scholarly journals Pathogenetic features of clinical current inflammatory diseases of internal genital organs on background intrauterine contraception (IUC)

1998 ◽  
Vol 47 (2) ◽  
pp. 24-26
Author(s):  
L. V. Ivanova ◽  
G. A. Okisheva ◽  
T. P. Spodobets
Keyword(s):  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Complex Treatment ◽  
Careful Selection ◽  
Surgical Operation ◽  
Intrauterine Contraception ◽  
Selection Of

Analysis of current inflammatory of uterus diseases and uterine appendages diseases was conducted at 1769 patients - age from 18-48 years. It is revealed, that the introduction IUC is responsible gynecological operation, requiring careful selection of woman with account of contraindicated, with observance of the rules aseptic and antiseptic subsequent strict regular medical check-up not less twice per year with vaginal bacteriological researching. The development of inflammatory process internal genital organs on a background IUC requires timely hospitalization, removal IUC and complex treatment as there is tendency, to spreading of infection for area of uterus and uterine appendages, that determines volume of surgical operation.

scholarly journals The state of lipid exchange and thrombotic link of hemostasis in patients with chronic non-specific inflammatory diseases of genitals

2019 ◽  
Vol 7 (1) ◽  
pp. 34-45
Author(s):  
Irina Sokolovska ◽  
Nadezhda Maryukhnich ◽  
Valentyna Zarytska ◽  
Olena Kyrpychenko ◽  
Valentina Nechiporenko ◽  
...  
Keyword(s):  
Vascular Endothelium ◽  
Inflammatory Process ◽  
Blood Count ◽  
Inflammatory Diseases ◽  
Full Blood Count ◽  
Complex Treatment ◽  
Lipid Exchange ◽  
Lipid Fractions ◽  
Endothelium Damage ◽  
Blood Characteristics

It has been stated that changes of lipid exchange and increasing of lipid peroxidation are accompanied by the inflammatory process, which show the increase of proatherogenic blood characteristics. In patients with chronic non-specific inflammatory diseases of genitals disorders of phagocytosis mechanisms, increasing of autointoxication and reaction of hypersensitivity of immediate type are revealed after full blood count index. On the basis of analyses results one can conclude that the increase of atherogenic properties of blood plasma in patients with chronic non-specific inflammatory diseases of genitals took place in accordance with vascular endothelium damage. The article is the first to show the effectiveness of complex treatment of different atherosclerotic pathogenesis links by means of correction of proatherogenic lipid fractions and antioxidative complexes.

EXPERIMENTAL ESTIMATION OF THE EFFICIENCY OF COMPLEX TREATMENT OF PERIODONTAL DISEASES USING AN ADAPTOGEN

2021 ◽  
pp. 18-21
Author(s):  
Алик Эдикович Петросян ◽  
Наталия Владимировна Чиркова ◽  
Арпине Бронислави Антонян ◽  
Жанна Владимировна Вечеркина
Keyword(s):  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Histological Study ◽  
Scientific Data ◽  
New Drugs ◽  
Complex Treatment ◽  
Comparative Aspect ◽  
Male Wistar Rats ◽  
Inflammatory Processes

Заболевания пародонта представляют собой серьезное воспалительное заболевание, которое с прогрессированием постепенно разрушает опорный аппарат зуба. Чаще всего, в практической стоматологии встречаются такие воспалительные заболевания как гингивит и пародонтит, тяжесть которых обусловлена степенью выраженности воспалительных процессов. Профилактика, диагностика и лечение данных состояний являются актуальной проблемой современной стоматологии. Научные данные подтверждают, что современные лекарственные средства оказывают влияние на все звенья этиологии и патогенеза, но тем не менее переход данных заболеваний в хроническую форму, а также неполноценный терапевтический эффект обуславливает актуальность поиска новых препаратов и комбинаций для профилактики и лечения воспалительных заболеваний пародонта. Анализ научной литературы показал, что в медицине широко используется комплексное лечение различных заболеваний органов и систем с применением адаптогенов, которые обладают не только богатым аминокислотным и витаминным составом, но и оказывают противовоспалительное, иммуномодулирующее, вяжущее и седативное действие. В данной статье представлены результаты гистологического исследования биоматериала слизистой губы крыс-самцов линии Вистар при экспериментальном моделировании воспалительного процесса в нем. Было проведено дифференцированное исследование влияния комплексного лечения с применением геля «Асепта с прополисом», модифицированного пантогематогеном на течение воспалительного процесса в сравнительном аспекте Periodontal diseases are a serious inflammatory disease that gradually destroys the supporting apparatus of the tooth as it progresses. Most often, in practical dentistry, there are such inflammatory diseases as gingivitis and periodontitis, the severity of which is due to the degree of severity of inflammatory processes. Prevention, diagnosis and treatment of these conditions are an urgent problem of modern dentistry. Scientific data confirm that modern medicines have an impact on all parts of the etiology and pathogenesis, but nevertheless, the transition of these diseases to a chronic form, as well as an incomplete therapeutic effect, determines the urgency of the search for new drugs and combinations for the prevention and treatment of inflammatory periodontal diseases. The analysis of scientific literature has shown that in medicine, complex treatment of various diseases of organs and systems is widely used with the use of adaptogens, which have not only a rich amino acid and vitamin composition, but also have anti-inflammatory, immunomodulatory, astringent and sedative effects. This article presents the results of a histological study of the biomaterial of the lip mucosa of male Wistar rats with experimental modeling of the inflammatory process in it. A differentiated study of the effect of complex treatment with the use of "Asepta with propolis" gel modified with pantohematogen on the course of the inflammatory process in a comparative aspect was conducted

scholarly journals EFFECT OF COMPLEX TREATMENT OF GINGIVITIS WITH THE USE OF CHEWING PHYTOSUBSTRATE IN WOMEN WITH EMERGENCIES CAUSED BY PREGNANCY ON THE CONTENT OF PROINFLAMMATORY CYTOKINES IN THE ORAL FLUID

2021 ◽  
Vol 17 (2) ◽  
pp. 68-73
Author(s):  
Sergey Chuykin ◽  
Natalia Kudashkina ◽  
Al'fiya Yashchuk ◽  
Marsel Tuigunov ◽  
Galina AKATYEVA ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Inflammatory Cytokines ◽  
Inflammatory Process ◽  
Oral Fluid ◽  
Inflammatory Diseases ◽  
Pathological Condition ◽  
Complex Treatment ◽  
Local Immunity ◽  
Tnf Α ◽  
Pro Inflammatory Cytokines

Introduction. Edema of pregnant women is a pathological condition in the second half of pregnancy, in which disorders of the functions of vital organs are noted and an exacerbation of chronic and sluggish inflammatory diseases occurs. Inflammatory periodontal disease and dental caries increase especially in the third trimester, and are most pronounced in complicated pregnancies. Changes in the cytokine profile in the mixed saliva of pregnant women reflect the state of local immunity and tissues of the oral cavity and indicate the participation of immunocompetent cells of the placenta and fetus in the response to the inflammatory process. Purpose: to characterize the effect of complex treatment of gingivitis with the use of a chewing phytosubstrate in women with edema caused by pregnancy on the level of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) in the oral fluid. Materials and methods: the level of cytokines IL-1β, IL-6, TNF-α in the oral fluid was determined before and after complex treatment of gingivitis with the inclusion of a chewing phytosubstrate in women with edema caused by pregnancy. Conclusion: Inclusion in the complex treatment of gingivitis in women with edema caused by pregnancy, a chewable phytosubstrate containing 0.1 g of dry matter extract (oak bark, alder stems, birch buds, chamomile flowers, thyme grass) and 1.0 g beeswax, has a pronounced therapeutic effect, reducing the content of pro-inflammatory cytokines in the oral fluid, which reflects the suppression of the inflammatory process.

Afterword

2020 ◽  
pp. 680-683
Author(s):  
Janice L. Waldron ◽  
Stephanie Horsley ◽  
Kari K. Veblen
Keyword(s):  
Social Media ◽  
Media Use ◽  
Careful Selection ◽  
Social Media Use ◽  
Pedagogical Tools ◽  
The Future ◽  
User Data ◽  
Selection Of ◽  
Data Surface

We all feel the implications of the force of social media—for good and for ill—in our lives and in our professional world. At the time of this writing, Facebook continues with its struggle to “clean up its act” as more revelations surrounding breaches of trust and hacked user data surface in the news and various countries attempt to hold Facebook to account. Despite this, social media use continues to grow exponentially, and the potential for responsible, ethical, and transparent social media to transform the ways in which we interact with and learn from each other increase with it. As we wait to see what the future holds for social media in society, we are reminded once again that it is the careful selection of pedagogical tools such as social media, as well the guided awareness of the challenges and benefits of those tools, that remains constant, even as tools may change, disappear, or fall out of fashion.

scholarly journals Clinical Pharmacology of Antibody-Drug Conjugates

Antibodies ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 20
Author(s):  
Iftekhar Mahmood
Keyword(s):  
Clinical Pharmacology ◽  
Patient Population ◽  
Inflammatory Diseases ◽  
Biologically Active ◽  
Myelogenous Leukemia ◽  
Optimum Dose ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Selection Of ◽  
Antibody Drug

Antibody-drug conjugates (ADCs) are biopharmaceutical products where a monoclonal antibody is linked to a biologically active drug (a small molecule) forming a conjugate. Since the approval of first ADC (Gemtuzumab ozogamicin (trade name: Mylotarg)) for the treatment of CD33-positive acute myelogenous leukemia, several ADCs have been developed for the treatment of cancer. The goal of an ADC as a cancer agent is to release the cytotoxic drug to kill the tumor cells without harming the normal or healthy cells. With time, it is being realized that ADCS can also be used to manage or cure other diseases such as inflammatory diseases, atherosclerosis, and bacteremia and some research in this direction is ongoing. The focus of this review is on the clinical pharmacology aspects of ADC development. From the selection of an appropriate antibody to the finished product, the entire process of the development of an ADC is a difficult and challenging task. Clinical pharmacology is one of the most important tools of drug development since this tool helps in finding the optimum dose of a product, thus preserving the safety and efficacy of the product in a patient population. Unlike other small or large molecules where only one moiety and/or metabolite(s) is generally measured for the pharmacokinetic profiling, there are several moieties that need to be measured for characterizing the PK profiles of an ADC. Therefore, knowledge and understanding of clinical pharmacology of ADCs is vital for the selection of a safe and efficacious dose in a patient population.

Catacomb culture wagons of the Eurasian steppes

Antiquity ◽  
2014 ◽  
Vol 88 (340) ◽  
pp. 378-394 ◽  
Author(s):  
N.I. Shishlina ◽  
D.S. Kovalev ◽  
E.R. Ibragimova
Keyword(s):  
Stable Isotope ◽  
Isotope Analysis ◽  
Burial Mound ◽  
Careful Selection ◽  
Southern Russia ◽  
The Subject ◽  
The Individual ◽  
Wheeled Vehicles ◽  
Selection Of ◽  
Catacomb Culture

The origin and development of wheeled vehicles continues to fascinate today no less than when Stuart Piggott (1974) first wrote about the subject inAntiquity40 years ago. A growing number of examples from the steppes of southern Russia and Ukraine are providing new insights into the design and construction of these complex artefacts. A recent example from the Ulan IV burial mound illustrates the techniques employed and the mastery of materials, with careful selection of the kinds of wood used for the wheels, axles and other elements. Stable isotope analysis of the individual interred in this grave showed that he had travelled widely, emphasising the mobility of steppe populations.

scholarly journals The Effects of Landscape Elements on the Breeding Sites of Bloodsucking Midge

2021 ◽  
Vol 13 (5) ◽  
pp. 2863
Author(s):  
Kaowen Grace Chang ◽  
Hungju Chien
Keyword(s):  
Ground Surface ◽  
Preventive Strategies ◽  
Careful Selection ◽  
Public Concern ◽  
Breeding Sites ◽  
Algae Growth ◽  
Potential Habitats ◽  
Landscape Factors ◽  
The Relationship ◽  
Selection Of

Forcipomyia taiwana, a bloodsucking midge that is one of the most irritating biting pests in Taiwan, has raised widespread public concern. However, we have little information about the extent to which landscape factors affect their potential habitats. As a result, landscape professionals do not have enough information to implement preventive strategies to control midges. The purpose of this study is to investigate the relationship between landscaping and algae growth for larval breeding sites of Forcipomyia taiwana. The intent is to determine the environmental strategies that make the planned landscape unsuitable for midges to breed. GIS based on data collected from 16 constructed landscape sites (317,187 m2 in total) was utilized to spatially examine the relationship between the occurrence of the algae for midge breeding sites and the ground surface types and planting characteristics in each landscape. The results revealed that the potential midge habitats can be controlled through careful selection of the ground surface, the improvement of the site drainage, and choosing plants with the appropriate characteristics. Apart from choosing the appropriate type of paving surface, the integrity of the paving installation and the coverage of the ecological surface also influence prevention efficacy.

WEIGHT GAINS IN THE FIRST FOUR WEEKS OF INFANCY: A COMPARISON OF THREE DIETS

PEDIATRICS ◽  
1956 ◽  
Vol 18 (3) ◽  
pp. 362-368
Author(s):  
Ruth T. Gross ◽  
Lincoln E. Moses
Keyword(s):  
Human Milk ◽  
Statistical Methods ◽  
Full Term ◽  
Clinical Judgement ◽  
Careful Selection ◽  
Term Infants ◽  
Weight Gains ◽  
The Many ◽  
Selection Of

Four hundred seven healthy, full-term infants were divided into three groups and fed, respectively, a formula of evaporated milk and water with 5% carbohydrate; human milk; and a special modified evaporated milk designed to simulate human milk. No other foods were added to the diet. A comparison of the three groups was made, based on weight gains from birth to the end of the first 4 weeks. The conclusions refer only to weight gains; no attempt was made to determine the superiority of any particular diet. The data show no significant differences in the 4-week weight gains among the three groups of infants, although sensitive statistical methods could be validly applied to the problem. These methods are explained. The authors wish to emphasize the many variables which must be taken into account in a study of this sort; the necessity for careful selection of valid statistical methods; the importance of critical clinical judgement in the evaluation of the results.

The Design for Assembly Guidelines Transform a Product Innovation From a Loser to a Winner

1998 ◽  
Author(s):  
David H. Myszka
Keyword(s):  
Product Innovation ◽  
Computer Models ◽  
Design For Assembly ◽  
Careful Selection ◽  
Significant Cost ◽  
Success Stories ◽  
Modeling Process ◽  
Design Activities ◽  
Manual Review ◽  
Selection Of

Abstract Several manufacturer’s are witnessing soaring profits as a result of cost reductions derived from Design for Manufacturing and Assembly (DFMA) analyses. These successes are prompting others to turn to more refined computer models of product assemblies. However, much can be gained from a very routine analysis, using nothing more than the basic Design for Assembly (DFA) guidelines. These gains can be realized at a mere fraction of the resources needed for the computer models. This method of analysis is especially appealing to engineers whose time constraints require careful selection of design activities. This paper argues that DFMA analysis does not need to be an elaborate modeling process to produce significant cost improvements. This point is illustrated with an example of a redesign of a cooking range door. A manual review of the DFA guidelines turned a design innovation from a loser into a winner. Success stories from such informal analyses should promote greater implementation across industries that are hesitant in adopting DFMA practices.

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