Clinical efficiency of ultraphonophoresis of Metrogyl Denta gel in mild periodontitis

BACKGROUND: Periodontal diseases are one of the most common in dentistry. Along with the complications of caries, periodontitis is one of the causes of tooth loss. In the etiology of this disease, the leading role is played by the microbial factor, as well as microcirculatory disorders in periodontal tissues. The complex mechanism of periodontitis development involves a comprehensive treatment approach aimed at different links in the pathogenesis of the development of this disease. Among the numerous physical factors used in the treatment of periodontal diseases, ultraphonophoresis, which combines the effects of ultrasound and a medicinal substance, is not widely used. The study of the effectiveness of the use of Metrogil Denta gel ultraphonophoresis in the treatment of inflammatory periodontal diseases is of considerable scientific and practical interest. AIM: This study aimed to investigate the effect of ultraphonophoresis of gel on the clinical course of chronic generalized periodontitis of moderate severity. MATERIALS AND METHODS: Sixty patients (aged 3162) with chronic generalized periodontitis of moderate severity were examined and treated. In the main group (n=30), treatment included high-frequency ultrasound and antibacterial preparation of Metrogyl Denta gel applied to the periodontal tissue (ultraphonophoresis of Metrogyl Denta gel). In the control group (n=30 patients), Metrogyl Denta gel was injected into the periodontal tissue. RESULTS: Application of Metrogyl Denta gel for moderate periodontitis did not improve local blood circulation. Six months after treatment, nearly half of the examined patients showed signs of inflammation, which was accompanied by a worsening of periodontal index (PI), SchillerPisarev tests results, and rheography finding. Twelve months after treatment, 63% of the patients developed complications. CONCLUSIONS: There was further deterioration in the clinical and functional parameters. After ultraphonophoresis of Metrogyl Denta gel, there was a decrease in the readings of the SchillerPisarev test, PI, and normalization of the qualitative and quantitative indicators of the rheoparodontogram, which indicated a decrease in inflammation and activation of local blood circulation in the periodontium. In the long term after treatment, despite the increase in hygiene index, the relative stability of clinical and functional parameters was maintained. Even a year after treatment, the level of indicators did not reach the level obtained before treatment.

Download Full-text

Стоматологічний статус осіб, схильних до регулярного активного куріння

CLINICAL DENTISTRY ◽

10.11603/2311-9624.2017.1.7698 ◽

2017 ◽

Cited By ~ 1

Author(s):

O. Ya. Lavrin ◽

V. V. Shcherba ◽

I. Ya. Krynytska

Keyword(s):

Periodontal Disease ◽

Periodontal Diseases ◽

Pathological Process ◽

Control Group ◽

Periodontal Tissue ◽

Active Smoking ◽

Periodontal Tissues ◽

Increased Risk ◽

Periodontal Index ◽

Central District

Smoking is associated with significantly increased risk of diseases of organs and tissues of the oral cavity, especially periodontal pathology and cancer of the mouth.The aim of the study – to investigate the prevalence, structure and clinical course of periodontal tissue diseases in people prone to regular active smoking.Materials and Methods. A study of 120 visitors who had undergone preventive examinations in the Clinic of Zbarazh Central District Municipal Hospital exposed to regular active smoking was performed. To assess the degree of inflammation in periodontal tissues we used marginally-papillary-alveolar index, periodontal index, the Green-Vermilyon index.Results and Discussion. Dental examination of persons exposed to regular active smoking, revealed periodontal disease in 102 individuals (85.0 %), intact periodont – 18 persons (15.0 %). At the same time, investigation of 30 control individuals showed periodontal disease in 12 persons (40.0 %), clinically healthy periodontal tissue – in 18 persons (60.0 %). PMA index of individuals exposed to regular active smoking, treated as severe gingivitis and was significantly higher than data of the control group in 2.5 times. Average numerical values of periodontal index in patients exposed to regular active smoking answered moderate periodontitis and significantly were higher than data of the control group in 4 times. Oral hygiene status in 62 % of those exposed to regular active smoking, was poor, 7 % – very poor, 22 % – satisfactory, 9 % – good. Average numerical values of Green-Vermilyon index in smokers was significantly higher than data of the control group in 3.1 times.Conclusions. Thus, smoking contributes to increasing of diffuse periodontal diseases and deepening of pathological process.

Download Full-text

METHOD FOR TREATING CHRONIC GENERALIZED PERIODONTITIS OF LIGHT AND MEDIUM GRAPES

The actual problems in dentistry ◽

10.18481/2077-7566-20-16-2-53-58 ◽

2020 ◽

Vol 16 (2) ◽

pp. 53-58

Author(s):

Karen Karakov ◽

Emilia Khachaturyan ◽

Marat Uzdenov ◽

Laura Uzdenoba ◽

Nelli Vanchenko ◽

...

Keyword(s):

Photodynamic Therapy ◽

Treatment Regimen ◽

Treatment Time ◽

Periodontal Diseases ◽

Periodontal Pocket ◽

Control Group ◽

Moderate Severity ◽

Affected Area ◽

Periodontal Tissues ◽

Complex Therapy

Subject. The article presents the data of a comparative analysis of the traditional method of treating chronic generalized periodontitis of mild to moderate severity and with the use of periodontal dressings in combination with an antibacterial photodynamic system. The goal is to study the effectiveness of the methodology of complex therapy for the treatment of periodontal diseases using periodontal dressings and antibacterial photodynamic therapy. Methodology. We observed 120 patients with inflammatory periodontal diseases aged 18 to 55 years (men ― 52, women ― 68), who were divided into the control and main groups. In the control group, treatment was carried out according to the traditional scheme of drug therapy, in the main ― according to the method of complex therapy. The treatment regimen according to this technique included the use of periodontal dressings and an antibacterial photodynamic therapy system: photosynthesis was applied to the affected area of the periodontal pocket, after which the pathogenic microorganisms were stained for 1-3 minutes, then the liquid was thoroughly washed from the periodontal pockets and the laser affected the affected area for 60 seconds. Results. The proposed treatment regimen using an antibacterial photodynamic system in combination with periodontal dressings allows to achieve a pronounced and prolonged anti-inflammatory effect in periodontal tissues without local and systemic use of antibiotics, reduces treatment time for mild periodontitis by 29, average ― by 57 %, reduces the likelihood recurrence, lengthens the duration of remission. Findings. The use of complex treatment of periodontitis of mild to moderate severity allows the method to accelerate the restoration of periodontal tissues, relieve inflammation, saturate the tissues with oxygen, reduce the rate of relapse by 2.6 times and reduce the duration of relapse of this disease within 24 months. Our data allow us to implement this treatment regimen in practical healthcare.

Download Full-text

Study of the influence of different methods of application of Metrogyl Denta gel on the microbiota of periodontal pockets in periodontitis

Российский стоматологический журнал ◽

10.17816/1728-2802-2021-25-1-42-47 ◽

2021 ◽

Vol 25 (1) ◽

pp. 42-47

Author(s):

Dmitry I. Morozov ◽

Alexander G. Volkov ◽

Egor E. Olesov ◽

Nataliya Zh. Dikopova ◽

Yulia A. Trefilova

Keyword(s):

High Frequency ◽

Periodontal Diseases ◽

Practical Interest ◽

Control Group ◽

Periodontal Tissue ◽

High Frequency Ultrasound ◽

Periodontal Tissues ◽

Group Data ◽

And Control ◽

Frequency Ultrasound

BACKGROUND: One of the most popular antibacterial drugs used in periodontology is Metrogil Denta gel. In recent years, it is most often prescribed as a means of local antibacterial therapy. However, there is practically no information about the use of Metrogil Denta gel ultraphonophoresis in the treatment of periodontal tissue diseases. Therefore, the development of the Metrogil Denta gel ultraphonophoresis technique and the study of its effectiveness in inflammatory periodontal diseases has significant theoretical and practical interest. AIM: This study aimed to explore the influence of various methods of using Metrogyl Denta gel on the microbiota of the periodontal pockets in periodontitis. MATERIALS AND METHODS: In the first group (main), composed of 20 patients with a diagnosis of moderate periodontitis, the treatment procedures included high-frequency ultrasound and application of antibacterial preparation of Metrogyl Denta gel for the periodontal tissue (ultraphonophoresis of Metrogyl Denta gel). In the second group (control), composed of 20 patients with a diagnosis of moderate periodontitis, phonophoresis was not prescribed, and Metrogyl Denta gel was applied into the surface of the gums of the upper and lower jaw two times a day for 10 days. RESULTS: Contents of the pathological periodontal pockets were examined twice: first after dental plaque removal in patients with periodontitis of the main and control groups and then after 10 ultraphonophoresis procedures using Metrogyl Denta gel as a contact medium in the study group or after 10 days of Metrogyl Denta gel applications in the control group. Data analysis revealed that ultraphonophoresis of Metrogyl Denta gel has a more pronounced antibacterial effect in comparison with the injection of this drug. CONCLUSIONS: The combined effect of high-frequency ultrasound and Metrogyl Denta gel makes it possible to create a drug reserve in the periodontal tissues.

Download Full-text

Assessment of Periodontal Tissue Status in Patients with Generalized Periodontitis and Essential Hypertension

Galician Medical Journal ◽

10.21802/gmj.2017.2.10 ◽

2017 ◽

Vol 24 (2) ◽

Author(s):

T I Vicharenko ◽

M. M. Rozhko

Keyword(s):

Essential Hypertension ◽

Oral Hygiene ◽

Main Group ◽

Stage Ii ◽

Control Group ◽

Periodontal Tissue ◽

Treatment Needs ◽

Periodontal Tissues ◽

Periodontal Index ◽

Community Periodontal Index

Vascular disorders play a significant role in the development of dystrophic inflammatory process. There is a direct correlation between the degree of damage to blood vessels in the jaw and a depth of the destructive process in periodontal tissue. A certain role is played by endogenous factors, such as: age, vitamin deficiency, diabetes mellitus, essential hypertension and others. Clinical and epidemiological studies using pathological techniques showed significant changes in vascular wall of the artery in the periodontium, the interdental artery in particular. Atherosclerosis, essential hypertension and periodontal pathology were proven to occur in individuals older than 40 years.The objective of the research was to determine periodontal tissue status in patients with stage II hypertension and generalized periodontitis of II degree of severity.Materials and methods. The study involved 36 patients with stage II hypertension and generalized periodontitis of II degree of severity (the main group). The patients’ age ranged from 35 to 54 years. The control group included 10 patients of corresponding age without generalized periodontitis and somatic pathology. To assess the status of periodontal tissues, we applied the Papillary-Marginal-Attached Index and the Community Periodontal Index of Treatment Needs. When diagnosing periodontal disease, the classification of M.F. Danilevskyi was used.Results. The analysis of the indicators of the Community Periodontal Index of Treatment Needs index showed the following results: in patients of the main group, the index was 2.38±0.07 points (p<0.001) pointing out a need for a course of professional oral hygiene. In patients of the control group, the index was 0.5±0.17 points indicating that there was no need for treatment, however, there was a need for improving oral hygiene. The indicators of the Papillary-Marginal-Attached Index in the main group were 55.49±1.96 points pointing out a severe degree of gingivitis.Conclusions. According to the analysis of the indicators of the Community Periodontal Index of Treatment Needs index (2.38±0.07), the patients of the main group had low hygiene level requiring a course of professional oral hygiene.

Download Full-text

Improvement of the scheme of treatment of periodontal tissue diseases in patients with urinary system pathology

SUCHASNA STOMATOLOHIYA ◽

10.33295/1992-576x-2021-4-16 ◽

2021 ◽

Vol 108 (4) ◽

pp. 16-19

Author(s):

Yu. Kilmukhametova ◽

◽

V. Batig ◽

O. Soltis ◽

M. Ostafiychuk ◽

...

Keyword(s):

Zinc Oxide ◽

Periodontal Diseases ◽

Periodontal Tissue ◽

Urinary System ◽

Traditional Treatment ◽

Treatment Regimens ◽

Periodontal Tissues ◽

Treatment And Prevention ◽

Periodontal Index ◽

Before And After

The aim of the study. Study of the effectiveness of our proposed scheme of treatment of periodontal tissues in patients with pathology of the urinary system comparing to a traditional scheme. Research methods. The study involved 72 patients with pathologies of the urinary system: glomerulonephritis, pyelonephritis and urolithiasis. They were divided into 2 groups: basic and comparison. The first group received our treatment, which consisted of professional hygiene and subsequent application of a combination of ointments of Thiotriazoline and Zinc Oxide, and rinsing with 0.05% solution of Chlorhexidine bigluconate for 5 days. The traditional treatment consisted of professional oral hygiene and rinsing with 0.05 % chlorhexidine bigluconate solution twice a day for 5 days. Patients before and after treatment were examined and indexed. In patients with a complex of antioxidant drugs, the results were better than in patients who underwent traditional treatment of periodontal tissues. Scientific novelty. Periodontal tissue pathology is one of the predominant groups of diseases of the oral cavity, so the problem of their treatment or prevention is quite relevant. Periodontal diseases in patients with pathology of the urinary system to date are studied insufficiently. There are not enough studies about the causes, features of the course, treatment and prevention of periodontal pathologies in this group of patients. Therefore, the development of new or improvement of existing treatment regimens in patients with diseases of the urinary system is of considerable interest to both scientists and practitioners. Conclusions. Our results showed that our proposed scheme of treatment of periodontal tissues in patients with pathologies of the urinary system is more effective than traditional treatment. Key words: periodontal tissue disease, pathology of the urinary system, Thiotriazoline, Zinc Oxide, Chlorhexidine bigluconate, PMA, Russell periodontal index, CPITN.

Download Full-text

Comparative analysis of polymorphic variants of IL-17A and MMP-1 genes with the risk of developing chronic periodontitis in petrochemical workers

Russian Journal of Occupational Health and Industrial Ecology ◽

10.31089/1026-9428-2020-60-10-687-693 ◽

2020 ◽

Vol 60 (10) ◽

pp. 687-693

Author(s):

Iskander I. Zaidullin ◽

Denis O. Karimov ◽

Lilija K. Karimova ◽

Milyausha F. Kabirova ◽

Rasima R. Galimova ◽

...

Keyword(s):

Ethylene Oxide ◽

Chronic Periodontitis ◽

Periodontal Diseases ◽

Clinical Manifestations ◽

Control Group ◽

Periodontal Tissues ◽

Dental Examination ◽

Number Of Patients ◽

Increased Risk ◽

Harmful Substances

The susceptibility to the development and progression of inflammatory periodontal diseases, which depends on genetic and external factors (smoking, stress, oral hygiene), varies widely. In the development of these diseases, an important role is played not only by the presence of periodontal pathogenic microorganisms, but also by the presence of congenital or acquired immunodeficiency, immunoregulatory defects. The immune system plays a key role in the physiological and pathological processes of periodontal tissues. In this regard, IL17, produced by CD4+ Th cells, which has both Pro-inflammatory and protective activity, is of particular interest in the pathogenesis of periodontitis. The aim of study was to identify the relationship between polymorphic loci of the IL-17A (rs2275913) and MMP-1 (rs1799750) genes and clinical manifestations of chronic periodontitis in petrochemical workers. Dental examination was performed in 92 ethylene oxide production workers with chronic periodontitis and 74 patients with chronic periodontitis who did not come into contact with chemical factors (control group). Genotyping of polymorphisms rs2275913 of the IL17A gene and rs1799750 of the MMP1 gene was performed by allele-specific real-time polymerase chain reaction (PCR). Hygienic assessment of the degree of air pollution of the working area with harmful substances was carried out by gas chromatography according to the guidelines for the determination of harmful substances in the air № 5098-89, № 3119-84. When comparing the results of studies of both groups, there were no statistically significant differences in the frequency distributions of allelic variants and genotypes of the IL-17A and MMP-1 genes. The AA/AG genotypes of the IL-17A gene were associated with an increased risk of severe disease compared to the GG genotype in workers in the main group (OR=6.1; 95% CI 1.33-28.5; p=0.021) and in the control group (OR=7.26; 95% CI 1.34-39.25; p=0.016). Carriers of the A allele in the control group increased the risk of severe chronic periodontitis by 2.4 times compared to carriers of the G allele (OR=2.41; 95% CI 1.19-4.87; p=0.014). During the dental examination of employees of the ethylene oxide plant, the clinical course of periodontal diseases was more severe in comparison with the control group, and the number of patients with severe periodontitis was twice as high. It was found that the AA/AG genotypes of the IL-17A gene and the carrier of the A allele are associated with increased susceptibility to the development of severe chronic periodontitis. The association between the MMP-1 gene polymorphism and the risk of severe forms of chronic periodontitis has not been established. A risk factor for the development of inflammatory periodontal diseases in employees of the petrochemical complex is a complex of harmful production factors.

Download Full-text

Application of Plant-Based Preparations in a Comprehensive Treatment of Inflammatory Periodontal Diseases

Ukraïnsʹkij žurnal medicini bìologìï ta sportu ◽

10.26693/jmbs06.05.038 ◽

2021 ◽

Vol 6 (5) ◽

pp. 38-44

Author(s):

O. D. Saliuk ◽

◽

P. H. Gerasimchuk ◽

L. O. Zaitsev ◽

I. I. Samoilenko ◽

...

Keyword(s):

Inflammatory Diseases ◽

Periodontal Diseases ◽

The Body ◽

Comprehensive Treatment ◽

Complex Treatment ◽

Medicinal Products ◽

Actual Problem ◽

Periodontal Tissues ◽

Wide Range ◽

Anti Inflammatory

In this article the review of foreign and domestic literary sources, which are devoted to the actual problem of modern dentistry – the treatment of inflammatory diseases of periodontal tissues: gingivitis and periodontitis are presented. The complex approach to their treatment involves the appointment of a significant amount of pharmacotherapeutic drugs. Therapeutic failures and iatrogenic complications have led to the fact that today the interests of doctors and population to medicinal products significantly increased. The purpose of the study is to analyze the data of scientific literature on the use of plant-based medicinal products for the treatment of periodontal inflammatory diseases over the past 10 years. Materials and methods. Comprehensive and systematic analysis of literature. Review and discussion. The analysis of information sources on the use of plant-based medicinal products in dentistry both independently and in the composition of medical and prophylactic means has established that the modern assortment of plant-based preparations in the pharmaceutical market of Ukraine to a certain extent is limited. The emergence of new plant-based species that have been tested in conditions of experimental pathology and require an evidence-based clinical base is noted. The composition of plant-based preparations used for the treatment of inflammatory periodontal diseases include vitamins, biologically active substances, glycosides, alkaloids, in connection with a wide range of action: antiseptic, anti-inflammatory, regenerating, hemostatic, antioxidative. The data on plant-based preparations that are most often used such as chamomile extracts, calendula, hypericum, plantain, kalanchoe, aloe, eucalyptus, milfoil, nettle, calamus and plant-based species are summarized. The medicinal agents considered are mainly recommended for local treatment of periodontal diseases in the form of dental care means, mouth rinse, gel, chewing gum, herbal liquer. It is known that the complex treatment of periodontal diseases includes a general influence on the body. The properties of green tea with its wide range of actions are investigated. With antioxidant properties, it can be a healthy alternative for controlling destructive changes in periodontal diseases. Attention is drawn to the proposed unique natural complex “Resverazin” due to a wide range of pharmacological action, low toxicity and relative safety. The drug produces antioxidant, anti-inflammatory, immune stimulating, vasodilative, neuroprotective action. Conclusion. Based on the literature analysis, it can be concluded that the accumulated experimental and clinical data on the therapeutic properties of plants prove perspective of their use in the complex treatment of inflammatory periodontal diseases. Future studies are mandatory for further confirmation of the effectiveness of these medicinal plants

Download Full-text

DISTURBANCE OF IRON METABOLISM AND ULTRASTRUCTURAL FEATURES OF THE GINGIVA IN PATIENTS WITH Β-THALASSEMIA MAJOR

Российский стоматологический журнал ◽

10.18821/1728-2802-2018-22-5-255-261 ◽

2018 ◽

Vol 22 (5) ◽

pp. 255-261

Author(s):

Ramida Vaqif qizi Shadlinskaya ◽

E. K Gasimov ◽

S. A Israfilova

Keyword(s):

Iron Metabolism ◽

Serum Iron ◽

Binding Capacity ◽

Periodontal Diseases ◽

Thalassemia Major ◽

Control Group ◽

Periodontal Tissues ◽

Metabolism Disorder ◽

Pathogenetic Factor ◽

Iron Binding Capacity

Introduction: β-thalassemia major is a hereditary blood disease, a main pathogenetic factor of which is the disruption of the synthesis of β-chains of hemoglobin. Inevitable metabolic disorders that occur during regular blood transfusion form an additional risk of damage and cellular modification of organs and tissues, including the oral cavity. Aim: determination of the pathogenetic role of iron metabolism disorder in the development of chronic inflammatory periodontal diseases in patients with β-thalassemia. Material and methods: 12 patients with β - thalassemia major who had periodontal diseases were examined in the Republican Center of Thalassemia in Baku (average age is 18 ± 1.3 years). The control group consisted of 16 somatically healthy individuals with intact gingiva tissues (the average age is 18.0 ± 0.7 years). Serum Iron, ferritin, hepcidin, total iron-binding capacity (TIBC), level of Il2, Il6, Il10, TNFα were measured from peripheral blood samples. To determine the ultra-structural study of the periodontal tissues in patients with β-thalassemia major, the method of electron microscopy studies of gingiva biopsies was used. Results of the study: The study revealed an increase in the level of serum iron and ferritin against the background of a progressively decreasing TIBC in patients with β-thalassemia major. Also activation of pro-inflammatory cytokines - TNFα, Il6, Il10 was observed in homozygous patients. Metabolic indicators are compared with ultrastructural features of cellular elements of a gum. Signs of accumulation of iron in cellular elements both of its own plate and of the epithelial cover were compared. The presence of iron was recorded in immunocompetent cells - macrophages and lymphocytes. Conclusion: Summarizing the data obtained, we can conclude that deproteinization of ferritin cores and their detection both in the cytoplasm and in the nucleoplasm of immunocompotent cells leads to irreversible degenerative changes in cellular elements of the gingiva. The authors link the development of the generalized inflammatory - degenerative process in the periodontium with revealed exchange -structural violations.

Download Full-text

THE PREVALENCE OF PERIODONTAL TISSUE DISEASES IN YOUNG INDIVIDUALS ON THE BACKGROUND OF CROWDED TEETH

Ukrainian Dental Almanac ◽

10.31718/2409-0255.1.2018.07 ◽

2018 ◽

pp. 28-31

Author(s):

A.V. Mandych

Keyword(s):

Comparison Group ◽

Periodontal Diseases ◽

Adult Population ◽

Study Groups ◽

Main Group ◽

Periodontal Tissue ◽

Facial Skeleton ◽

Old Patients ◽

Periodontal Tissues ◽

Upper Jaw

The abnormalities of maxillodental system take one of the leading places among diseases of the maxillofacial area. Thus, they are diagnosed more than in 50% cases among the younger population and in 30% cases among the adult population. Most often, there are prerequisites for the incorrect position of individual teeth: anomalies are formed at the genetic level because of heredity of pathologies of size, amount, shape of teeth and size of the jaw bones of the facial skeleton. If the position of the teeth is incorrect, the periodontium retains the occlusal load of the functional injury. Therefore, the aim of our research was to study the prevalence of periodontal tissue diseases in young individuals on the background of crowded teeth. The material and research methods. The study was conducted on the base of Dental Center of Danylo Galytsky Lviv National Medical University during 2015−2017 years. 1146 people at the age from 18 to 44 years were examined. Every participant of research underwent general dental examination, as well as a special examination aimed at clarification of orthodontic treatment. The diagnosis of periodontal tissue diseases was made according to the classification of N. F. Danilevskyi and was determined using paraclinical indicators. The obtained results were worked out statistically using functions of MS Excel and Statistica 6. Results of the research and their discussion. The total number of the examined with orthodontic pathology was found on average in 77.24% of patients (885 people). At the same time, abnormalities of dental jaw system were not detected in about 261 (22.76%) of the examined. As a result of the conducted studies we found that among the examined without dental jaw abnormalities 38.89±.,32% of patients had intact periodontium, that was 1.6 times more for data in individuals with crowding − 23.73±2.00, p<0.01. At the same time, in patients of the main group the prevalence of periodontal tissue diseases was 1.2 times higher than in the examined of the comparative group (76.27±2.00% against 61.11±3.32%, respectively, p<0.01). It should be noted, that with the increase of the age of patients the prevalence of periodontal tissue diseases increased in both study groups, but in patients with crowded teeth this tendency was more pronounced. So, in the younger age group in patients with crowding the prevalence of periodontal diseases was 1.5 times higher in relation to the data of their peers from the comparison group (71.37±3.00% vs. 46.99±5.48%, p<0.01). In 27−35-year-old patients the prevalence of periodontal tissue diseases amounted to 72.38±4.03% of the examined of the main group and 65.62±5.94% of the examined of the comparison group, but the obtained data were not statistically significant, p>0.05. At the same time, in the patients of the main group aged 36−44 years the prevalence of periodontal tissue diseases was maximal and exceeded the value of their peers in the comparison group by 1.2 times (92.08±2.69% vs. 73.91±5.29%, respectively, p<0.01). The analysis of the obtained data allowed to assert that on average crowding of teeth on the upper jaw was found in 237 patients (52.55%) and on the lower jaw in 214 patients (47.45%). Thus, the maximum frequency of crowded teeth on the upper jaw was observed in the examined in the age range of 27−35 years, 60.16±4.41% of patients, with the minimum prevalence of this pathology in the youngest group (18−26 years), 49.34±4, 72%. The analysis of diagnostic structure of periodontal tissue diseases showed that inflammatory diseases of periodontal tissues (gingivitis, localized periodontitis) were found in patients with crowded teeth, on average 1.2 times more often than in patients without orthodontic pathology (42.42±1.88% vs. 36.33±3.54%, respectively, p<0.05). Conclusions. Thus, as a result of the conducted studies, higher prevalence of periodontal tissue diseases was proved in patients with crowding of teeth, which made progress in increasing the age of the examined than in patients without orthodontic pathology.

Download Full-text

Вплив поліморфізму генів PTHR1 та COL1A1 на розвиток захворювань тканин пародонта у людей молодого віку

CLINICAL DENTISTRY ◽

10.11603/2311-9624.2017.2.7936 ◽

2017 ◽

Author(s):

M. A. Luchynskyi ◽

Y. V. Boliuk ◽

V. M. Luchynskyi

Keyword(s):

Young People ◽

Periodontal Diseases ◽

Main Group ◽

Control Group ◽

Type I ◽

Periodontal Tissue ◽

Endogenous Factors ◽

Stage Of Development ◽

The Difference ◽

Collagen Chain

At the present stage of development of dentistry, the leading Ukrainian and foreign scientists devote a considerable part of the research to a deeper study of the etiology and pathogenetic mechanisms of periodontal tissue diseases and the influence of various exogenous and endogenous factors on their course.The aim of the study – to learn the ability and methods of forecasting and early diagnosis of the periodontal tissue lesions in young people. Materials and Methods. During our research we examined 24 young people with periodontal tissue diseases, who were included to the main group, and 15 healthy people, who formed the control group. The complex clinical examination was performed in each research group. It was studied the distribution of polymorphous variants of the type I parathormone receptor and the α1-chain of collagen gene with a help of polymerase chain reaction by restrictase cleavage of DNA fragments and electrophoresis in polyacrylamide gel (AA/BA 29:1). Results and Discussion. The distribution of genotypes by PTHR1 gene in control group was similar to those in main group (p>0.05). Also we didn’t find the difference between frequencies of the separate alleles in people with periodontal tissue pathology and without it (p>0.05). Yes, the repetitions of the allele 5 encoding normal type I parathormone receptor were found more often, comparing with the allele 6 that is responsible for the formation of unfunctional PTHR1 (р<0.001) in both main and control groups. The dominance of the genotype TT, which corresponds to the pathology, was found in young people with the periodontal tissue lesions – (38.46 ± 4.79) %, while among the control group the genotype of norm GG was met the most often – (68.24±5.08) %. Also, the frequency of repetitions of the allele T encoding the imperfect collagen chain was (57.60±3.79) % in young people with periodontal diseases, and in the control group this figure was (13.27±2.81) %, p<0.001. Conclusions. According to our results the presence of allele T and genotype TT that correspond the imperfect collagen chain may be one of the causes of periodontal tissue pathology.

Download Full-text