Title- Role of herbal products in curing Vitiligo

2021 ◽  
Vol 2 (3) ◽  
pp. 68-73
Author(s):  
Pratik Talukder ◽  
Tiasha Majumdar
Keyword(s):  
Oxidative Stress ◽  
Secondary Metabolites ◽  
Skin Disorder ◽  
The Body ◽  
Pharmacological Properties ◽  
Herbal Products ◽  
Health Disorders ◽  
Destruction Of Melanocytes

Plants produce a wide diversity of secondary metabolites which serve them as defence compounds against herbivores, and other plants and microbes, but also as signal compounds. In general, secondary metabolites exhibit a wide array of biological and pharmacological properties. Because of this, some plants or products isolated from them have been and are still used to treat infections, health disorders or diseases. Vitiligo is a skin disorder that is caused due to oxidative stress in the body resulting in the destruction of melanocytes, which are the cells responsible for the pigmentation of the skin. On their destruction the skin gets depigmented resulting in patches of skin losing their colour. In this review we focus on how plant based herbal products help in curing vitiligo.

Oxidative stress in Vitiligo patients and administration of Munzij and Mushil therapy, a poly herbal Unani formulation – hospital-based study

2020 ◽  
Vol 17 (3) ◽  
Author(s):  
Towseef Amin Rafeeqi ◽  
Farhat Jabeen ◽  
M A Waheed ◽  
Gulam Mohammed Husain ◽  
Alokananda Chakraborthy
Keyword(s):  
Oxidative Stress ◽  
Healthy Subjects ◽  
Skin Disorder ◽  
Antioxidant Status ◽  
The Body ◽  
Oxygen Species ◽  
Statistical Significant Difference ◽  
Significant Difference ◽  
Gpx Activity

AbstractBackgroundVitiligo, a skin disorder is viewed as a multifactorial process with major role of reactive oxygen species in concert to destroy or incapacitate melanocytes. In Unani system of medicine the treatment of Bars (Vitiligo) starts with removal of harmful materials from the body with Munzij and Mushil (MM), a poly herbal Unani formulation.MethodsHerein, oxidative stress related parameters as MDA, SOD, GPx and CAT have been estimated in the 21 clinically diagnosed Vitiligo in-patients and subsequently these parameters were evaluated during and after administration of MM therapy and compared with 21 healthy subjects.ResultsThere was significant difference in the parameters viz., SOD (p<0.001) and CAT (p<0.005) activity at the baseline with no statistical significant difference in MDA and GPx activity among Vitiligo subjects and controls. After MM therapy there was no statistical significant difference among the values of these parameters in Vitiligo subjects.ConclusionsThe results suggest that there is imbalance in the oxidant-antioxidant status of Vitiligo subjects and the MM therapy is not found to significantly change the levels of oxidative stress related parameters.

scholarly journals The Possible Role of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Ovidiu-Dumitru Ilie ◽  
Emanuela Paduraru ◽  
Madalina-Andreea Robea ◽  
Ioana-Miruna Balmus ◽  
Roxana Jijie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Locomotor Activity ◽  
Prolonged Exposure ◽  
Bifidobacterium Longum ◽  
The Body ◽  
The Other ◽  
Control Group

Background. As every organ within the body, the brain is also extremely susceptible to a plethora of noxious agents that change its chemistry. One component frequently found in current products against harmful species to crops is rotenone whose effect under prolonged exposure has been demonstrated to cause neurodegenerative disorders such as Parkinson’s disease. The latest reports have indeed revealed that rotenone promotes Parkinson’s in humans, but studies aiming to show congruent effects in zebrafish (Danio rerio) are lacking. Material and Methods. In this context, the aim of the present study was to demonstrate how chronic administration of rotenone for 3 weeks impairs the locomotor activity and sociability and induces oxidative stress in zebrafish. Results. There were no statistically significant differences following the analysis of their social interaction and locomotor tests ( p > 0.05 ). However, several exceptions have been noted in the control, rotenone, and probiotics groups when we compared their locomotor activity during the pretreatment and treatment interval ( p < 0.05 ). We further assessed the role of rotenone in disturbing the detoxifying system as represented by three enzymes known as superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA). Despite the fact that there were no statistically significant changes within SOD and GPx levels between the control group and rotenone, probiotics, and rotenone + probiotics ( p > 0.05 ), relevant changes have been observed between the analyzed groups ( p < 0.05 and p < 0.005 , respectively). On the other hand, significant differences ( p < 0.05 ) have been observed for MDA when we analyzed the data between the control group and the other three groups. Conclusions. Our results suggest that rotenone can be successfully used to trigger Parkinson’s disease-related symptomatology in zebrafish.

scholarly journals Comparison of Oxidant-Antioxidant Status in Patients with Vitiligo and Healthy Population

2015 ◽  
Vol 12 (2) ◽  
pp. 132-136 ◽  
Author(s):  
S Agrawal ◽  
A Kumar ◽  
TK Dhali ◽  
SK Majhi
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Vitamin E ◽  
Vitamin C ◽  
Control Group ◽  
Healthy Population ◽  
Significant Difference ◽  
Destruction Of Melanocytes ◽  
And Control

Background Vitiligo is a well-recognized pigmentary disorder of the skin and /or mucous membrane characterized by circumscribed ivory or chalky white macules devoid of identifiable melanocytes. The pathogenesis of vitiligo is complex and still not well understood. According to autocytotoxic hypothesis, oxidative stress has been suggested to be the initial pathogenic event in melanocyte degeneration. The role of free radicals and oxidative damage in the pathophysiology of vitiligo has been documented in recent studies.Objective To evaluate the role of oxidative stress in patients with vitiligo and of healthy controls by measuring levels of the oxidant malondialdehyde (MDA) and antioxidants vitamin C and vitamin E in serum and catalase (CAT) in erythrocytes.Method A total of 80 clinically diagnosed cases of vitiligo and 80 control subjects were included in the study to assess the activity of MDA, vitamin C and vitamin E in serum and CAT in erythrocytes of patients and controls by using the spectrophotometric assay.Result There was statistically significant increase in the levels of MDA in patients with vitiligo compared to the control group (p<0.001). No significant difference was found in the levels of vitamin C (p=0.411) and vitamin E (p=0.771) between the patients with vitiligo and control group. The levels of CAT in the vitiligo patients were found to be significantly lower than those of controls (p<0.001).Conclusion Increased oxidative stress and decreased catalase have been observed in vitiligo patients and the data suggesting that the free radicals may be involved in the destruction of melanocytes or dysregulation of melanogenesis.Kathmandu University Medical Journal Vol.12(2) 2014: 132-136

scholarly journals Chlorophyll enhances oxidative stress tolerance inCaenorhabditis elegansand extends its lifespan

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e1879 ◽  
Author(s):  
Erjia Wang ◽  
Michael Wink
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Secondary Metabolites ◽  
Model System ◽  
The Body ◽  
Aging Effects ◽  
Oxidative Stress Tolerance ◽  
C Elegans ◽  
Dependent Pathway

Green vegetables are thought to be responsible for several beneficial properties such as antioxidant, anti-mutagenic, and detoxification activities. It is not known whether these effects are due to chlorophyll which exists in large amounts in many foods or result from other secondary metabolites. In this study, we used the model systemCaenorhabditis elegansto investigate the anti-oxidative and anti-aging effects of chlorophyllin vivo. We found that chlorophyll significantly improves resistance to oxidative stress. It also enhances the lifespan ofC. elegansby up to 25% via activation of the DAF-16/FOXO-dependent pathway. The results indicate that chlorophyll is absorbed by the worms and is thus bioavailable, constituting an important prerequisite for antioxidant and longevity-promoting activities inside the body. Our study thereby supports the view that green vegetables may also be beneficial for humans.

scholarly journals Amino acids targeted based metabolomics study in non-segmental Vitiligo: a pilot study

2021 ◽  
Author(s):  
Rezvan Marzabani ◽  
Hassan Rezadoost ◽  
Peyman Chopanian ◽  
Nikoo Mozafari ◽  
Mohieddin Jafari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Treatment Process ◽  
The Body ◽  
Molar Ratios ◽  
Metabolomics Study ◽  
Amino Acid Profiles ◽  
Set Up ◽  
And Oxidative Stress

AbstractIntroductionVitiligo is an asymptomatic disorder that results from the loss of pigments (melanin), causing skin or mucosal depigmentation and impairs beauty.ObjectiveDue to the complexity of the pathogenesis of this disease and various theories including self-safety theory, oxidative stress, neurological theory and internal defects of melanocytes behind it, and finally, the vast role of amino acids in body metabolism and various activities of the body, amino acids targeted based metabolomics was set up to follow any fluctuation inside this disease.MethodologyThe study of amino acid profiles in plasma of people with non-segmental vitiligo using a liquid chromatography equipped with fluorescent detector was performed to find remarkable biomarkers for the diagnosis and evaluation of disease severity of patients with vitiligo. Twenty-two amino acids derivatized with o-phthalaldehyde (OPA) and fluorylmethyloxycarbonyl chloride (FMOC), were precisely determined. Next, the concentrations of these twenty-two amino acids and their corresponding molar ratios were calculated in 37 patients (including 18 females and 19 males) and corresponding 34 healthy individuals (18 females and 16 males). Using R programing, the data were completely analyzed between the two groups of patients and healthy to find suitable and reliable biomarkers.ResultsInterestingly, comparing the two groups, in the patient group, tyrosine, cysteine, the ratio of tyrosine to lysine and the ratio of cysteine to ornithine were increased while, arginine, lysine, ornithine and glycine ratios to cysteine have been decreased. These amino acids were selected for identification of patients with accuracy of detection of approximately 0.95 using the assessment of logistic regression.ConclusionThese results indicate a disruption of the production of melanin, increased immune activity and oxidative stress, which are also involved in the effects of vitiligo. Therefore, these amino acids can be used as biomarker for the evaluation of risk, prevention of complications in individuals at risk and monitoring of treatment process.

scholarly journals Battle between plants as antioxidants with free radicals in human body

2020 ◽  
Vol 9 (3) ◽  
pp. 191-199 ◽  
Author(s):  
Fatemeh Jamshidi-kia ◽  
Joko Priyanto Wibowo ◽  
Mostafa Elachouri ◽  
Rohollah Masumi ◽  
Alizamen Salehifard-Jouneghani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Human Body ◽  
Defense Mechanisms ◽  
Natural Antioxidants ◽  
Redox Status ◽  
The Body ◽  
Antioxidant Agents ◽  
Endogenous Antioxidants

Free radicals are constructed by natural physiological activities in the human cells as well as in the environment. They may be produced as a result of diet, smoking, exercise, inflammation, exposure to sunlight, air pollutants, stress, alcohol and drugs. Imbalanced redox status may lead to cellular oxidative stress, which can damage the cells of the body, resulting in an incidence of various diseases. If the endogenous antioxidants do not stop the production of reactive metabolites, they will be needed to bring about a balance in redox status. Natural antioxidants, for example plants, play an important part in this context. This paper seeks to report the available evidence about oxidative stress and the application of plants as antioxidant agents to fight free radicals in the human body. For this purpose, to better understand oxidative stress, the principles of free radical production, the role of free radicals in diseases, antioxidant defense mechanisms, and the role of herbs and diet in oxidative stress are discussed.

scholarly journals ROLE OF BILWADI AGADA IN PREVENTION OF COVID - 19

2020 ◽  
Vol 8 (7) ◽  
pp. 3939-3944
Author(s):  
Varun Rajpuria ◽  
Anitta James
Keyword(s):  
Prevention And Control ◽  
Distress Syndrome ◽  
The Body ◽  
Ayurvedic Medicine ◽  
Pharmacological Properties ◽  
Upper Respiratory Tract ◽  
Corona Virus ◽  
Upper Respiratory ◽  
And Control

Agada Tantra is a specialized branch of Ayurveda which mainly deals with Visha (Poison) and its management mainly through special formulations called Agada Yogas which counteract the deleterious actions of poison over the body. There are numerous such formulations which are unique because of their potent ingredients and fast action. Bilwadi Agada is one among such Yogas. In December 2019, a series of acute atypical respiratory disease occurred in Wuhan and then rapidly spread to other areas. It was soon discovered that a novel Corona Virus was responsible, and this was named as the Severe Acute Respiratory Syndrome Corona Virus-2 (2019) due to its high homology to SARS-CoV-2 which caused Acute Respiratory Distress Syndrome and high mortality during 2002–2003 in China. According to Ayurveda, this novel Corona is a Jangama Visha as it is of zoonotic origin. It affects the upper respiratory tract so is the movement of Jangama Visha which moves upward and affects those areas. It is also mentioned in Ayurvedic treatise that the Jangaman Visha should be treated with Sthavara dravyas. Bilwadi gutika is an Ayurvedic medicine prepared from thirteen medicinal plants triturated in goat’s urine. When we compare the primary symptoms of COVID-19 and the indications of Bilwadi gutika, we can see so many similarities. The main objective of this article is to discuss the therapeutic and pharmacological properties of Bilwadi Agada and thereby understanding its role in prevention and control of COVID-19 pandemic.

scholarly journals Protective Role of Myricetin on Markers of Oxidative Stress in Human Erythrocytes Subjected to Oxidative Stress

2009 ◽  
Vol 4 (2) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Kanti Bhooshan Pandey ◽  
Neetu Mishra ◽  
Syed Ibrahim Rizvi
Keyword(s):  
Oxidative Stress ◽  
Protective Role ◽  
Protein Carbonyl ◽  
Human Erythrocytes ◽  
The Body ◽  
Protein Carbonyl Content ◽  
Tert Butylhydroperoxide ◽  
Markers Of Oxidative Stress ◽  
Dose Dependent

The protective effect of myricetin against tert-butylhydroperoxide (t-BHP) induced oxidative stress in human erythrocytes was investigated. Incubating erythrocytes with t-BHP (10−5M) caused development of oxidative stress, as evidenced by significant ( p < 0.05) increase in erythrocyte malondialdedyde (MDA) and protein carbonyl content, and decrease in intracellular reduced glutathione (GSH), membrane sulphydryl (-SH) groups. Incubation of erythrocytes with myricetin, simultaneously with t-BHP, protected the erythrocytes from oxidative stress, an effect which was dose-dependent. The results demonstrate that myricetin attenuates t-BHP induced oxidative damage, suggesting that supplementation of diet with myricetin/myricetin rich food may be beneficial in all pathological conditions where the antioxidant system of the body is overwhelmed.

THE ROLE OF THE GLUTATHIONE SYSTEM IN MAINTAINING REDOX-HOMEOSTASIS AND ANTIOXIDANT PROTECTION IN INFLAMMATORY AND DEGENERATIVE DISEASES OF THE ORGAN OF VISION

2021 ◽  
Vol 19 (4) ◽  
pp. 382-391
Author(s):  
V. G. Marmysh ◽  
Keyword(s):  
Oxidative Stress ◽  
Redox Homeostasis ◽  
The Body ◽  
Protection System ◽  
Antioxidant Protection ◽  
Degenerative Diseases ◽  
Glutathione System ◽  
Intracellular Glutathione ◽  
Antioxidant Protection System

Objective. To review and analyze literature data as well as evaluate the role of the glutathione antioxidant system in inflammatory and degenerative diseases of the organ of vision. Material and Methods. Multiple sources of foreign and domestic literature concerning the problem of oxidative stress, antioxidant protection system, glutathione and their role in inflammatory and degenerative diseases of the organ of vision were analyzed using main scientific and medical databases. More than 120 sources in the medical literature over the past 15 years were evaluated, 50 of them have been selected for final summary. Results. It was found that oxidative stress, based on free radical oxidation reactions, including LPO processes, plays a leading role in the development of inflammatory and degenerative diseases of the organ of vision. The key link in the eye’s antioxidant protection system is the glutathione system, which includes glutathione itself (GSH) and glutathionedependent enzymes: glutathione peroxidase (GPO), glutathione reductase (GR), glutathione-S-transferase (GST). Inflammatory and degenerative diseases of the eye are accompanied by reduction of the intracellular glutathione pool and imbalance between its reduced and oxidized forms (GSH / GSSG). Conclusions. Oxidative stress has a high correlation with inflammation and is the most important pathogenetic mechanism in inflammatory and degenerative diseases of the eye. The key role in antioxidant protection and maintenance of redox homeostasis of eye tissues belongs to the glutathione system, which includes GSH itself and glutathione-dependent enzymes (GPO, GR, GST). Inflammatory and degenerative processes in the eye are accompanied by decrease of the intracellular glutathione pool (GSH) and imbalance between its reduced and oxidized forms (GSH / GSSG). A shift in this balance significantly affects normal cell functioning, up to its apoptosis, and triggers multiple pathological conditions within the body, including diseases of the organ of vision.

scholarly journals Antioxidant properties of flavonoids

2015 ◽  
Vol 23 (4) ◽  
pp. 239-44 ◽  
Author(s):  
Sofna D.S. Banjarnahor ◽  
Nina Artanti
Keyword(s):  
Oxidative Stress ◽  
Drug Discovery ◽  
Secondary Metabolites ◽  
Functional Activity ◽  
Antioxidant Properties ◽  
Plant Secondary Metabolites ◽  
Traditional Medicines

Flavonoids represent a remarkable group of plant secondary metabolites and have long been used as traditional medicines with scientifically proven pharmacological benefits. They serve vast-ranging medicinal activities that may lead drug discovery with novel and potential therapeutic evidence. Latest research magnifies primarily functional activity of flavonoids as antioxidant against oxidative stress. This review enlightens the prospective role of flavonoids as antioxidant.

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