ABCG2 polymorphism, age and leukocyte count may contribute to oral mucositis in oncopediatric patients

Abstract The study investigated the relationship between genetic polymorphisms and the development of oral mucositis in pediatric patients undergoing chemotherapy involving methotrexate. A longitudinal study was conducted with 64 patients, and oral mucositis was evaluated by the modified Oral Assessment Guide, which aims to diagnose and classify oral mucositis. Epithelial cells were obtained by mouthwash and DNA was extracted. The polymorphisms MTHFR (rs1801133), DNMT3B (rs2424913), ABCC2 (rs717620), ABCG2 (rs2231137) and ABCG2 (rs2231142) were analyzed by PCR-RFLP method. Demographic, hematological and biochemical data were collected from medical records. Statistical analysis was performed using the SPSS software adopting a p-value of 0.05. Male sex predominated (56.2%), and the mean age was 10.8 years (± 4.9). Oral mucositis affected 65.6% of the patients, of which 61.9% developed the severe form of the disease. For the ABCG2 gene (rs2231142), the rare A allele and CA genotype were more frequent in individuals with mucositis (p= 0.02; RR = 0.60; CI = 0.387 - 0.813). The severity of the disease was mainly observed in younger patients (median = 9 years; p=0.02). Patients with severe oral mucositis presented lower leukocytes count (median = 2.150 mm3) compared to patients with the mild/moderate form (median = 4.200 mm3; p=0.03). Female patients and each 10,000-platelet increase were protective factors against the onset of oral mucositis (p=0.02). It is concluded that rs2231142 polymorphism increases the likelihood of oral mucositis and younger patients and patients with low leukocytes counts are more likely to develop severe form.

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Hubungan Antara Usia dan Masa Kerja dengan Keluhan Muskulo-skeletal pada Pekerja Mebel di Desa Leilem Dua Kecamatan Sonder

Medical Scope Journal ◽

10.35790/msj.1.2.2020.27201 ◽

2020 ◽

Vol 1 (2) ◽

Author(s):

Jerro H. Tambuwun ◽

Nancy S. H. Malonda ◽

Paul A. T. Kawatu

Keyword(s):

Severe Form ◽

Survey Study ◽

P Value ◽

Musculoskeletal Complaints ◽

Chi Square ◽

Cross Sectional ◽

Work Period ◽

Chi Square Test ◽

Body Map ◽

The Relationship

Abstract: Musculoskeletal complaints vary from mild to severe form. Musculoskeletal com-plaints and disorders could occur due to work or conditions at work inter alia odd posture, static and repetitive movements, as well as physical exposure such as temperature and vibration. This study was aimed to determine the relationship between age and work period and musculoskeletal complaints among furniture workers at Desa Leilem Dua, Sonder. This was an analytical survey study with a cross sectional design. Population of this study consisted of 210 workers, meanwhile respondents were 68 workers. We used the Nordic Body Map questionnaire and the chi square test with a confidence level of 95% (α=0.05). The results showed that 17 respondents aged ≥30 years had moderate complaints and 36 respondents had severe complaints meanwhile 12 respondents aged <30 years had moderate complaints and 3 respondents had severe complaints. Moreover, 21 respondents who had work period <10 years had moderate complaints and 10 respondents had severe complaints; 8 respondents who had work period ≥10 years had moderate complaints and 29 respondents had severe complaints. The chi-square obtained a p-value of 0.002 for the relationship between age and musculoskeletal complaints and a p-value of 0.000 for the relationship between work period and musculoskeletal complaints. In conculsion, there was a significant relationship between age and musculoskeletal complaints as well as between work period and musculoskeletal complaints among furniture workers at Desa Leilem Dua, Sonder.Keywords: musculoskeletal complaints, furniture worker Abstrak: Keluhan muskuloskeletal dapat bervariasi dari keluhan ringan sampai berat. Keluhan dan gangguan muskuloskeletal dapat terjadi karena faktor pekerjaan atau kondisi saat bekerja berupa postur janggal, gerakan statis dan berulang, juga berupa pajanan fisik seperti suhu dan getaran. Penelitian ini bertujuan untuk mengetahui adanya hubungan antara usia dan masa kerja dengan keluhan muskuloskeletal pada pekerja mebel di Desa Leilem Dua Kecamatan Sonder. Jenis penelitian ialah survei analitik dengan desain potong lintang. Populasi penelitian ini ialah 210 pekerja sedangkan yang menjadi responden ialah 68 orang. Instrumen penelitian yang digunakan yaitu Nordic Body Map dengan uji bivariat meng-gunakan uji chi-square (α=0,05). Hasil penelitian mendapatkan 17 responden berusia ≥30 dengan keluhan sedang dan 36 responden dengan keluhan berat; 12 responden yang berusia <30 tahun dengan keluhan sedang dan 3 responden dengan keluhan berat. Terdapat 21 responden dengan masa kerja <10 tahun mengalami keluhan sedang dan 10 responden mengalami keluhan berat; 8 responden dengan masa kerja ≥10 tahun mengalami keluhan sedang dan 29 responden mengalami keluhan berat. Hasil uji chi-square terhadap hubungan antara usia dan keluhan muskuloskeletal mendapatkan nilai p=0,002 dan terhadap hubungan antara masa kerja dan keluhan muskuloskeletal mendapatkan nilai p=0,000. Simpulan penelitian ini ialah terdapat hubungan bermakna antara usia dan masa kerja dengan keluhan muskuloskeletal pada pekerja mebel di Desa Leilem Dua Kecamatan Sonder.Kata kunci: keluhan muskuloskeletal, pekerja mebe

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Keterkaitan pola pangan harapan (PPH) dengan kejadian stunting pada balita

Jurnal SAGO Gizi dan Kesehatan ◽

10.30867/gikes.v3i1.300 ◽

2022 ◽

Vol 3 (1) ◽

pp. 7

Author(s):

Mimi Amarita

Keyword(s):

Nutritional Quality ◽

Research Data ◽

Observational Research ◽

P Value ◽

Cross Sectional ◽

Food Pattern ◽

Independent Test ◽

Spss Software ◽

Cross Sectional Design ◽

The Relationship

Background: Food security from the consumption pillar is reflected by the loyal ability of citizens to consume food that is sufficient in quantity and nutritional quality, safe, diverse and affordable. Consumption of adequate and nutritionally balanced food is a form that must be met to minimize nutritional problems including stunting.Objectives: This study aims to determine the relationship between the Expected Food Pattern (PPH) and the incidence of stunting in toddlers.Methods: The type of research used is observational research, using a cross sectional design. The research sample is 90 samples. The research location is in North Kluet District, Aceh Regency. Data analysis using SPSS Software Independent Test t-test. Research data will be presented in the form of univariate and bivariate analysis.Results: The results showed that there was no difference in the Expected Food Pattern (PPH) score between stunting toddlers and the PPH score for normal toddlers, the p value = 0.553 (p > 0.553).Conclusion: In conclusion, the PPH score in stunting toddlers with normal toddlers does not show a difference on average in North Kluet District, South Aceh.

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Evaluation of four scoring systems in prognostication of acute pancreatitis for elderly patients

10.21203/rs.3.rs-21912/v1 ◽

2020 ◽

Author(s):

Yajie Li ◽

Jun Zhang ◽

Jihong Zou

Keyword(s):

Acute Pancreatitis ◽

Elderly Patients ◽

Pancreatic Necrosis ◽

Scoring Systems ◽

Apache Ii ◽

P Value ◽

Younger Patients ◽

Prognostic Assessment ◽

The Difference ◽

Severity Of The Disease

Abstract Objectives : To evaluate the four scoring systems, including Ranson, BISAP, Glasgow, and APACHE II in the prognostic assessment of acute pancreatitis (AP) for elderly patients. Methods: A retrospective study of 918 patients presenting with AP was done at Zhongda Hospital Southeast University, from January 2015 to December 2018. The patients were divided into two groups: 368 patients who were ≥60 years old, and 550 patients who were <60 years old. Four scoring systems were used to analyze all patients. Results: The severity of the disease, and mortality are significantly different between the two groups (p-value <0.05), while the difference between the two groups about pancreatic necrosis is statistically insignificant (p-value =0.399). The differences of the AUCs (Area under curves) in prognostication of SAP (severe acute pancreatitis) between the two groups are statistically significant (p-value <0.05) for Ranson and APACHE II, while for BISAP and Glasgow, the differences are statistically insignificant. All the four scoring systems are effective and similar in prediction of pancreatic necrosis and death for both groups.Conclusions: Prediction of severity, pancreatic necrosis and death in AP for elderly patients can be performed very well by using BISAP. APACHE II is more suitable for younger patients when dealing with severity. Ranson and Glasgow can be used to evaluate all AP patients in most cases, however, Ranson is more effective for younger patients when used to assess severity.

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Association between HOXA10 (rs267601473) polymorphism and recurrent spontaneous abortion

Journal of Shahid Sadoughi University of Medical Sciences ◽

10.18502/ssu.v27i2.1045 ◽

2019 ◽

Author(s):

Manouchehr Mazdapour ◽

Mahmood DehghaniAshkezari ◽

SeyedMorteza Seifati

Keyword(s):

Spontaneous Abortion ◽

Recurrent Spontaneous Abortion ◽

Infertile Woman ◽

Control Group ◽

P Value ◽

Chi Square ◽

Significant Difference ◽

Pcr Rflp ◽

Chi Square Test ◽

Spss Software

Introduction: Recurrent spontaneous abortion is defined as the occurrence of more than two clinical miscarriages in one woman. Several factors, including endocrine irregularities, genetics and environmental factors, are involved in this kind of infertility.The aim of this study was to survey the association of HOXA10 (rs267601473) polymorphism with the risk of recurrent spontaneous abortion in our population. Methods: In the present case-control study, the HOXA10 (rs267601473) polymorphism was investigated in 70 infertile woman and 100 healthy participants using PCR-RFLP methods. Then, the data were analyzed by SPSS software version 18 and also were compared using Chi-square test and Logistic regression model. The p-value was found to be statistically significant (p<0.05). Results: Our results showed significant association between the HOXA10 (rs267601473) polymorphism and recurrent spontaneous abortion (OR=0.143, 95% CI=0.056-0.368; p<0.0001). Our findings showed that T allele frequency in women with recurrent spontaneous abortion had significant difference compared to the control group (OR=0.2, 95% CI=0.11-0.4; p<0.0001). Conclusion: The results of this study reveal that the HOXA10 (rs267601473) polymorphism is significantly associated with recurrent spontaneous abortion in our population.

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The Association of Non-Steroidal Anti-Inflammatory Drugs with COVID-19 Severity and Mortality

Archives of Clinical Infectious Diseases ◽

10.5812/archcid.106847 ◽

2020 ◽

Vol 15 (4) ◽

Author(s):

Hamid Reza Samimagham ◽

Mohsen Arabi ◽

Dariush Hooshyar ◽

Mitra KazemiJahromi

Keyword(s):

Mortality Rate ◽

Significant Relationship ◽

Lymphocyte Count ◽

Health Policies ◽

P Value ◽

History Of ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Severity Of The Disease ◽

The Relationship

Background: No specific study has investigated the effect of non-steroidal anti inflammatory drugs (NSAIDs) and especially the effects of Ibuprofen on COVID-19, so far. Objectives: The purpose of this study was to investigate the effect of Ibuprofen on the severity of COVID-19 and mortality caused by the disease. Methods: This study was conducted on 158 patients with COVID-19 who had consumed Ibuprofen, Gelofen, and Novafen for at least one week in the last three months. Patients were divided into three groups (mild, moderate and sever). The relationship among the severity of the disease and the history of ibuprofen consumption, diabetes, history of cardiovascular problems, hypertension, and GFR was investigated. Also, the association between the history of ibuprofen consumption, GFR ≤ 60 mL/min, hypertension, LDH ≥ 500 U/L, lymphocyte count ≤ 1500, and mortality was examined. Results: Our findings showed a significant relationship between the history of Ibuprofen before COVID-19 and the severity of COVID-19, as well as the mortality rate (P value < 0.001, adjusted odd ratio: 2, respectively). This study also showed a significant relationship among the severity of the disease and the history of smoking, diabetes, hypertension, history of cardiovascular diseases, and GFR. In addition, a significant relationship was found among GFR ≤ 60 mL/min mortality, diabetes, LDH ≥ 500 U/L, and lymphocyte count ≤ 1500. Conclusions: Our study showed a significant relationship between the history of the consumption of ibuprofen and its compounds before COVID-19 and the severity of COVID-19, as well as the mortality rate of the patients with this disease, and accordingly, this result can suggest health policies during the epidemic of COVID-19.

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Evaluation of the Relationship Between Epidemiological Factors and Laboratory Findings With the Cause of Neutropenia in Children: A Cross-Sectional Study

Jundishapur Journal of Medical Sciences ◽

10.32598/jsmj.20.3.2137 ◽

2021 ◽

Vol 20 (3) ◽

pp. 256-261

Author(s):

Javad Tafaroji ◽

◽

Hosein Heydari ◽

Sajad Rezvan ◽

Enayatollah Noori ◽

...

Keyword(s):

Medical Records ◽

Analytical Study ◽

Length Of Hospital Stay ◽

Cross Sectional Study ◽

Absolute Count ◽

Laboratory Findings ◽

Cross Sectional ◽

Spss Software ◽

Severity Of The Disease ◽

The Relationship

Background and Objectives: Neutropenia is the absolute count of neutrophils less than 1500 per cubic millimeter. Because the early detection of the cause of neutropenia and appropriate measures to reduce its mortality and financial costs are important, this study was conducted to investigate the relationship between the cause of neutropenia and the severity of neutropenia with clinical and laboratory findings to take appropriate measures. Subjects and Methods This study was a cross-sectional descriptive-analytical study. In this study, 111 patients with neutropenia were studied in Hazrat Masoumeh Hospital in Qom City, Iran, by a census method in 3 years from 2014 to 2016. Necessary information was obtained from the patients' medical records through a questionnaire. Data were analyzed by SPSS software. Results The study findings showed relationships between the cause of the disease and variables of age (P= 0.007), the severity of neutropenia (P<0.001), disease outcome (P<0.001), length of hospital stay (P<0.001), Hb (P<0.001), and WBC (P<0.001). The causes of neutropenia in the studied patients were viral (54.1%), sepsis (24.3%), malignancy (10.8%), anemia (4.5%), idiopathic (3.6%) and ITP (2.7%). Conclusion The present study showed a significant relationship between demographic and laboratory findings with the cause and severity of the disease. Therefore, considering these factors at the beginning of hospitalization can play a crucial role in promoting proper management in the treatment of patients with neutropenia.

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The association between allergic rhinitis and Polymorphism of Toll like receptors 2 & 4 genes

10.51429/ejmm30305 ◽

2021 ◽

Vol 30 (3) ◽

pp. 37-42

Author(s):

Abdelhakim F. Ghallab ◽

Rasha A. El sayed ◽

Mostafa G. Sobhy

Keyword(s):

Allergic Rhinitis ◽

University Hospital ◽

Control Group ◽

P Value ◽

Single Nucleotide ◽

Pcr Rflp ◽

Atopic State ◽

Major Allele ◽

Polymerase Chain ◽

The Relationship

Background: Allergic rhinitis is atopic disorder, 10% to 25% of the population worldwide are suffering from it, The prevalence is increasing during the last 10 years. Objectives: To study the relationship among polymorphism of single nucleotide in TLR2 and TLR4 genes and the risk of allergic rhinitis disease. Methodology: This study was done on 60 patients suffering from allergic rhinitis and 30 healthy subjects as a control group from April 2019 to March 2020. The patients were collected from Otorhinolaryngology Department of Benha University Hospital. Test of Skin prick (SPT) was done to assess atopic state. Blood samples were collected to detect TLR gene polymorphism by Polymerase chain reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: The genotypic frequencies of TLR2 Arg753Gln showed increased frequency of the homozygous (GG) genotype among the controls (80%) more than the allergic rhinitis patients (30%). The heterozygous (AG) genotype was increased among the allergic rhinitis patients (62.5%) more than in the healthy group (15%) with OR =9.4, 95% CI (2.4-37.7) and significant P-value. Also, the homozygous mutant (AA) genotype has more trend in the patients (7.5%) than in the control subjects (5%), with OR = 0. 6, 95% CI (0.1-6.7) and non-significant P-value. The genotypic frequencies Statistical data in TLR4 Asp299Gly revealed that the homozygous (AA) genotype has more frequency in the controls (70%) than the allergic rhinitis patients (20%). The heterozygous (AG) genotype was more prevalent among the allergic rhinitis patients (65%) than the controls (30%) with OR =4.3, 95% CI (1.4-13.8) and significant P-value. Conclusion: GG genotype of TLR2 and AA genotype of TLR4 are least affected by allergic rhinitis disease and the major allele in both gene is protective against the disease.

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HUBUNGAN KUALITAS KEHIDUPAN KERJA TERHADAP KINERJA PERAWAT PELAKSANA

Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal ◽

10.32583/pskm.9.4.2019.413-420 ◽

2019 ◽

Vol 9 (4) ◽

pp. 413-420

Author(s):

Amella Gusty ◽

Dachriyanus Dachriyanus ◽

Leni Merdawati

Keyword(s):

District Hospital ◽

Simple Random Sampling ◽

Work Life ◽

Quality Of Work Life ◽

P Value ◽

Work Context ◽

Cross Sectional ◽

Quality Of Work ◽

The Relationship

Kinerja perawat merupakan hasil yang dicapai dalam melaksanakan asuhan keperawatan di rumah sakit. Terciptanya asuhan keperawatan yang optimal sangat diperlukan dukungan dari pihak rumah sakit salah satunya adalah menciptakan kualitas kehidupan kerja baik bagi perawat. Penelitian ini bertujuan untuk mengetahui hubungan antara kualitas kehidupan kerja terhadap kinerja perawat pelaksana di RSUD Teluk Kuantan. Jenis penelitian kuantitatif dengan pendekatan cross sectional. Jumlah sampel 120 responden yang diperoleh melalui proportionate simple random sampling. Hasil penelitian menunjukkan kualitas kehidupan kerja perawat RSUD Teluk Kuantan berada pada kategori sedang, kinerja perawat berada pada kategori kurang baik. Berdasarkan analisis kedua variabel teridentifikasi bahwa tidak ada hubungan antara kualitas kehidupan kerja dengan kinerja perawat pelaksana dengan p value 0,817. Dimensi work context merupakan komponen yang memiliki hubungan dengan kinerja perawat pelaksana dengan p value 0,008, dimensi work life tidak berhubungan secara signifikan dengan kinerja perawat. Kesimpulan penelitian diketahui tidak ada hubungan antara kualitas kehidupan kerja dengan kinerja perawat pelaksana. Ada hubungan dimensi work context dengan kinerja perawat pelaksana. Tidak ada hubungan dimensi work life dengan kinerja perawat. Kata kunci: kualitas kehidupan kerja, kinerja, perawat pelaksana THE RELATIONSHIP BETWEEN THE QUALITY OF WORK LIFE AND THE PERFORMANCE OF IMPLEMENTERS NURSES ABSTRACT Nurse performance is the result achieved in implementing nursing care in a hospital. The creation of optimal nursing care is very much needed support from the hospital, one of which is to create a good quality of work life for nurses. This study aims to determine the relationship between the quality of work life and the performance of nurses at the Kuantan District Hospital. This type of quantitative research with cross sectional approach. The number of samples of 120 respondents obtained through proportionate simple random sampling. The results showed that the quality of work life of nurses at the Kuantan District Hospital was in the medium category, the nurses' performance was in the unfavorable category. Based on the analysis of the two variables, it was identified that there was no relationship between the quality of work life with the performance of implementing nurses with a p value of 0.817. The work context dimension is a component that has a relationship with the performance of nurses implementing with p value 0.008, the dimension of work life does not significantly correlate with nurse performance. The conclusion of the research is that there is no relationship between the quality of work life and the performance of the implementing nurses. There is a relationship between the dimensions of the work context and the performance of the nurses. There is no relationship between the dimensions of work life and nurse performance. Keywords: quality of work life, performance, implementers nurse

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HUBUNGAN KOMUNIKASI TERAPEUTIK PERAWAT DENGAN KECEMASAN ANAK USIA PRASEKOLAH AKIBAT HOSPITALISASI

Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal ◽

10.32583/pskm.9.2.2019.135-140 ◽

2019 ◽

Vol 9 (2) ◽

pp. 135-140

Author(s):

Qurrotul Aeni ◽

Andriyani Mustika Nurwijayanti ◽

Muhammad Khabib Burhanuddin Iqomh

Keyword(s):

Research Data ◽

School Age Children ◽

P Value ◽

School Age ◽

Therapeutic Communication ◽

Cross Sectional ◽

Communication Anxiety ◽

Children’S Anxiety ◽

The Relationship ◽

Severe Anxiety

Introduction: anxiety is a condition that will be experienced by children who experience hospitalization and must get attention and management. Anxiety during hospitalization that is not properly addressed will hinder treatment and affect child development. The purpose of the study: to determine the relationship between therapeutic communication nurses and the anxiety of preschool children due to hospitalizationMethod: The study design used descriptive correlation with a cross-sectional approach. The number of samples is 31 with purposive sampling. Collecting research data using a questionnaire.Results: The results showed a majority of therapeutic communication was 61.3%, anxiety in children due to hospitalization of 100% with severe anxiety was 58.1%, there was a relationship between therapeutic communication and children's anxiety (p = 0.001). Suggestions need to be carried out further research on the factors that influence the low therapeutic communication in nurses.Discussion: The results of the statistical analysis using the Spearman's Rho test got p value 0.001 (p <0.05) the relationship between therapeutic communication and the anxiety of pre-school age children who experienced hospitalization, therapeutic communication can be used as an action to prevent anxiety due to hospitalization in pre-school age children.Suggestion: need to do further research on the factors that influence the low therapeutic communication in nurses Keywords: therapeutic communication, anxiety, hospitalization.

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THE IMPLEMENTATION OF ISO 9001:2015 TO IMPROVE QUALITY OF SERVICE AT PUSAT KESIHATAN UNIVERSITI (PKU), UNIVERSITI UTARA MALAYSIA(UUM)

Journal of Technology and Operations Management ◽

10.32890/jtom2018.13.2.7 ◽

2018 ◽

Vol 13 (Number 2) ◽

pp. 67-77

Author(s):

Anis Syamimi Abd Rahim ◽

Mohd Norhasni Mohd Asaad

Keyword(s):

Quality Of Service ◽

Customer Satisfaction ◽

Descriptive Statistics ◽

Iso 9001 ◽

Quality Of Services ◽

Research Questions ◽

Spss Software ◽

The Relationship ◽

Universiti Utara Malaysia

The purpose of this study is to review the implementation of ISO 9001:2015 in order to improve the quality of services at Pusat Kesihatan Universiti (PKU), Universiti Utara Malaysia. The respondents of this study were customers at the PKU, UUM. The questionnaire was distributed to 50 respondents. The data were analyzed using SPSS software version 24. The data were tested using descriptive statistics, and correlation analysis to answer the research questions and to achieve the objectives. The findings show that customers agree that implementation of ISO 9001:2015 give service at PKU, UUM is good and satisfied. Through the correlation test, the results showed that the relationship between the implementation of ISO 9001:2015 has a positive and significant impact on customer satisfaction and the effect of implementing ISO 9001:2015 has a positive and significant impact in improving quality of service at PKU, UUM.Through mean and standard deviation tests, results show that tangible dimensions are the main dimensions of customer satisfaction while dimensions with low values are dimensions of responsiveness.Therefore, all aspects of service in PKU, UUM will be strengthened and all aspects of the weaknesses could be addressed to improve the service in order to maintain good quality services.

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