scholarly journals Deaths among the elderly with ICU infections

2017 ◽  
Vol 70 (4) ◽  
pp. 733-739 ◽  
Author(s):  
Álvaro Francisco Lopes de Sousa ◽  
Artur Acelino Francisco Luz Nunes Queiroz ◽  
Layze Braz de Oliveira ◽  
Luana Kelle Batista Moura ◽  
Denise de Andrade ◽  
...  

ABSTRACT Objective: to evaluate the clinical outcome of elderly patients admitted to intensive care units who had nosocomial infection, correlating the findings with sociodemographic and clinical variables. Method: descriptive research, performed with 308 elderly patients. The collection was made from medical records and covers the years 2012 to 2015. Uni-/bivariate analyses were performed. Results: a statistical association was found between the clinical outcome types and the variables age, length of stay, presence of previous comorbidities, main diagnosis, respiratory and urinary tract infections, use of central venous and indwelling urinary catheters, mechanical ventilation, and tracheostomy. The survival curve showed higher mortality among the elderly from the age of 80 on. Conclusion: the clinical outcome of the elderly who acquire infection in the intensive care unit is influenced by sociodemographic and clinical variables that increase mortality rates.

2017 ◽  
Vol 30 (2) ◽  
pp. 131
Author(s):  
Konlawij Trongtrakul ◽  
Sujaree Poopipatpab ◽  
Ploynapas Limphunudom ◽  
Chawika Pisitsak ◽  
Kaweesak chittawatanarat ◽  
...  

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e20018-e20018
Author(s):  
U. P. Hegde ◽  
N. Chakraborty ◽  
A. Chhabra ◽  
S. Ray

e20018 Background: Cutaneous melanoma incidence is rapidly rising in the elderly population. Imbalances of the immune system are described due to aging associated changes between CD4+, CD8+, T helper (Th) 1, Th 2 and T regulatory and T effector lymphocytes (lym). We describe clinical outcome in 10 elderly patients (pts) with cutaneous metastatic melanoma (CMM) and results of the immune studies done in a subgroup. Methods: Between October 2002 and October 2008, 10 elderly pts with treatment naïve CMM, 6 males and 4 female, median ages 76, range 57–84 years were treated at the University of Connecticut Health Center. Metastatic sites included soft tissue in 2 patients (pts), lung and/or liver with lymph node (LN) involvement (6 pts) and distant LN metastasis (2pts). Eight pts opted for treatment and received single or combination chemotherapy (5pts), high dose Interleukin 2 (2 pts), complete tumor resection followed by tumor derived heat shock protein vaccine (1 pt on clinical trial) and bio chemotherapy (1pt). One patient declined treatment (included in follow up). In vitro immune characteristics were studied in HLA-A2 positive subgroup (5pts) and included cytotoxic T lym (CTL) generation against self and non self peptides (Mart-1 27–35 and influenza MP derived peptide flu 58–66), proliferative activity of CD4+ lym in response to anti CD3 antibody under Th1 and Th2 conditions and regulatory T lym activity of CD4+CD25+ lym against CTL. Results: All patients tolerated treatments well resulting in 1 complete response, 4 partial responses, and 4 stable diseases. During 6 year follow up period, 6 patients died while 4 patients are living (one with disease). The median survival of all patients is 28.1 month (mo) while in those surviving (4pts) is 72 mo. Immune studies revealed preserved proliferative activity of CD4+ lym with stronger Th1 induction than Th2. The CTL responses to self and non self antigens were preserved while regulatory T lym showed weak activity against CTL. Conclusions: Some elderly patients with metastatic melanoma demonstrate improved outcomes and favorable immune characteristics. Further studies are needed to understand the impact of aging immune system on cutaneous melanoma. No significant financial relationships to disclose.


2011 ◽  
Vol 19 (6) ◽  
pp. 1344-1351 ◽  
Author(s):  
Verônica Cunha Rodrigues de Oliveira ◽  
Lilia de Souza Nogueira ◽  
Rafaela Andolhe ◽  
Katia Grillo Padilha ◽  
Regina Marcia Cardoso de Sousa

This study compared clinical outcomes among adult, elderly and very elderly patients admitted to Intensive Care Units (ICUs) located in São Paulo, Brazil. This retrospective, longitudinal and comparative study included 279 adult (≥18 and <60 years), 216 elderly (≥60 and <80 years) and 105 very elderly (≥80 years) patients. Adult patients differed from other groups regarding the unit to which they were referred and severity, according to the Simplified Acute Physiology Score II. Adults were most frequently sent to hospitalization wards; elderly and very elderly patients who survived hospitalization in critical units showed sharper improvement before discharge. There were differences in relation to mortality between adult and elderly patients, with a higher rate in the elderly group; however, the mortality rate of very elderly and adult patients was similar. In general, the results indicated that older age was not associated with undesirable outcomes in ICUs.


2011 ◽  
Vol 2 (2) ◽  
pp. 133-136
Author(s):  
Marion Creutzberg ◽  
Nair Cristina Fortuna Aguilera ◽  
Patrícia Cristina Cardoso ◽  
Thiago Lapuente Barbosa ◽  
Lieli Dapieve Ceolin ◽  
...  

Objetivos: identificar o risco para úlceras de pressão (UP) em idosos de Unidade de Terapia Intensiva (UTI); comparar o risco de UP com as variáveis sexo, faixa etária e especialidade; comparar o risco de UP entre idosos, adultos jovens e médios. Método: estudo exploratório, analítico e retrospectivo realizado em uma UTI com amostra de 216 pacientes. Resultados: o risco de UP nas duas avaliações manteve-se elevado. Não houve diferença de risco de UP entre os pacientes idosos e os adultos jovens e médios. Conclusão: a avaliação do risco de UP é imprescindível para a qualidade da assistência em UTI.Descritores: Úlcera por Pressão, Idoso, Unidades de Terapia Intensiva.Risk factors for pressure ulcers in elderly patients in a Intensive Care UnitObjectives: To identify risk of pressure ulcers (PU) on elderly in Intensive Care Unit (ICU), to compare the risk of PU with gender, age and specialty and to compare the risk of PU in the elderly, young and middle adults. Method: exploratory, analytical and retrospective in ICU with a sample of 216 patients. Results: the risk for PU in the two ratings remained high. There was no difference in risk for PU among the elderly and young and middle adults. Conclusion: the assessment of risk for PU is essential to the quality of ICU care.Descriptors: Pressure Ulcer, Aged, Intensive Care Units.Los factores de riesgo para las úlceras por presión en ancianos en la Unidad de Cuidados IntensivosObjetivos: identificar el riesgo para las úlceras por presión (UPP) en la Unidad de Terapia Intensiva (UTI), para comparar el riesgo de la UPP con el sexo, la edad y la especialidad y para comparar el riesgo entre los adultos mayores, jóvenes y la mediana edad. Método: exploración, análisis y retrospectiva en la UTI con una muestra de 216 pacientes. Resultados: el riesgo de UPP en las dos clasificaciones se mantuvieron altos. No hubo diferencias en el riesgo de la UPP entre los adultos mayores y jóvenes y de mediana edad. Conclusión: la evaluación del riesgo de la UPP es esencial para la calidad de la atención en la UCI.Descriptores: Úlcera por Presión, Anciano, Unidades de Cuidados Intensivos.


2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S752-S752
Author(s):  
Radhika Rastogi ◽  
Abhishek Deshpande ◽  
Phuc Le ◽  
Pei-Chun Yu ◽  
Peter Imrey ◽  
...  

Abstract Background Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality in the elderly. Few studies compare the elderly (>65) and very elderly (≥85 years). We aimed to describe characteristics and patterns of care for very elderly patients hospitalized with CAP. Methods We conducted a retrospective cohort study using administrative data from 2010 to 2015 of about 660 US hospitals in the Premier database. Adults aged ≥65 years hospitalized with CAP, identified by either a principal ICD-9 code of pneumonia or a principal diagnosis of sepsis or respiratory failure coupled with a secondary code for pneumonia, were included. We compared demographics, insurance status, comorbidities, presentation characteristics and treatments among three age groups: 65–74, 75–84, and ≥ 85 years. Results The final sample included 488,382 patients aged ≥65 years, a third of whom were ≥85 years. Geriatricians cared for <1% of patients during hospitalization, regardless of patient age. Compared with those aged 65–74 years, the patients ≥85 were more likely to be female, of white race, have Medicare insurance, and a principal diagnosis of aspiration pneumonia (17.1% vs. 7%) (Table 1). The oldest group had higher rates of cardiac comorbidities, chronic kidney disease and dementia, but lower rates of diabetes, obesity, pulmonary disease, and smoking. On presentation, more of the very elderly had concomitant urinary tract infections. They were less likely to receive opiates and benzodiazepines, but more likely to receive foley catheters and antipsychotic medications. Antibiotics given in the first 2 days were similar across the groups. Fewer very elderly patients were admitted to the ICU or got ventilation compared with younger groups. More of the very elderly were discharged to hospice and fewer were discharged home. Compared with younger ages, the very elderly had similar lengths of stay but lower costs, and higher in-hospital mortality and 30-day readmission. Conclusion The very elderly represent a unique population with distinct clinical characteristics and outcomes from younger elderly patients. They have different co-morbidities and appear to receive less aggressive treatment with lower costs and higher mortality despite similar lengths of stay. Disclosures All authors: No reported disclosures.


2008 ◽  
Vol 16 (2) ◽  
pp. 218-223 ◽  
Author(s):  
Cleber Ricardo de Sousa ◽  
Leilane Andrade Gonçalves ◽  
Maria Cecília Toffoleto ◽  
Karine Leão ◽  
Kátia Grillo Padilha

The age of patients is a controversial issue in admission to intensive care unit (ICU). The aim of this study was to compare severity and nursing workload of elderly patients with 60-69, 70-79, and e"80 years of age and to identify predictors of nursing workload in elderly patients. A cross sectional study was performed with a sample of 71 elderly patients admitted to three ICU in the city of Sao Paulo, Brazil from October to November 2004. Data were prospectively collected using Nursing Activities Score (NAS) and Simplified Acute Physiology Score II (SAPS II). There was no significant difference in nursing workload among the elderly patients age subgroups (p=0.84). Multiple regression analysis indicated that the independent risk factors of high nursing workload were severity, age e"70 years, and to be a surgical ICU patient. Age as an isolated factor should not be discriminative for elderly patients admission to ICU.


2021 ◽  
Author(s):  
Panai Song ◽  
Dong Yang ◽  
Jine Li ◽  
Ning Zhuo ◽  
Xiao Fu ◽  
...  

Abstract The microbiology and outcomes of peritoneal dialysis (PD) related peritonitis in elderly patients have not been thoroughly investigated. We aimed to investigate the microbiological distribution and clinical outcome in elderly patients with PD-associated peritonitis to guide clinical practice. We conducted a prospective, one center cohort study in Hunan province, China from September 1, 2014 to December 31, 2020. Among incident patients (n =279), basic clinical characteristics, pathogen distribution and prognosis of elderly PD patients (up to 65 years, n = 64) were compared with those of PD patients aged under 65 years (n = 215). The survival rate and technical survival rate were analyzed by Kaplan-Meier method. Among the 279 patients there were 394 peritonitis episodes, including 88 in elderly group, and 306 in younger groups. G+ bacteria were the main pathogenic bacteria in both groups (43.2% and 38.0%, respectively). Staphylococcus was the most common G+ bacteria. Peritonitis caused by fungal infection was significantly higher in elderly patients (P = 0.01), however, there is no significant difference in the proportions of G + bacteria and G- bacteria between the two groups. The most common G- bacteria was Escherichia coli. Interestingly, we found that Acinetobacter baumannii, polymicrobial infection and culture negative peritonitis in the elderly patients was significantly higher than that in other patients. Additionally, elderly PD patients had higher peritonitis-related mortality (HR=7.27, P = 0.01). However, the technical survival rate was similar (P = 0.67) in both elderly and other patients. Taken together, this retrospective cohort study found that elderly patients had a higher probability of peritonitis caused by of Acinetobacter baumannii, fungi and polymicrobial infections. In addition, the elderly peritonitis patients had a higher risk of mortality. Understanding the characteristics of microbiology and clinical outcome in elderly patients will help us to take effective measures to reduce the incidence of elderly PD-associated peritonitis.


2019 ◽  
Vol 178 (1) ◽  
pp. 30-33
Author(s):  
Ju. A. Shcherbuk ◽  
V. I. Zakharov ◽  
A. Ju. Shcherbuk ◽  
V. V. Donskov ◽  
E. V. Cherepanova ◽  
...  

Theobjectivewas to research the effect of burdened comorbid status on the course of severe traumatic brain injury (TBI) in the elderly.Material and methods. 243 injured elderly patients (182 men and 61 women) with severe TBI and burdened comorbid status.Results. It was found that the postoperative period was characterized by more severe course of injury associated with the development of infectious and inflammatory complications.Conclusion. Early medical rehabilitation does not have a significant impact on the state of comorbid status, but is important in the prevention of infectious and inflammatory complications due to the early activation of the victims and the elimination of hypodynamia in intensive care and neurosurgical departments.


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