Contribution of hypertension and other risk factors to survival and mortality in the Russian population

Aim. To study the contribution of hypertension (HTN) to survival and mortality in the Russian population.Material and methods. This prospective observational cohort included representative samples from 11 Russian regions (men and women aged 25-64 years, n=18251) examined in 2012-2014 as part of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study. The examination included a questionnaire (12 modules), anthropometric and blood pressure (BP) measurements, as well as biochemical blood tests. HTN was considered aa a systolic BP ≥140 mm Hg and/or diastolic BP ≥90 mm Hg, or when a subject receives antihypertensives. Treatment efficacy was considered as the proportion of persons (%) who achieved target BP among those taking antihypertensives. Depending on HTN status, all participants were divided into 4 groups: 1) those without HTN;2) those with HTN, taking antihypertensive agents and having systolic BP ≤140 mm H. and diastolic BP ≤90 mm Hg (effective therapy);3) those with HTN, taking medications, but not achieving target BP (ineffective therapy); 4) those with HTN, not taking antihypertensives. The life status of participants was updated every 2 years. Kaplan-Meier survival curves, as well as univariate and multivariate Cox proportional hazards models were created.Results. The presence of HTN significantly reduced survival (p<0,001) in the cohort, which is significant when adjusted for age (men — relative risk (RR)=1,47, p<0,001, women — RR=1,17, p<0,001). In the multivariate model, the male sex (RR=2,3 p<0,001), age increase, smoking, tachycardia, and HTN are significant for all-cause mortality only for men, but not for women. However, for women, absence of higher education was significant. The presence of HTN significantly worsens cardiovascular survival in both sexes (p<0,0001). HTN increases the risk of a composite endpoint for both men and women (p<0,001). Analysis of Kaplan-Meier curves showed the worst survival rate in persons with HTN, taking antihypertensive drugs, but not reaching target BP levels.Conclusion. The presence of HTN significantly worsens the survival rate of men and women. Special attention of medical community should be directed to increasing the proportion of effectively treated patients with HTN.

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Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study

Frontiers in Nutrition ◽

10.3389/fnut.2021.762240 ◽

2021 ◽

Vol 8 ◽

Author(s):

Xuejin Gao ◽

Li Zhang ◽

Siwen Wang ◽

Yaqin Xiao ◽

Deshuai Song ◽

...

Keyword(s):

Risk Factors ◽

Short Bowel Syndrome ◽

Proportional Hazards ◽

Proportional Hazards Model ◽

Cox Proportional Hazards ◽

Cox Proportional Hazards Model ◽

Clinical Trial Registration ◽

Short Bowel ◽

Kaplan Meier ◽

Clinical Consequences

Background: Patients with short bowel syndrome (SBS) are at a high risk of cholestasis or cholelithiasis. This study aimed to determine the incidence, risk factors, and clinical consequences of cholelithiasis in adults with SBS over an extended period.Methods: All eligible adults diagnosed with SBS and admitted to a tertiary hospital center between January 2010 and December 2019 were retrospectively identified from the hospital records database. Kaplan–Meier analysis was used to estimate the cumulative incidence of SBS during the 10-year period. For assessment the risk factors for cholelithiasis, we used multivariate Cox proportional hazards model with estimation of hazard ratio (HR) with 95% confidence intervals (95 %CI).Results: This study enrolled 345 eligible patients with SBS. Kaplan–Meier analysis revealed that 72 patients (20.9%) developed cholelithiasis during the 10-year observation period. In multivariate analyses using the Cox proportional hazard model revealed that the remnant jejunum (HR = 2.163; 95% confidence interval [CI]: 1.156–4.047, p = 0.016) and parenteral nutrition dependence (HR = 1.783; 95% CI: 1.077–2.952, p = 0.025) were independent risk factors for cholelithiasis in adults with SBS. Twenty-eight patients developed symptoms and/or complications in the cholelithiasis group. Proportions of acute cholecystitis or cholangitis and acute pancreatitis were significantly increased in the cholelithiasis group compared with the non-cholelithiasis group (31.9 vs. 7.7%, p < 0.01; and 6.9 vs. 1.1%, p = 0.003, respectively).Conclusion: Because of the adverse clinical consequences of cholelithiasis, adult patients with SBS should be closely monitored, and preventive interventions should be considered.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT04867538.

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Prevalence, Classification, and Risk Factors for Postoperative Lower Extremity Lymphedema in Women With Gynecologic Malignancies: A Retrospective Study

International Journal of Gynecological Cancer ◽

10.1097/igc.0000000000000405 ◽

2015 ◽

Vol 25 (4) ◽

pp. 751-757 ◽

Cited By ~ 59

Author(s):

Hitoshi Hareyama ◽

Kenichi Hada ◽

Kumiko Goto ◽

Sawako Watanabe ◽

Minako Hakoyama ◽

...

Keyword(s):

Risk Factors ◽

Lower Extremity ◽

Lymph Nodes ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Cancer Type ◽

Kaplan Meier ◽

Gynecology And Obstetrics ◽

Independent Risk Factors ◽

Stage 1

ObjectiveLower extremity lymphedema (LEL) is a major long-term complication of radical surgery. We aimed to estimate the incidence and grading of LEL in women who underwent lymphadenectomy and to evaluate risk factors associated with LEL.Materials and MethodsWe retrospectively reviewed 358 patients with cervical, endometrial, and ovarian cancer who underwent transabdominal complete systematic pelvic and para-aortic lymphadenectomy between 1997 and 2011. Lower extremity lymphedema was graded according to criteria of the International Society of Lymphology. Incidence of LEL and its correlation with various clinical characteristics were investigated using Kaplan-Meier survival and Cox proportional hazards methods.ResultsOverall incidence of LEL was 21.8% (stage 1, 60%; stage 2, 32%; and stage 3, 8%). Cumulative incidence increased with observation period: 12.9% at 1 year, 20.3% at 5 years, and 25.4% at 10 years. Age, cancer type, stage (International Federation of Gynecology and Obstetrics), body mass index, hysterectomy type, lymphocyst formation, lymph node metastasis, and chemotherapy were not associated with LEL. Multivariate analysis confirmed that removal of circumflex iliac lymph nodes (hazard ratio [HR], 4.28; 95% confidence interval [CI], 2.09–8.77; P < 0.0001), cellulitis (HR, 3.48; 95% CI, 2.03–5.98; P < 0.0001), and number of removed lymph nodes (HR, 0.99; 95% CI, 0.98–0.99; P = 0.038) were independent risk factors for LEL.ConclusionsPostoperative LEL incidence increased over time. The results of the present study showed a significant correlation with removal of circumflex iliac lymph nodes and cellulitis with the incidence of LEL. Multicenter or prospective studies are required to clarify treatment efficacies.

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Risk Factors for Mortality in Chinese Patients on Continuous Ambulatory Peritoneal Dialysis

Peritoneal Dialysis International ◽

10.3747/pdi.2013.00164 ◽

2015 ◽

Vol 35 (2) ◽

pp. 199-205 ◽

Cited By ~ 8

Author(s):

Fan Zhang ◽

Hong Liu ◽

Xiaoli Gong ◽

Fuyou Liu ◽

Youming Peng ◽

...

Keyword(s):

Risk Factors ◽

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Proportional Hazards ◽

Proportional Hazards Model ◽

Patient Survival ◽

Cox Proportional Hazards ◽

Cox Proportional Hazards Model ◽

Hazards Model ◽

Kaplan Meier

ObjectiveThe intent of this study was to evaluate the clinical outcome and risk factors affecting mortality of the continuous ambulatory peritoneal dialysis (CAPD) patients in a single peritoneal dialysis (PD) center over a period of 10 years.Patients and methodsWe retrospectively analyzed patients on PD from June 2001 to June 2011. The clinical and biochemical data were collected from the medical records. Clinical variables included gender, age at the start of PD, smoking status, body mass index (BMI), cause of end-stage renal disease (ESRD), presence of diabetes mellitus and blood pressure. Biochemical variables included hemoglobin, urine volume, residual renal function (RRF), serum albumin, blood urea nitrogen (BUN), creatinine, total cholesterol, triglyceride, comorbidities, and outcomes. Survival curves were made by the Kaplan-Meier method. Univariate and multivariate analyses to identify mortality risk factors were performed using the Cox proportional hazard regression model.ResultsA total of 421 patients were enrolled, 269 of whom were male (63.9%). The mean age at the start of PD was 57.9 ± 14.8 years. Chronic glomerulonephritis was the most common cause of ESRD (39.4%). Estimation of patient survival by Kaplan-Meier was 92.5%, 80.2%, 74.4%, and 55.7% at 1, 3, 5, and 10 years, respectively. Patient survival was associated with age (hazard ratio [HR]: 1.641 [1.027 – 2.622], p = 0.038), cardiovascular disease (HR: 1.731 [1.08 – 2.774], p = 0.023), hypertriglyceridemia (HR: 1.782 [1.11 – 2.858], p = 0.017) in the Cox proportional hazards model analysis. Estimation of technique survival by Kaplan-Meier was 86.7%, 68.8%, 55.7%, and 37.4% at 1, 3, 5, and 10 years, respectively. In the Cox proportional hazards model analysis, age (HR: 1.672 [1.176 – 2.377], p = 0.004) and hypertriglyceridemia (HR: 1.511 [1.050 – 2.174], p = 0.026) predicted technique failure.ConclusionThe PD patients in our center exhibited comparable or even superior patient survival and technical survival rates, compared with reports from other centers in China and other countries.

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Faktor risiko loss to follow up terapi ARV pada pasien HIV

Berita Kedokteran Masyarakat ◽

10.22146/bkm.12732 ◽

2017 ◽

Vol 33 (4) ◽

pp. 173

Author(s):

Listy Handayani ◽

Riris Andono Ahmad ◽

Yanri Wijayanti Subronto

Keyword(s):

Risk Factors ◽

Health Insurance ◽

Antiretroviral Therapy ◽

Protective Factor ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Loss To Follow Up ◽

Kaplan Meier ◽

Adherence Counseling

Risk factors for loss to follow up of antiretroviral therapy in HIV patientsPurposeThis study aimed to determine risk factors for loss to follow-up of antiretroviral therapy among HIV-infected patients in Dr. Sardjito Yogyakarta, 2011-2014.MethodsA retrospective cohort study was conducted involving 499 HIV patients. Observations were conducted for four years using medical records. Data analysis was performed using Kaplan-Meier and Cox proportional hazards regression tests.ResultsThere were 190 loss to follow-up patients. Risk factors for loss to follow-up of ARV therapy were: a student (AHR = 2.42; 95% CI = 1.20-4.89), the distance ≥ 10 km (AHR = 1.58; 95% CI = 1:09 to 2:31), using health insurance (AHR = 1.67; 95% CI = 1:11 to 2:51) and homosexual as a protective factor of loss to follow-up of antiretroviral therapy (HR = 0:49; 95% CI = 0.30-0.80).ConclusionBeing a college student, the distance between home and ARV service ≥10 km and using health insurance were the risk factors for loss to follow-up of ARV treatment. Adherence counseling for students, cooperation with the drug taking supervisor and decentralization ARV service, as well as effective and efficient services for patients who use health insurance need to be strengthened.

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Efficacy Analysis of Multidisciplinary Treatment for Wilm’s Tumor in Single Center

10.21203/rs.3.rs-1185550/v1 ◽

2022 ◽

Author(s):

Bing Yan ◽

Fengming Ji ◽

Chengchuang Wu ◽

Ye Li ◽

Haoyu Tang ◽

...

Keyword(s):

Risk Factors ◽

Proportional Hazards ◽

Proportional Hazards Model ◽

Multidisciplinary Treatment ◽

Cox Proportional Hazards ◽

Cox Proportional Hazards Model ◽

Histological Type ◽

Factors Affecting ◽

Hazards Model ◽

Kaplan Meier

Abstract Objective: To analyze the efficacy of multidisciplinary treatment (MDT) for Wilm’s tumor (WT) in Kunming Children’s Hospital, and investigate the risk factors affecting the prognosis of WT.Method: The clinic-pathological data were collected and analyzed in patients with unilateral WT treated in Kunming Children's Hospital from January 2017 to July 2021. Research objects were selected according to inclusion criteria and exclusion criteria. The risk factors and independent risk factors that affect the prognosis of patients with WT were determined by Kaplan-Meier survival analysis and Cox proportional hazards model, respectively. Outcome: A total of 68 children were included in this study, and the 5-year overall survival (OS) rate was 92.65%. Kaplan-Meier survival analysis results showed that ethnicity (P=0.020), the tumor volume of resection (P=0.001), histological type (P<0.001), and postoperative recurrence (P<0.001) were the factors affecting the prognosis of children with WT. The results of the Cox proportional hazards model showed that only the histological type (P=0.028) was the independent risk factor for the prognosis of WT.Conclusion: The efficacy of MDT for WT was satisfying. The histological type has important predictive value for the prognosis of WT, and the patient with unfavorable histology has a poor prognosis.

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Abstract 16415: Racial Differences in Incidence of Atrial Fibrillation After Cryptogenic Stroke

Circulation ◽

10.1161/circ.142.suppl_3.16415 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

David B Laslett ◽

Abdullah Haddad ◽

Dianna Gaballa ◽

Hardik Mangrolia ◽

Olivia Follis ◽

...

Keyword(s):

Risk Factors ◽

Atrial Fibrillation ◽

Racial Differences ◽

Cumulative Incidence ◽

Proportional Hazards ◽

Current Knowledge ◽

Cryptogenic Stroke ◽

Cox Proportional Hazards ◽

Kaplan Meier ◽

Artery Disease

Introduction: The incidence of atrial fibrillation (AF) is lower among non-whites compared to whites, despite a higher burden of AF risk factors. Current knowledge of first detection of AF after cryptogenic stroke (CS) by an implantable cardiac monitor (ICM) is based on a predominantly white cohort. The incidence of new AF after CS among minorities is unknown. We hypothesized that the incidence of AF after CS would be lower in non-whites. Methods: We reviewed charts of all patients without a history of AF undergoing implantation of an ICM after CS at our hospital from July 2014 to December 2019. Incidence of AF was identified through review of ICM monitoring for each patient, including adjudication of AF episodes for accuracy. Kaplan Meier survival analysis was performed, and cumulative incidence of AF using adjusted Cox proportional hazards regression was compared by race. Results: We identified 417 patients who underwent ICM implant after CS during the study period, with a mean follow-up time of 1.5 ± 1.1 years. Mean age was 62 ± 12 years, and 46% (n=190) were male. The majority of patients were non-white (white, 15%, n=63; black, 59%, n=244; Hispanic, 26%, n=110). At baseline, blacks, Hispanics, and whites were of similar age (mean 62.2, 62.1, and 61.5 years, respectively), and blacks and Hispanics had more AF risk factors, including heart failure, hypertension, diabetes, chronic kidney disease, and higher BMI, than whites. Hispanics had more coronary artery disease than whites and blacks (25.5%, 17.5%, 9.1% respectively, p < 0.001). Among blacks, the cumulative incidence of newly detected AF at one, two, and three years was 13.0%, 18.9%, and 23%, which was similar to Hispanics (12.9%, 18.2%, and 20.9%). By comparison, the incidence in whites was significantly higher (20.8%, 34.3%, 40.3%; blacks p=0.02; Hispanics p=0.01) Conclusion: In patients undergoing ICM after CS, the incidence of newly detected AF is approximately double in whites compared to both blacks and Hispanics.

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Ocular adnexal lymphoma (OAL)-outcomes for 82 patients (pts) treated at a single center.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.8071 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 8071-8071

Author(s):

Craig Anthony Portell ◽

Mary E Aronow ◽

Lisa A. Rybicki ◽

Arun D Singh ◽

John W. Sweetenham

Keyword(s):

Risk Factors ◽

Proportional Hazards ◽

Systemic Disease ◽

Cleveland Clinic ◽

Cox Proportional Hazards ◽

High Rate ◽

Healthy Population ◽

Kaplan Meier ◽

Disease Site ◽

Contralateral Eye

8071 Background: OALs comprise 1-2% of NHL and are extranodal marginal zone (EMZL) in 80% of cases. We present a retrospective review of 82 pts with OAL managed at the Cleveland Clinic between January 2004 and November 2011. Methods: 82 pts with NHL of the OA were identified. All biopsies were performed/reviewed at the Cleveland Clinic. Survival and relapse were estimated using the Kaplan-Meier method. Risk factors for relapse and survival were identified using Cox proportional hazards analysis. Risk factors included age at diagnosis (dx), gender, prior autoimmune disease, prior lymphoma history (hx), hx of other malignancy, bilateral disease, and ocular disease site. Results: The table lists pt characteristics. Median follow-up was 25.8 months (range 0.3-307.4). Age at dx (HR=1.45, CI 1.04-2.02) and prior lymphoma hx (HR=3.35, CI 1.33-8.46) were predictive of relapse in a multivariate analysis. There was no difference in relapse rates between pts with EMZL and other lymphoma types (p=0.82). Relapse occurred in 26 (31.7%) pts with most common sites being ipsilateral eye (n=8), contralateral eye (n=3), distant lymph node (n=11), and other organs (n=11). Most common organ was breast (n=4). Of the 10 pts who had eye-only relapses, 8 received rituximab (R) and 2 were observed. Of the 16 with extraocular relapse, 9 received radiation (RT), 2 received R, 3 received other therapies, and 2 were observed. 7 deaths were recorded with a 5 year overall survival of 84.2%. Survival was similar to a matched healthy population (p=0.69). Causes of death were lymphoma in 4, another cancer in 1, and unknown in 2. Conclusions: OAL relapse patterns differ depending on initial treatment. Initial RT was more likely to relapse at distant sites; where as initial R was more likely to relapse in the OA. RT should be used for localized OAL. With bilateral ocular or systemic disease, R results in a high rate of long-term disease control. [Table: see text]

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Homocysteine Predicts Incident Isolated Systolic Hypertension in Older Adults

Circulation ◽

10.1161/circ.103.suppl_1.9999-19 ◽

2001 ◽

Vol 103 (suppl_1) ◽

pp. 1347-1347

Author(s):

Rachel P Wildman ◽

Lewis H Kuller

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Older Adults ◽

Systolic Hypertension ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Isolated Systolic Hypertension ◽

Kaplan Meier ◽

Blood Pressures ◽

Amino Acid Methionine

0019 Untreated isolated systolic hypertension (ISH) indicates arterial stiffening and carries a risk for both stroke and cardiovascular disease. Elevated plasma homocysteine, a metabolite of the essential amino acid methionine, has been linked to vascular stiffness. 187 normotensive (defined as systolic blood pressure (SBP) < 160 mmHg and diastolic blood pressure < 90 mmHg) men and women (mean age 71.29 + 6.3 yrs) were followed for an average of 7 years for incident ISH. ISH was defined as a SBP ≥160 mmHg (while maintaining a DBP of < 90 mmHg) at least one time at 3 year follow-up visits, or the initiation of antihypertensive therapy. The mean baseline systolic and diastolic blood pressures (DBP) were 127 and 69 mmHg, respectively. Over the 7 year period, 59(31.5%) participants developed ISH, 76% qualified by antihypertensive use, and 24% by blood pressure values. The Kaplan Meier Estimate of 7 year survival free from ISH was 67% (95% CI: 61%, 74%). The relationship between incident ISH and the traditional cardiovascular risk factors, creatinine, homocysteine, and carotid artery intima-media wall thickness (IMT) was assessed by Cox proportional hazards regression. The strongest predictor of incident ISH was baseline SBP. For participants with baseline SBPs of < 130, 130-139, and 140+ mmHg, the corresponding 7 year survival free from ISH was 80% (95% CI: 73%, 88% ), 53% (95%CI: 38%, 67%), and 44% (95% CI: 26%, 62%). Factors independently associated with time to ISH were higher triglycerides (upper tertile,RR=2.0, p=0.012), homocysteine levels (> 12.0 μmol/l, RR=2.2, p=0.005), and baseline SBP (per 10 mmHg,RR=1.4, p=0.003). The results were similar when the analysis was restricted to the 157 participants with a baseline SBP of < 140 mmHg. Baseline IMT was found to be univariately related to time to ISH (RR per each 1.0 mm increment=3.0; p=0.016). In multivariate analysis, this association remained independent of triglycerides and homocysteine, but not baseline SBP (RR per each 1.0 mm increment=2.5; p=0.049). In conclusion, among normotensive older adults, 32% can be expected to develop ISH over a 7 year period, and higher triglyceride and homocysteine levels are risk factors.

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Risk Factors for Survival After Heart Transplantation in Children and Young Adults: A 22-Year Study of 179 Transplants

World Journal for Pediatric and Congenital Heart Surgery ◽

10.1177/2150135118782190 ◽

2018 ◽

Vol 9 (5) ◽

pp. 557-564 ◽

Cited By ~ 3

Author(s):

Shawn Shah ◽

Alfred Asante-Korang ◽

Sharon R. Ghazarian ◽

Gary Stapleton ◽

Carrie Herbert ◽

...

Keyword(s):

Risk Factors ◽

Cardiac Surgery ◽

Heart Transplantation ◽

Mechanical Circulatory Support ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Circulatory Support ◽

Kaplan Meier ◽

Diagnostic Characteristics

Background: This article reviews all patients who underwent heart transplantation (HTx) within a single institution (172 patients underwent 179 HTx [167 first-time HTxs, 10 second HTxs, 2 third HTxs]) to describe diagnostic characteristics, management protocols, and risk factors for mortality. Methods: Descriptive analysis was performed for the entire cohort using mean, standard deviation, median, interquartile range, and overall range, as appropriate. Univariable and multivariable Cox proportional hazards models were performed to identify prognostic factors for outcomes over time. The primary outcome of interest was mortality, which was modeled by Kaplan-Meier analysis. Results: Median age at HTx was 263 days (range, 5 days to 24 years; mean = 4.63 ± 5.95 years; 18 neonates, 79 infants). Median weight at HTx was 7.5 kg (range, 2.2-113 kg; mean = 19.36 ± 23.54). Diagnostic categories were cardiomyopathy (n = 62), primary transplantation for hypoplastic left heart syndrome (HLHS) or HLHS-related malformation (n = 33), transplantation after cardiac surgery for HLHS or HLHS-related malformation (n = 17), non-HLHS congenital heart disease (n = 55), and retransplant (n = 12). Operative mortality was 10.1% (18 patients). Cumulative total follow-up is 1,355 years. Late mortality was 18.4% (33 patients). Overall Kaplan-Meier five-year survival was 76.2%. One hundred twenty-one patients are alive with a mean follow-up of 7.61 ± 6.46 years. No survival differences were seen among the five diagnostic subgroups ( P = .064) or between immunosensitized patients (n = 31) and nonimmunosensitized patients (n = 141; P = .422). Conclusions: Excellent results are expected for children undergoing HTx with comparable results among diagnostic groups. Pretransplant mechanical circulatory support and posttransplant mechanical circulatory support are risk factors for decreased survival. Survival after transplantation for HLHS or HLHS-related malformation is better with primary HTx in comparison to HTx after prior cardiac surgery.

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168. Epidemiology, Risk Factors and Outcome of Bloodstream Infection Within the First Year After Kidney Transplantation

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.243 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S108-S108

Author(s):

Napadol Siritip ◽

Arkom Nongnuch ◽

Thanate Dajsakdipon ◽

Charat Thongprayoon ◽

Wisit Cheungpasitporn ◽

...

Keyword(s):

Risk Factors ◽

Kidney Transplantation ◽

Bloodstream Infection ◽

Induction Therapy ◽

Proportional Hazards ◽

Bloodstream Infections ◽

Cox Proportional Hazards ◽

First Year ◽

Gram Negative ◽

Kaplan Meier

Abstract Background Bloodstream infections (BSIs) are an important cause of morbidity and mortality among kidney transplant (KT) recipients, especially within the first year. We investigated for an epidemiology, risk factors and outcome of this specific infection following KT. Methods We conducted a retrospective study of all adult KT recipients who developed BSI within the first year after KT from January to December 2016 at a large referral single transplant center in Bangkok, Thailand. The cumulative incidence of BSI after transplant was estimated with Kaplan–Meier methodology. Clinical characteristics, microbiological data, and outcome were extracted. Risk factors for BSI were assessed with multivariate Cox proportional hazards models. Results A total of 26 (15.2%) episodes of BSI occurred in 171 KT recipients, 58.5% of them were men and the mean ± SD age was 43 ± 12 years. The majority received deceased-donor allograft (58.5%) and induction therapy (59%). The Kaplan–Meier estimated for BSIs were 12.3% at 3 months, 13.5% at 6 months, and 15.2% at 12 months after KT. Gram-negative bacteria were responsible for 92% of BSI, with Escherichia coli was the most common causative pathogen (65%) and 71% of those produced extended-spectrum β-lactamases enzyme. The genitourinary tracts were the predominant source of BSIs (85%). In a multivariate analysis, the second kidney transplantation [HR, 4.55; 95% CI, 1.24–16.79 (P =0.02)] and receiving induction therapy [HR, 3.05; 95% CI, 1.15–8.10 (P<0.03)] were associated with BSI. One patient (4%) developed acute cellular rejection and one patient (4%) died from septic shock. Conclusion One-sixth of KT recipients could develop gram-negative bloodstream infection within the first year after KT especially those underwent the second transplantation or received induction therapy. Disclosures All authors: No reported disclosures.

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