scholarly journals Clinical research on new drugs (Phase I). Profile of scientific publications: data from the pre-clinical phase and bioethical aspects

2008 ◽  
Vol 23 (6) ◽  
pp. 531-535 ◽  
Author(s):  
Vanessa de Souza Brick ◽  
William Saad Hossne ◽  
Rogério Saad Hossne
Keyword(s):  
Data Collection ◽  
Phase I ◽  
New Drugs ◽  
Human Beings ◽  
Scientific Publications ◽  
Future Studies ◽  
Clinical Phase ◽  
Sample Characteristics ◽  
Phase Data ◽  
Phase Phase

PURPOSE: To trace a profile of scientific publications, phase I, in order to know whether or not they show pre-clinical phase data, emphasizing bioethical aspects. METHODS: Sixty-one scientific articles, published in 2007, involving research in human beings using new drugs, medicines and vaccines during phase I were analysed. A schedule for data collection was elaborated in which it would be possible to analyse and evaluate those articles. The schedule included items related to the pre-clinical phase associated to the clinical phase, and items related to the sample characteristics. RESULTS: Most of research works were carried out in USA. Taking into consideration that a large number of works have been dedicated to oncologic affections, most of them were carried out in voluntary ill individuals. Information on the pre-clinical phase, phase I, was very poor or absent. Even though some authors consider the phase I research as a promising one and also suggest some future studies on phase II, the reader is not able to consider the same way, as long as there is a shortage of information on the pre-clinical phase. CONCLUSION: The profile of scientific publications showed that data deserve some reflections and analysis to better evaluate the publications on phase I.

scholarly journals ASPECTS OF LEXICAL AND STYLISTIC CHANGES IN CRISIS

2021 ◽  
Vol 03 (03) ◽  
pp. 34-42
Author(s):  
Khalid Ahmed Hassan AHMED
Keyword(s):  
Data Collection ◽  
Theoretical Framework ◽  
Human Beings ◽  
Wide Spread ◽  
Future Studies ◽  
Qualitative Survey ◽  
Corona Virus ◽  
New Concepts ◽  
Existing Form ◽  
Stylistic Changes

This study aims at exploring linguistic changes in periods of crisis. We feel that great linguistic changes will appear due to the wide spread of the fatal diseases that affect human beings existence on this earth. To fight the disease people should raise their awareness of the disease through language as a linguistic media that helps them to some extent building defenses against the disease. This linguistic shift will be followed with some modifications on the existing form of language either by coining new lexicons or reformulating new terms with new concepts and values. On the stylistic matters some changes are also expected to let people express themselves either socially or economically. The interest of this study will be directed to changes in lexical usage or changes of stylistic issues of the crisis under investigation, namely in this present study the pandemic of Corona Virus that is commonly known as Covid 19. The study will be a qualitative survey of the changes that this disease has led to. The related theoretical framework and literature will be outlined as guidelines for this study. Its importance, methodology and the procedures will also be stated to show the techniques of data collection in order to obtain the main results and the discussion, then finally a summary of the main findings, recommendations and suggestions for further future studies will bring the paper to its logical end.

The Role of nitro (NO2-), chloro (Cl), and fluoro (F) Substitution in the Design of Antileishmanial and Antichagasic Compounds

2020 ◽  
Vol 21 ◽  
Author(s):  
Boniface Pone ◽  
Ferreira Igne Elizabeth
Keyword(s):  
Chagas Disease ◽  
Mammalian Cells ◽  
Neglected Tropical Diseases ◽  
New Drugs ◽  
Pharmacokinetic Studies ◽  
Scientific Publications ◽  
Antitrypanosomal Activity ◽  
Chemical Groups

: Neglected tropical diseases (NTDs) are responsible for over 500,000 deaths annually and are characterized by multiple disabilities. Leishmaniasis and Chagas disease are among the most severe NTDs, and are caused by the Leishmania sp, and Trypanosoma cruzi, respectively. Glucantime, pentamidine and miltefosine are commonly used to treat leishmaniasis, whereas nifurtimox, benznidazole are current treatments for Chagas disease. However, these treatments are associated with drug resistance, and severe side effects. Hence, the development of synthetic products, especially those containing N02, F, or Cl, which chemical groups are known to improve the biological activity. The present work summarizes the information on the antileishmanial and antitrypanosomal activity of nitro-, chloro-, and fluoro-synthetic derivatives. Scientific publications referring to halogenated derivatives in relation to antileishmanial and antitrypanosomal activities were hand searched in databases such as SciFinder, Wiley, Science Direct, PubMed, ACS, Springer, Scielo, and so on. According to the literature information, more than 90 compounds were predicted as lead molecules with reference to their IC50/EC50 values in in vitro studies. It is worth to mention that only active compounds with known cytotoxic effects against mammalian cells were considered in the present study. The observed activity was attributed to the presence of nitro-, fluoro- and chloro-groups in the compound backbone. All in all, nitro and h0alogenated derivatives are active antileishmanial and antitrypanosomal compounds and can serve as baseline for the development of new drugs against leishmaniasis and Chagas disease. However, efforts on in vitro and in vivo toxicity studies of the active synthetic compounds is still needed. Pharmacokinetic studies, and the mechanism of action of the promising compounds need to be explored. The use of new catalysts and chemical transformation can afford unexplored halogenated compounds with improved antileishmanial and antitrypanosomal activity.

New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings

2008 ◽  
Vol 9 (12) ◽  
pp. 1157-1165 ◽  
Author(s):  
Enrique M Ocio ◽  
María-Victoria Mateos ◽  
Patricia Maiso ◽  
Atanasio Pandiella ◽  
Jesús F San-Miguel
Keyword(s):  
Multiple Myeloma ◽  
Phase I ◽  
Mechanisms Of Action ◽  
Clinical Findings ◽  
New Drugs

KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

2008 ◽  
Vol 5 (10) ◽  
pp. 2140-2155 ◽  
Author(s):  
Christian G. Hartinger ◽  
Michael A. Jakupec ◽  
Stefanie Zorbas-Seifried ◽  
Michael Groessl ◽  
Alexander Egger ◽  
...  
Keyword(s):  
Phase I ◽  
Phase I Study ◽  
Anticancer Agent ◽  
Preclinical Development ◽  
Tumor Patients ◽  
Clinical Phase ◽  
Redox Active

scholarly journals Cognitive Dissonance Theory

Psychology ◽  
2014 ◽  
Author(s):  
David C. Vaidis ◽  
Alexandre Bran
Keyword(s):  
Cognitive Dissonance ◽  
Human Beings ◽  
General Psychology ◽  
Social Situations ◽  
Cognitive Dissonance Theory ◽  
Historical Sources ◽  
Scientific Publications ◽  
Very Large Array ◽  
Dissonance Theory ◽  
First Time

Appearing for the first time in the mid-20th century, the term “cognitive dissonance” appears nowadays about eight hundred times in PsycINFO and the original book has been cited more than forty-five thousand times in scientific publications: that is more than twice a day for about sixty years. The theory of cognitive dissonance was molded by Leon Festinger at the beginning of the 1950s. It suggests that inconsistencies among cognitions (i.e., knowledge, opinion, or belief about the environment, oneself, or one’s behavior) generate an uncomfortable motivating feeling (i.e., the cognitive dissonance state). According to the theory, people feel uncomfortable when they experience cognitive dissonance and thus are motivated to retrieve an acceptable state. The magnitude of existing dissonance depends on the importance of the involved cognitions. Experiencing a higher level of dissonance causes pressure and motivation to reduce the dissonance. Findings from several studies show that dissonance occurs when people do not act in accordance with their attitude (e.g., writing supportive arguments in favor of a topic that they do not agree upon; performing a task they disapprove). Festinger 1957 (cited under Core Historical Sources) considers three ways to cope with cognitive dissonance: (a) changing one or several involved elements in the dissonance relationship (e.g., moving an opinion to fit a behavior), (b) adding new elements to reduce the inconsistency (e.g., adopting opinions that fit a behavior), and (c) reducing the importance of the involved elements. Early theorists in this field suggested improvement to the cognitive dissonance theory by adding restrictions for the emergence of the phenomena. Three major developments have to be considered: the commitment purpose and freedom, the consequence of the act purpose, and the self-involvement. Since the 2010s, the theory has been refined with new integrative models and methodological breakthrough. Mostly studied in human beings, several studies shift paradigms to other animals such as nonhuman primates, rats, and birds. The cognitive dissonance theory has been applied to a very large array of social situations and leads to original experimental designs. It is arguably one of the most influential theories in social psychology, general psychology, and cross-discipline sciences more generally.

scholarly journals Reading Habits of Users of Sardar Patel University: A Study

2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Dr. Shishir H. Mandalia
Keyword(s):  
Data Collection ◽  
Vital Role ◽  
Human Beings ◽  
Reading Habits ◽  
Knowledge And Skills ◽  
Continued Education ◽  
New Knowledge ◽  
The World ◽  
The Individual ◽  
The University

Reading plays a vital role in life of a human. Reading provides experience through which the individual may expand his horizons of knowledge, identify, extend and intensify his interest and gains deeper understanding of himself, of other human beings and of the world. The study carried out to assess the reading habits of user of Sardar Patel University, VallabhVidyanagar, Anand, Gujarat. As a research tool; questionnaire was used for the data collection. Collected data were analyzed and tables were used to present the results of findings. Reading especially is a resource for continued education, for the acquisition of new knowledge and skills, for gaining information through media, especially newspapers, books, radio, television, and the computers. In this article investigator attempts to investigate the reading habits of users of the university.

scholarly journals Clinical Drug Trials on Human Beings viz-a-viz Sanctions related to Animal Experimentation: Need to do Introspection?

2012 ◽  
Vol 46 (3) ◽  
pp. 113-116
Author(s):  
Roosy Aulakh ◽  
Chander Shekhar Gautam ◽  
Prabhjot Singh Cheema
Keyword(s):  
Animal Experimentation ◽  
New Drugs ◽  
Drug Trials ◽  
Human Beings ◽  
Animal Protection ◽  
Research Organizations ◽  
Legal Sanctions ◽  
Clinical Drug Trials ◽  
Health Care Law ◽  
Clinical Drug

ABSTRACT Health care law is totally localized in its nature, but research for the development of new drugs has crossed man-made geographical limits. Weaker legal sanctions, poverty, illiteracy and inaccessibility to legal system have all contributed to make India a favored hub for contact research organizations. Many recent clinical drug trials in India have sparked controversy. However, in India today, we are more bothered about animal protection, but show little concern for volunteers in human trials. It is gradually becoming difficult to conduct research on animals; however, research on human beings is far easier. Sanctions against violation of rights of human volunteers in clinical trials are often only a perceived phenomenon. They are not protected as they should be. Regulatory framework needs thorough introspection, debate, reconsideration and strict implementation. These guidelines should not only be recommendatory but mandatory in nature and those who indulge in violations, shall be punished as per the law of the land effectively. How to cite this article Gautam CS, Aulakh R, Cheema PS. Clinical Drug Trials on Human Beings viz-a-viz Sanctions related to Animal Experimentation: Need to do Introspection? J Postgrad Med Edu Res 2012;46(3):113-116.

scholarly journals Urban living environment assessment index system based on psychological security

2019 ◽  
Author(s):  
Xia Huiyi ◽  
◽  
Nankai Xia ◽  
Liu Liu ◽  
◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Data Collection ◽  
Urban Environment ◽  
Evaluation System ◽  
Living Environment ◽  
Mobile Internet ◽  
Practical Significance ◽  
Human Beings ◽  
Urban Living

With the development of urbanization and the continuous development, construction and renewal of the city, the living environment of human beings has also undergone tremendous changes, such as residential community environment and service facilities, urban roads and street spaces, and urban public service formats. And the layout of the facilities, etc., and these are the real needs of people in urban life, but the characteristics of these needs or their problems will inevitably have a certain impact on the user's psychological feelings, thus affecting people's use needs. Then, studying the ways in which urban residents perceive changes in the living environment and how they perceive changes in psychology and emotions will have practical significance and can effectively assist urban management and builders to optimize the living environment of residents. This is also the long-term. One of the topics of greatest interest to urban researchers since then. In the theory of demand hierarchy proposed by American psychologist Abraham Maslow, safety is the basic requirement second only to physiological needs. So safety, especially psychological security, has become one of the basic needs of people in the urban environment. People's perception of the psychological security of the urban environment is also one of the most important indicators in urban environmental assessment. In the past, due to the influence of technical means, the study of urban environmental psychological security often relied on the limited investigation of a small number of respondents. Low-density data is difficult to measure the perceptual results of universality. With the leaping development of the mobile Internet, Internet image data has grown geometrically over time. And with the development of artificial intelligence technology in recent years, image recognition and perception analysis based on machine learning has become possible. The maturity of these technical conditions provides a basis for the study of the urban renewal index evaluation system based on psychological security. In addition to the existing urban visual street furniture data obtained through urban big data collection combined with artificial intelligence image analysis, this paper also proposes a large number of urban living environment psychological assessment data collection strategies. These data are derived from crowdsourcing, and the collection method is limited by the development of cost and technology. At present, the psychological security preference of a large number of users on urban street images is collected by forced selection method, and then obtained by statistical data fitting to obtain urban environmental psychology. Security sense training set. In the future, when the conditions are mature, the brainwave feedback data in the virtual reality scene can be used to carry out the machine learning of psychological security, so as to improve the accuracy of the psychological security data.

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