Management of non traumatic surgical emergencies during the COVID-19 pandemia

ABSTRACT In December 2019, in Wuhan, China, the first cases of what would be known as COVID-19, a disease caused by an RNA virus called SARS-CoV-2, were described. Its spread was rapid and wide, leading the World Health Organization to declare a pandemic in March 2020. The disease has distinct clinical presentations, from asymptomatic to critical cases, with high lethality. Parallel to this, patients with non-traumatic surgical emergencies, such as acute appendicitis and cholecystitis, continue to be treated at the emergency services. In this regard, there were several doubts on how to approach these cases, among them: how to quickly identify the patient with COVID-19, what is the impact of the abdominal surgical disease and its treatment on the evolution of patients with COVID-19, in addition to the discussion about the role of the non-operative treatment for abdominal disease under these circumstances. In this review, we discuss these problems based on the available evidence.

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Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients

Scientific Reports ◽

10.1038/s41598-021-94624-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Maria Clara Saad Menezes ◽

Alicia Dudy Müller Veiga ◽

Thais Martins de Lima ◽

Suely Kunimi Kubo Ariga ◽

Hermes Vieira Barbeiro ◽

...

Keyword(s):

Mechanical Ventilation ◽

Peripheral Blood ◽

World Health ◽

Control Group ◽

Pyrin Domain ◽

Peripheral Blood Gene Expression ◽

Severe Group ◽

Health Organization ◽

The Impact

AbstractThe role of innate immunity in COVID-19 is not completely understood. Therefore, this study explored the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection on the expression of Pattern Recognition Receptors (PRRs) in peripheral blood cells and their correlated cytokines. Seventy-nine patients with severe COVID-19 on admission, according to World Health Organization (WHO) classification, were divided into two groups: patients who needed mechanical ventilation and/or deceased (SEVERE, n = 50) and patients who used supplementary oxygen but not mechanical ventilation and survived (MILD, n = 29); a control group (CONTROL, n = 17) was also enrolled. In the peripheral blood, gene expression (mRNA) of Toll-like receptors (TLRs) 3, 4, 7, 8, and 9, retinoic-acid inducible gene I (RIGI), NOD-like receptor family pyrin domain containing 3 (NLRP3), interferon alpha (IFN-α), interferon beta (IFN-β), interferon gamma (IFN-γ), interferon lambda (IFN-λ), pro-interleukin(IL)-1β (pro-IL-1β), and IL-18 was determined on admission, between 5–9 days, and between 10–15 days. Circulating cytokines in plasma were also measured. When compared to the COVID-19 MILD group, the COVID-19 SEVERE group had lower expression of TLR3 and overexpression of TLR4.

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Higher Hemoglobin Levels Are Associated With Better Physical Performance Among Older Adults Without Anemia: A Longitudinal Analysis

10.21203/rs.3.rs-736515/v1 ◽

2021 ◽

Author(s):

Ligiana Pires Corona ◽

Flavia Cristina Drummond Andrade ◽

Tiago Silva Alexandre ◽

Tábatta Renata Pereira Brito ◽

Daniella Pires Nunes ◽

...

Keyword(s):

Older Adults ◽

Physical Performance ◽

Well Being ◽

World Health ◽

Aging Study ◽

Definition Of ◽

Health Organization ◽

The Impact

Abstract Background Anemia is the most common hematological abnormality among older adults, and it is associated with decreased physical performance. But the role of hemoglobin in the absence of anemia remains unclear. Thus, this study aimed to assess the impact of hemoglobin levels on physical performance in Brazilian older adults without anemia. Methods The study is longitudinal in that it relies on two waves of the Saúde, Bem-Estar e Envelhecimento (SABE; Health, Well-being, and Aging) study: 2010 and 2015–2016. Mixed-effects linear regression was used to determine the effects of the hemoglobin concentrations on the Short Physical Performance Battery-SPPB over time among the 1,020 who had complete data and did not have anemia in 2010. In the follow-up, there were 562 without anemia. Analyses were stratified by sex. Results In analyses adjusted for age, education, grip strength, comorbidities, and body mass index, hemoglobin levels were positively associated with physical performance scores among older women (β = 0.15, p < 0.05) and men (β = 0.18, p < 0.05) without anemia. Conclusion Our study demonstrates that higher hemoglobin levels were associated with better physical performance among older men and women without anemia. This finding is important because, in clinical practice, most health professionals focus on the World Health Organization definition of anemia. Our study suggests the importance of hemoglobin levels among older adults, even those without anemia.

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COVID-19 Pandemic in Nigeria: Misconception Among Individuals, Impact on Animals and the Role of Mathematical Epidemiologists

10.20944/preprints202004.0492.v2 ◽

2021 ◽

Author(s):

Oluwasegun Micheal Ibrahim ◽

Damilola Daniel Ekundayo

Keyword(s):

Severe Acute Respiratory Syndrome ◽

World Health ◽

The Novel ◽

Good People ◽

The World ◽

Novel Virus ◽

The Government ◽

Health Organization ◽

The Impact

In March 2020, the World Health Organization declared coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2, to be a pandemic. Since the declaration, Nigeria economy has been greatly impacted thus resulting in a recession. This paper considers a couple of misconceptions among Nigerian people in the COVID-19 pandemic era thereby causing the spread of the novel virus and hence making the situation difficult for the government to handle. In particular, we discuss the first and second waves of the pandemic as it affects the Nigerian people. The impact of the pandemic on animals and the role of mathematical epidemiologists in combatting the spread is discussed herein. We give some recommendations that could be adopted by the government and the good people of Nigeria to reduce the further spread of the virus.

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COVID-19: Relationship and Impact on Breastfeeding—A Systematic Review

Nutrients ◽

10.3390/nu13092972 ◽

2021 ◽

Vol 13 (9) ◽

pp. 2972

Author(s):

Marcelino Pérez-Bermejo ◽

Belén Peris-Ochando ◽

María Teresa Murillo-Llorente

Keyword(s):

Systematic Review ◽

Selection Criteria ◽

Rna Virus ◽

Health Condition ◽

World Health ◽

Protective Measures ◽

Bibliographic Search ◽

Health Organization ◽

The Impact ◽

Mother To Child

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus that was declared a Public Health Emergency of International Concern by the World Health Organization (WHO). One major problem faced is whether breastfeeding by mothers infected with the virus is safe. The objective of this work is to study the impact that the SARS-CoV-2 virus can have on breastfeeding, and whether the virus or antibodies can be transmitted from mother to child through milk. We carried out a systematic review of studies focusing on the impact of SARS-CoV-2 on breastfeeding by mothers infected with the virus. The bibliographic search was done through Medline (Pubmed), MedlinePlus and Google Scholar. From 292 records, the title and summary of each were examined according to the criteria, and whether they meet the selection criteria was also analysed. A total of 30 articles are included, of which 26 deal with the study of RNA virus in breastmilk and its involvement in breastfeeding and four on the study of SARS-CoV-2 antibodies in milk. Most studies have been conducted in China. Breastfeeding by mothers infected with SARS-CoV-2 is highly recommended for infants, if the health of the mother and the infant allow for it. Direct breastfeeding and maintaining appropriate protective measures should be encouraged. Should the mother’s health condition not permit direct breastfeeding, infants should be fed with pumped breastmilk or donor milk.

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A SURGICAL AUDIT OF GENERAL SURGERY CASES IN A TERTIARY CARE HOSPITAL AND THE IMPACT OF COVID-19 ON THE SAME

10.36106/ijsr/8406943 ◽

2021 ◽

pp. 39-41

Author(s):

Ravi Landge ◽

Sumit Satish Malgaonkar ◽

Girish Bakhshi ◽

Ajay Bhandarwar ◽

Jaymin Gupta

Keyword(s):

General Surgery ◽

Emergency Services ◽

Tertiary Care ◽

World Health ◽

Care Hospital ◽

Real Risk ◽

Health Organization ◽

Surgical Audit ◽

Surgery Department ◽

The Impact

BACKGROUND: After the COVID-19 pandemic was declared on March 11, 2020 by the World Health Organization (WHO), routine clinical and surgical practices were affected, including General Surgery services. We aimed to compare how our General Surgery department was affected during this time period of Covid, we have included various parameters, we have also statistically shown how the elective and emergency services were before the Covid outbreak and during the COVID-19 pandemic in our institution. MATERIAL AND METHODS: We retro spectively compared General Surgery practices, including elective, emergency and septic surgeries in a surgical unit of Sir JJ Group of Hospitals over a span of 3 years (April 2018 - March 2021), including the era before and during Covid. RESULTS: The frequency of all the surgeries performed during the pandemic was lower as compared to previous two years before the pandemic in our study, also there was a signicant drop in the number of laparoscopic surgeries. CONCLUSION: The General Surgery practices in our institution have been drastically affected by the COVID-19 pandemic. This setback needs a denite strategy to be formulated to decrease the morbidity and mortality from the neglected elective surgical cases, the real risk-benet ratio must be met before operating such cases.

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Multifaceted Medical and Scientific Approaches and the Role of the Public in Combating the COVID-19 Pandemic in the Digital Era

Journal of Biomedical Research & Environmental Sciences ◽

10.37871/jbres1179 ◽

2021 ◽

Vol 2 (1) ◽

pp. 008-010

Author(s):

V Mahant

Keyword(s):

Etiologic Agent ◽

Lifestyle Changes ◽

World Health ◽

Modern History ◽

The Public ◽

Digital Era ◽

Spanish Flu ◽

Health Organization ◽

The Impact

Epidemics and pandemics have been recurrent in history. One of the worst pandemics in the modern history was the 1918 H1N1 flu (“Spanish flu”) that claimed the lives of an estimated 50 million people globally [1]. The current pandemic, a severe acute respiratory syndrome coronavirus (SARS-CoV-2), the etiologic agent of COVID-19, was first reported in the city of Wuhan (China) in December 2019. According to the World Health Organization (WHO), at the time of writing, there were over 84 million confirmed cases and over 1.8 million deaths in 218 countries linked to COVID-19 [2], and the numbers of cases continue to climb globally. The viral transmission has been reported as predominantly horizontal while reports of vertical transmission have been limited [3]. The impact of COVID-19 on morbidity, mortality, lifestyle changes, and trillions of dollars in the economy is unprecedented in the modern history. There are significant synergies and a concerted role for multifaceted medical and scientific approaches to be utilized to engage the public in combating COVID-19 effectively.

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Calcium Signals during SARS-CoV-2 Infection: Assessing the Potential of Emerging Therapies

Cells ◽

10.3390/cells11020253 ◽

2022 ◽

Vol 11 (2) ◽

pp. 253

Author(s):

Sascha Berlansky ◽

Matthias Sallinger ◽

Herwig Grabmayr ◽

Christina Humer ◽

Andreas Bernhard ◽

...

Keyword(s):

Immune Escape ◽

Rna Virus ◽

Research Effort ◽

Respiratory Illness ◽

World Health ◽

Calcium Signals ◽

Emerging Therapies ◽

Health Organization ◽

First Time

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). This respiratory illness was declared a pandemic by the world health organization (WHO) in March 2020, just a few weeks after being described for the first time. Since then, global research effort has considerably increased humanity’s knowledge about both viruses and disease. It has also spawned several vaccines that have proven to be key tools in attenuating the spread of the pandemic and severity of COVID-19. However, with vaccine-related skepticism being on the rise, as well as breakthrough infections in the vaccinated population and the threat of a complete immune escape variant, alternative strategies in the fight against SARS-CoV-2 are urgently required. Calcium signals have long been known to play an essential role in infection with diverse viruses and thus constitute a promising avenue for further research on therapeutic strategies. In this review, we introduce the pivotal role of calcium signaling in viral infection cascades. Based on this, we discuss prospective calcium-related treatment targets and strategies for the cure of COVID-19 that exploit viral dependence on calcium signals.

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The role of the World Health Organization country programs in the development of virology in Spain, 1951-1975

História Ciências Saúde-Manguinhos ◽

10.1590/s0104-59702020000300010 ◽

2020 ◽

Vol 27 (suppl 1) ◽

pp. 187-210

Author(s):

María Isabel Porras ◽

María José Báguena

Keyword(s):

Public Health ◽

World Health Organization ◽

Health Knowledge ◽

World Health ◽

Historical Archives ◽

The World ◽

Health Organization ◽

The Impact ◽

Selection Of

Abstract Within the framework of recent historiography about the role of the World Health Organization (WHO) in modernizing public health and the multifaceted concept of global health, this study addresses the impact of the WHO’s “country programs” in Spain from the time it was admitted to this organization in 1951 to 1975. This research adopts a transnational historical perspective and emphasizes attention to the circulation of health knowledge, practices, and people, and focuses on the Spain-0001 and Spain-0025programs, their role in the development of virology in Spain, and the transformation of public health. Sources include historical archives (WHO, the Spanish National Health School), various WHO publications, the contemporary medical press, and a selection of the Spanish general press.

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Treatment Options in COVID-19: The Role of Bioavailable Antiviral Ribonucleoside Analog on NHC in vitro

Journal of Regenerative Biology and Medicine ◽

10.37191/mapsci-2582-385x-2(1)-024 ◽

2020 ◽

Author(s):

Lara Bittmann

Keyword(s):

World Health Organization ◽

Clinical Picture ◽

Treatment Options ◽

World Health ◽

Wuhan City ◽

The World ◽

Novel Coronavirus ◽

Health Organization

On December 31, 2019, WHO was informed of cases of pneumonia of unknown cause in Wuhan City, China. A novel coronavirus was identified as the cause by Chinese authorities on January 7, 2020 and was provisionally named "2019-nCoV". This new Coronavirus causes a clinical picture which has received now the name COVID-19. The virus has spread subsequently worldwide and was explained on the 11th of March, 2020 by the World Health Organization to the pandemic.

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Novel Coronavirus 2019 Outbreak: A Global Epidemic

Letters in Drug Design & Discovery ◽

10.2174/1570180817999200802033916 ◽

2020 ◽

Vol 17 (12) ◽

pp. 1458-1464

Author(s):

Sweta Kamboj ◽

Rohit Kamboj ◽

Shikha Kamboj ◽

Kumar Guarve ◽

Rohit Dutt

Keyword(s):

World Health ◽

Upper Respiratory Tract ◽

Global Epidemic ◽

The Public ◽

The Government ◽

Tract Disease ◽

The 1960S ◽

Novel Coronavirus ◽

Health Organization ◽

The Impact

Background: In the 1960s, the human coronavirus was designated, which is responsible for the upper respiratory tract disease in children. Back in 2003, mainly 5 new coronaviruses were recognized. This study directly pursues to govern knowledge, attitude and practice of viral and droplet infection isolation safeguard among the researchers during the outbreak of the COVID-19. Introduction: Coronavirus is a proteinaceous and infectious pathogen. It is an etiological agent of severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS). Coronavirus, appeared in China from the seafood and poultry market last year, which has spread in various countries, and has caused several deaths. Methods: The literature data has been taken from different search platforms like PubMed, Science Direct, Embase, Web of Science, who.int portal and complied. Results: Corona virology study will be more advanced and outstanding in recent years. COVID-19 epidemic is a threatening reminder not solely for one country but all over the universe. Conclusion: In this review article, we encapsulated the pathogenesis, geographical spread of coronavirus worldwide, also discussed the perspective of diagnosis, effective treatment, and primary recommendations by the World Health Organization, and guidelines of the government to slow down the impact of the virus are also optimistic, efficacious and obliging for the public health. However, it will take a prolonged time in the future to overcome this epidemic.

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