scholarly journals HCV and HIV infection and co-infection: injecting drug use and sexual behavior, AjUDE-Brasil I Project

2006 ◽  
Vol 22 (4) ◽  
pp. 839-848 ◽  
Author(s):  
Keli Bahia Felicíssimo Zocratto ◽  
Waleska Teixeira Caiaffa ◽  
Fernando Augusto Proietti ◽  
Anna Bárbara Carneiro-Proietti ◽  
Sueli Aparecida Mingoti ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Drug Use ◽  
Hiv Infection ◽  
Drug Users ◽  
Cross Sectional ◽  
Behavioral Indicators ◽  
Immunodeficiency Virus ◽  
Serological Status ◽  
Multi Center Study ◽  
Structured Questionnaire

This study aimed to characterize sexual and drug-use behaviors in injecting drug users (IDUs) in relation to single hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infection and HCV/HIV co-infection. The sample consisted of 272 IDUs enrolled in the AjUDE-Brasil I Project, a cross-sectional multi-center study conducted in five Brazilian cities in 1998. Data were collected with a structured questionnaire using self-reported risk behavior, and HCV and HIV serological status used ELISA on filter paper. IDUs were clustered in four distinct groups: HCV/HIV seronegative; HCV mono-infected; HIV mono-infected; and HCV/HIV co-infected. Active sharing of injecting equipment was associated with HCV infection (p = 0.001). Sexual behavior variables, especially male same-sex sexual relations, were consistently associated with HIV infection. HCV/HIV co-infection was associated with both sexual and drug use variables. It was possible to distinguish different behavioral indicators for HCV and HIV infection and co-infection in this population.

Reducing the Risk of Human Immunodeficiency Virus Infection Associated With Illicit Drug Use

PEDIATRICS ◽  
1994 ◽  
Vol 94 (6) ◽  
pp. 945-947
Author(s):  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Use ◽  
Hiv Infection ◽  
Drug Users ◽  
Illicit Drug ◽  
Health Benefit ◽  
Illicit Drug Use ◽  
Injection Drug ◽  
Relative Safety ◽  
Immunodeficiency Virus

Injection and other illicit drug use plays a major role in the transmission of infection with human immunodeficiency virus (HIV), including cases among infants, children, and adolescents.1,2 Transmission to adolescents and adults occurs either directly from contaminated drug paraphernalia, including needles and syringes, or through sexual contact with an infected partner. Transmission to infants occurs transplacentally or perinatally from mothers who are most often either drug users themselves, or who have become infected from sexual partners who are injection drug users. It is therefore clear that a reduction in the transmission of HIV infection secondary to illicit drug use and the use of contaminated injection equipment is a pediatric concern and should be part of any prevention program. The adverse consequences of illicit drug use are multiple and certainly not limited to the potential acquisition and transmission of HIV infection. Ideally, treatment and prevention programs should seek to reduce drug use itself, not solely HIV infection. However, many users of injection drugs do not enter drug treatment, remain in treatment, or maintain complete abstinence while in treatment. Therefore, promoting safer injection practices can provide an important public health benefit in lowering the risk of HIV transmission, while simultaneous efforts continue to reduce and eliminate drug use. Initiatives with the singular objective of increasing access to sterile equipment are understandably controversial, as they do not directly address the causes and broader consequences of illicit drug use. In addition, there are continuing concerns that any program increasing access to sterile needles and syringes might actually increase injection drug use by creating the impression of relative safety and tacit community approval for such behavior.

Risky Sexual Behavior as a Factor in Spreading HIV Infection in Russia. Part II

2018 ◽  
Vol 6 (4) ◽  
pp. 105-116 ◽  
Author(s):  
Margarita E. Pozdnyakova
Keyword(s):  
Sexual Behavior ◽  
Drug Use ◽  
Hiv Infection ◽  
Risky Sexual Behavior ◽  
Drug Users ◽  
Target Group ◽  
Sexual Practices ◽  
Special Role ◽  
Infected People ◽  
The Impact

This work continues an article on risky sexual behavior and the spread of HIV infection. In this part, based on the results of surveys of the working-age population, the youth and the target group of psychoactive substance users, the relationship between increase in drug use and sexual behavior is examined. It is shown that use of certain drugs is connected to increase in sexual activity. Injecting drug users play a special role in the spread of HIV infection. The survey of the target group of drug users allowed us to describe a modern portrait of an injecting drug user, as well as the peculiarities of drug use and common high-risk sexual practices in this group. The impact on the rate of infection from the Russian penitentiary system is considered. It was revealed that with an annual decrease in the number of prisoners, the proportion of HIV-infected people is constantly growing, while HIV infection is by far the most frequent cause of death for convicts in Russia. The factors that influence HIV incidence rate among the convicts are examined.

scholarly journals RISKY SEXUAL BEHAVIOR IN PEOPLE LIVING WITH HIV

2019 ◽  
pp. 79-87
Author(s):  
D. V. Antonova ◽  
V. V. Bocharov ◽  
N. S. Chrustaleva
Keyword(s):  
Sexual Behavior ◽  
Hiv Infection ◽  
Risky Sexual Behavior ◽  
Drug Users ◽  
Published Data ◽  
People Living With Hiv ◽  
Immunodeficiency Virus ◽  
Living With Hiv ◽  
First Time ◽  
Effective Design

Relevance. There is a continuing growth of infection with the human immunodeficiency virus (HIV) and the need for effective design of preventive measures.Intention. To explore features of risky sexual behavior in people living with HIV with and without substance abuse and in healthy respondents.Methodology. The study involved 136 individuals in the groups as follows: 1st (n = 50) – drug users with blood-borne HIV infection, 2nd (n = 50) – heterosexual HIV infection, 3rd (n = 36) – without HIV infection. A specially developed clinical map was used, as well as an original questionnaire recording the characteristics of risky behavior and the main characteristics of the life situation of the disease (“Infection risk and the disease situation”). Statistical data processing included the Fisher criterion (ϕ-criterion).Results and Discussion. The characteristics of respondents’ sexual behavior related to gender, the presence/absence of HIV and the transmission route were revealed in the study. It has been established that HIV-infected and healthy respondents do not differ in the frequency of barrier protection methods (condoms) use. Various variants of risky sexual behavior were noted in all groups, in particular, unjustified rejection of condoms. The results are partially confirmed in the published data. In the Russian sample, non-use of condoms and the prevalence of “trust in a partner” were studied for the first time.Conclusion. Important components of prevention programs include increasing sexual literacy and working with people who use psychostimulants and other drugs.

scholarly journals Recreational Drug use and Risk of HIV Infection Among Young Men Who Have Sex with men: A Cross-Sectional Study in Tianjin, China

2021 ◽  
Author(s):  
Changping Li ◽  
Zeyang Yu ◽  
Yang Chen ◽  
Honglu Zhang ◽  
Huijie Huang ◽  
...  
Keyword(s):  
Drug Use ◽  
Hiv Infection ◽  
Drug Users ◽  
Cross Sectional Study ◽  
Recreational Drug ◽  
Recreational Drugs ◽  
Sectional Study ◽  
Cross Sectional ◽  
Recreational Drug Use ◽  
Sex With Men

Abstract Background- Recreational drug use among young men who have sex with men (YMSM) was a public health issue of worldwide concern. Evidence had shown the relevance between recreational drug use and human immunodeficiency virus (HIV) infection. This study aimed to investigate the current prevalence state of recreational drug use among YMSM in Tianjin, discern the characteristics of YMSM who used recreational drugs or not and examine the interaction effect of recreational drug use and unprotected anal intercourse (UAI) on HIV infection.Methods- In 2018, a cross-sectional study was conducted in Tianjin, China. The snowball sampling method was used to recruit YMSM. Participants were recruited from gay bars, gay bathhouses, social network sites (WeChat, QQ, gay chat website), gay apps and peer referrals. Structured questionnaires were used to collect data.Results- A total of 1075 YMSM met the eligibility criteria and were included in the study eventually. The overall HIV prevalence was 4.3% (46/1075). Of all the recreational drugs involved in this study (rush poppers, methamphetamine, capsule No.0), rush poppers (406/517,78.5%) were the most popular among YMSM in Tianjin. Compared with non-drug users, drug users were more likely to have first sex earlier, be bisexual, be male sex worker (MSW), have a higher education level, seek sex partners through physical venues, engage in UAI, have sexually transmitted infection (STI), and receive HIV testing. Moreover, recreational drug use and UAI were associated with the increased risk of HIV infection [adjusted OR:3.6 (95%CI: 1.7-7.6) and 4.9 (95%CI: 2.2-10.4), respectively]. There was additive interaction of recreational drug use and UAI on HIV infection [relative excess risk due to interaction (RERI): 6.949 (95%CI: 0.011‐13.887); attributable proportion due to interaction (AP): 0.809 (95%CI: 0.578‐1.039)].Conclusions- Recreational drug use was common and correlated with HIV infection among YMSM in Tianjin. There was an urgent need to build novel targeted HIV prevention strategies to discern and reduce recreational drug use among YMSM in China.

Renal Phosphate Handling in Antiretroviral-naïve HIV-infected Patients

2020 ◽  
Vol 20 ◽  
Author(s):  
Tewogbade Adeoye Adedeji ◽  
Simeon Adelani. Adebisi ◽  
Nife Olamide Adedeji ◽  
Olusola Akanni Jeje ◽  
Rotimi Samuel Owolabi
Keyword(s):  
Hiv Infection ◽  
Plasma Phosphate ◽  
Cross Sectional ◽  
Phosphate Retention ◽  
Significant Difference ◽  
Immunodeficiency Virus ◽  
Life Threatening ◽  
Moderate Chronic Kidney Disease ◽  
One Year ◽  
Sectional Analysis

Background: Human immunodeficiency virus (HIV) infection impairs renal function, thereby affecting renal phosphate metabolism. Objectives: We prospectively estimated the prevalence of phosphate abnormalities (mild, moderate to life-threatening hypophosphataemia, and hyperphosphataemia) before initiating antiretroviral therapy (ART). Methods: A cross-sectional analysis was performed on 170 consecutive newly diagnosed ART-naïve, HIV-infected patients attending our HIV/AIDS clinics over a period of one year. Fifty (50) screened HIV-negative blood donors were used for comparison (controls). Blood and urine were collected simultaneously for phosphate and creatinine assay to estimate fractional phosphate excretion (FEPi %) and glomerular filtration rate (eGFR). Results: eGFR showed significant difference between patients’ and controls’ medians (47.89ml/min/1.73m2 versus 60ml/min/1.73m2, p <0.001); which denotes a moderate chronic kidney disease in the patients. Of the 170 patients, 78 (45.9%) had normal plasma phosphate (0.6-1.4 mmol/L); 85 (50%) had hyperphosphataemia. Grades 1, 2 and 3 hypophosphataemia was observed in 3 (1.8%), 3 (1.8%), and 1(0.5%) patient(s) respectively. None had grade 4 hypophosphataemia. Overall, the patients had significantly higher median of plasma phosphate than the controls, 1.4 mmol/L (IQR: 1.0 – 2.2) versus 1.1 mmol/L (IQR: 0.3 – 1.6), p <0.001, implying hyperphosphataemia in the patients; significantly lower median urine phosphate than the controls, 1.5 mmol/L (IQR: 0.7 -2.1) versus 8.4 mmol/L (IQR: 3.4 – 16), p <0.001), justifying the hyperphosphataemia is from phosphate retention; but a non-significantly lower median FEPi% than the controls, 0.96 % (IQR: 0.3 -2.2) versus 1.4% (IQR: 1.2 -1.6), p > 0.05. Predictors of FEPi% were age (Odds ratio, OR 0.9, p = 0.009); weight (OR 2.0, p < 0.001); CD4+ cells count predicted urine phosphate among males (p = 0.029). Conclusion: HIV infection likely induces renal insufficiency with reduced renal phosphate clearance. Thus, hyperphosphataemia is highly prevalent, and there is mild to moderate hypophosphataemia but its life-threatening form (grade 4) is rare among ART-naïve HIV patients.

scholarly journals Seroprevalence of human immunodeficiency virus infection among tuberculosis patients at tertiary care combined hospital

2015 ◽  
Vol 3 (3) ◽  
pp. 130-135
Author(s):  
Rakesh Basavareddy ◽  
Asha Basavareddy ◽  
Shimoga Laxman Ravi ◽  
Bilagumba Ramu Kiran ◽  
Gadwalkar R. Srikant
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Clinical Features ◽  
Oral Candidiasis ◽  
Tertiary Care ◽  
Chi Square ◽  
Cross Sectional ◽  
Hiv Seroprevalence ◽  
Adequate Knowledge ◽  
Immunodeficiency Virus

Abstract Background and Objectives: Tuberculosis (TB) and the human immunodeficiency virus (HIV) infection have reached epidemic proportions in our country. This study was undertaken to know the seroprevalence of HIV infection among TB patients and to evaluate the various clinical features of TB in seropositive and seronegative patients. This study was undertaken in Vijayanagara Institute of Medical Sciences, Bellary. It was cross-sectional comparative observational study conducted from December 2010 to May 2012. Materials and Methods: A total of 100 consecutive patients diagnosed with TB satisfying inclusion criteria were selected for the study. All patients went through a detailed evaluation along with testing for HIV seroprevalence. Chi-square and Student’s t-tests used to find the significance between two groups. Results: The overall HIV seroprevalence among TB patients was 8%. Seroprevalence was highest in the age group between 31 and 40 years at 29.41% (odds ratio [OR] = 11.11, P = 0.003). It was found that seropositive TB patients were more likely to present with significant weight loss (OR = 19.25, P= 0.000), and have lymphadenopathy OR = 13.24, P = 0.002) and oral candidiasis (OR = 49.44, P = 0.000) on examination. Bilateral chest radiographic involvement (OR = 57.40, P = 0.000) and the disseminated variety of the disease (OR = 29.67, P = 0.001) are also more probable. Conclusions: Human immunodeficiency virus seroprevalence is quite high among TB patients in Bellary. During the evaluation of TB patients, the possibility of HIV co-infection should be kept in mind, and thus adequate knowledge of the likely clinical features is absolutely necessary.

scholarly journals Outcomes of Ligation without Revascularization in Pseudoaneurysms of Peripheral Arteries in Intravenous Drug Users

2019 ◽  
Vol 57 (217) ◽  
Author(s):  
Lokesh Shekher Jaiswal ◽  
Narendra Pandit ◽  
Shailesh Adhikary
Keyword(s):  
Drug Use ◽  
Femoral Artery ◽  
Drug Users ◽  
Saphenous Vein Graft ◽  
Limb Ischemia ◽  
Intravenous Drug ◽  
Intravenous Drug Users ◽  
Cross Sectional ◽  
Autologous Vein ◽  
Graft Thrombosis

Introduction: Management of pseudoaneurysms in intravenous drug users is complex andchallenging due to an associated infection and unavailability of autologous vein grafts. Here weobserve the outcomes of ligation and local debridement as a primary modality of treatment in thissubset of patients with pseudoaneurysms. Methods: This is a descriptive cross sectional study of 15patients over a period of 4 years whopresented with pseudoaneurysm of peripheral artery from intravenous drug use. In this study,we describe the presentations and management outcomes in 15 patients with peripheral arterialpseudoaneurysmfrom IV drug use. Results: The most common site involved was common femoral artery among 12 (80%) patientsfollowed by superficial femoral artery among 8 (13.3%) patients and external iliac artery in 1 (6.7%)patient. Twelve (80%) patients were having signs of infection. All patients underwent surgicalintervention which comprised of excision of pseudoaneurysm and ligation of artery withoutrevascularization among 12 (80%) patients and with revascularization with autologous venous graftamong 3 (20%) patients. There was no mortality or a major bleeding requiring re-exploration. Noneof the patients developed limb ischemia necessitating amputation.One patient with femoral arteryligation without revascularization at one year of follow up is having claudication on brisk walking.There was one saphenous vein graft thrombosis in immediate postoperative period. Conclusions: With the use of ligation without revascularization technique, there was no mortality ormajor bleeding requiring re-exploration. None of the patients developed limb ischemia necessitatingamputation so this treatment modality seems promising in treatment of pseudoaneurysms inintravenous drug users.

scholarly journals Knowledge, Attitudes, and Intentions towards HIV Pre-Exposure Prophylaxis among Nursing Students in Spain

2020 ◽  
Vol 17 (19) ◽  
pp. 7151
Author(s):  
Guillermo López-Díaz ◽  
Almudena Rodríguez-Fernández ◽  
Eva María Domínguez-Martís ◽  
Diego Gabriel Mosteiro-Miguéns ◽  
David López-Ares ◽  
...  
Keyword(s):  
Nursing Students ◽  
Hiv Infection ◽  
Knowledge Score ◽  
Cross Sectional ◽  
Santiago De Compostela ◽  
Sexually Transmitted ◽  
Immunodeficiency Virus ◽  
Exposure Prophylaxis ◽  
The University ◽  
Study Participants

Human immunodeficiency virus (HIV) infection is one of the main causes of morbidity and mortality worldwide. Among the preventive approaches proposed to control this disease is pre-exposure prophylaxis (PrEP), whose effectiveness depends on the medication adherence. The aim of the present study was to determine the knowledge and attitudes about PrEP among a sample of Spanish nursing students as well as their intentions of receiving it in case it was indicated. An observational cross-sectional descriptive study was carried out. A total of 570 nursing students from the University of Santiago de Compostela (Spain), ≥18 years old and of both sexes were invited to self-complete a questionnaire between February and March 2020. A total of 352 students decided to participate in the study. Participants had low knowledge [overall knowledge score 1(0–2)] and a neutral attitude towards PrEP. The intention of receiving PrEP improved significantly after the completion of the questionnaire and the administration of information about PrEP (p = 0.039; before: 23.58% and after: 93.77%). Nursing staff play an important role in the prevention of sexually transmitted diseases, so their training in preventive strategies, such as PrEP, could help to reduce the incidence of new cases of HIV infection.

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