scholarly journals Novel enhancer for male fertility dysfunction in STZ diabetic rats

2021 ◽  
Vol 9 (4) ◽  
pp. 189-206
Keyword(s):  
Plant Extract ◽  
Male Fertility ◽  
Diabetes Complications ◽  
Sperm Count ◽  
Diabetic Rats ◽  
Reproductive Hormones ◽  
Healthy Group ◽  
Treatment Of Diabetes ◽  
Male Hormones ◽  
Positive Effect

This new study evaluated effect of aqueous leaves extracts of Chrozophora tinctoria (L.) Rafin on male reproductive hormones and histological features of the testis diabetic rats. The results obtained showed remarkable increased of sperm count, viability and motility after treatment. Testosterone, FSH and LH hormones also increased with oral administration of the plant extract at dose 70 mg/kg of body weight. The results suggested the anti hyperglycemic property of the extract as well as its positive effect to maintain male hormones concentrations. Histological examination of the testis revealed improvement of spermatogenesis and Leydig cell proliferation with all doses of the extract. However, the histoarchitecture of the testis rats received 70 and 90 mg/kg of the plant extract, was found to be similar to the healthy group. These findings suggest that the extract can maintain the damage fertility in diabetic rats. These promising results may explain the use of this plant in the future for therapeutic treatment of diabetes complications associated subfertility.

Novel enhancer for male fertility dysfunction in STZ diabetic rats

2021 ◽  
Vol 9 (4) ◽  
pp. 177-190
Author(s):  
Muna Hasson Saoudi ◽  
◽  
Mohammed A. Auda ◽  
Keyword(s):  
Plant Extract ◽  
Male Fertility ◽  
Diabetes Complications ◽  
Sperm Count ◽  
Diabetic Rats ◽  
Reproductive Hormones ◽  
Healthy Group ◽  
Treatment Of Diabetes ◽  
Male Hormones ◽  
Positive Effect

This new study evaluated effect of aqueous leaves extracts of Chrozophora tinctoria (L.) Rafin on male reproductive hormones and histological features of the testis diabetic rats. The results obtained showed remarkable increased of sperm count, viability and motility after treatment. Testosterone, FSH and LH hormones also increased with oral administration of the plant extract at dose 70 mg/kg of body weight. The results suggested the anti hyperglycemic property of the extract as well as its positive effect to maintain male hormones concentrations. Histological examination of the testis revealed improvement of spermatogenesis and Leydig cell proliferation with all doses of the extract. However, the histoarchitecture of the testis rats received 70 and 90 mg/kg of the plant extract, was found to be similar to the healthy group. These findings suggest that the extract can maintain the damage fertility in diabetic rats. These promising results may explain the use of this plant in the future for therapeutic treatment of diabetes complications associated subfertility.

scholarly journals The relationship between diet, energy balance and fertility in men

2020 ◽  
Vol 90 (5-6) ◽  
pp. 514-526 ◽  
Author(s):  
Edyta Suliga ◽  
Stanisław Głuszek
Keyword(s):  
Energy Balance ◽  
Male Fertility ◽  
Sperm Count ◽  
Direct Analysis ◽  
Reproductive Hormones ◽  
Semen Parameters ◽  
The Right ◽  
Meta Analyses ◽  
The Impact ◽  
The Relationship

Abstract. Research conducted in recent years provides more and more evidence that diet can have a significant impact on male fertility. The aim of the study was to analyze the relationship between diet, energy balance and fertility in men. A comprehensive literature search of published studies in various languages, was carried out in electronic databases. The direct analysis included 96 works published between 2008 and 2018, including 12 randomized controlled trials and 23 systematic reviews and meta-analyses. A strong adherence to a healthy dietary pattern is positively correlated with total sperm count, progressive motility and total motile sperm count (all p < 0.05). However, attention is drawn to the fact that foods that are considered “healthy” can sometimes contain a significant amount of pollution, which negatively affect the semen parameters. An adequate intake of antioxidants or their supplementation have been quite effective in the prevention and treatment of male infertility. The improvement of pregnancy rate after antioxidant therapy ranged in various studies from 11% to 41%. An important problem, however, may be choosing the right dose of the supplement or finding an appropriate combination of antioxidants that may be more effective than any single antioxidant. The normalization of men’s body weight is beneficial for the quality of sperm and the concentration of male reproductive hormones. Further, long-term studies require the assessment of the impact of drastic weight loss after bariatric surgery on male fertility.

scholarly journals Effect of Lunasia amara Blanco on Sperm Number, Sperm Motility, and Testicular Histology of Male Rats

2015 ◽  
Vol 4 (2) ◽  
pp. 31
Author(s):  
Muhammad Ja’far Luthfi
Keyword(s):  
Sperm Motility ◽  
Male Fertility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Male Rats ◽  
Quality Analysis ◽  
Sprague Dawley ◽  
Sperm Analysis ◽  
Testicular Histology ◽  
Positive Effect

<p>Sanrego (<em>Lunasia amara</em>), has been used in the folk medicine to increase and/or to treat male fertility. However there is no scientific evidence to confirm the positive effect of the plant on an improvement of male fertility. The objective of this research was to study the effects of the plant (on adult Sprague-Dawley male rats) at the doses of 30 mg/kg, 60 mg/kg, and 90 mg/kg on the sperm count, motility, and testicular histology. Administration were given by force-feeding between 10.00 am and 12.00 pm daily for a period of 42 days followed by sperm quality analysis and testicular histology evaluation. The sperm analysis showed that the sanrego increased the sperm count and sperm motility. The testicular histology also revealed positive effect of the plant on spermatogenesis.   Overall the present study showed the sanrego is potential plant to increase male fertility.</p>

scholarly journals Heavy Metal Toxicosis and Male Fertility: The Role of Pentahydroxyflavone Quercetin: a Review

2021 ◽  
Vol 25 (7) ◽  
pp. 1277-1287
Author(s):  
S.I. Salihu ◽  
I.L. Yusuf ◽  
A. Abba ◽  
M.B. Tijjani ◽  
U.A. Maina ◽  
...  
Keyword(s):  
Sexual Behaviors ◽  
Male Fertility ◽  
Sperm Count ◽  
Hydroxysteroid Dehydrogenase ◽  
Reproductive Organs ◽  
Reproductive Hormones ◽  
Neuroprotective Activity ◽  
And Function ◽  
Daily Sperm Production

The effect of heavy metals (HMs) has been extensively studied. They cause diverse clinical manifestation through various mechanisms. Male fertility is among the most disturbing effect of HMs affecting family life in human and reproduction in animals. Notably among these effects is interference with the reproductive hormones, morphology and function of reproductive organs, sexual behaviors, and the spermiogram. Quercetin is a dietary flavanoid from edible plants and, has proven pharmacological properties in the treatment and management of many disease conditions. Quercetin ameliorates the adverse effects of HMs on male reproductive hormones by increasing the activity of 3β-hydroxysteroid dehydrogenase (3β- HSD) and 17β-hydroxysteroid dehydrogenase (17β-HSD) in the synthesis of testosterone. Quercetin chelates HMs, scavenge free radicals, and other cytotoxicant capable of disrupting the morphology and function of the male reproductive system. Apart from it neuroprotective activity on the pituitary gland and increased steroidogenesis, quercetin mitigate neurotransmitter that aid in copulation and improve histopathological changes in the brain due to HMs toxicity to improve sexual behavior. Quercetin was also found to be effective in increasing sperm count, daily sperm production, mortility, viability, and also decreased in the percentage of abnormal sperm morphology due to HMs toxicity. In conclusion quercetin was found to be effective in mitigating HMs toxicity that affects male fertility, and so, it is recommended to be incorporated into the treatment and management of HMs toxicity. Individuals who are at risk of HMs toxicity should take dietary plants that contain quercetin to minimize the effects of these metals.

Determinants of infertility in couples and methods for their correction

2021 ◽  
Vol 20 (1) ◽  
pp. 105-112
Author(s):  
E.V. Shikh ◽  
◽  
A.A. Makhova ◽  
E.D. Khaytovich ◽  
◽  
...  
Keyword(s):  
Sperm Motility ◽  
Male Fertility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Added Sugar ◽  
Trans Fats ◽  
Factors Affecting ◽  
Micronutrient Intake ◽  
Positive Effect

Nutrition is one of the main environmental factors affecting the reproductive system. The modern diet is characterized by higher consumption of high-calorie foods, saturated fats, trans fats, refined grains and added sugar. Despite the heterogeneity of the populations studied, in general, the data confirm a steady downward trend in male sperm quality in most Western countries, including an increase in the prevalence of conditions such as complete asthenozoospermia (lack of motility) and isolated asthenozoospermia (low sperm motility due to varicocele, infections or genetic factors). Clear patterns between nutrition and fertility have been identified. Studies have shown a significant positive effect of additional exogenous micronutrient intake on total sperm count (ω-3 and CoQ10); sperm concentration (selenium, zinc, ω-3 and CoQ10); sperm motility (selenium, zinc, ω-3, CoQ10 and carnitine); morphology (selenium, ω-3, CoQ10 and carnitine). Additional exogenous intake of micronutrients that affect sperm can be used as an effective and safe factor in modulating male fertility. Key words: coenzyme Q10, lipoic acid, male fertility, selenium, sperm, zinc

Effect of new dietary supplement on sperm quality

2012 ◽  
Vol 153 (45) ◽  
pp. 1787-1792 ◽  
Author(s):  
Mária Horváth ◽  
Endre Czeizel
Keyword(s):  
Adverse Effect ◽  
Clinical Trial ◽  
Dietary Supplement ◽  
Male Fertility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Before And After ◽  
The Usa ◽  
New Treatments

Introduction: There is a decline in male fertility thus new treatments are needed. Aims: To test the efficacy of a new dietary supplement developed in the USA and registered as a curing drug in Hungary (OGYI). Methods: In a clinical trial 100 men with low sperm quality (spermium count 5–20 M/ml, good motility 10–40%, and adverse shape 30–50%) were examined. Results: Sperm parameters were measured before and after a 3-month treatment and after another 3-month without treatment. This dietary supplement statistically and clinically significantly improved sperm count and motility. In 74 cases this dietary supplement demonstrated a beneficial effect on sperm quality (more than 10% increase in sperm count, or quality of motility, or shape); in 16 cases the improvement exceeded 30%. No adverse effect could be accounted for this treatment. Conclusions: This new dietary supplement may contribute to the treatment of male infertility. Orv. Hetil., 2012, 153, 1787–1792.

scholarly journals Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men

2021 ◽  
Vol 18 (4) ◽  
pp. 1742
Author(s):  
Thea Emily Benson ◽  
Anne Gaml-Sørensen ◽  
Andreas Ernst ◽  
Nis Brix ◽  
Karin Sørig Hougaard ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Male Fertility ◽  
Parental Education ◽  
Negative Binomial ◽  
Semen Quality ◽  
Sperm Count ◽  
Smoking Status ◽  
Sperm Concentration ◽  
First Trimester ◽  
Negative Binomial Regression Model

Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross–sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18–20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile–divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre–pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.

scholarly journals Glycemic Control Potential of Chemically Characterized Extract from Withania frutescens L. Roots in Severe Diabetes-Induced Mice

2021 ◽  
Vol 11 (9) ◽  
pp. 3998
Author(s):  
Abdelfattah El Moussaoui ◽  
Hamza Mechchate ◽  
Mohammed Bourhia ◽  
Imane Es-safi ◽  
Ahmad Mohammad Salamatullah ◽  
...  
Keyword(s):  
Chemical Analysis ◽  
Plant Extract ◽  
Biochemical Parameters ◽  
Pharmaceutical Drugs ◽  
Glucose Lowering ◽  
Natural Agents ◽  
Severe Diabetes ◽  
Treatment Of Diabetes ◽  
Different Doses

Diabetes mellitus is a metabolic syndrome that causes impairment, mortality, and many other complications. Insulin and several synthetic medications are currently used in the treatment of diabetes. However, these pharmaceutical drugs are costly, and therefore medicines place priority on alternatives to fight this lethal disease. This modest study aims to investigate the chemical composition, antidiabetic and antihyperglycemic potentials along with subacute toxicity (bodyweight change and biochemical parameters) of hydroethanol extract from Withania frutescens L. roots (WFRE). The chemical analysis was carried out using GC–MS after extract silylation. The chemical analysis identified many potentially active compounds that may determine the antidiabetic results of WFRE. The antidiabetic effect of WFRE was evaluated in mice with severe diabetes using oral administration of doses up to 400 mg/kg for 28 days. The results of the antidiabetic and antihyperglycemic tests indicate that WFRE possesses promising glucose-lowering effects and, as a result, it may serve as an antidiabetic alternative for long-term use. The 4-week treatments with different doses of plant extract did not alter the bodyweight appearance of the diabetic mice nor their biochemical parameters (AST and ALT). The findings obtained indicate that the studied plant extract controlled severe diabetes in mice. Therefore, Withania frutescens L. can serve society as it provides natural agents to control diabetes.

scholarly journals Tert-butylhydroquinone attenuates doxorubicin-induced dysregulation of testicular cytoprotective and steroidogenic genes, and improves spermatogenesis in rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Godwin Adakole Ujah ◽  
Victor Udo Nna ◽  
Joseph Bagi Suleiman ◽  
Chinedum Eleazu ◽  
Chukwuemeka Nwokocha ◽  
...  
Keyword(s):  
Body Weight ◽  
Sperm Count ◽  
Reproductive Hormones ◽  
Nuclear Antigen ◽  
Albino Rats ◽  
Target Cells ◽  
Negative Effects ◽  
Related Proteins ◽  
Proliferating Cell ◽  
Cancerous Cells

AbstractDoxorubicin (DOX) is a broad-spectrum chemotherapeutic drug used in the treatment of cancers. It acts by generating reactive oxygen species in target cells. The actions are, however, not limited to cancerous cells as it attacks healthy cells, killing them. This study investigated the benefits of the antioxidant, tert-butylhydroquinone (tBHQ), on testicular toxicity following DOX therapy. Twenty-four adult male albino rats were assigned randomly into four groups (n = 6), namely: normal control (NC), tBHQ, DOX and tBHQ + DOX groups. tBHQ (50 mg/kg body weight in 1% DMSO) was administered orally for 14 consecutive days, while a single DOX dose (7 mg/kg body weight) was administered intraperitoneally on Day 8. DOX decreased sperm count, motility and viability, and decreased the levels of steroidogenesis-related proteins, and reproductive hormones. Furthermore, DOX decreased the expression of antioxidant cytoprotective genes, and decreased the protein level of proliferating cell nuclear antigen in the testis. Conversely, DOX increased the expression of pro-inflammatory and pro-apoptotic genes in the testis. These negative effects were ameliorated following the intervention with tBHQ. Our results suggest that tBHQ protects the testis and preserves both steroidogenesis and spermatogenesis in DOX-treated rats through the suppression of oxidative stress, inflammation and apoptosis.

scholarly journals Effect of Polyherbal Mixtures on the Treatment of Diabetes

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Aparajeya Panda ◽  
Somanatha Jena ◽  
Pramod Kumar Sahu ◽  
Sanghamitra Nayak ◽  
Payodhar Padhi
Keyword(s):  
Blood Glucose ◽  
Elevated Level ◽  
Treated Group ◽  
Diabetic Rats ◽  
Lipid Levels ◽  
Beneficial Effects ◽  
Estimated Parameters ◽  
Treatment Of Diabetes ◽  
Dose Levels ◽  
Elevated Lipid

The study focuses on polyherbal antidiabetic formulations of different plants used in the treatment of diabetes mixed in different concentrations. In the present study eleven medicinal plants with proven antidiabetic and related beneficial effects were selected for the preparation of five mixtures. The efficacy of prepared mixtures has been tested on streptozotocin- (STZ-) induced diabetic rats and compared with a commercially available drug glibenclamide. The mixtures at the dose levels of 400 mg/kg b.w. produced a significant decrease in blood glucose level by 69.6%, 70.97%, 64.45%, 71.82%, and 64.44% after 21 days of treatment. The elevated level of SGPT, SGOT, and ALP in the diabetic controlled group reflected the significant alteration of liver function by STZ induction and was found to be equipotent to glibenclamide in restoration of the elevated enzyme levels to normal. The elevated lipid levels (triglyceride and total cholesterol) were restored to near normal by these mixtures for all the estimated parameters. The results of the mixtures on treated group were found to restore the glycemic level to the near normal level thereby indicating antihyperglycemic activity of the formulated mixtures.

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