt-1 or PlGF were observed between women with high, intermediate or low disease activity (p= 0.07 and p= 0.41), whereas sFlt-1 and PlGF did not correlate with DAS28-CRP score (r=-0.01 and r=-0.05, respectively). Four (2%) women with a sFlt-1/PlGF-ratio ≤38 developed preeclampsia in comparison to three (43%) women with a ratio &gt; 38, corresponding to a negative predictive value of 98.1%. Sulfasalazine users (n = 57) did not show altered levels of sFlt-1 or PlGF in comparison to non-sulfasalazine users (n = 164, p= 0.91 and p= 0.11). Conclusion Our study shows that in pregnant women with RA, the sFlt-1/PlGF-ratio is not altered due to disease activity and a cut-off ≤38 can be used to exclude preeclampsia. Additionally, sulfasalazine use did not affect sFlt-1 or PlGF levels in this population.

scholarly journals Radioimmunoassay of plasma ouabain in healthy and pregnant individuals

2000 ◽  
Vol 165 (3) ◽  
pp. 669-677 ◽  
Author(s):  
O Vakkuri ◽  
SS Arnason ◽  
A Pouta ◽  
O Vuolteenaho ◽  
J Leppaluoto
Keyword(s):  
Pregnant Women ◽  
Human Plasma ◽  
High Performance ◽  
Chemical Nature ◽  
Solid Phase ◽  
Plasma Concentrations ◽  
First Trimester ◽  
Plasma Samples ◽  
Third Trimester ◽  
Endogenous Substances

Ouabain was recently isolated from human plasma, bovine hypothalamus and bovine adrenal in attempts to identify endogenous substances inhibiting the cell membrane sodium pump. A number of radioimmunoassays have been developed in order to study the clinical significance of ouabain. The results have been controversial with regard to the presence and chemical nature of plasma ouabain-like immunoreactivity. We have now measured ouabain in healthy and pregnant individuals using solid-phase extraction of plasma samples followed by a new radioimmunoassay with the extraordinary sensitivity of at least 2 fmol/tube (5 pmol/l). Plasma extracts, a previously isolated human plasma ouabain-like compound and bovine hypothalamic inhibitory factor displaced the tracer in parallel and eluted identically with ouabain in high-performance liquid chromatography. Plasma ouabain immunoreactivity was found to be much lower than reported previously: 12.6+/-1.3 pmol/l in healthy men (mean+/-s.e., n=20) and 9.4+/-0.7 pmol/l in women (n=14). In pregnant women (n=28) plasma ouabain concentration was 16.3+/-4.0 pmol/l during the first trimester, 18.8+/-4.3 pmol/l during the second trimester and 24.3+/-4.0 pmol/l during the third trimester (all P<0.01 compared with non-pregnant women). Plasma ouabain 3-5 days after the delivery was 13.6+/-1.1 pmol/l (n=10, P<0.05-0.01 compared with second and third trimesters). The pregnancy-related changes in the plasma concentrations of ouabain resembled those of cortisol. Therefore cortisol was measured from the same plasma samples and a significant positive correlation was found (r=0.512, P=0.006). The similar profiles of plasma ouabain and cortisol during pregnancy and their rapid decreases postpartum are consistent with the adrenal cortical origin of ouabain and also show that the secretions of these hormones are possibly under the control of same factors.

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