scholarly journals Connection of urethral microbiota with the semen quality and the concentration of endocrine disrupters in men semen

2018 ◽  
Vol 19 (4) ◽  
pp. 60-66
Author(s):  
S. V. Chigrinets ◽  
G. V. Bryuhin
Keyword(s):  
Bisphenol A ◽  
Seminal Fluid ◽  
Semen Quality ◽  
Statistical Processing ◽  
Test System ◽  
P Value ◽  
Study Objective ◽  
Comparison Groups

The study objective is to investigate the correlations between opportunistic microorganisms of the urethra and the quality of ejaculate, as well as the concentration of ubiquitory endocrine disruptors (bisphenol A and triclosan) in men semen.Materials and methods. We analysed 63 semen samples of men with normo- and patozoospermia. In seminal fluid the concentration of bisphenol A and triclosan was determined by gas chromatography with mass spectrometry. The microbiocenosis of the urethra was studied by real-time polymerase chain reaction using the Androflor test system. The results were subjected to statistical processing using the Mann — Whitney U-test and correlation analysis. A p-value less than 0.05 was considered significant.Results. Bisphenol A was found in 100 % of the semen samples. Triclosan was detected in 84.9 % of the samples. Comparison groups on the quality of ejaculate (normo- and pathozoospermia) were statistically significantly different in the concentration of bisphenol A and triclosan in seminal fluid (p <0.001) and (p = 0.003) respectively. The study established statistically significant correlations between bisphenol A concentration, seminal triclosan and urethral microbiota: Lactobacillus spp. (r = 0.501, p = 0.003), Corynebacterium spp. (r = 0.425, p = 0.015), Anaerococcus spp. (r = 0.371, p = 0.045), Eubacterium spp. (r = 0.357, p = 0.037) for bisphenol A and Staphylococrns spp. (r = 0.392, p = 0.026), Streptococcus spp. (r = —0.486, p = 0.005) for triclosan.Conclusion. In this study the connection of the urethral microbiota with the quality of the ejaculate and the concentration of endocrine dis-ruptors (bisphenol A and triclosan) in men semen was established. In this regard, it is necessary to take into account the role of asymptomatic urethral dysbiosis when administering patients with poor ejaculate quality.

scholarly journals Environmental exposure to endocrine disruptors on semen quality of men

2018 ◽  
Vol 19 (3) ◽  
pp. 42-47
Author(s):  
S. V. Chigrinets ◽  
G. V. Bryuhin
Keyword(s):  
Bisphenol A ◽  
Dna Fragmentation ◽  
Endocrine Disruptors ◽  
Semen Quality ◽  
World Health ◽  
Plasma Testosterone ◽  
Total Testosterone ◽  
Study Objective ◽  
Normal Morphology

The study objective is to investigate the correlations between endocrine disruptors (bisphenol A, triclosan and 4-nonylphenol) exposure, measured on semen and semen quality of men, total testosterone in the plasma.Materials and methods. We measured semen bisphenol A, triclosan and 4-nonylphenol concentrations of 41 men by gas chromatography/ mass spectrometry. According to the World Health Organization guidelines, we divided our patients into 2 groups: normozoospermia and patozoospermia. And furthermore, total plasma testosterone and index DNA fragmentation spermatozoa were determined. The results were statistically processed using the Mann–Whitney U-test and correlation analysis. A p-value less than 0.05 was considered significant.Results. Bisphenol A was detected in 100 % of semen samples, triclosan – in 85,4 %, 4-nonylphenol – in 97,6 %, with a median concentration of 0.108, 0.17 and 0.165 ng/ml respectively. The groups were different statistically significant for levels of bisphenol A, triclosan and index DNA fragmentation spermatozoa (р <0.001, р = 0.033, р = 0.005 respectively). We found significant negative correlations between concentration of triclosan and percentage of normal morphology (p = 0.004), percentage of progressively motile spermatozoa (p = 0.049) and the positive correlation – between concentration of triclosan and percentage of DNA fragmentation spermatozoa (p <0,001). Аlso we found significant negative correlations between concentration of bisphenol A and total count (p = 0.04), percentage of progressively motile spermatozoa (p <0.001), percentage of normal morphology (p = 0.002), levels of total testosterone in plasma (p = 0.047). We demonstrated the synergy of investigated endocrine disruptors on semen quality.Conclusion. Semen bisphenol A and triclosan concentrations have a negative correlation with the parameters of the ejaculate. Environmental levels of bisphenol A negatively correlated with testosterone levels in plasma.

scholarly journals Environmental Exposure to Endocrine Disruptor of Bisphenol A and Semen Quality of Men

2018 ◽  
Vol 73 (5) ◽  
pp. 338-343
Author(s):  
Stanislav V. Chigrinets ◽  
Gennady V. Brukhin
Keyword(s):  
Reproductive Health ◽  
Male Infertility ◽  
Bisphenol A ◽  
Seminal Fluid ◽  
Concentration Level ◽  
Semen Quality ◽  
Roc Curves ◽  
Total Testosterone ◽  
Idiopathic Male Infertility

Background: The reproductive health disorders in men are one of the urgent problems of international medicine. The prevalence of idiopathic male infertility has the highest rate. Oxidative stress, genetic factor, and endocrine disruptors are considered to be the most probable causes for the idiopathic male infertility. In this regard, studying the effect of endocrine disruptors, in particular bisphenol A on male reproductive health, becomes actual and relevant. Aims: The aim of the study was to reveal the relationship between the concentration level of bisphenol A (BPA) in seminal fluid and semen quality in men with normo- or pathozoospermia, as well as between the concentration level of bisphenol A and the level of total testosterone and estradiol in plasma. Materials and methods: 53 samples of seminal fluid of men with normo- or pathoospermia were studied. In seminal fluid the concentration of bisphenol A was determined by gas chromatography with mass spectrometry (GC-MS). The spermiological analysis was performed according to the WHO recommendations (2010) including the evaluation of sperm count/concentration, motility and morphology, and DNA fragmentation index. In addition, the concentration of total testosterone and estradiol in plasma was determined. The results were statistically processed using the Mann–Whitney U test, the correlation analysis, the paired regression method, and the ROC curves to determine the cut-off point for BPA in the seminal fluid. The results were considered statistically significant at p0.05. Results: In 100% of the ejaculate samples BPA with a median concentration of 0.15 (0.06–0.31) ng/ml was detected. Using the Spearman rank correlation coefficient, statistically significant correlations between the concentration of BPA and the total count (r=-0.330, p=0.016), concentration (r=-0.309; p=0.024), the proportion of progressively motile spermatozoa (r=-0.575; p=0.001), the proportion of spermatozoa with normal morphology (r=-0.397, p=0.003), the degree of sperm DNA fragmentation (r=0.349, p=0.025), and the concentration of total testosterone (r =-0.616; p0.001) were registered. A statistically significant inverse linear relationship (r=-0.406, p=0.003) and (r =-0.364, p=0.048) was determined by a paired linear regression between the BPA concentration in the seminal fluid and the proportion of progressively motile spermatozoa, and the total testosterone level respectively. To assess the risk of pathozoospermia, the threshold value of seminal BPA concentration was determined using the analysis of ROC-curves; the cut-off point was 0.1025 ng/ml. Conclusions: BPA in the seminal fluid influences negatively on the quality of the sperm and suppress the level of total testosterone in plasma.

scholarly journals Once-a-day Tadalafil administration improves the spermogram parameters in fertile patients

2015 ◽  
Vol 87 (3) ◽  
pp. 210 ◽  
Author(s):  
Antonio Corvasce ◽  
Giuseppe Albino ◽  
Teresa Leonetti ◽  
Agnese Filomena Buonomo ◽  
Ettore Cirillo Marucco
Keyword(s):  
Seminal Fluid ◽  
Semen Quality ◽  
Type A ◽  
Daily Treatment ◽  
Sperm Cells ◽  
Average Increase ◽  
Once Daily ◽  
Positive Effects ◽  
Semen Volume

Objectives: We explored the safety of Tadalafil once-daily treatment for 12 week and its effects on semen quality in a clinical subpopulation of men with psychogenic erectile dysfunction (ED). Patients and Methods: Twenty-seven men, between 19 and 35 years, unaware of their fertility status, suffering from psychogenic ED were enrolled. The examination of the seminal fluid was performed twice before administration of Tadalafil and twice after three months of continuous daily administration of Tadalafil 5 mg. The volume of the seminal fluid, the concentration of sperm, the concentration of sperm with type “a+b” motility, the concentration of sperm with type “a” motility, the concentration of normal sperm were taken into consideration. The results before treatment with Tadalafil (T0) and after 3 months of treatment (T3m) were compared. Results: The administration of once-daily Tadalafil 5mg, brings to an average increase of the total number of sperm cells, both total and fast motility (type a) and the percentage of nemasperms, and to an average increase of semen volume of only 0.41 ml. These quantitative and qualitative improvements of the seminal fluid resulted statistically significant as regard motility, nemasperm percentage and seminal fluid volume. No unespected safety findings were observed. Conclusions: Tadalafil administration improves the quality of sperm cells and seminal fluid: in particular motility, percentage of nemasperms and volume of seminal fluid. We emphasize the safety of the once-daily treatment with tadalafil 5mg and the positive effects on spermatogenesis.

scholarly journals Collaboration-Based Academic Supervision Model with Peer Evaluation Approach to Improve Pedagogical Competence and Quality of School Performance: The Role of Principal's Motivation as Moderation Variables

2021 ◽  
Vol 5 (2) ◽  
pp. 268
Author(s):  
Sarlota Singerin
Keyword(s):  
School Performance ◽  
Structural Equation ◽  
Numerical Data ◽  
P Value ◽  
Peer Evaluation ◽  
Evaluation Approach ◽  
Pedagogical Competence ◽  
Supervision Model

Teaching skills are one of the skills that must be possessed by a teacher. Whether or not the pedagogical competence possessed by teachers can be seen from the quality of school performance. Supervision still tends to lead to inspection. So far, the implementation of academic supervision is considered effective. In order for the Academic Supervision to provide objective and detailed results, collaborative self-evaluation is carried out, namely peer evaluation to find teacher strengths that need to be maintained and deficiencies that must be corrected. This study aims to determine the effect of collaboration-based Academic Supervision model with Peer Evaluation Approach to Improve Pedagogical Competence and Quality of School Performance: The Role of Principal's Motivation as Moderation Variable. This research is a quantitative study with numerical data analyzed using the Structural Equation Model (SEM) assisted by the Smart PLS application. The results showed that Academic Supervision has an effect on Pedagogical Competence with a P-Value of 0.000 (p <0.05). Academic Supervision affects the Quality of Performance with a P value of 0.000 (p <0.05). motivation is able to moderate positively pedagogical competence with a P value of 0.032 (p <0.05). Motivation is not able to moderate supervision of the quality of performance with a P value of 0.138 (p> 0.05). Supervision is able to explain the Pedagogical Competence (Y1) variable of 69.4%. Supervision is able to explain the Performance Quality variable (Y2) of 40.1%. The principal should be able to periodically monitor the learning carried out by the teacher in the classroom, so that the principal knows the problems faced by the teacher in learning. Researchers who want to research further on this topic can use other variables and a wider sample.

scholarly journals Erythropoietin level in normal and abnormal human seminal fluid

2021 ◽  
Vol 21 (4) ◽  
pp. 54-59
Author(s):  
D. Yu. Sosnin ◽  
K. R. Galkovich ◽  
A. V. Krivtsov1
Keyword(s):  
Seminal Plasma ◽  
Seminal Fluid ◽  
Solid Phase ◽  
Human Sperm ◽  
Test System ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Study Objective ◽  
Synthesis Of Hormones

Background. There are not enough publications devoted to the study of erythropoietin in human sperm. According to the results of these studies, the erythropoietin takes part in the regulation of spermatogenesis, affecting the synthesis of hormones, in particular steroid ones. Currently, the physiological and pathogenetic effects of erythropoietin on human ejaculate have not been thoroughly studied. In this regard, the study of this protein in the ejaculate in patients with diseases of the male reproductive system, as well as in their absence, is relevant.The study objective is to determine the concentration of erythropoietin in ejaculate samples of healthy and men with oligoastenozoospermia.Materials and methods. Samples of ejaculate of 52 men of reproductive age were examined. The ejaculate was examined using the SQA-V sperm analyzer (MES, Israel). According to the results of the study, two groups were identified: the main group (n = 18) with reduced fertility and the control group (n = 34) with normal spermogram indicators. In seminal plasma samples, the concentration of erythropoietin was determined by solid-phase enzyme immunoassay using the test system “Erythropoietin-IFA-BEST” (A-8776) (Vector-best LLC, Russia).Results. Erythropoietin was detected in all ejaculate samples, the results ranged from 9.37 to 193.95 mME / ml and varied 20.7 times (p = 0.3). The median concentration in the main group was 64.49 mME / ml (41.96; 118.16 mME / ml) and 1.36 times higher than the results of the comparison group, which were 47.16 mME / ml (18.15; 90.94 mME / ml). No statistically significant regularities were found between the concentration of erythropoietin and the indicators of ejaculate fertility (r <|0,3|).Conclusion. In oligoastenozoospermia, there is a tendency to increase the content of erythropoietin in the seminal plasma, which requires further research, taking into account a more detailed stratification of the groups examined for reasons that caused a decrease in the number of spermatozoa.

Protective role of ascorbic acid to enhance semen quality of rabbits treated with sublethal doses of aflatoxin B1

Toxicology ◽  
2001 ◽  
Vol 162 (3) ◽  
pp. 209-218 ◽  
Author(s):  
M.H. Salem ◽  
K.I. Kamel ◽  
M.I. Yousef ◽  
G.A. Hassan ◽  
F.D. EL-Nouty
Keyword(s):  
Ascorbic Acid ◽  
Aflatoxin B1 ◽  
Semen Quality ◽  
Protective Role ◽  
Sublethal Doses

HUBUNGAN PERAN SERTA KADER POSYANDU DENGAN PERAWATAN HIPERTENSI PADA LANJUT USIA (LANSIA) DI DESA SALAMREJO SENTOLO KULON PROGO

2016 ◽  
Vol 5 (2) ◽  
pp. 168-174
Author(s):  
Sugiyanto Sugiyanto
Keyword(s):  
Elderly People ◽  
Rank Correlation ◽  
Sampling Technique ◽  
P Value ◽  
Spearman Rank Correlation ◽  
Cross Sectional ◽  
Treatment Of Hypertension ◽  
Coefficient Corrélation

Background: One of the most prevalent cardiovascular problems in elderly people is hypertension.Health cadres are those who voluntarily dedicate their time to have concern about elderly people’s health status in the community. Health cadres’ roles are important to promote elderly people quality of life, including their hypertension management. Objectives: This research aimed to analyzethe correlation between the role of health cadres of elderly posyandu and the treatment of hypertension at Salamrejo Village Sentolo Kulon Progo. Methods:This research was a correlational study with a cross sectional approach. The sample of this study was selectedwith a total sampling technique, drawn 57 hypertension patients. Data were analyzedwith Spearman rank correlation. Results:The result showed that coefficient correlation value of Spearman’s rho (r) between the role of cadres of elderly posyandu and the treatment of hypertension patients was 0.294 and p-value was 0.026 (p< 0.05). Conclusion:It can be concluded that there was a positive and significant correlation between the role of cadres of elderly posyandu and the treatment of hypertension. Key word:cadres, elderly posyandu, hypertension

A retrospective analysis of factors affecting palliative care consult in patients undergoing cytoreductive surgery and HIPEC.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 815-815
Author(s):  
Laila Babar ◽  
Herman Lo ◽  
Obaid Ashraf ◽  
Ashish Sethi ◽  
Zara Alvi ◽  
...  
Keyword(s):  
Palliative Care ◽  
Cytoreductive Surgery ◽  
National Average ◽  
P Value ◽  
Inclusion Criteria ◽  
Factors Affecting ◽  
Life Threatening ◽  
Better Than

815 Background: The National Cancer Institute defines palliative care as care given to improve the quality of life (QOL) for patients with life threatening diseases. The role of palliative care (PC) within oncology is ever evolving and as more studies are being conducted, its role in the improvement of QOL for patients is being widely recognized. Patients undergoing cytoreductive surgery (CRS) are at a higher risk for morbidity and mortality and often have severe post-operative symptoms that can worsen their QOL. Here we studied the factors affecting PC consult in order to better overcome them. Methods: We queried our Electronic Medical Record EPIC for a list of patients who underwent cytoreductive surgery with HIPEC or HITEC in the hospital from April 2016-April 2019. Data was manually extracted and patients who didn’t meet our criteria were excluded. Patients were divided on the basis of palliative care consults and differences between the groups were analyzed. Odds ratios(OR) with p-value 0.05 and confidence interval (CI) 95% were calculated. Results: We identified 55 patients of whom 34 met our inclusion criteria, 11 male and 23 female with an average age of 56.3 years at the time of diagnosis. 8 patients (23%) had PC; more than 1 comorbidity and age > 40 was associated with a higher likelihood of PC (OR:0.12; CI:0.02-0.76; p:0.02) and (OR: 0.015; CI: 0.0007-0.3029; P: 0.006) respectively. Gender, insurance type and marital status did not corelate with PC. Mean age (58.1 vs 55.7) showed a trend towards higher rates of PC in older population. Conclusions: Approximately one quarter of patients undergoing CRS with HIPEC had a concurrent PC consult. Though this is better than the national average of 11-16%, it continues to be a very small number. PC is not only an end of life service, in fact studies have shown early consultations lead to higher patient satisfaction, improved QOL and better communication. Efforts must be made to engage PC early in the course of treatment and recognize it as an integral part of cancer care.

scholarly journals PERAN REGULASI EMOSI TERHADAP KUALITAS HIDUP DENGAN WORK LIFE BALANCE SEBAGAI MEDIATOR PADA PEREMPUAN PERAN GANDA

2019 ◽  
Vol 3 (2) ◽  
pp. 403
Author(s):  
Gardenia Junissa Siregar ◽  
Rostiana Rostiana ◽  
Heryanti Satyadi
Keyword(s):  
Quality Of Life ◽  
Emotion Regulation ◽  
Dual Role ◽  
Work Life ◽  
Work Life Balance ◽  
World Health ◽  
P Value ◽  
Life Balance

Kualitas hidup merupakan aspek yang penting dalam kehidupan, terlebih lagi untuk perempuan yang telah menjadi ibu. Regulasi emosi merupakan strategi yang dilakukan untuk merespon emosi yang terjadi. Secara teoritis regulasi emosi dapat dikatakan berperan untuk menentukan kualitas hidup, namun penelitian menemukan hasil berbeda, dimana hubungan kedua variabel tersebut dinyatakan cukup lemah. Work life balance merupakan keadaan ketika seseorang dapat menyeimbangkan perannya sebagai pekerja dan di dalam keluarga. Oleh karena itu, penelitian ini bertujuan untuk melihat peran regulasi emosi terhadap kualitas hidup dengan work life balance sebagai mediator. Populasi dalam penelitian ini adalah para perempuan peran ganda, yang memiliki aktivitas keseharian, selain menjadi ibu dan istri di dalam keluarga. Teknik pengambilan sampel yang digunakan adalah purposive sampling dengan jumlah sampel sebanyak 400 orang perempuan peran ganda. Penelitian ini menggunakan tiga alat ukur, yaitu World Health Organizational Quality of Life (WHOQOL-BREF), Emotion Regulation Questionnaire (ERQ) dan Work Life Balance Scale (WLBS). Pengujian model penelitian dilakukan dengan menggunakan Path Analysis Structural Model menggunakan LISREL 8.80. Hasil pengujian model menunjukan bahwa work life balance dapat berperan sebagai mediator dengan nilai (p-value>0.05) yaitu p-value 1.000 sehingga model dapat dikatakan berada pada kategori good fit. Hasil nilai standardized solution untuk peran regulasi emosi terhadap kualitas hidup yang awalnya sebesar 0.10 juga mengalami peningkatan menjadi 0.1224. Sehingga dapat mengindikasikan bahwa peranan regulasi emosi terhadap kualitas hidup akan lebih besar, ketika para perempuan peran ganda memiliki work life balance. Quality of life is an important aspect of life, especially for women who have become mothers. Emotion regulation is a strategy undertaken to respond to emotions that arise. Theoretically, emotional regulation can be said to play a role in determining the quality of life, however, studies found different results, where the relationship between the two variables was stated to be quite weak. Work-life balance is a condition when a person can balance their role as a worker and in the family. Therefore, this study aims to look at the role of emotion regulation on quality of life with work-life balance as a mediator. The population in this study are dual role women, who have daily activities, besides being mothers and wives in the family. The sampling technique used was purposive sampling with a total sample of 400 dual role women. This research uses three measuring instruments, namely World Health Organizational Quality of Life (WHOQOL-BREF), Emotion Regulation Questionnaire (ERQ) and Work Life Balance Scale (WLBS). Research model testing was done using the Path Analysis Structural Model using LISREL 8.80. The model testing result shows that work life balance can act as a mediator with (p-value> 0.05), which is p-value 1,000, that the model can be said to be in the good fit category. The results of the standardized solution for the role of emotion regulation on the quality of life which was originally at 0.10 also increased to 0.1224. It indicates that the role of emotion regulation on quality of life will be greater, when dual role women have work-life balance.

NON - RANDOMIZED SINGLE BLIND STUDY TO OBSERVE THE ROLE OF ANTI MIASMATIC MEDICINE IN PATIENTS WITH MIGRAINE

2020 ◽  
pp. 22-26
Author(s):  
Yashvi Mandavia ◽  
Vinodini V Patil ◽  
Arun B. Jadhav
Keyword(s):  
Mean Difference ◽  
P Value ◽  
Age Group ◽  
Common Condition ◽  
Randomized Clinical Study ◽  
Males And Females ◽  
Single Blind ◽  
Paired T Test

Background: Migraine is fairly common condition affecting about 15% of the population globally and In GBD 2015, it absolutely was ranked as third highest reason for disability worldwide in both males and females under the age of fty years. Thus it is absolutely necessary and interesting to study the effectiveness of homoeopathic anti miasmatic remedies in patients with migraine. Methods: 30 cases of migraine were included in this non randomized clinical study out of 40 registered cases and the data collected during the study was analyzed with paired t test. The study was conducted for period of 18 months. Result: The study showed that the prevalence of migraine was more amongst females (83.33%) compared to male (16.66%). Moreover the age group 15-20 year age group ( 23.33%) followed by 25-30 years and 40-45 years (20%). During the study it was found that Natrum Muriaticum was indicated in moat of the cases ( 13.33%), followed by pulsetilla (10%) followed by lachesis, silicea and belladonna (6.66% each). The most common miasm was found to be sycotic miasm ( 53.33%) followed by psora miasm ( 30%) and syphilitic miasm ( 13.33%). Conclusion: After the study of 30 patients it was found that administration of anti miasmatic medicines in the patients with migraine showed changes in the frequency of episode of headache (Mean difference -2.167, SD of difference 0.7915, p value <0.001), intensity of pain (Mean difference -1.700, SD of difference 1.179, p value <0.001) and changes in quality of life score, MIDAS scores (Mean difference -2.167, SD of difference 0.7915, p value <0.001) which were statistically signicant.

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