scholarly journals Effect of Quail Egg Administration on Some Liver Function Related Parameters

2017 ◽  
Vol 9 (2) ◽  
pp. 149-152
Author(s):  
Patrick E. ABA
Keyword(s):  
Serum Protein ◽  
Fasting Blood Glucose ◽  
Negative Control Group ◽  
Oral Route ◽  
Negative Control ◽  
Diabetic Rats ◽  
Total Serum Protein ◽  
Total Serum ◽  
Control Group ◽  
Group 5

There are a lot of testimonies on the therapeutic efficacies of quail egg on diabetics and on liver disorders. This study investigated synthetic and conjugatory states of the liver in diabetic rats administered varying concentrations of quail egg solution. Thirty (30) adult male albino Wistar rats were assigned to 5 groups of 6 rats each. Groups 2-5 of rats were injected with alloxan monohydrate intraperitoneally at the dose of 160 mg/kg, while rats in group 1 served as normal control. Upon establishment of fasting blood glucose level above 126 mg/dl, the rats in groups 2-4 were administered 30, 15 and 7.5 mg/ml of quail egg solution respectively for 7 days. Rats in groups 1 and 5 received distilled water (10 ml/kg) each. All treatments were through the oral route. At the end of the 7 days duration of the study, blood samples for serum protein and bilirubin assays were collected. Results indicated that the quail egg administration to alloxanized rats did not alter total serum protein and albumin values, but improved significantly (p<0.5) the conjugated bilirubin values compared to that of the negative control group (group 5). It was concluded that administration of quail egg solution to alloxanized rats aided hepatic conjugatory ability with little or no effect on its synthetic function.

scholarly journals Anti-diabetic Potential of Aqueous Extract of Moringa oleifera, Ocimum gratissimum and Vernonia amygdalina in Alloxan-Induced Diabetic Rats

2020 ◽  
Author(s):  
A. L. Ayobami ◽  
E. A. Kade ◽  
K. A. Oladimeji ◽  
S. Kehinde ◽  
K. Gurpreet
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Fasting Blood Glucose ◽  
Negative Control Group ◽  
Negative Control ◽  
Diabetic Rats ◽  
The Body ◽  
Control Group ◽  
Vernonia Amygdalina ◽  
Ocimum Gratissimum

AbstractThe incidence of diabetes mellitus (DM) is increasing globally and it is a major source of concern. This study was undertaken to assess the antidiabetic effect of the aqueous extract of Moringa oleifera, Ocimum gratissimum and Vernonia amygdalina. Sixty adult Wistar rats with body weight of 120-150 g were randomly assigned to groups of five rats each (n=12). Groups 1 served as normal control; Groups 2-5 were diabetic groups; group 2 served as negative control; group 3-5 received 100, 200 and 400 mg/kg of triherbal formula respectively. The body weight (BW) and fasting blood glucose level (FBSL) of the rats were monitored weekly. At the end of the experiment, all the rats were anaesthetized intraperitoneally (I.P) and blood samples were collected by cardiac puncture for biochemical analysis. There was an increase in the BW of the control group and varying doses of tri-herbal formation. It caused 88.0% decrease in FBSL; 371.7%, 386.6% and 296.0% with respect to 100, 200 and 400 mg/kg. Sub-chronic study of the effect of the extract showed a significant increase (P<0.05) in packed cell volume (PCV), white blood counts in rat induced diabetes. The histological studies showed that the diabetic rats with the architecture of the pancreas distorted, was restored to normal by the extract. Its LD50 was found to be greater than 1000 mg/kg indicating its safety in rats. This study has shown that triherbal formula has hypoglycemic and haematogical effects.

The Effect of Herbal Infusion on Fasting Blood Glucose (FBS) and Malondyaldehyde (MDA) Levels in Diabetic Rats

2020 ◽  
Vol 1009 ◽  
pp. 9-14
Author(s):  
Apriliani Ismi Fauziah ◽  
Lintang Dian Saraswati ◽  
Ari Udiyono ◽  
Beti Safitri
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Aloe Vera ◽  
Control Sample ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats

Aloe vera, ginger, and sappan wood have recently gained attention as a potent antioxidant. This study was undertaken to analyze the possible effects of oral administration of herbal infusion (the combination of Aloe vera, ginger, and sapang wood) on fasting blood glucose (FBS) and malondialdehyde (MDA) levels in diabetic rats. Forty male albino rats (150-250 gm) were divided into five groups (n=8 in each group): alloxan-induced diabetic (negative control group/K-), acarbose treated (positive control group/K+), diabetic rats treated with herbal infusion dose 6.75 mg/150 gmbw (P1), diabetic rats treated with herbal infusion dose 13.5 mg/150 gmbw (P2), and diabetic rats treated with herbal infusion dose 20.25 mg/150 gmbw (P3). Male albino rats induced with a dose of alloxan 120 mg/kgbw and also 5% glucose after 6 hours of alloxan induction. FBS and MDA levels of each rat were measured before induction of alloxan was performed as a control sample. After seven days and 14 days of herbal infusion administration, FBS parameters was investigated with a glucometer. In the last week, the concentration of MDA in serum blood was determined using a UV-VIS spectrophotometer with a wavelength of 545 nm. Diabetic rats exhibited a significant decrease in FBS and MDA. Administration of herbal infusion was reduced FBS significantly between groups (ANOVA, Bonferroni, p<0.05). The concentration of MDA in serum blood was decreased significantly on K-, K+, P1, P2, P3 compared to the control group (ANOVA, LSD, P<0.05). It could be postulated herbal infusion has anti-hyperglycemic and anti-diabetic effects of FBS and MDA in male albino rats Wistar strain.

scholarly journals Replacement of vitamin-mineral premix by Spirulina and its effect on the performance of broiler

2018 ◽  
Vol 2 ◽  
pp. 39
Author(s):  
Shahinur Nahar Moury ◽  
Md. Touhiduzzaman Sarker ◽  
Adhita Sri Prabakusuma ◽  
Md. Imrul Hasan Russel ◽  
Md. Shahidul Islam
Keyword(s):  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Feed Conversion ◽  
Final Body Weight ◽  
Group 4 ◽  
Group 6 ◽  
Group 5 ◽  
And Control ◽  
Group 1

The main purpose of this study was to explore the effects of Spirulina (Spirulina platensis) as a feed supplement by replacing Vitamin-Mineral Premix on the performance of broiler. The study explored that final body weight was 1039, 1070, 1044, 1065, 1117 and 893 g/bird in group 1, 2, 3, 4, 5 and 6 where significantly (p<0.5) higher weight observed in Spirulina group (5) but lower in negative control group (6). Feed intake observed more or less similar in all groups (1483±24g; p>0.5). Feed conversion ratio (kg FI/kg LWG) observed significantly different like 1.72, 1.65, 1.69, 1.62, 1.61 and 1.99 in group 1, 2, 3, 4, 5 and 6 respectively (p<0.5) where higher in negative group (6) and control group (1), but is lowest and similar in 75% Spirulina group (4) and highest (100%) Spirulina group (5). %Ash of different dietary groups were 46.35, 46.54, 48.93, 49.93, 55.07 and 46.92 of group 1, 2, 3, 4, 5 and 6 respectively. The %ash of bone was gradually increased among dietary groups and the best result was obtained in 100% Spirulina group 5 (55.07). It also revealed that diets containing no vitamin-mineral premix with 100% Spirulina improve the performance of broiler. The findings suggest that poultry farmer can use spirulina as a feed item for broiler for more yield.

scholarly journals Stimulantia Effect Of Single Bulb Garlic Extract (Allium Sativum Var.Solo Garlic) in Swiss Webster Mice

2020 ◽  
Vol 17 (2) ◽  
pp. 107-115
Author(s):  
Ika Buana Januarti
Keyword(s):  
Ethanolic Extract ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Stimulant Effect ◽  
Swimming Time ◽  
Significant Difference ◽  
Garlic Bulb ◽  
The Difference ◽  
Group 5

Stimulant is an agent that stimulates the central nervous system thereby increasing physical and mental abilities and minimizing fatigue. The use of synthetic caffeine stimulants of 10 mg / kg BW is known to have side effects of increasing total cholesterol and increasing LDL, therefore alternative stimulants from natural ingredients are needed. Natural materials that have been studied contain flavonoids and phenolic as a stimulant compound is a single garlic bulbs. The purpose of this study was to determine the stimulant effect of a single garlic bulbs ethanolic extract on mice from the difference in swimming time. The research experimental used Pre test and Post test control design. Sample of this research used mice which were divided into 6 groups. Group 1 pretest dose 5 g / kgBB, group 2 (negative control), group 3 (caffeine), group 4 extract dose 5g / kgBB, group 5 dose 10g / kgBB and group 6 dose 20g / kgBB. Data was analyze using one way Anova continued with Post Hoc test. The group of single garlic bulb ethanolic extract dose 20 g / kgBB had the highest stimulant effect with 222,722 minutes fatigue time difference and statistically have significant difference (p <0.05) than the negative control group. Group of single garlic bulb extract can influence the time of fatigue of mice by extending the swimming time of mice so that it has a longer fatigue time which means it has a stimulant effect

scholarly journals Effects of goat milk kefir fortified with vitamin D3 on Interleukin-18 levels in diabetic rats

Food Research ◽  
2020 ◽  
Vol 4 (S3) ◽  
pp. 197-201
Author(s):  
K.D. Anggraeni ◽  
G. Anjani ◽  
M. Ardiaria ◽  
C. Nissa ◽  
S.Y. Huang ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Vitamin D3 ◽  
Fasting Blood Glucose ◽  
Goat Milk ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Control Group Design

Hyperglycemia causes increased oxidative stress through an imbalance of reactive oxygen species and antioxidative mechanisms. It stimulates the production of inflammatory mediators and cytokines such as TNF-α, interleukin (IL)-1, and IL-18. Goat milk kefir and vitamin D3 have potential as antioxidants and anti-inflammatory agents that can repair damage to pancreatic β cells. This study analyzed the effects of goat milk kefir fortified with vitamin D3 on the IL-18 level in diabetic rats. An experimental randomized pre-post test with control group design was conducted on 20 male Wistar rats divided into four groups, namely negative control (K-), positive control (K+), treatment with unfortified kefir (P1), and treatment with kefir fortified with vitamin D3. The intervention lasted 34 days. Fasting blood glucose and IL-18 levels were measured before and after intervention. Blood glucose and IL-18 levels were analyzed using the glucose oxidase p-aminophenol method and enzyme-linked immunosorbent assay, respectively. No significant increase in the IL-18 level was found in the P1 group with a median of 56.5 (10–252.7) pg/mL to 148.2 (106.8–428.3) pg/mL (p = 0.465) or P2 group with a median of 117.3 (91.8–146.8) pg/mL to 246.7 (168.8–311) pg/mL (p = 0.068), and no significant increase was observed in blood glucose levels in the P1 group (366.9±134.8 mg/dL to 462.1±156.9 mg/dL, p = 0.357) or P2 group (415.0±203.8 mg/dL to 258±129 mg/dL, p = 0.463). Goat milk kefir fortified with vitamin D3 could maintain blood glucose and IL-18 levels.

THE RELATION BETWEEN LIVER GROWTH AND SOMATIC GROWTH IN THE RAT

1958 ◽  
Vol 17 (2) ◽  
pp. 149-157 ◽  
Author(s):  
G. C. KENNEDY ◽  
WINIFRED M. PEARCE
Keyword(s):  
Serum Protein ◽  
Somatic Growth ◽  
Progressive Increase ◽  
Diabetic Rats ◽  
Metabolic Adaptation ◽  
Calorie Intake ◽  
Total Serum Protein ◽  
Total Serum ◽  
Liver Growth ◽  
Hypothalamic Lesions

SUMMARY The persistent high calorie intake and rapid somatic growth in young rats, which was initiated by a super-abundant milk supply in the first weeks of life, was accompanied by an accelerated growth in the size and number of cells in the liver. The adult concentration of serum protein was also attained earlier. An increased food intake in the adult which was produced by hypothalamic lesions, did not significantly affect growth of the skeleton, but it had the same effect on the liver as very rapid somatic growth. The increase in weight of the liver could not be accounted for merely by increased consumption of protein. If part of the liver was removed from an adult rat, both the rate of regeneration and the ultimate size and composition of the remainder were also determined by the calorie intake. The increased size of the liver of hyperphagic rats was associated with a greater blood volume, and consequently an increase in total serum protein, although the concentration of serum protein remained normal. Although hyperphagia after hypothalamic lesions may continue for many weeks, with a progressive increase in obesity, the maximum weight of the liver was often achieved within 1 or 2 days. The chemical composition of the liver, however, changed progressively, and the effects closely resembled those brought about by insulin in the liver of diabetic rats. The similarity suggested that insulin might regulate the metabolic adaptation of the liver to a very high intake of food.

scholarly journals The problem of dose in homeopathy: evaluation of the effect of high dilutions of Arsenicum album 30cH on rats intoxicated with arsenic.

2021 ◽  
Vol 9 (33) ◽  
pp. 128-137
Author(s):  
Olney Leite Fontes ◽  
Fátima Cristiane Lopes Goularte Farhat ◽  
Amarilys Toledo Cesar ◽  
Marilisa Guimarães Lara ◽  
Maria Imaculada Lima Montebelo ◽  
...  
Keyword(s):  
Negative Control Group ◽  
Positive Control ◽  
Oral Route ◽  
Negative Control ◽  
Control Group ◽  
Before And After ◽  
Male Wistar Rats ◽  
High Dilutions ◽  
Living Organisms

Background: Although scientific studies have confirmed the action of homeopathic high dilutions in living organisms an endless debate on the choice of the most fitting dilution, the frequency of administration and the dose (amount of medicine) still remains. Aims: This study sought to assess the in vivo effect of 2 different concentrations of Arsenicum album 30cH in order to elucidate some problems in the homeopathic notion of dose. Methods: Male Wistar rats previously intoxicated with sodium arsenate by peritoneal injection were treated with undiluted Ars 30cH and Ars 30cH in 1% solution administered by oral route. Atomic absorption spectroscopy was employed to measure the levels of arsenic retained in the animals as well as the amounts eliminated through urine. Urine samples were collected before and after and during treatment. A positive control group (intoxicated animals) and negative control group (non-intoxicated animals) were administered only the vehicle used to prepare the medicine (ethanol). Results: The groups treated with undiluted Ars 30cH and Ars 30cH in 1% solution eliminated significant amounts of arsenic through urine when compared to the control groups. The group treated with undiluted Ars 30cH eliminated significantly higher amounts of arsenic than the group treated with the same medicine in 1% solution. Conclusion: These results suggest that undiluted Ars 30cH was more effective than in 1% solution in this experimental model.

Effect of Administration of CHAGURO Made of Chayote (Sechium edule) and Tuna (Thunnus sp.) on Rats Induced with Streptozotocin-Nicotinamide and a High-Fat Diet

2021 ◽  
Vol 9 (1) ◽  
pp. 258-266
Author(s):  
Toto Sudargo ◽  
Bianda Aulia ◽  
Atika Anif Prameswari ◽  
Alim Isnansetyo ◽  
Indun Dewi Puspita ◽  
...  
Keyword(s):  
Blood Glucose ◽  
High Fat Diet ◽  
Fasting Blood Glucose ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Sprague Dawley ◽  
High Fat ◽  
Tuna Fish ◽  
Sechium Edule

This study was conducted to develop Chaguro, a low-cost supplementary food made of chayote (Sechium edule (Jacq.) Swartz) and tuna fish (Thunnus sp.), for diabetes and dyslipidemia diet therapy. In order to find a formula with effective hypoglycaemic and antidyslipidemic properties, dried tuna and chayote were mixed at different ratios: F1 (75% tuna, 25% chayote), F2 (50% tuna, 50% chayote), and F3 (25% tuna, 75% chayote). Thirty male Sprague Dawley rats were assigned into healthy control group or groups induced with streptozotocin-nicotinamide and a high-fat diet. Chaguro was administered 2.7 g/ kgBW/ day using a gavage for 28 days. The administration of all Chaguro formulas improved blood markers compared to the negative control group (p < 0.001). Chaguro F2 lowered fasting blood glucose (97.07±1.18 vs 266.31±5.31), total cholesterol (113.59±2.22 vs 208.78±4.31), triglycerides (89.93±2.51 vs 142.35±2.83), LDL-c (33.87±1.87 vs 87.85±3.34) and increased HDL-c (69,08±1,85 vs 23,91±1,64) level the most compared to the negative control group (p < 0.001). Streptozotocin-induced weight loss was also prevented in all diabetic rats fed with Chaguro, with the bodyweight being similar to that of healthy controls at the end of the intervention (p < 0.001). This study found that Chaguro may be a potential food product to help lower blood glucose and improve lipid profile in diabetes and dyslipidemia.

Oral Rehydration Salt-Liquid as an Alternative Storage Medium - A Preliminary Study

2011 ◽  
Vol 35 (4) ◽  
pp. 393-396 ◽  
Author(s):  
P Subramaniam ◽  
U Eswara ◽  
KL Girish Babu ◽  
B Vardhan
Keyword(s):  
Test Group ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Oral Rehydration Salt ◽  
Control Group ◽  
Oral Rehydration ◽  
Pdl Cells ◽  
The Mean ◽  
Group 5

Objective: To assess the efficacy of Oral Rehydration Salt-Liquid (ORS-L) in the maintenance of the viability of Periodontal ligament cells (PDL). Materials and Method: Twenty freshly extracted teeth were used for this study. They were then randomly divided into 3 groups: Positive control group - 5 teeth which were immediately subjected to collagenase assay, without immersing in ORS-L; Negative control group - 5 teeth with an extra oral dry time of 24 hours, followed by subjecting to collagense assay without immersing in ORS-L and Test group (ORS-L) - 10 teeth with an extra oral dry period of 30 minutes, followed by immersion in ORS-L for a period of 45 minutes and then subjected to collagenase assay. The mean number of viable PDL cells were counted on a hemocytometer under 20X magnification. Results: The mean number of viable PDL cells was highest in the positive control group. In comparison to the negative control group, the test group showed a higher number of viable PDL cells. Conclusion: The study found that ORS-L was an effective solution in maintaining the viability of PDL cells.

scholarly journals Efficacy of Ivermectin, Liquid Paraffin, and Carbaryl against Mange of Farmed Rabbits in Central Kenya

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Kennedy O. Ogolla ◽  
Joyce Chebet ◽  
Robert M. Waruiru ◽  
Peter K. Gathumbi ◽  
Paul O. Okumu ◽  
...  
Keyword(s):  
Liquid Paraffin ◽  
Strong Association ◽  
Negative Control Group ◽  
Field Trials ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Common Disease ◽  
Laboratory Trial ◽  
Group 5

Mange is a common disease of rabbits globally, and knowledge of efficacy of drugs used in its treatment is critical for effective disease control. The current study evaluated the efficacy of three commonly used therapeutic agents in Kenya against mange. In a controlled laboratory trial, 20 adult rabbits were recruited for the study (16 of which were infested with mange, while 4 were mange-free). The 16 mange-infested rabbits were randomly allocated into 4 treatment groups each consisting of 4 rabbits, while 4 mange-free rabbits formed the negative control group. Treatments were administered as follows: group 1 (G1) received two ivermectin injections at an interval of 14 days, group 2 (G2) was treated with a combination of carbaryl and liquid paraffin applied every other day up to the end of the experiment, group 3 (G3) was treated with liquid paraffin droplets applied daily until the lesion cleared, while group 4 (G4, infected-untreated) received distilled water applied topically on their ears and group 5 (G5, uninfected-untreated negative control) was not treated with any preparation. The lesions were scored and sampled daily to check the viability of the mites. A field efficacy trial of the test compounds was performed using 105 mange-infested rabbits. The results revealed that all the test agents: ivermectin, liquid paraffin, carbaryl-water, and carbaryl-liquid paraffin combination were effective against mange, recording the lesion score of zero for psoroptic mange by day 21 in the laboratory and field trials. Lesion scores in the treated groups were significantly reduced (p<0.05) at the termination of study compared with those of the positive control group in the laboratory trial. A point-biserial correlation revealed a strong association (rpb = 0.79, p<0.05) between the presence of viable mites and degree of psoroptic lesions in the field trial.

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